Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway (Zea mays)

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Disjunct reactions / unknown compartmentPlastidPeroxisome 1CYTOSOLvitamin B6 transporterpyridoxal 5'-phosphatepyridoxamine 5'-phosphate5'-O-beta-D-glucosylpyridoxinepyridoxalD-glyceraldehyde 3-P1.4.3.5PDX22.4.1.160GRMZM2G120652ATP2.7.1.35pyridoxamine 5'-phosphatepyridoxaminepyridoxinePLP-dependent enzyme side-activity1.1.1.65ADPO2H2O2NH3pyridoxal 5'-phosphate1.4.3.5ATP2.7.1.35pyridoxamine 5'-phosphatepyridoxalpyridoxamine 5'-phosphatepyridoxaminepyridoxinePLP-dependent enzyme side-activityADPO2H2O2NH3PDX1Dihydroxyacetone-PD-ribose 5PD-ribulose 5-Ppyridoxal 5'-phosphatepyridoxamine 5'-phosphatePLP-dependent enzyme side-activity Mitochondriavitamin B6 transporterpyridoxal 5'-phosphatepyridoxamine 5'-phosphatePLP-dependent enzyme side-activitypyridoxalpyridoxaminepyridoxineglycosylpyridoxine hydrolaseH2OD-glucose(photo)chemical / enzymatic pyridoxal oxidation4-pyridoxic acidpyridoxal2.6.1.30pyridoxal 5'-phosphatepyridoxamine 5'-phosphatepyridoxamine 5'-phosphatepyridoxalpyridoxaminepyridoxine3.1.3.74H2OPO4GRMZM5G850015GRMZM2G023528GRMZM2G061988GRMZM2G061988GRMZM2G069758GRMZM2G398107GRMZM2G069758GRMZM2G398107GRMZM2G022130ORORvitamin B6 transportervitamin B6 transporter


Description

Several forms of the vitamin are known, but pyridoxal 5’-phosphate (PLP) is the biologically active form and is a cofactor in various reactions of amino acid metabolism, including transamination, deamination, and decarboxylation, racemization and others. In plants PLP is synthesized de novo in the cytosol by the two-protein (PDX1/PDX2) PLP synthase complex from pentose phosphate, triose phosphate, and glutamine pre-cursors (reviewed in Fitzpatrick, 2011). PLP can also be made in chloroplasts or cytosol from pyridoxamine 5'-phosphate (PMP) or pyridoxine 5'-phosphate (PNP) by the salvage enzyme pyridoxamine 5'-phosphate oxidase. Pyridoxine glucosides are major forms of vitamin B6 in plants (Gregory and Ink, 1987). The details of vitamin B6 biosynthesis (especially its compartmentation) in plants are far from being elucidated. This diagram is an attempt to capture the current state of the art

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Bibliography

  1. Gerdes S, Lerma-Ortiz C, Frelin O, Seaver SM, Henry CS, de Crécy-Lagard V, Hanson AD; ''Plant B Vitamin Pathways and their Compartmentation: a Guide for the Perplexed.''; J Exp Bot, 2012 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110988view14:59, 25 June 2020L Dupuisconnected lines
89888view13:03, 6 October 2016MkutmonModified description
78448view10:27, 7 January 2015MaintBotadded missing graphIds
73526view23:37, 29 January 2014KhanspersModified title
71902view17:51, 22 October 2013MaintBotRemoved source from datanodes with empty id
70256view21:41, 15 July 2013MaintBotupdated to 2013 schema
65176view19:12, 5 June 2013MaintBotModified categories
55416view19:07, 14 December 2012SvetaGModified title
54618view06:28, 5 December 2012SvetaGModified description
54617view06:07, 5 December 2012SvetaGPeriodical save, work in progress
54616view05:47, 5 December 2012SvetaGPeriodical save, work in progress
54615view05:35, 5 December 2012SvetaGSpecify description
54614view04:40, 5 December 2012SvetaGPeriodical save, work in progress
54326view23:28, 27 November 2012SvetaGSpecify description
54325view23:27, 27 November 2012SvetaGPeriodical save, work in progress
54324view23:20, 27 November 2012SvetaGSpecify description
54323view23:15, 27 November 2012SvetaGSpecify description
53372view00:31, 6 November 2012PjaiswalModified title
53197view23:43, 30 October 2012PjaiswalModified categories
53104view01:06, 30 October 2012MaintBotModified categories
53098view21:28, 29 October 2012PjaiswalOntology Term : 'vitamin B6 metabolic pathway' added !
53097view21:27, 29 October 2012PjaiswalOntology Term : 'plant cell' added !
53096view21:27, 29 October 2012PjaiswalModified categories
53095view21:26, 29 October 2012PjaiswalNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(photo)chemical / enzymatic pyridoxal oxidationGeneProduct
1.1.1.65GeneProduct1.1.1.65 (Enzyme Nomenclature)
1.4.3.5GeneProduct1.4.3.5 (Enzyme Nomenclature)
2.4.1.160GeneProduct2.4.1.160 (Enzyme Nomenclature)
2.6.1.30GeneProduct2.6.1.30 (Enzyme Nomenclature)
2.7.1.35GeneProduct2.7.1.35 (Enzyme Nomenclature)
3.1.3.74GeneProduct3.1.3.74 (Enzyme Nomenclature)
4-pyridoxic acidMetabolite
5'-O-beta-D-glucosylpyridoxineMetabolite
ADPMetabolite
ATPMetabolite
D-glucoseMetabolite
D-glyceraldehyde 3-PMetabolite
D-ribose 5PMetabolite
D-ribulose 5-PMetabolite
Dihydroxyacetone-PMetabolite
GRMZM2G022130GeneProductGRMZM2G022130 (Gramene Maize)
GRMZM2G023528GeneProductGRMZM2G023528 (Gramene Maize)
GRMZM2G061988GeneProductGRMZM2G061988 (Gramene Maize)
GRMZM2G069758GeneProductGRMZM2G069758 (Gramene Maize)
GRMZM2G120652GeneProductGRMZM2G120652 (Gramene Maize)
GRMZM2G398107GeneProductGRMZM2G398107 (Gramene Maize)
GRMZM5G850015GeneProductGRMZM5G850015 (Gramene Maize)
H2OMetabolite
H2O2Metabolite
NH3Metabolite
O2Metabolite
ORMetabolite
PDX1GeneProduct
PDX2GeneProduct
PLP-dependent enzyme side-activityGeneProduct
PO4Metabolite
glycosylpyridoxine hydrolaseGeneProduct
pyridoxalMetabolite
pyridoxal 5'-phosphateMetabolite
pyridoxamineMetabolite
pyridoxamine 5'-phosphateMetabolite
pyridoxineMetabolite
vitamin B6 transporterGeneProduct

Annotated Interactions

No annotated interactions

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