MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there.
Comments
This pathway show all microRNA gene cluster involed in the wikipathway pathway "DNA damage response (Homo sapiens)". More info can be found there.
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP1545(r45378) with a 52% conversion rate.
Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMedEurope PMCScholia
Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMedEurope PMCScholia
Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V; ''p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.''; Mol Syst Biol, 2008 PubMedEurope PMCScholia
Woods K, Thomson JM, Hammond SM; ''Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.''; J Biol Chem, 2007 PubMedEurope PMCScholia
Yamakuchi M, Lowenstein CJ; ''MiR-34, SIRT1 and p53: the feedback loop.''; Cell Cycle, 2009 PubMedEurope PMCScholia
Quintavalle M, Elia L, Condorelli G, Courtneidge SA; ''MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.''; J Cell Biol, 2010 PubMedEurope PMCScholia
O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT; ''c-Myc-regulated microRNAs modulate E2F1 expression.''; Nature, 2005 PubMedEurope PMCScholia
Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMedEurope PMCScholia
Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT; ''Widespread microRNA repression by Myc contributes to tumorigenesis.''; Nat Genet, 2008 PubMedEurope PMCScholia
Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T, McCue P, Pestell RG; ''A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.''; J Cell Biol, 2008 PubMedEurope PMCScholia
Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMedEurope PMCScholia
Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, Linsley PS, Cleary MA; ''MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.''; Mol Cell Biol, 2008 PubMedEurope PMCScholia
Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z, Zheng X; ''miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.''; Nucleic Acids Res, 2008 PubMedEurope PMCScholia
Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMedEurope PMCScholia
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMedEurope PMCScholia
Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMedEurope PMCScholia
Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMedEurope PMCScholia
Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N; ''MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.''; J Clin Invest, 2008 PubMedEurope PMCScholia
Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY; ''MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.''; Cancer Res, 2007 PubMedEurope PMCScholia
Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMedEurope PMCScholia
Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMedEurope PMCScholia
Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M; ''Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.''; Mol Cell Biol, 2010 PubMedEurope PMCScholia
Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMedEurope PMCScholia
Cuesta R, MartÃÂnez-Sánchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMedEurope PMCScholia
Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMedEurope PMCScholia
Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G; ''Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.''; Blood, 2010 PubMedEurope PMCScholia
Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A; ''miR-221 overexpression contributes to liver tumorigenesis.''; Proc Natl Acad Sci U S A, 2010 PubMedEurope PMCScholia
Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER; ''p53-mediated activation of miRNA34 candidate tumor-suppressor genes.''; Curr Biol, 2007 PubMedEurope PMCScholia
Pothof J, Verkaik NS, van IJcken W, Wiemer EA, Ta VT, van der Horst GT, Jaspers NG, van Gent DC, Hoeijmakers JH, Persengiev SP; ''MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.''; EMBO J, 2009 PubMedEurope PMCScholia
Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M; ''p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.''; Proc Natl Acad Sci U S A, 2010 PubMedEurope PMCScholia
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