Glyoxylate, anapleurotic and succinyl CoA (GAS) pathway (Mycobacterium tuberculosis)

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1AcL-Malate02CO2OxaloacetatePyruvatephosphoenolpyruvateSuccinateglyoxylateIsocitrateCitrateSuccinyl-CoACO2Succinyl-CoACO2


Description

Schematic of the GAS pathway which is characterised by flux through the glyoxylate shunt and anaplerotic reactions for oxidation of pyruvate and succinyl CoA synthetase for the generation of succinyl CoA. From: (http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002091)

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Bibliography

  1. Beste DJ, Bonde B, Hawkins N, Ward JL, Beale MH, Noack S, Nöh K, Kruger NJ, Ratcliffe RG, McFadden J; ''13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation.''; PLoS Pathog, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117427view10:46, 21 May 2021EweitzModified title
105016view08:32, 28 June 2019Fehrhartsome graphical upgrade
105015view08:30, 28 June 2019Fehrhartconnected missing line
87774view11:05, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
87773view11:04, 25 July 2016MirellaKalafatiModified title
74095view13:07, 29 March 2014EgonwFixed a character encoding issue.
73789view12:56, 24 February 2014Andrafinished drawing the pathway from the paper
73788view12:47, 24 February 2014AndraModified description
73787view12:47, 24 February 2014AndraModified description
73784view11:40, 24 February 2014AndraAdded main reference where the pathway is from
73783view11:38, 24 February 2014AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
02Metabolite952 (Chemspider)
CO2Metabolite274 (Chemspider)
CitrateMetabolite29081 (Chemspider)
IsocitrateMetabolite4573809 (Chemspider)
L-MalateMetabolite4573566 (Chemspider)
OxaloacetateMetabolite2509917 (Chemspider)
PyruvateMetabolite96901 (Chemspider)
SuccinateMetabolite140973 (Chemspider)
Succinyl-CoAMetabolite83179 (Chemspider)
glyoxylateMetabolite2849615 (Chemspider)
phosphoenolpyruvateMetabolite980 (Chemspider)

Annotated Interactions

No annotated interactions

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