Transcriptional activation by NRF2 (Bos taurus)
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Egonw
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1
S-P
Phase II enzymes
CCAAT/XRE
S-P
T-P
Nucleus
ARE
T-P
Sulforaphane
MAF
GSTA2
C/EBP-beta
NFE2L2
Caffeic acid phenethyl ester
GCLC
GCLM
KEAP1
PIK3CA
MAPK8
HMOX1
NFE2L2
NQO1
C/EBP-beta
Curcumin
KEAP1
NFE2L2
PRKCA
6-HITC
EPHB2
AIMP2
Description
Based on
Surh, 2003, figure 4
.
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP3(r29720)
with a 83% conversion rate.
Try the New WikiPathways
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the new wikipathways.org
.
Quality Tags
Ontology Terms
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Bibliography
Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
105999
view
11:52, 16 August 2019
MaintBot
HMDB identifier normalization
80933
view
15:31, 30 June 2015
Mkutmon
homology conversion
72383
view
15:30, 13 November 2013
Egonw
Added a few metabolite identifiers.
72382
view
15:28, 13 November 2013
Egonw
Fixed the PubChem-compound database name.
71409
view
19:01, 17 October 2013
MaintBot
Automated update of data sources
63349
view
22:21, 9 May 2013
MaintBot
Updated to 2013 gpml schema
40523
view
19:29, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33630
view
10:04, 1 December 2009
MaintBot
Removed group label
30557
view
22:02, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
6-HITC
Metabolite
7991398 (Chemspider)
Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
AIMP2
GeneProduct
520979 (Entrez Gene)
C/EBP-beta
GeneProduct
Caffeic acid phenethyl ester
Metabolite
4445100 (Chemspider)
Curcumin
Metabolite
HMDB02269 (HMDB)
EPHB2
GeneProduct
535137 (Entrez Gene)
GCLC
GeneProduct
512468 (Entrez Gene)
GCLM
GeneProduct
525659 (Entrez Gene)
GSTA2
GeneProduct
HMOX1
GeneProduct
513221 (Entrez Gene)
KEAP1
GeneProduct
532791 (Entrez Gene)
MAF
GeneProduct
782481 (Entrez Gene)
MAPK8
GeneProduct
539941 (Entrez Gene)
NFE2L2
GeneProduct
497024 (Entrez Gene)
NQO1
GeneProduct
519632 (Entrez Gene)
PIK3CA
GeneProduct
282306 (Entrez Gene)
PRKCA
GeneProduct
282001 (Entrez Gene)
Sulforaphane
Metabolite
5350 (PubChem-compound)
Annotated Interactions
No annotated interactions
Views
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Discussion
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View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions