Eukaryotic transcription initiation (Saccharomyces cerevisiae)

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1, 2TFIIF5Steps 4) Transcription elongation by NTPsdsDNAPrimary RNA transcript33RNA polymerase III5(mRNA, snRNPs)53TFIIA35cell growth5TFIIFTFIIHTFIIDGene Regulatory ProteinsTATA5TFIIETFIIDRNA polymerase IIHOMOLOGY MAPPRNA pol II3RNA polymerase ITFIIFSteps 1) TBP binds TATA box(recognize surface DNA geometry)TATA Box binding5TFIIB335TATATFIIBproteinSteps 2) Association of TIFs and RNA polymeraseTFIIHSteps 5) RNA elongation with CDT phosphorylation(small stable RNAs)3Steps 3) DNA melting by association with TFIIHTFIIA55TFIIE3(large ribosomal RNAs)Transcription Initiation Factors (TIFs)TATACCL1GTF2E2POLR3DILKSUA7TFB3POLR3ERPO21RPC11RET1SPT15RPB7KIN28RPB2RPB11TAF9SSL2POLR2IRAD3POLR2KTAF5RPO26TOA2Polr1eGTF2E1GTF2H2RPA190GTF2H1RPC19TAF12TAF7TFG2TFB2TAF13RPB5RPA135RPB8TAF6TFB4RPC25RPB3


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm

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Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117292view11:03, 20 May 2021EweitzModified title
77440view20:27, 8 September 2014MaintBotremoved old homology label
71355view18:31, 17 October 2013MaintBotRemoved source from datanodes with empty id
70240view21:28, 15 July 2013MaintBotupdated to 2013 schema
67213view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
41819view04:49, 2 March 2011MaintBotRemoved redundant pathway information and comments
35529view13:59, 12 February 2010Thomasadded literature
35518view13:52, 12 February 2010ThomasModified description
34363view22:31, 9 December 2009MaintBotAutomatic update of empty xrefs
21576view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:RNA transcription Reactome]] moved to [[Pathway:WP425]]: Moved to stable identifier
8546view14:03, 7 January 2008MaintBotAdded to category $category
8544view14:02, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL1GeneProduct856136 (Entrez Gene)
GTF2E1GeneProduct
GTF2E2GeneProduct
GTF2H1GeneProduct
GTF2H2GeneProduct
ILKGeneProduct
KIN28GeneProduct851450 (Entrez Gene)
POLR2IGeneProduct
POLR2KGeneProduct
POLR3DGeneProduct
POLR3EGeneProduct
Polr1eGeneProduct
RAD3GeneProduct856918 (Entrez Gene)
RET1GeneProduct854382 (Entrez Gene)
RPA135GeneProduct856119 (Entrez Gene)
RPA190GeneProduct854519 (Entrez Gene)
RPB11GeneProduct854157 (Entrez Gene)
RPB2GeneProduct854322 (Entrez Gene)
RPB3GeneProduct854791 (Entrez Gene)
RPB5GeneProduct852451 (Entrez Gene)
RPB7GeneProduct852013 (Entrez Gene)
RPB8GeneProduct854399 (Entrez Gene)
RPC11GeneProduct851615 (Entrez Gene)
RPC19GeneProduct855609 (Entrez Gene)
RPC25GeneProduct853713 (Entrez Gene)
RPO21GeneProduct851415 (Entrez Gene)
RPO26GeneProduct856317 (Entrez Gene)
SPT15GeneProduct856891 (Entrez Gene)
SSL2GeneProduct854663 (Entrez Gene)
SUA7GeneProduct856201 (Entrez Gene)
TAF12GeneProduct851723 (Entrez Gene)
TAF13GeneProduct854875 (Entrez Gene)
TAF5GeneProduct852497 (Entrez Gene)
TAF6GeneProduct852766 (Entrez Gene)
TAF7GeneProduct855267 (Entrez Gene)
TAF9GeneProduct855276 (Entrez Gene)
TFB2GeneProduct855981 (Entrez Gene)
TFB3GeneProduct852071 (Entrez Gene)
TFB4GeneProduct856169 (Entrez Gene)
TFG2GeneProduct852888 (Entrez Gene)
TOA2GeneProduct853807 (Entrez Gene)

Annotated Interactions

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