B cell receptor signaling pathway (Gallus gallus)

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CY->PMCY->PMDephosphorylationNucleusCY->PMDEndosomeEndoplasmic reticulumDControlCY->NUCY->NUCY->PMCY->PMCY->NUDCY->PMDMTCY->NUExtracellularARP2/3MitochondriaMethylationENInhibitionDemethylationDGODCY->PMDDCYPM(Protein-protein interaction)SumoylationDRecruitmentDDeacetylationMolecule in the pathwayTranslocationReceptorCY->NUAutophosphorylationComplexMolecular associationCY->PMCY->PMGolgi apparatusAcetylationProteolytic cleavageEnzyme ComplexECProteins in a complex interactionCY->PMPhosphorylationCY->PMDCY->PMNU->CYCytoplasmMACY->PMCY->MTDNUReaction through unknown mechanisms/moleculesDPalmitoylationNU->CYPlasma membraneDMT->CYAccesion Number: NetPath 12ActivationCY->NUGlycosylationCY->PMUbiquitinationERLigandCY->PMCY->NUCY->PMDesumoylationCY->PMPM->CYPM->CYDCY->NUDeubiquitinationCY->PMDMAP3K7LCP2RCJMB04_19o18ACTR2NFATC1PRKCERCJMB04_20j15MAPK1RHOACD79BPLEKHA1GTF2ILYNRASA1CD22ACTR3PIK3CGCD19HCLS1RPS6KA1SOS1SOS2HDAC5CD72STAP1HNRPKPRKCBCASP9NFATC3HDAC7APRKCQSH2B2LIME1PIP4K2BFOXO1ARCJMB04_19o18CRKLIKBKBDAPP1PRKCERCJMB04_20j15CBLBGAB1NFATC2RCJMB04_19h23ARPC5LYNPIP5K1ABCL2CDK6CD79AHDAC5CDK2AKT1HCKMAP4K1PTPN6ELK1PRKCDPTPRCMAPK14Gene SymbolRAPGEF1ARPC1BBCL6GRB2HDAC7AMAPK3IGHMATF2RAPGEF1TECCR2PIP4K2ACCND3PIK3AP1ZAP70CD79ABAXATP2B4RELAPTK2PIP5K1CGSK3AFCGR2BNFATC2HCLS1BCAR1RCJMB04_12k21BTKPIP4K2BNEDD9CTNNB1DAPP1BLKRB1PLEKHA1RCJMB04_17i9CTNNB1NFATC3PTPN11PTPN18NCK1CARD11BANK1CD5MAPK8PIK3R2PIP5K2CSHC1RCJMB04_24n15AKT1VAV2PIK3R1CBLRCJMB04_4j14CDK7CRKPTPN6RCJMB04_29l6JUNPLEKHA2SH3BP2BTKGSK3BCRKINPP5DCD81PDK2ITPR1CYCSMAPK4PLCG1PIK3AP1RAP2APIP4K2BLCKINPP5DPDPK1IKBKGLAT2RPS6PTPN6PLCG2DUSP6CCNA2DOK3RASGRP3CARD11MAP2K2PLCG2CREB1FYNBAXARPC2HCLS1WASCHST15CSKLYNARPC4GAB1DOK1PILRBSLA2RELPPP3R1PRKCBGRB2CCND2PTK2BCYCSARPC3BLNKPRKCDIKBKBNFKBIABRAFRCJMB04_20j15CCNE1RELBCL2L11GAB2MAPKAPK2MAP2K1BCL10STAT3DUSP4ITKRELARCJMB04_19h23LAT2BLNKVAV1RASGRP3SHC1GTF2IPPP3CACASP7PLEKHA2ITPR2CDK4RCJMB04_19o18RPS6KA1RAF1


Description

The B cell receptor includes membrane μ heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12

Comments

GenMAPP notes 
NetPath 12 - B Cell Receptor Signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP23(r20725) with a 72% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
118017view11:35, 23 May 2021EweitzModified title
89907view13:24, 6 October 2016MkutmonModified description
73857view00:57, 26 February 2014MaintBotupdated schema
67074view10:02, 26 June 2013Christine ChichesterOntology Term : 'B cell receptor signaling pathway' added !
40956view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35703view23:13, 12 February 2010AlexanderPico
33883view17:54, 9 December 2009MaintBotAutomatic update of empty xrefs
31522view21:41, 13 August 2009MaintBotFixed text labels
30363view20:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTR2GeneProduct396147 (Entrez Gene)
ACTR3GeneProduct374197 (Entrez Gene)
AKT1GeneProduct395928 (Entrez Gene)
ARPC1BGeneProduct416490 (Entrez Gene)
ARPC2GeneProduct429041 (Entrez Gene)
ARPC3GeneProduct416837 (Entrez Gene)
ARPC4GeneProduct416051 (Entrez Gene)
ARPC5GeneProduct429075 (Entrez Gene)
ATF2GeneProduct395727 (Entrez Gene)
ATP2B4GeneProduct419934 (Entrez Gene)
BANK1GeneProduct422711 (Entrez Gene)
BAXGeneProduct
BCAR1GeneProduct415691 (Entrez Gene)
BCL10GeneProduct424528 (Entrez Gene)
BCL2GeneProduct396282 (Entrez Gene)
BCL2L11GeneProduct
BCL6GeneProduct424912 (Entrez Gene)
BLKGeneProduct422035 (Entrez Gene)
BLNKGeneProduct395733 (Entrez Gene)
BRAFGeneProduct396239 (Entrez Gene)
BTKGeneProduct374075 (Entrez Gene)
CARD11GeneProduct416476 (Entrez Gene)
CASP7GeneProduct423901 (Entrez Gene)
CASP9GeneProduct426970 (Entrez Gene)
CBLGeneProduct374038 (Entrez Gene)
CBLBGeneProduct418406 (Entrez Gene)
CCNA2GeneProduct396172 (Entrez Gene)
CCND2GeneProduct374047 (Entrez Gene)
CCND3GeneProduct419928 (Entrez Gene)
CCNE1GeneProduct426117 (Entrez Gene)
CD19GeneProduct
CD22GeneProduct
CD5GeneProduct395757 (Entrez Gene)
CD72GeneProduct395923 (Entrez Gene)
CD79AGeneProduct
CD79BGeneProduct419940 (Entrez Gene)
CD81GeneProduct374256 (Entrez Gene)
CDK2GeneProduct
CDK4GeneProduct
CDK6GeneProduct420558 (Entrez Gene)
CDK7GeneProduct771294 (Entrez Gene)
CHST15GeneProduct423952 (Entrez Gene)
CR2GeneProduct
CREB1GeneProduct395099 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
CSKGeneProduct396396 (Entrez Gene)
CTNNB1GeneProduct395964 (Entrez Gene)
CYCSGeneProduct420624 (Entrez Gene)
DAPP1GeneProduct768342 (Entrez Gene)
DOK1GeneProduct430423 (Entrez Gene)
DOK3GeneProduct429960 (Entrez Gene)
DUSP4GeneProduct395642 (Entrez Gene)
DUSP6GeneProduct374272 (Entrez Gene)
ELK1GeneProduct
FCGR2BGeneProduct
FOXO1AGeneProduct374231 (Entrez Gene)
FYNGeneProduct396294 (Entrez Gene)
GAB1GeneProduct422456 (Entrez Gene)
GAB2GeneProduct419027 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
GSK3AGeneProduct
GSK3BGeneProduct418335 (Entrez Gene)
GTF2IGeneProduct417486 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct419280 (Entrez Gene)
HCLS1GeneProduct426867 (Entrez Gene)
HDAC5GeneProduct
HDAC7AGeneProduct426885 (Entrez Gene)
HNRPKGeneProduct426516 (Entrez Gene)
IGHMGeneProduct
IKBKBGeneProduct426792 (Entrez Gene)
IKBKGGeneProduct
INPP5DGeneProduct424745 (Entrez Gene)
ITKGeneProduct416247 (Entrez Gene)
ITPR1GeneProduct395412 (Entrez Gene)
ITPR2GeneProduct418212 (Entrez Gene)
JUNGeneProduct424673 (Entrez Gene)
LAT2GeneProduct417489 (Entrez Gene)
LCKGeneProduct
LCP2GeneProduct395438 (Entrez Gene)
LIME1GeneProduct
LYNGeneProduct421127 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAP3K7GeneProduct421808 (Entrez Gene)
MAP4K1GeneProduct
MAPK1GeneProduct373953 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK3GeneProduct
MAPK4GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
NCK1GeneProduct
NEDD9GeneProduct395736 (Entrez Gene)
NFATC1GeneProduct420815 (Entrez Gene)
NFATC2GeneProduct419346 (Entrez Gene)
NFATC3GeneProduct415711 (Entrez Gene)
NFKBIAGeneProduct396093 (Entrez Gene)
PDK2GeneProduct
PDPK1GeneProduct416588 (Entrez Gene)
PIK3AP1GeneProduct374268 (Entrez Gene)
PIK3CGGeneProduct417706 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PILRBGeneProduct
PIP4K2AGeneProduct420504 (Entrez Gene)
PIP4K2BGeneProduct419999 (Entrez Gene)
PIP5K1AGeneProduct429983 (Entrez Gene)
PIP5K1CGeneProduct420072 (Entrez Gene)
PIP5K2CGeneProduct
PLCG1GeneProduct
PLCG2GeneProduct415805 (Entrez Gene)
PLEKHA1GeneProduct423940 (Entrez Gene)
PLEKHA2GeneProduct395435 (Entrez Gene)
PPP3CAGeneProduct395113 (Entrez Gene)
PPP3R1GeneProduct378804 (Entrez Gene)
PRKCBGeneProduct416567 (Entrez Gene)
PRKCDGeneProduct415905 (Entrez Gene)
PRKCEGeneProduct421409 (Entrez Gene)
PRKCQGeneProduct
PTK2GeneProduct396416 (Entrez Gene)
PTK2BGeneProduct421998 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PTPN18GeneProduct
PTPN6GeneProduct427947 (Entrez Gene)
PTPRCGeneProduct386580 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RAP2AGeneProduct769797 (Entrez Gene)
RAPGEF1GeneProduct417173 (Entrez Gene)
RASA1GeneProduct427327 (Entrez Gene)
RASGRP3GeneProduct421460 (Entrez Gene)
RB1GeneProduct386582 (Entrez Gene)
RCJMB04_12k21GeneProduct423302 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_19h23GeneProduct423669 (Entrez Gene)
RCJMB04_19o18GeneProduct427272 (Entrez Gene)
RCJMB04_20j15GeneProduct427243 (Entrez Gene)
RCJMB04_24n15GeneProduct378890 (Entrez Gene)
RCJMB04_29l6GeneProduct414829 (Entrez Gene)
RCJMB04_4j14GeneProduct417637 (Entrez Gene)
RELGeneProduct396500 (Entrez Gene)
RELAGeneProduct
RHOAGeneProduct395442 (Entrez Gene)
RPS6GeneProduct396148 (Entrez Gene)
RPS6KA1GeneProduct386579 (Entrez Gene)
SH2B2GeneProduct771172 (Entrez Gene)
SH3BP2GeneProduct422883 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
SLA2GeneProduct
SOS1GeneProduct425964 (Entrez Gene)
SOS2GeneProduct423572 (Entrez Gene)
STAP1GeneProduct428761 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
TECGeneProduct396407 (Entrez Gene)
VAV1GeneProduct
VAV2GeneProduct373938 (Entrez Gene)
WASGeneProduct
ZAP70GeneProduct420086 (Entrez Gene)

Annotated Interactions

No annotated interactions
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