Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B.; ''Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage.''; PubMedEurope PMCScholia
Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z.; ''Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition.''; PubMedEurope PMCScholia
Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B.; ''Reversal of DNA alkylation damage by two human dioxygenases.''; PubMedEurope PMCScholia
Dango S, Mosammaparast N, Sowa ME, Xiong LJ, Wu F, Park K, Rubin M, Gygi S, Harper JW, Shi Y.; ''DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.''; PubMedEurope PMCScholia
Sundheim O, Vågbø CB, Bjørås M, Sousa MM, Talstad V, Aas PA, Drabløs F, Krokan HE, Tainer JA, Slupphaug G.; ''Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.''; PubMedEurope PMCScholia
Zhao X, Yang Y, Sun BF, Zhao YL, Yang YG.; ''FTO and obesity: mechanisms of association.''; PubMedEurope PMCScholia
Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC.; ''Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.''; PubMedEurope PMCScholia
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI.; ''A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.''; PubMedEurope PMCScholia
Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougnères P, Kovacs P, Marre M, Balkau B, Cauchi S, Chèvre JC, Froguel P.; ''Variation in FTO contributes to childhood obesity and severe adult obesity.''; PubMedEurope PMCScholia
Chen B, Liu H, Sun X, Yang CG.; ''Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3.''; PubMedEurope PMCScholia
Duguid EM, Rice PA, He C.; ''The structure of the human AGT protein bound to DNA and its implications for damage detection.''; PubMedEurope PMCScholia
Rasimas JJ, Dalessio PA, Ropson IJ, Pegg AE, Fried MG.; ''Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase.''; PubMedEurope PMCScholia
Tubbs JL, Pegg AE, Tainer JA.; ''DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.''; PubMedEurope PMCScholia
Lindahl T, Demple B, Robins P.; ''Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.''; PubMedEurope PMCScholia
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C.; ''N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.''; PubMedEurope PMCScholia
Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J.; ''Crystal structure of the FTO protein reveals basis for its substrate specificity.''; PubMedEurope PMCScholia
Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J.; ''Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.''; PubMedEurope PMCScholia
Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE.; ''Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.''; PubMedEurope PMCScholia
Merkestein M, Sellayah D.; ''Role of FTO in Adipocyte Development and Function: Recent Insights.''; PubMedEurope PMCScholia
Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C.; ''ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.''; PubMedEurope PMCScholia
Mitra S, Kaina B.; ''Regulation of repair of alkylation damage in mammalian genomes.''; PubMedEurope PMCScholia
Daniels DS, Mol CD, Arvai AS, Kanugula S, Pegg AE, Tainer JA.; ''Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.''; PubMedEurope PMCScholia
Vora RA, Pegg AE, Ealick SE.; ''A new model for how O6-methylguanine-DNA methyltransferase binds DNA.''; PubMedEurope PMCScholia
At the beginning of this reaction, 1 molecule of 'Alkylated DNA with 3-methylcytosine', 1 molecule of 'Oxygen', and 1 molecule of '2-Oxoglutarate' are present. At the end of this reaction, 1 molecule of 'Formaldehyde', 1 molecule of 'Repaired DNA after oxidative dealkylation', 1 molecule of 'CO2', and 1 molecule of 'Succinate' are present.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH3 protein'.
At the beginning of this reaction, 1 molecule of 'Oxygen', 1 molecule of '2-Oxoglutarate', and 1 molecule of 'Alkylated DNA with 1-methyladenine' are present. At the end of this reaction, 1 molecule of 'Formaldehyde', 1 molecule of 'Repaired DNA after oxidative dealkylation', 1 molecule of 'CO2', and 1 molecule of 'Succinate' are present.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH2 protein'.
Reactive cellular catabolites can cause DNA damage by 6-O-methylation of guanine. 6-O-methylguanine can pair ambiguously with both C and T, and can cause transition mutations. Active reversal of such damage can be facilitated by proteins having 6-O-methylguanine-DNA methyltransferase (MGMT) activity.
MGMT removes the methyl group from the guanine and transfers it to the cysteine residue at position 145 on the protein itself. MGMT thus methylated is not regenerated, as the S-methylcysteine is very stable. This is an energetically expensive approach to DNA repair as one entire protein molecule is sacrificed per lesion that is corrected in this manner (Yang et al. 2011).
At the beginning of this reaction, 1 molecule of 'Oxygen', 1 molecule of 'Alkylated DNA with 1-ethyladenine', and 1 molecule of '2-Oxoglutarate' are present. At the end of this reaction, 1 molecule of 'Repaired DNA after oxidative dealkylation', 1 molecule of 'CO2', 1 molecule of 'Succinate', and 1 molecule of 'Acetaldehyde' are present.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH3 protein'.
At the beginning of this reaction, 1 molecule of 'Alkylated DNA with 3-methylcytosine', 1 molecule of 'Oxygen', and 1 molecule of '2-Oxoglutarate' are present. At the end of this reaction, 1 molecule of 'Formaldehyde', 1 molecule of 'Repaired DNA after oxidative dealkylation', 1 molecule of 'CO2', and 1 molecule of 'Succinate' are present.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH2 protein'.
At the beginning of this reaction, 1 molecule of 'Oxygen', 1 molecule of '2-Oxoglutarate', and 1 molecule of 'Alkylated DNA with 1-methyladenine' are present. At the end of this reaction, 1 molecule of 'Formaldehyde', 1 molecule of 'Repaired DNA after oxidative dealkylation', 1 molecule of 'CO2', and 1 molecule of 'Succinate' are present.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH3 protein'.
At the beginning of this reaction, 1 molecule of 'Oxygen', 1 molecule of 'Alkylated DNA with 1-ethyladenine', and 1 molecule of '2-Oxoglutarate' are present. At the end of this reaction, 1 molecule of 'Repaired DNA after oxidative dealkylation', 1 molecule of 'CO2', 1 molecule of 'Succinate', and 1 molecule of 'Acetaldehyde' are present.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH2 protein'.
Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=73942
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This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH3 protein'.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH2 protein'.
MGMT removes the methyl group from the guanine and transfers it to the cysteine residue at position 145 on the protein itself. MGMT thus methylated is not regenerated, as the S-methylcysteine is very stable. This is an energetically expensive approach to DNA repair as one entire protein molecule is sacrificed per lesion that is corrected in this manner (Yang et al. 2011).
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH3 protein'.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH2 protein'.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH3 protein'.
This reaction takes place in the 'nucleus' and is mediated by the 'damaged DNA binding activity' of 'ABH2 protein'.