Transcriptional activation by NRF2 in response to phytochemicals (Homo sapiens)

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1NucleusS-PT-PT-PCCAAT/XREARES-PPhase II enzymesKEAP1NQO1NRF2PI3KGCLCJNK6-HITCKEAP1P38PKCGSTA2ERKNRF2C/EBP-betaC/EBP-betaGCLMNRF2CurcuminCaffeic acid phenethyl esterMAFHO-1Sulforaphane


Description

Based on Surh, 2003, figure 4. Nrf2 induces the expression of many antioxidant enzymes. It is therefore thought to be involved in oxidative stress response.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  2. Niture SK, Khatri R, Jaiswal AK; ''Regulation of Nrf2-an update.''; Free Radic Biol Med, 2014 PubMed Europe PMC Scholia
  3. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127273view00:02, 1 September 2023Khanspersupdated phosphosite
127249view17:35, 28 August 2023Khanspersadded literature reference and updated description
127189view22:12, 9 August 2023Khanspersupdated phosphosites
126220view15:05, 16 April 2023EgonwLicense is CCZero
120028view22:58, 15 October 2021Khanspersupdated phospho sites
116707view09:35, 11 May 2021EweitzModified title
106155view12:05, 16 August 2019MaintBotHMDB identifier normalization
98703view18:19, 28 September 2018KhanspersModified title
94689view22:49, 4 October 2017KhanspersModified description
94688view22:49, 4 October 2017KhanspersModified description
94687view22:49, 4 October 2017KhanspersModified description
92783view21:24, 5 July 2017AlexanderPicoUpdated overall layout and state positions
92717view19:41, 29 June 2017Khanspersminor layout change
92716view19:40, 29 June 2017Khansperscorrected misplaced state
92714view19:35, 29 June 2017Khanspersoverhaul and update states
79527view10:22, 24 March 2015Zariadded ID for GSTA2
74850view02:48, 1 May 2014NsalomonisAdded SLC7A11
73388view16:42, 25 January 2014EgonwAdded another missing metabolite identifier.
73387view16:39, 25 January 2014EgonwAdded a missing metabolite identifier.
68891view17:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
67421view10:59, 26 June 2013DdiglesOntology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
66318view17:34, 17 June 2013MaintBotModified title
48217view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
46085view02:20, 15 December 2011AllanKuchinskyupdated HGNC IDs
44881view10:08, 6 October 2011MartijnVanIerselOntology Term : 'oxidative stress response pathways' added !
44880view10:08, 6 October 2011MartijnVanIerselModified description
41042view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
39757view07:19, 17 January 2011AlexanderPicomore specific title
38881view18:56, 24 September 2010KhanspersChanged line types
38830view11:54, 24 September 2010Jildaunucleus
32036view13:27, 14 August 2009MaintBotFixed group labels
29720view21:20, 1 June 2009Khanspersadded ref for metabolite
28165view09:44, 29 January 2009ThomasModified categories
28164view09:44, 29 January 2009ThomasModified description
28163view09:42, 29 January 2009Thomasextended pathway
20675view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Keap1-Nrf2]] moved to [[Pathway:WP3]]: Moved to stable identifier
20254view08:19, 28 October 2008HubertPeriodical save, work in progress
19325view11:38, 2 October 2008HubertNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-HITCMetabolite7991398 (Chemspider) Full name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
C/EBP-betaGeneProduct1051 (Entrez Gene)
Caffeic acid phenethyl esterMetaboliteCHEBI:8062 (ChEBI)
CurcuminMetaboliteHMDB02269 (HMDB)
ERKGeneProduct2048 (Entrez Gene)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GSTA2GeneProductGSTA2 (HGNC)
HO-1GeneProduct3162 (Entrez Gene)
JNKGeneProduct5599 (Entrez Gene)
KEAP1GeneProduct9817 (Entrez Gene)
MAFGeneProduct4094 (Entrez Gene)
NQO1GeneProduct1728 (Entrez Gene)
NRF2GeneProduct4780 (Entrez Gene)
P38GeneProduct7965 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
PKCGeneProduct5578 (Entrez Gene)
SulforaphaneMetaboliteHMDB05792 (HMDB)

Annotated Interactions

No annotated interactions

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