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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none HO O HO From Cholersterol Biosynthesis Signaling Steroid Hormone 17-a-OH-Pregnenolone HO =O CH OH 17-a-OH-Progesterone To Androgen Synthesis and Metabolism C =O CH C =O CH C O =O CH C 3 3 3 2 OH HO OH =O CH C 3 O O =O CH C 2 OH HO OH 11-Deoxycortisol Cortisol Cortisone O =O CH C 2 OH C O H HO Aldosterone 11b, 21-Dihydroxy-3,20- 5b-Pregnan-18-al 3a,11b,21-Trihydroxy-20-Oxo- 5b-Pregnan-18-al 17a,21-Dihydroxy-5b- Pregnane-3,11,20-trione Urocortisone Urocortisol Cortol Cortolone 11b,17a 21-Trihydroxy-5b Pregnane 3,20-dione Glucuronides 3a-OH-5b-Pregnane-20-one 5b-Pregnane-3,20-dione HO CH C 3 H H -OH Glucocorticoids * * Progesterone Degradation Cyp11a1 Steroid delta-Isomerase Corticosterone 18-Monooxy 3-Oxo-5b-Steroid Dh 3B-OH-delta-Steroid Dh 20b-Hydroxysteroid Dh Steroid delta-Isomerase Cortisone beta-reductase Cyp21a1 Cyp11b1 Cyp17a1 Cyp17a1 3B-OH-delta-Steroid Dh RGD:708361 (R)20-hydroxysteroid Dh RGD:708361 Hsd11b2 Hsd11b1 Cholesterol Pregnenolone Progesterone 11-Deoxycorticosterone Corticosterone 18-Hydroxy-Corticosterone Pregnanediol Name: Glucocorticoid Metabolism Last Modified: 10/17/2013 Organism: Rattus norvegicus
Description
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Quality Tags
Fix interactions Comment: 376 out of 379 lines are not properly connected.
Please help improving this pathway by connecting the ends of interactions to nodes.
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Review changes for Approved Revision 116969 Martina Kutmon .
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Annotate nodes Comment: 16 out of 25 DataNodes have a missing external reference. Check DataNode table at the bottom of the page.
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Ontology Terms
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History
External references
DataNodes
Name Type Database reference Comment (R)20-hydroxysteroid Dh GeneProduct 11-Deoxycorticosterone Metabolite 18-Hydroxy-Corticosterone Metabolite 20b-Hydroxysteroid Dh GeneProduct 3-Oxo-5b-Steroid Dh GeneProduct 3B-OH-delta-Steroid Dh GeneProduct Cholesterol Metabolite Corticosterone Metabolite Corticosterone 18-Monooxy GeneProduct Cortisone beta-reductase GeneProduct Cyp11a1 GeneProduct 29680 (Entrez Gene) Cyp11b1 GeneProduct 24293 (Entrez Gene) Cyp17a1 GeneProduct 25146 (Entrez Gene) Cyp21a1 GeneProduct 24298 (Entrez Gene) Hsd11b1 GeneProduct 25116 (Entrez Gene) Hsd11b2 GeneProduct 25117 (Entrez Gene) Pregnanediol Metabolite Pregnenolone Metabolite Progesterone Metabolite RGD:708361 GeneProduct 191574 (Entrez Gene) Steroid delta-Isomerase GeneProduct
Annotated Interactions
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