Glyoxylate, anapleurotic and succinyl CoA (GAS) pathway (Mycobacterium tuberculosis)

Revision as of 12:47, 24 February 2014 by Andra (Talk | contribs)

Description

Schematic of the GAS pathway which is characterised by flux through the glyoxylate shunt and anaplerotic reactions for oxidation of pyruvate and succinyl CoA synthetase for the generation of succinyl CoA. From: (http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002091)

View approved pathways at the new wikipathways.org.

Beste DJ, Bonde B, Hawkins N, Ward JL, Beale MH, Noack S, Nöh K, Kruger NJ, Ratcliffe RG, McFadden J; ''13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation.''; PLoS Pathog, 2011 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
117427	view	10:46, 21 May 2021	Eweitz	Modified title
105016	view	08:32, 28 June 2019	Fehrhart	some graphical upgrade
105015	view	08:30, 28 June 2019	Fehrhart	connected missing line
87774	view	11:05, 25 July 2016	MirellaKalafati	Ontology Term : 'classic metabolic pathway' added !
87773	view	11:04, 25 July 2016	MirellaKalafati	Modified title
74095	view	13:07, 29 March 2014	Egonw	Fixed a character encoding issue.
73789	view	12:56, 24 February 2014	Andra	finished drawing the pathway from the paper
73788	view	12:47, 24 February 2014	Andra	Modified description
73787	view	12:47, 24 February 2014	Andra	Modified description
73784	view	11:40, 24 February 2014	Andra	Added main reference where the pathway is from
73783	view	11:38, 24 February 2014	Andra	New pathway

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Name	Type	Database reference
02	Metabolite	952 (Chemspider)
Ac	Metabolite
CO2	Metabolite	274 (Chemspider)
Citrate	Metabolite	29081 (Chemspider)
Isocitrate	Metabolite	4573809 (Chemspider)
L-Malate	Metabolite	4573566 (Chemspider)
Oxaloacetate	Metabolite	2509917 (Chemspider)
Pyruvate	Metabolite	96901 (Chemspider)
Succinate	Metabolite	140973 (Chemspider)
Succinyl-CoA	Metabolite	83179 (Chemspider)
glyoxylate	Metabolite	2849615 (Chemspider)
phosphoenolpyruvate	Metabolite	980 (Chemspider)

No annotated interactions