Tamoxifen metabolism (Pan troglodytes)

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1-5SulfationDeaminationMCF-7 cell proliferationAlcohol metabolismMain pathwayAlternate pathwaySulfationSulfationcis-4-hydroxy-N-desmethyltamoxifenPAPdeaminohydroxytamoxifenUGT1A8CYP2C19trans-4-SulfoxytamoxifenFMO3_PANTRA4ZZ70_PANTRB1NL93_PANTRCYP2C9B1NL93_PANTRQ9N256_PANTRFMO1B1NL93_PANTRSULT1E1N,N-didesmethyltamoxifenSSRIPAPSB1NL93_PANTRB1NL93_PANTRUGT1A4SULT2A1cis-4-hydroxytamoxifen-N-glucuronideMetaboliteCYP2E1alpha-hydroxytamoxifenSULT1A1PAPSCYP1A1SULT2A1UGT1A4trans-4-hydroxytamoxifen-N-glucuronideTamoxifen-N-oxideCYP2A6trans-tamoxifen-N-glucuronidecis-N-desmethyltamoxifen-O-glucuronideCP2D6_PANTRCP2D6_PANTRtrans-tamoxifen-4-O-glucuronideSULT1A1CP2D6_PANTRSULT2A1CP2D6_PANTRalpha-hydroxy-N-desmethyltamoxifentrans-4-hydroxy-N-desmethyltamoxifencis-4-hydroxytamoxifenPAPtrans-N-desmethyltamoxifen-O-glucuronideUGT1A4B1NL93_PANTRtrans-tamoxifenUGT1A10CYP2C8N-desmethyltamoxifenUGT2B7SULT1E1CYP2C19trans-4-hydroxytamoxifenA4ZZ70_PANTRcis-tamoxifen-4-O-glucuronideCYP2C9CYP2C19UGT2B15trans-4-SulfoxytamoxifenB1NL93_PANTRCYP1B1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP691(r29331) with a 85% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Jordan VC; ''Chemoprevention of breast cancer with selective oestrogen-receptor modulators.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  2. Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4.''; Biochem Pharmacol, 2006 PubMed Europe PMC Scholia
  3. Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D; ''Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen.''; Ann N Y Acad Sci, 2009 PubMed Europe PMC Scholia
  4. Jordan VC; ''New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer.''; Steroids, 2007 PubMed Europe PMC Scholia
  5. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A; ''Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.''; Biochem Pharmacol, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106913view13:38, 17 September 2019MaintBotHMDB identifier normalization
87704view09:03, 25 July 2016MirellaKalafatiOntology Term : 'drug pathway' added !
74161view09:44, 2 April 2014EgonwReplaced an outdated HMDB identifier with the ChEBI one.
71881view10:15, 19 October 2013EgonwFixed the PubChem-compound database name.
69235view18:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
58902view04:47, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41539view01:57, 2 March 2011MaintBotRemoved redundant pathway information and comments
33515view15:19, 30 November 2009MaintBotRemoved group label
32767view18:31, 4 September 2009MaintBotModified categories
31555view21:53, 13 August 2009MaintBotFixed text labels
30414view21:14, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A4ZZ70_PANTRGeneProductENSPTRG00000019458 (Ensembl)
B1NL93_PANTRGeneProductENSPTRG00000019460 (Ensembl)
CP2D6_PANTRGeneProductENSPTRG00000034370 (Ensembl)
CYP1A1GeneProductENSPTRG00000007280 (Ensembl)
CYP1B1GeneProductENSPTRG00000011843 (Ensembl)
CYP2A6GeneProduct
CYP2C19GeneProductENSPTRG00000002779 (Ensembl)
CYP2C8GeneProductENSPTRG00000002781 (Ensembl)
CYP2C9GeneProductENSPTRG00000002780 (Ensembl)
CYP2E1GeneProductENSPTRG00000003099 (Ensembl)
FMO1GeneProductENSPTRG00000001674 (Ensembl)
FMO3_PANTRGeneProductENSPTRG00000001670 (Ensembl)
MetaboliteMetabolite
N,N-didesmethyltamoxifenMetabolite3036172 (PubChem-compound)
N-desmethyltamoxifenMetabolite3032890 (PubChem-compound)
PAPMetaboliteHMDB00061 (HMDB)
PAPSMetabolite10214 (PubChem-compound)
Q9N256_PANTRGeneProductENSPTRG00000007281 (Ensembl)
SSRIMetabolite
SULT1A1GeneProductENSPTRG00000022685 (Ensembl)
SULT1E1GeneProductENSPTRG00000016118 (Ensembl)
SULT2A1GeneProductENSPTRG00000011219 (Ensembl)
Tamoxifen-N-oxideMetabolite
UGT1A10GeneProduct
UGT1A4GeneProduct
UGT1A8GeneProduct
UGT2B15GeneProductENSPTRG00000022951 (Ensembl)
UGT2B7GeneProduct471218 (Entrez Gene)
alpha-hydroxy-N-desmethyltamoxifenMetabolite
alpha-hydroxytamoxifenMetabolite
cis-4-hydroxy-N-desmethyltamoxifenMetabolite
cis-4-hydroxytamoxifenMetabolite
cis-4-hydroxytamoxifen-N-glucuronideMetabolite
cis-N-desmethyltamoxifen-O-glucuronideMetabolite
cis-tamoxifen-4-O-glucuronideMetabolite
deaminohydroxytamoxifenMetabolite3033897 (PubChem-compound)
trans-4-SulfoxytamoxifenMetabolite
trans-4-hydroxy-N-desmethyltamoxifenMetabolite3035980 (PubChem-compound)
trans-4-hydroxytamoxifen-N-glucuronideMetabolite
trans-4-hydroxytamoxifenMetabolite449459 (PubChem-compound)
trans-N-desmethyltamoxifen-O-glucuronideMetabolite
trans-tamoxifen-4-O-glucuronideMetabolite
trans-tamoxifen-N-glucuronideMetabolite5460873 (PubChem-compound)
trans-tamoxifenMetaboliteCHEBI:41774 (ChEBI)

Annotated Interactions

No annotated interactions
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