Regulation of actin cytoskeleton (Canis familiaris)
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Actomyosin
assembly contraction
RTK
+p
?
stress fiber
Actin polymerization
GF
PI3K
Filipodia
Focal adhesion
assembly
Stabilization
of actin
Actin polymerization
stress fiber
Gene Expression
RTK
GPCR
Lamellipodia
RAS
PI3K
Growth Factor (GF)
Chemotatic factor
Focal complex
assembly
-p
GPCR
RAS
Chemotactic factor
Actin
polymerization
FGF4
Apc2
PIP2
MAPK6
INS1
SSH2
PDGFRA
MAPK1
CHRM2
LOC100856477
PIP4K2B
BRAF
RRAS
Acetylcholine
LOC100856038
CD14
FGF23
LOC442937
LOC612404
PIK3R4
PDGFRB
FGF11
Bradykinin
ARHGEF6
MYL3
CSK
PXN
PIK3CG
MAPK4
KRAS
FGF12
FGF20
Focal Adhesion
pathway
FGF8
PIK3CA
PFN1
RAF1
Focal Adhesion
pathway
PIK3C2G
FGF9
VCL
FGF21
LOC490390
LOC100856339
PIK3C3
EZR
NRAS
FGF14
LIMK1
ARHGEF7
ARPC5
FGFR2
FGF16
DIAP3
ROCK2
PIP2
VIL1
DIAP1
SOS2
FGF2
SOS1
FGF1
PIK3R1
CHRM3
PAK4
LOC100856539
FN1
FGFR4
MAPK3
PIP5KL1
C11orf13
FGF18
PIP4K2C
PAK3
ACTB
VCL
WAS
GSN
PIK3R2
FGFR3
PIP5K1C
PIP4K2A
Adherens junction
pathway
BAIAP2
FGF15
FGF17
LOC100686332
ARHGEF4
PDGFB
PIK3R5
ACTB
MYH10
LOC607701
PIK3C2A
ITGA1
BDKRB1
RRAS2
FGF3
MAPK Signaling
pathway
F2R
PDGFA
FGF7
MOS
CHRM4
MYLK
RAC1
ACTN1
CDC42
PAK2
LOC442775
FGF6
APC
BAIAP2
PIP4K2A
CHRM1
WASF1
LOC442937
BCAR1
CFL1
MAP2K1
IQGAP1
ABI2
MYL1
BDKRB2
PIK3CD
MRAS
ACTB
PIP5K1B
LPS
CYFIP2
SLC9A1
PAK7
RAC3
ARHGAP35
FGD1
ROCK1
PPP1R12A
PIP5K1A
FGF5
ARPC5
TMSB4X
EGFR
RAC2
PIK3C2B
PAK1
GNA13
RHOA
RDX
CRK
GIT1
PTK2
EGF
ARHGEF6
MSN
MAP2K2
LOC442937
WASF2
RAC1P4
FGF13
GNA12
INS2
NCKAP1
PFN1
SSH3
CFL2
PIK3CB
DOCK1
FGF10
SSH1
VAV1
ARHGEF1
PIP3
CHRM5
Description
http://www.genome.jp/kegg/pathway/hsa/hsa04810.html
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP51(r45278)
with a 89% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
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Bibliography
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History
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Revision
Action
Time
User
Comment
128552
view
04:35, 12 February 2024
Eweitz
Modified title
72086
view
21:21, 24 October 2013
Mkutmon
added datasource to "Focal Adhesion pathway" and "MAPK Signaling pathway"
71469
view
19:17, 17 October 2013
MaintBot
Automated update of data sources
68550
view
22:35, 5 July 2013
MaintBot
Updated to 2013 gpml schema
48152
view
18:46, 9 May 2012
MaintBot
Updating from human to fix xrefs
40707
view
21:51, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33987
view
18:33, 9 December 2009
MaintBot
Automatic update of empty xrefs
32262
view
13:01, 15 August 2009
MaintBot
Fixed text labels
31789
view
12:14, 14 August 2009
MaintBot
Fixed group labels
31289
view
20:06, 13 August 2009
MaintBot
Fixed text labels
30747
view
23:06, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABI2
GeneProduct
488485 (Entrez Gene)
ACTB
GeneProduct
403580 (Entrez Gene)
ACTN1
GeneProduct
480369 (Entrez Gene)
APC
GeneProduct
479139 (Entrez Gene)
ARHGAP35
GeneProduct
403543 (Entrez Gene)
ARHGEF1
GeneProduct
ARHGEF4
GeneProduct
483856 (Entrez Gene)
ARHGEF6
GeneProduct
610290 (Entrez Gene)
ARHGEF7
GeneProduct
485552 (Entrez Gene)
ARPC5
GeneProduct
480037 (Entrez Gene)
Acetylcholine
Metabolite
51-84-3 (CAS)
Adherens junction pathway
Pathway
Apc2
GeneProduct
BAIAP2
GeneProduct
403473 (Entrez Gene)
BCAR1
GeneProduct
479648 (Entrez Gene)
BDKRB1
GeneProduct
490847 (Entrez Gene)
BDKRB2
GeneProduct
403658 (Entrez Gene)
BRAF
GeneProduct
475526 (Entrez Gene)
Bradykinin
Metabolite
58-82-2 (CAS)
C11orf13
GeneProduct
CD14
GeneProduct
607076 (Entrez Gene)
CDC42
GeneProduct
403934 (Entrez Gene)
CFL1
GeneProduct
476022 (Entrez Gene)
CFL2
GeneProduct
490649 (Entrez Gene)
CHRM1
GeneProduct
483776 (Entrez Gene)
CHRM2
GeneProduct
403858 (Entrez Gene)
CHRM3
GeneProduct
403827 (Entrez Gene)
CHRM4
GeneProduct
611314 (Entrez Gene)
CHRM5
GeneProduct
487472 (Entrez Gene)
CRK
GeneProduct
100684309 (Entrez Gene)
CSK
GeneProduct
487649 (Entrez Gene)
CYFIP2
GeneProduct
479317 (Entrez Gene)
DIAP1
GeneProduct
DIAP3
GeneProduct
DOCK1
GeneProduct
486934 (Entrez Gene)
EGF
GeneProduct
403657 (Entrez Gene)
EGFR
GeneProduct
404306 (Entrez Gene)
EZR
GeneProduct
484056 (Entrez Gene)
F2R
GeneProduct
488942 (Entrez Gene)
FGD1
GeneProduct
491901 (Entrez Gene)
FGF10
GeneProduct
612454 (Entrez Gene)
FGF11
GeneProduct
607829 (Entrez Gene)
FGF12
GeneProduct
478676 (Entrez Gene)
FGF13
GeneProduct
492174 (Entrez Gene)
FGF14
GeneProduct
485537 (Entrez Gene)
FGF15
GeneProduct
FGF1
GeneProduct
607724 (Entrez Gene)
FGF16
GeneProduct
491974 (Entrez Gene)
FGF17
GeneProduct
607952 (Entrez Gene)
FGF18
GeneProduct
611641 (Entrez Gene)
FGF20
GeneProduct
FGF21
GeneProduct
484395 (Entrez Gene)
FGF23
GeneProduct
611773 (Entrez Gene)
FGF2
GeneProduct
403857 (Entrez Gene)
FGF3
GeneProduct
FGF4
GeneProduct
483680 (Entrez Gene)
FGF5
GeneProduct
608459 (Entrez Gene)
FGF6
GeneProduct
486735 (Entrez Gene)
FGF7
GeneProduct
403915 (Entrez Gene)
FGF8
GeneProduct
403868 (Entrez Gene)
FGF9
GeneProduct
477340 (Entrez Gene)
FGFR2
GeneProduct
415125 (Entrez Gene)
FGFR3
GeneProduct
488808 (Entrez Gene)
FGFR4
GeneProduct
489095 (Entrez Gene)
FN1
GeneProduct
403845 (Entrez Gene)
Focal Adhesion pathway
Pathway
WP306 (WikiPathways)
GIT1
GeneProduct
491180 (Entrez Gene)
GNA12
GeneProduct
GNA13
GeneProduct
490901 (Entrez Gene)
GSN
GeneProduct
474819 (Entrez Gene)
INS1
GeneProduct
INS2
GeneProduct
IQGAP1
GeneProduct
479050 (Entrez Gene)
ITGA1
GeneProduct
489210 (Entrez Gene)
KRAS
GeneProduct
403871 (Entrez Gene)
LIMK1
GeneProduct
489800 (Entrez Gene)
LOC100686332
GeneProduct
100686332 (Entrez Gene)
LOC100856038
GeneProduct
100856038 (Entrez Gene)
LOC100856339
GeneProduct
100856339 (Entrez Gene)
LOC100856477
GeneProduct
100856477 (Entrez Gene)
LOC100856539
GeneProduct
100856539 (Entrez Gene)
LOC442775
GeneProduct
LOC442937
GeneProduct
442937 (Entrez Gene)
LOC490390
GeneProduct
490390 (Entrez Gene)
LOC607701
GeneProduct
607701 (Entrez Gene)
LOC612404
GeneProduct
612404 (Entrez Gene)
LPS
Metabolite
C00338 (KEGG Compound)
MAP2K1
GeneProduct
478347 (Entrez Gene)
MAP2K2
GeneProduct
611939 (Entrez Gene)
MAPK Signaling pathway
Pathway
WP382 (WikiPathways)
MAPK1
GeneProduct
477575 (Entrez Gene)
MAPK3
GeneProduct
479790 (Entrez Gene)
MAPK4
GeneProduct
491690 (Entrez Gene)
MAPK6
GeneProduct
478311 (Entrez Gene)
MOS
GeneProduct
486959 (Entrez Gene)
MRAS
GeneProduct
477082 (Entrez Gene)
MSN
GeneProduct
491924 (Entrez Gene)
MYH10
GeneProduct
479497 (Entrez Gene)
MYL1
GeneProduct
478896 (Entrez Gene)
MYL3
GeneProduct
476644 (Entrez Gene)
MYLK
GeneProduct
488012 (Entrez Gene)
NCKAP1
GeneProduct
478828 (Entrez Gene)
NRAS
GeneProduct
403872 (Entrez Gene)
PAK1
GeneProduct
607885 (Entrez Gene)
PAK2
GeneProduct
612814 (Entrez Gene)
PAK3
GeneProduct
492067 (Entrez Gene)
PAK4
GeneProduct
484513 (Entrez Gene)
PAK7
GeneProduct
485772 (Entrez Gene)
PDGFA
GeneProduct
491597 (Entrez Gene)
PDGFB
GeneProduct
442986 (Entrez Gene)
PDGFRA
GeneProduct
442860 (Entrez Gene)
PDGFRB
GeneProduct
442985 (Entrez Gene)
PFN1
GeneProduct
PIK3C2A
GeneProduct
485399 (Entrez Gene)
PIK3C2B
GeneProduct
478938 (Entrez Gene)
PIK3C2G
GeneProduct
477681 (Entrez Gene)
PIK3C3
GeneProduct
490477 (Entrez Gene)
PIK3CA
GeneProduct
488084 (Entrez Gene)
PIK3CB
GeneProduct
477085 (Entrez Gene)
PIK3CD
GeneProduct
489644 (Entrez Gene)
PIK3CG
GeneProduct
483266 (Entrez Gene)
PIK3R1
GeneProduct
487235 (Entrez Gene)
PIK3R2
GeneProduct
609956 (Entrez Gene)
PIK3R4
GeneProduct
477064 (Entrez Gene)
PIK3R5
GeneProduct
612805 (Entrez Gene)
PIP2
Metabolite
C04637 (KEGG Compound)
PIP3
Metabolite
C05981 (KEGG Compound)
PIP4K2A
GeneProduct
608414 (Entrez Gene)
PIP4K2B
GeneProduct
491034 (Entrez Gene)
PIP4K2C
GeneProduct
474417 (Entrez Gene)
PIP5K1A
GeneProduct
475846 (Entrez Gene)
PIP5K1B
GeneProduct
476331 (Entrez Gene)
PIP5K1C
GeneProduct
485054 (Entrez Gene)
PIP5KL1
GeneProduct
609122 (Entrez Gene)
PPP1R12A
GeneProduct
475411 (Entrez Gene)
PTK2
GeneProduct
475108 (Entrez Gene)
PXN
GeneProduct
486299 (Entrez Gene)
RAC1
GeneProduct
403955 (Entrez Gene)
RAC1P4
GeneProduct
RAC2
GeneProduct
481271 (Entrez Gene)
RAC3
GeneProduct
RAF1
GeneProduct
484648 (Entrez Gene)
RDX
GeneProduct
479446 (Entrez Gene)
RHOA
GeneProduct
403954 (Entrez Gene)
ROCK1
GeneProduct
480181 (Entrez Gene)
ROCK2
GeneProduct
482970 (Entrez Gene)
RRAS2
GeneProduct
476865 (Entrez Gene)
RRAS
GeneProduct
476413 (Entrez Gene)
SLC9A1
GeneProduct
478171 (Entrez Gene)
SOS1
GeneProduct
483042 (Entrez Gene)
SOS2
GeneProduct
490682 (Entrez Gene)
SSH1
GeneProduct
477526 (Entrez Gene)
SSH2
GeneProduct
491183 (Entrez Gene)
SSH3
GeneProduct
483699 (Entrez Gene)
TMSB4X
GeneProduct
VAV1
GeneProduct
485016 (Entrez Gene)
VCL
GeneProduct
479252 (Entrez Gene)
VIL1
GeneProduct
488522 (Entrez Gene)
WAS
GeneProduct
491867 (Entrez Gene)
WASF1
GeneProduct
475024 (Entrez Gene)
WASF2
GeneProduct
487343 (Entrez Gene)
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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History
External references
DataNodes
Annotated Interactions
No annotated interactions