Complement and coagulation cascades (Pan troglodytes)
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Cell adhesion,
migration,
profileration, etc
Alternative Pathway
Thrombin
C4a
Cell lysis
Extrinsic pathway
C4b/2a
Cross-linked
fibrin polymer
Degredation
C3
Convertase
C5a
C3a
Coagulation Cascade
C3b/Bb
C3b
Cell adhesion,
migration,
profileration, etc
Complement Cascade
C3b/4b, C3b, C3d
Fibrinolytic system
Classical Pathway
Platelet, monocyte,
lymphocyte,
endothelial cells,
smooth muscle cells
activation, etc
Kinin kallikrein system
fibrin degredation
products
Vascular injury
Mediators
Muscle contraction,
Chemotaxis,
Phagocyte recruitment
Inflammation, etc.
Lectin Pathway
Clot
Zymosan,
insulin, etc.
Antibody/antigen
complex
Collagen,
basement membrane,
activated platelets, etc.
membrane attack complex
CRRY
F7
C1QB
CR1
Bradykinin
F3
KLKB1
SERPIND1
SERPINA1
ADN
F9
SERPINE1
PLAUR
C1QC
VWF
Hc
SERPINF2
MASP2
PROC
Daf2
C1R
F13B
C4
C6
KNG1
CFH
CFI
109821
F12
CD59A
C3AR1
F5
Fibrin monomer
C1S
C7
SERPING1
F8
Daf1
PLAU
CPB2
PLAT
CD46
C9
C4BP
C5AR1
MASP1
H2-BF
C1QA
PROS1
C8G
CR2
C3
F10
TFPI
A2M
BDKRB1
THBD
F2R
MBL1
SERPINC1
FGB
PLG
C2
SERPINA5
F2
Description
No description
Comments
GenMAPP notes
http://www.genome.jp/dbget-bin/get
pathway?org name=mmu&mapno=04610
GenMAPP remarks
Adapted from KEGG (see notes)
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP558(r22582)
with a 58% conversion rate.
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Quality Tags
Ontology Terms
Saving...
No Tags!
Bibliography
''''; https://www.genome.jp/dbget-bin/www_bget?pathway+map04610,
History
View all...
Compare
Revision
Action
Time
User
Comment
122636
view
17:53, 22 April 2022
Khanspers
122583
view
10:00, 18 April 2022
Eweitz
Modified title
89201
view
04:00, 23 August 2016
Ariutta
Ontology Term : 'hemostasis pathway' added !
89200
view
04:00, 23 August 2016
Ariutta
Ontology Term : 'coagulation cascade pathway' added !
89199
view
04:00, 23 August 2016
Ariutta
Ontology Term : 'complement system pathway' added !
71692
view
19:42, 17 October 2013
MaintBot
Automated update of data sources
69308
view
18:43, 8 July 2013
MaintBot
Updated to 2013 gpml schema
41618
view
02:02, 2 March 2011
MaintBot
Removed redundant pathway information and comments
38707
view
19:28, 23 September 2010
AlexanderPico
34346
view
22:20, 9 December 2009
MaintBot
Automatic update of empty xrefs
33587
view
09:51, 1 December 2009
MaintBot
Removed group label
31610
view
22:13, 13 August 2009
MaintBot
Fixed text labels
30507
view
21:44, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
A2M
GeneProduct
465372 (Entrez Gene)
ADN
GeneProduct
BDKRB1
GeneProduct
Bradykinin
Metabolite
C1QA
GeneProduct
749231 (Entrez Gene)
C1QB
GeneProduct
469214 (Entrez Gene)
C1QC
GeneProduct
456612 (Entrez Gene)
C1R
GeneProduct
466939 (Entrez Gene)
C1S
GeneProduct
451808 (Entrez Gene)
C2
GeneProduct
C3
GeneProduct
455644 (Entrez Gene)
C3AR1
GeneProduct
466942 (Entrez Gene)
C4
GeneProduct
C4BP
GeneProduct
C5AR1
GeneProduct
468931 (Entrez Gene)
C6
GeneProduct
449612 (Entrez Gene)
C7
GeneProduct
738238 (Entrez Gene)
MGI:88235 LL:109828
C8G
GeneProduct
C9
GeneProduct
CD46
GeneProduct
469663 (Entrez Gene)
CD59A
GeneProduct
CFH
GeneProduct
457601 (Entrez Gene)
CFI
GeneProduct
471271 (Entrez Gene)
CPB2
GeneProduct
452582 (Entrez Gene)
CR1
GeneProduct
449643 (Entrez Gene)
CR2
GeneProduct
457690 (Entrez Gene)
CRRY
GeneProduct
Daf1
GeneProduct
Daf2
GeneProduct
F10
GeneProduct
452679 (Entrez Gene)
F12
GeneProduct
462304 (Entrez Gene)
F13B
GeneProduct
735857 (Entrez Gene)
F2
GeneProduct
451158 (Entrez Gene)
F2R
GeneProduct
471510 (Entrez Gene)
F3
GeneProduct
457038 (Entrez Gene)
F5
GeneProduct
457500 (Entrez Gene)
F7
GeneProduct
744785 (Entrez Gene)
F8
GeneProduct
473838 (Entrez Gene)
F9
GeneProduct
465887 (Entrez Gene)
FGB
GeneProduct
461558 (Entrez Gene)
Fibrin monomer
Metabolite
H2-BF
GeneProduct
Hc
GeneProduct
KLKB1
GeneProduct
493182 (Entrez Gene)
KNG1
GeneProduct
460916 (Entrez Gene)
MASP1
GeneProduct
460925 (Entrez Gene)
MASP2
GeneProduct
736039 (Entrez Gene)
MBL1
GeneProduct
PLAT
GeneProduct
472748 (Entrez Gene)
PLAU
GeneProduct
738078 (Entrez Gene)
PLAUR
GeneProduct
450103 (Entrez Gene)
PLG
GeneProduct
463117 (Entrez Gene)
PROC
GeneProduct
459593 (Entrez Gene)
PROS1
GeneProduct
460533 (Entrez Gene)
SERPINA1
GeneProduct
467541 (Entrez Gene)
SERPINA5
GeneProduct
SERPINC1
GeneProduct
457528 (Entrez Gene)
SERPIND1
GeneProduct
745390 (Entrez Gene)
SERPINE1
GeneProduct
472467 (Entrez Gene)
SERPINF2
GeneProduct
SERPING1
GeneProduct
748148 (Entrez Gene)
TFPI
GeneProduct
470603 (Entrez Gene)
THBD
GeneProduct
469898 (Entrez Gene)
VWF
GeneProduct
451773 (Entrez Gene)
109821
GeneProduct
Annotated Interactions
No annotated interactions
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Discussion
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