G1 to S cell cycle control (Mus musculus)

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1TTTCC/GCGCpuCheckpointudp1cakeRbDependent KinasesDNA replicationCyclin DscomplexeG2 Phase-M phasepG1 CyclinpG1 PhaseDNA polymerasesCyclin EspE2fppG1/S transition Phaseborigen recognitionG1/S transition CyclinDependent KInasespG1/S Cell Cyclephosphorylation of proteinsinvolved in G1/S transitioninactivebCell cycle DNA replication genesDegradationCdk4Ccnd1CdkOrc4lTfdp1CdkCdk4E2fOrc1lCdc2aMcm3Cdkn2aOrc3lCcnb1-rs1Tfdp2Cdkn2cRbCdk7Cdk2Pola2Prim2E2f2p53Ccnd3Pole2Rbl1E2f4Ccnd2Cdkn2bWee1Cdkn1bRpa2Rpa3Cdc2aE2f3Mnat1Cdkn1aCdk6Pkmyt1CyclinDTrp53CyclinDCcna1RbCdk6Mcm2Mdm2Mcm5Gadd45aCdkn2dE2f1E2f5AtmCcne1Cdc45lCcng2dp1Mcm7PoleCdkCyclinEE2fPcnaPrim1Orc5lCcne2Mcm6Mcm4CcnhCdc25aOrc6lRb1Orc2lRpa1Cdk7Cdkn1cE2f6CyclinECdkMycu


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.

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Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
84705view22:06, 15 March 2016Khanspersremoved problematic shapes, added states
78432view10:26, 7 January 2015MaintBotadded missing graphIds
72012view12:23, 24 October 2013Mkutmonfixed unconnected lines
71720view20:16, 17 October 2013MaintBotAutomated update of data sources
69776view12:30, 11 July 2013Mkutmonfixed unconnected lines
69081view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
67268view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
41269view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35821view21:54, 17 February 2010KhanspersAdded lit ref
35820view21:53, 17 February 2010KhanspersModified description
33387view14:42, 30 November 2009MaintBotRemoved group label
32957view20:34, 28 September 2009MaintBotadded connectors
32956view20:27, 28 September 2009MaintBotPeriodical save, work in progress
32087view13:41, 14 August 2009MaintBotFixed group labels
21552view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:WP413]]: Moved to stable identifier
7946view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:Mus musculus:Cell Cycle-G1 to S control Reactome]]: Renaming species
7598view16:03, 18 December 2007MaintBotfixed category names
7206view12:33, 4 November 2007MaintBotAdded categories to GPML
7184view21:02, 2 November 2007Nsalomonisassigned groups
7183view20:48, 2 November 2007Nsalomonisremoved-Crebs
6623view04:16, 13 June 2007Nsalomonisadded additional valid edges, except where edges should connect groups
6622view04:13, 13 June 2007Nsalomonisattempting to add valid edges
6621view04:10, 13 June 2007Nsalomonisreversed bracket... last save didn't show up
6423view22:18, 22 May 2007A.C.Zambongpml file for [[Mouse:Cell_Cycle-G1_to_S_control_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AtmGeneProduct11920 (Entrez Gene)
Ccna1GeneProduct12427 (Entrez Gene)
Ccnb1-rs1GeneProduct12429 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Ccne2GeneProduct12448 (Entrez Gene)
Ccng2GeneProduct12452 (Entrez Gene)
CcnhGeneProduct66671 (Entrez Gene)
Cdc25aGeneProduct12530 (Entrez Gene)
Cdc2aGeneProduct12534 (Entrez Gene)
Cdc45lGeneProduct12544 (Entrez Gene)
CdkGeneProduct
Cdk2GeneProduct12566 (Entrez Gene)
Cdk4GeneProduct12567 (Entrez Gene)
Cdk6GeneProduct12571 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Cdkn2aGeneProduct12578 (Entrez Gene)
Cdkn2bGeneProduct12579 (Entrez Gene)
Cdkn2cGeneProduct12580 (Entrez Gene)
Cdkn2dGeneProduct12581 (Entrez Gene)
CyclinDGeneProduct
CyclinEGeneProduct
E2fGeneProduct
E2f1GeneProduct13555 (Entrez Gene)
E2f2GeneProduct242705 (Entrez Gene)
E2f3GeneProduct13557 (Entrez Gene)
E2f4GeneProduct104394 (Entrez Gene)
E2f5GeneProduct13559 (Entrez Gene)
E2f6GeneProduct50496 (Entrez Gene)
Gadd45aGeneProduct13197 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
Mnat1GeneProduct17420 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pkmyt1GeneProduct268930 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
RbGeneProduct
Rb1GeneProduct19645 (Entrez Gene)
Rbl1GeneProduct19650 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
Tfdp1GeneProduct21781 (Entrez Gene)
Tfdp2GeneProduct211586 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wee1GeneProduct22390 (Entrez Gene)
dp1GeneProduct
p53GeneProduct

Annotated Interactions

No annotated interactions
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