Folate metabolism (Bos taurus)

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71518842512299, 1928136, 271426223, 2417TTTTBInterconversionNegative effectBBBReactionBBBUnspecified effectPositive effectMain functionsBBBBBTransformationBTBTBBNucleotide biosynthesisFormation of methionineTransportBBGeneric enzymeUnspecified interactionMETABOLITEIEBindingInfluence on expressionINTRACELULARCNSynthesis of cholineBTBINORGANIC IONConversionTBPLASMATBBBBBCompetitionBFormation of HemeBMTRPTGISIronFADLA (n-6)Niacin2-Ketobutyric acidLeukotriene B4BUric acidUric acidAA (n-6)a-tocopherolEPA (n-3)ZincEPA (n-3)FOLIC ACID5,10-METHYL-THFCalciumTCystathionePTGDSSELWTXNRD2GlutathioneLeukotriene C4ALA (n-3)S-Adenosylmethionine15-HETENADPHTCN1DHA (n-3)PTGESL-Glutamic acidAscorbic acidCopperSerineSODCarnitineIETryptophanPGE2H2O2GPX3a TocopherolPGF2aH2OManganeseHomocysteineSeleniumAdipic acid F2-IsoprostaneCOX2Leukotriene B4O2LeukotrieneE4GlutathioneiPF2-alphaBetaineFOLIC ACIDGlutathione disulfideXDH1-methylnicotinamidePNPONADPPGD2HypoxanthineLipoic acidZincPGI2Leukotriene A4Leukotriene F4Methionine sulfoxideIronPGE2TXNRD1CysteineMTHFRS-Adenosylmethionine Methylmalonic acid 5-HPETEGlycinePGG2BCOX1ALA (n-3)TRXR 3Methylmalonic acidThromboxane A2Leukotriene D4Leukotriene D4CobalaminCATL-Glutamic acidS-Adenosylhomocysteine TTPGFS15-HETESEPX1FMN12-Ketobutyric acidPGE3NADPHPyrodoxal-5'-phosphateMethionineRiboflavinVitamin B12CBSEthanolamineAA (n-6)PGG3PGH2CobalaminThioredoxinSerine1-MethylnicotinamideLipoxin B4CholineC22:5 (n-6)Tromboxane A2S-Adenosylhomocysteine 5,10-METHYL-THFAscorbic acidAdipic acidGPX4HomocysteineGlycinePGF2aNADPEthanolamineGPX 6SELKVitamin B12ALOX5PGH3PGD2ROSTHASLeukotriene C4CalciumDHA (n-3)GPX1LA (n-6)LeukotrieneE4Lipoxin A4Thromboxane B2KMOCNXR_027890.2Hypoxanthined5 desaturaseCopperSeleniumPGI2CysteineXanthineNicotinamideLipoxin A4d4 desaturaseFADS2Pyrodoxal-5'-phosphateHemeGPX 2L-MethionineEndoperoxidaseC22:5 (n-6)1023201112, 21165


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP176(r30153) with a 51% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134297view06:15, 20 July 2024EgonwFixed a reference
120905view14:16, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
120356view15:27, 28 November 2021EgonwFixed a PubMed ID
117520view11:08, 21 May 2021EweitzModified title
107053view14:14, 17 September 2019MaintBotChEBI identifier normalization
106009view11:53, 16 August 2019MaintBotHMDB identifier normalization
98246view14:20, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96339view15:36, 8 March 2018MkutmonUpdated homology conversion
96338view15:35, 8 March 2018MkutmonOntology Term : 'folate metabolic pathway' added !
86818view16:41, 11 July 2016EgonwConnecting lines.
85065view11:31, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82706view08:57, 23 October 2015EgonwoxLDL has a separate identifier.
80891view15:30, 30 June 2015Mkutmonhomology conversion
74466view16:08, 24 April 2014EgonwFixed a PubMed ID.
72574view15:52, 23 November 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
72367view09:46, 13 November 2013EgonwReplaced old PubChem data sources with their new equivalents.
72366view09:40, 13 November 2013EgonwFixed the type of two proteins.
71408view19:01, 17 October 2013MaintBotAutomated update of data sources
63348view22:21, 9 May 2013MaintBotUpdated to 2013 gpml schema
58813view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40522view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
33765view00:04, 9 December 2009MaintBotAutomatic update of empty xrefs
33195view18:18, 5 November 2009KhanspersModified categories
32527view12:58, 17 August 2009MaintBotFixed text labels
32214view12:44, 15 August 2009MaintBotFixed text labels
31708view11:51, 14 August 2009MaintBotFixed group labels
31225view19:43, 13 August 2009MaintBotFixed text labels
30644view22:31, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-MethylnicotinamideMetaboliteHMDB00699 (HMDB)
1-methylnicotinamideMetaboliteHMDB00699 (HMDB)
15-HETEMetaboliteHMDB02218 (HMDB)
2-Ketobutyric acidMetaboliteHMDB00005 (HMDB)
5,10-METHYL-THFMetaboliteHMDB01396 (HMDB)
5-HPETEMetaboliteHMDB01193 (HMDB)
AA (n-6)MetaboliteHMDB01043 (HMDB)
ALA (n-3)MetaboliteHMDB01388 (HMDB)
ALOX5Protein404074 (Entrez Gene)
Adipic acid MetaboliteHMDB00448 (HMDB)
Adipic acidMetaboliteHMDB00448 (HMDB)
Ascorbic acidMetaboliteHMDB00044 (HMDB)
BGeneProduct
BetaineMetaboliteHMDB00043 (HMDB)
C22:5 (n-6)MetaboliteHMDB01976 (HMDB)
CATProtein531682 (Entrez Gene)
CBSProtein514525 (Entrez Gene)
CNGeneProduct
COX1Protein3283879 (Entrez Gene)
COX2Protein3283880 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
CarnitineMetaboliteHMDB00062 (HMDB)
CholineMetaboliteHMDB00097 (HMDB)
CobalaminMetaboliteHMDB02174 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathioneMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DHA (n-3)MetaboliteHMDB02183 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB)
EndoperoxidaseProtein
EthanolamineMetaboliteHMDB00149 (HMDB)
F2-IsoprostaneMetaboliteHMDB04659 (HMDB)
FADMetabolite703 (PubChem)
FADS2Protein521822 (Entrez Gene)
FMN1Protein342184 (Entrez Gene)
FOLIC ACIDMetaboliteHMDB00121 (HMDB)
GPX 2Protein
GPX 6Protein
GPX1Protein281209 (Entrez Gene)
GPX3Protein281210 (Entrez Gene)
GPX4Protein286809 (Entrez Gene)
Glutathione disulfideMetabolite65359 (PubChem) Type your comment here
GlutathioneMetaboliteHMDB00125 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetabolite
HomocysteineMetaboliteHMDB00742 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IEGeneProduct
IronMetaboliteHMDB00692 (HMDB)
KMOProtein
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
LA (n-6)MetaboliteHMDB00673 (HMDB)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene F4Metabolite
LeukotrieneE4MetaboliteHMDB02200 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
MTHFRProtein497032 (Entrez Gene)
MTRProtein280869 (Entrez Gene)
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
Methylmalonic acid MetaboliteHMDB00202 (HMDB)
Methylmalonic acidMetaboliteHMDB00202 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NiacinMetaboliteHMDB01406 (HMDB)
NicotinamideMetabolite7847104 (PubChem)
O2MetaboliteHMDB01377 (HMDB)
PGD2MetaboliteHMDB01403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB02664 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB03235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB01381 (HMDB)
PGH3Metabolite
PGI2Metabolite
PGI2MetaboliteHMDB01335 (HMDB)
PNPOProtein512573 (Entrez Gene)
PTGDSProtein286858 (Entrez Gene)
PTGESProtein282019 (Entrez Gene)
PTGISProtein282021 (Entrez Gene)
Pyrodoxal-5'-phosphateMetaboliteHMDB01491 (HMDB)
ROSMetabolitehttp://en.wikipedia.org/wiki/Reactive_oxygen_species
RiboflavinMetaboliteHMDB00244 (HMDB) Type your comment here
S-Adenosylhomocysteine MetaboliteHMDB00939 (HMDB)
S-Adenosylmethionine MetaboliteHMDB01185 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SELKProtein615114 (Entrez Gene)
SELWProtein
SEPX1Protein618441 (Entrez Gene)
SODProtein
SeleniumMetaboliteHMDB01349 (HMDB)
SerineMetaboliteHMDB00187 (HMDB)
TGeneProduct524443 (Entrez Gene)
TCN1Protein616239 (Entrez Gene)
THASProtein
TRXR 3Protein
TTGeneProduct
TXNRD1Protein282388 (Entrez Gene)
TXNRD2Protein282389 (Entrez Gene)
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
Tromboxane A2MetaboliteHMDB01452 (HMDB)
TryptophanMetaboliteHMDB00929 (HMDB)
Uric acidMetaboliteHMDB00289 (HMDB)
Vitamin B12MetaboliteHMDB00607 (HMDB)
XDHProtein280960 (Entrez Gene)
XR_027890.2ProteinENSBTAG00000007115 (Ensembl) Type your comment here
XanthineMetaboliteHMDB00292 (HMDB)
ZincMetaboliteHMDB01303 (HMDB)
a TocopherolMetaboliteHMDB01893 (HMDB)
a-tocopherolMetaboliteHMDB01893 (HMDB)
d4 desaturaseProtein
d5 desaturaseProtein
iPF2-alphaMetaboliteHMDB04659 (HMDB)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1075"
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