Actin cytoskeleton regulation (Bos taurus)
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Actomyosin
assembly contraction
RTK
+p
?
stress fiber
Actin polymerization
GF
PI3K
Filipodia
Focal adhesion
assembly
Stabilization
of actin
Actin polymerization
stress fiber
Gene Expression
RTK
GPCR
Lamellipodia
RAS
PI3K
Growth Factor (GF)
Chemotatic factor
Focal complex
assembly
-p
GPCR
RAS
Chemotactic factor
Actin
polymerization
FGF4
Apc2
PIP2
MAPK6
INS1
SSH2
PDGFRA
MAPK1
CHRM2
FGFR1
PIP4K2B
BRAF
RRAS
Acetylcholine
PAK6
CD14
FGF23
ACTG1
FGF22
PIK3R4
PDGFRB
FGF11
Bradykinin
ARHGEF6
MYL3
CSK
PXN
PIK3CG
MAPK4
KRAS
FGF12
FGF20
Focal Adhesion
pathway
FGF8
PIK3CA
PFN1
RAF1
Focal Adhesion
pathway
PIK3C2G
FGF9
VCL
FGF21
ENAH
PIK3R3
PIK3C3
EZR
NRAS
FGF14
LIMK1
ARHGEF7
ARPC5
FGFR2
FGF16
DIAP3
ROCK2
PIP2
VIL1
DIAP1
SOS2
FGF2
SOS1
FGF1
PIK3R1
CHRM3
PAK4
F2
FN1
FGFR4
MAPK3
PIP5KL1
RASSF7
FGF18
PIP4K2C
PAK3
ACTB
VCL
LOC100336547
GSN
PIK3R2
FGFR3
PIP5K1C
PIP4K2A
Adherens junction
pathway
BAIAP2
FGF15
FGF17
GNG12
ARHGEF4
PDGFB
PIK3R5
ACTB
MYH10
BRK1
PIK3C2A
ITGA1
BDKRB1
RRAS2
FGF3
MAPK Signaling
pathway
F2R
PDGFA
FGF7
MOS
CHRM4
MYLK
RAC1
ACTN1
CDC42
PAK2
LOC442775
FGF6
APC
BAIAP2
PIP4K2A
CHRM1
WASF1
ACTG1
BCAR1
CFL1
MAP2K1
IQGAP1
ABI2
MYL1
BDKRB2
PIK3CD
MRAS
ACTB
PIP5K1B
LPS
CYFIP2
SLC9A1
PAK7
RAC3
ARHGAP35
FGD1
ROCK1
PPP1R12A
PIP5K1A
FGF5
ARPC5
TMSB4X
EGFR
RAC2
PIK3C2B
PAK1
GNA13
RHOA
RDX
CRK
GIT1
PTK2
EGF
ARHGEF6
MSN
MAP2K2
ACTG1
WASF2
RAC1P4
FGF13
GNA12
INS2
NCKAP1
PFN1
SSH3
CFL2
PIK3CB
DOCK1
FGF10
SSH1
VAV1
ARHGEF1
PIP3
CHRM5
Description
http://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP51(r45278)
with a 90% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
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Ontology Terms
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Bibliography
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History
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Revision
Action
Time
User
Comment
120933
view
09:05, 1 February 2022
Egonw
Made four pathways clickable
117595
view
11:36, 21 May 2021
Eweitz
Modified title
80894
view
15:30, 30 June 2015
Mkutmon
homology conversion
72126
view
07:48, 25 October 2013
Mkutmon
added datasource for pathway datanodes
71429
view
19:03, 17 October 2013
MaintBot
Automated update of data sources
63458
view
17:18, 10 May 2013
MaintBot
Updated to 2013 gpml schema
48126
view
05:45, 9 May 2012
MaintBot
Updating from human to fix xref duplication
40593
view
19:33, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33830
view
00:28, 9 December 2009
MaintBot
Automatic update of empty xrefs
32520
view
12:56, 17 August 2009
MaintBot
Fixed text labels
32207
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12:41, 15 August 2009
MaintBot
Fixed text labels
31695
view
11:48, 14 August 2009
MaintBot
Fixed group labels
31218
view
19:40, 13 August 2009
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Fixed text labels
30631
view
22:26, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABI2
GeneProduct
537711 (Entrez Gene)
ACTB
GeneProduct
280979 (Entrez Gene)
ACTG1
GeneProduct
404122 (Entrez Gene)
ACTN1
GeneProduct
524770 (Entrez Gene)
APC
GeneProduct
533233 (Entrez Gene)
ARHGAP35
GeneProduct
540310 (Entrez Gene)
ARHGEF1
GeneProduct
513377 (Entrez Gene)
ARHGEF4
GeneProduct
505852 (Entrez Gene)
ARHGEF6
GeneProduct
533823 (Entrez Gene)
ARHGEF7
GeneProduct
524352 (Entrez Gene)
ARPC5
GeneProduct
614345 (Entrez Gene)
Acetylcholine
Metabolite
51-84-3 (CAS)
Adherens junction pathway
Pathway
Apc2
GeneProduct
BAIAP2
GeneProduct
507837 (Entrez Gene)
BCAR1
GeneProduct
527550 (Entrez Gene)
BDKRB1
GeneProduct
532119 (Entrez Gene)
BDKRB2
GeneProduct
538896 (Entrez Gene)
BRAF
GeneProduct
536051 (Entrez Gene)
BRK1
GeneProduct
540092 (Entrez Gene)
Bradykinin
Metabolite
58-82-2 (CAS)
CD14
GeneProduct
281048 (Entrez Gene)
CDC42
GeneProduct
532712 (Entrez Gene)
CFL1
GeneProduct
534553 (Entrez Gene)
CFL2
GeneProduct
539332 (Entrez Gene)
CHRM1
GeneProduct
281684 (Entrez Gene)
CHRM2
GeneProduct
522170 (Entrez Gene)
CHRM3
GeneProduct
281685 (Entrez Gene)
CHRM4
GeneProduct
512928 (Entrez Gene)
CHRM5
GeneProduct
281686 (Entrez Gene)
CRK
GeneProduct
512841 (Entrez Gene)
CSK
GeneProduct
509246 (Entrez Gene)
CYFIP2
GeneProduct
518833 (Entrez Gene)
DIAP1
GeneProduct
DIAP3
GeneProduct
DOCK1
GeneProduct
537203 (Entrez Gene)
EGF
GeneProduct
530315 (Entrez Gene)
EGFR
GeneProduct
407217 (Entrez Gene)
ENAH
GeneProduct
513095 (Entrez Gene)
EZR
GeneProduct
281574 (Entrez Gene)
F2
GeneProduct
280685 (Entrez Gene)
F2R
GeneProduct
526585 (Entrez Gene)
FGD1
GeneProduct
100124501 (Entrez Gene)
FGF10
GeneProduct
326285 (Entrez Gene)
FGF11
GeneProduct
613386 (Entrez Gene)
FGF12
GeneProduct
FGF1
GeneProduct
281160 (Entrez Gene)
FGF13
GeneProduct
506924 (Entrez Gene)
FGF14
GeneProduct
FGF15
GeneProduct
FGF16
GeneProduct
540758 (Entrez Gene)
FGF17
GeneProduct
FGF18
GeneProduct
533929 (Entrez Gene)
FGF20
GeneProduct
539083 (Entrez Gene)
FGF21
GeneProduct
785576 (Entrez Gene)
FGF22
GeneProduct
519657 (Entrez Gene)
FGF2
GeneProduct
281161 (Entrez Gene)
FGF23
GeneProduct
530239 (Entrez Gene)
FGF3
GeneProduct
618481 (Entrez Gene)
FGF4
GeneProduct
618474 (Entrez Gene)
FGF5
GeneProduct
536771 (Entrez Gene)
FGF6
GeneProduct
540317 (Entrez Gene)
FGF7
GeneProduct
616885 (Entrez Gene)
FGF8
GeneProduct
326284 (Entrez Gene)
FGF9
GeneProduct
613731 (Entrez Gene)
FGFR1
GeneProduct
281768 (Entrez Gene)
FGFR2
GeneProduct
404193 (Entrez Gene)
FGFR3
GeneProduct
281769 (Entrez Gene)
FGFR4
GeneProduct
317696 (Entrez Gene)
FN1
GeneProduct
Focal Adhesion pathway
Pathway
WP306
GIT1
GeneProduct
515088 (Entrez Gene)
GNA12
GeneProduct
515159 (Entrez Gene)
GNA13
GeneProduct
505611 (Entrez Gene)
GNG12
GeneProduct
286850 (Entrez Gene)
GSN
GeneProduct
535077 (Entrez Gene)
INS1
GeneProduct
INS2
GeneProduct
IQGAP1
GeneProduct
532715 (Entrez Gene)
ITGA1
GeneProduct
535951 (Entrez Gene)
KRAS
GeneProduct
541140 (Entrez Gene)
LIMK1
GeneProduct
535225 (Entrez Gene)
LOC100336547
GeneProduct
100336547 (Entrez Gene)
LOC442775
GeneProduct
LPS
Metabolite
C00338 (KEGG Compound)
MAP2K1
GeneProduct
533199 (Entrez Gene)
MAP2K2
GeneProduct
510434 (Entrez Gene)
MAPK Signaling pathway
Pathway
WP382
MAPK1
GeneProduct
327672 (Entrez Gene)
MAPK3
GeneProduct
531391 (Entrez Gene)
MAPK4
GeneProduct
MAPK6
GeneProduct
538094 (Entrez Gene)
MOS
GeneProduct
444869 (Entrez Gene)
MRAS
GeneProduct
540803 (Entrez Gene)
MSN
GeneProduct
540426 (Entrez Gene)
MYH10
GeneProduct
317655 (Entrez Gene)
MYL1
GeneProduct
317657 (Entrez Gene)
MYL3
GeneProduct
618352 (Entrez Gene)
MYLK
GeneProduct
NCKAP1
GeneProduct
100300817 (Entrez Gene)
NRAS
GeneProduct
506322 (Entrez Gene)
PAK1
GeneProduct
533729 (Entrez Gene)
PAK2
GeneProduct
513673 (Entrez Gene)
PAK3
GeneProduct
534526 (Entrez Gene)
PAK4
GeneProduct
539742 (Entrez Gene)
PAK6
GeneProduct
539224 (Entrez Gene)
PAK7
GeneProduct
513432 (Entrez Gene)
PDGFA
GeneProduct
505908 (Entrez Gene)
PDGFB
GeneProduct
540106 (Entrez Gene)
PDGFRA
GeneProduct
282301 (Entrez Gene)
PDGFRB
GeneProduct
527165 (Entrez Gene)
PFN1
GeneProduct
513895 (Entrez Gene)
PIK3C2A
GeneProduct
537790 (Entrez Gene)
PIK3C2B
GeneProduct
537396 (Entrez Gene)
PIK3C2G
GeneProduct
513301 (Entrez Gene)
PIK3C3
GeneProduct
534815 (Entrez Gene)
PIK3CA
GeneProduct
282306 (Entrez Gene)
PIK3CB
GeneProduct
517948 (Entrez Gene)
PIK3CD
GeneProduct
504531 (Entrez Gene)
PIK3CG
GeneProduct
530001 (Entrez Gene)
PIK3R1
GeneProduct
282307 (Entrez Gene)
PIK3R2
GeneProduct
282308 (Entrez Gene)
PIK3R3
GeneProduct
286865 (Entrez Gene)
PIK3R4
GeneProduct
507414 (Entrez Gene)
PIK3R5
GeneProduct
614838 (Entrez Gene)
PIP2
Metabolite
C04637 (KEGG Compound)
PIP3
Metabolite
C05981 (KEGG Compound)
PIP4K2A
GeneProduct
533289 (Entrez Gene)
PIP4K2B
GeneProduct
539211 (Entrez Gene)
PIP4K2C
GeneProduct
540005 (Entrez Gene)
PIP5K1A
GeneProduct
100125224 (Entrez Gene)
PIP5K1B
GeneProduct
537654 (Entrez Gene)
PIP5K1C
GeneProduct
508819 (Entrez Gene)
PIP5KL1
GeneProduct
523736 (Entrez Gene)
PPP1R12A
GeneProduct
PTK2
GeneProduct
506270 (Entrez Gene)
PXN
GeneProduct
517456 (Entrez Gene)
RAC1
GeneProduct
281440 (Entrez Gene)
RAC1P4
GeneProduct
RAC2
GeneProduct
327671 (Entrez Gene)
RAC3
GeneProduct
619066 (Entrez Gene)
RAF1
GeneProduct
521196 (Entrez Gene)
RASSF7
GeneProduct
538490 (Entrez Gene)
RDX
GeneProduct
517111 (Entrez Gene)
RHOA
GeneProduct
338049 (Entrez Gene)
ROCK1
GeneProduct
785911 (Entrez Gene)
ROCK2
GeneProduct
282041 (Entrez Gene)
RRAS2
GeneProduct
519269 (Entrez Gene)
RRAS
GeneProduct
616503 (Entrez Gene)
SLC9A1
GeneProduct
317654 (Entrez Gene)
SOS1
GeneProduct
537682 (Entrez Gene)
SOS2
GeneProduct
100138040 (Entrez Gene)
SSH1
GeneProduct
538233 (Entrez Gene)
SSH2
GeneProduct
512652 (Entrez Gene)
SSH3
GeneProduct
514643 (Entrez Gene)
TMSB4X
GeneProduct
VAV1
GeneProduct
617345 (Entrez Gene)
VCL
GeneProduct
783645 (Entrez Gene)
VIL1
GeneProduct
281573 (Entrez Gene)
WASF1
GeneProduct
531488 (Entrez Gene)
WASF2
GeneProduct
504482 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions