Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)

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6, 96, 146, 92, 1687, 10, 112, 36, 95, 156, 14U4 ATAC snRNPU6 ATAC snRNP RNA Polymerase II RNA Polymerase II holoenzyme complex U4U5U6 trisnRNP complex U11 snRNP TFIIF snRNP Sm core complex capped, methylated pre-mRNPCBC complex RNA Polymerase II holoenzyme complex Cap Binding Complex CPSF Nucleoplasmic mature intronless derived mRNATAPAly/Ref complex snRNP Sm core complex SF3A TFIIF U5 snRNP RNA Polymerase II CF II U6 ATAC snRNP U11 snRNP U6 snRNP CstF pre-EJC complex RNA Polymerase II holoenzyme complex Cleavage and Polyadenylation Complex snRNP Sm core complex snRNP Sm core complex SF3B U1 snRNP Spliceosomal E Complex SF3B U4 snRNP Nup62 Complex TFIIF CF II SF3B CF II TFIIF Cap Binding Complex U6 snRNP capped, methylated pre-mRNACBC Complex snRNP Sm core complex CF I Cap Binding Complex Cleavage and Polyadenylation Complex Cap Binding Complex Cap Binding Complex RNA Polymerase II Cap Binding Complex U1 snRNP capped, methylated pre-mRNACBC Complex U1 snRNP Mature intronless derived mRNA complex Cap Binding Complex SF3A CF I Cap Binding Complex Export Receptor bound mature mRNA Complex Spliceosomal Active C Complex Magoh-Y14 complex RNA Polymerase II holoenzyme complex U5 snRNP mRNA U6 snRNP EJC complex U12 snRNP Spliceosomal A Complex capped pre-mRNACBCRNA Pol II U1 snRNP Cap Binding Complex U2 snRNP TFIIF RNA Polymerase II CF II Cap Binding Complex U6 ATAC snRNP capped, methylated pre-mRNACBC Complex SF3B snRNP Sm core complex RNA Polymerase II CstF U4 ATACU5U6 ATAC Complex Spliceosomal E Complex U4 ATAC snRNP CPSF U11 snRNP SF3A pre-EJC complex U6 ATAC snRNP SF3A snRNP Sm core complex Cleavage and Polyadenylation Complex RNA polymerase II TFIIF U6 snRNP SF3B SF3B CstF Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complex Nuclear Pore Complex U5 snRNP ATAC B Complex SF3B U5 snRNP RNA Polymerase II holoenzyme complex hnRNP proteins mRNA 3'-end cleavage factor Cap Binding Complex EJC complex 3' end cleaved, ligated exon containing complex Cap Binding Complex Nup107 Complex TAP3'-polyadenylated, capped mRNA complex CF II U4 ATAC snRNPU6 ATAC snRNP Cap Binding Complex CF I U4 snRNP ATAC C Complex with lariat containing 5'-end cleaved mRNA Magoh-Y14 complex RNA Polymerase II holoenzyme complex TFIIF U2 snRNP capped, methylated pre-mRNACBC Complex RNA Polymerase II holoenzyme complex snRNP Sm core complex Magoh-Y14 complex RNA polymerase II EJC complex Spliceosomal B Complex snRNP Sm core complex capped, methylated pre-mRNACBC Complex Cap Binding Complex Mature Intronless Transcript Derived Histone mRNATAPAly/Ref complex CstF snRNP Sm core complex pre-EJC complex CF I Cap Binding Complex Magoh-Y14 complex TFIIF Spliceosomal E Complex cytosolSF3B Mature SLBP independent Histone mRNAeIF4E complex U6 snRNP U12 snRNP Cap Binding Complex CPSF pre-EJC complex U12 snRNP snRNP Sm core complex Exon Junction Complex SF3A Export Receptor bound mature mRNA Complex RNA Polymerase II snRNP Sm core complex snRNP Sm core complex Mature intronless derived mRNATAPAly/Ref complex 3'-polyadenylated, capped mRNA complex RNA Polymerase II holoenzyme complex CF I CPSF intron-containing complex RNA polymerase II TFIIF U4 ATAC snRNP capped, methylated pre-mRNACBC Complex U5 snRNP RNA Polymerase II holoenzyme complex U4 ATAC snRNP Cleavage and Polyadenylation Complex Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complex RNA Polymerase II holoenzyme complex RNA Polymerase II Nup62 Complex ATAC C Complex U6 ATAC snRNP RNA Polymerase II Mature Intronless transcript derived Histone mRNASLBPCBP80CBP20 TFIIF CstF capped, methylated pre-mRNACBC Complex Spliceosomal Intermediate C Complex Cap Binding Complex ATAC A Complex TFIIF RNA Polymerase II holoenzyme complex RNA Polymerase II holoenzyme complex CPSF snRNP Sm core complex Cap Binding Complex U4 snRNPU6 snRNP complex pre-EJC complex Nup107 Complex U5 snRNP capped, methylated pre-mRNACBC Complex CPSF snRNP Sm core complex TFIIF CstF capped, methylated pre-mRNACBC Complex Magoh-Y14 complex Ligated exon containing complex U5 snRNP CF II Mature Intronless Transcript Derived Histone mRNATAPAly/Ref Complex Cap Binding Complex U6 snRNP SF3B CF I Cleavage and Polyadenylation Complex RNA polymerase II U6 snRNP RNA Polymerase II snRNP Sm core complex CF II U5 snRNP U2 snRNP ATAC A Complex U5 snRNP CF II snRNP Sm core complex Magoh-Y14 complex RNA Polymerase II holoenzyme complex SF3A TFIIF RNA Polymerase II snRNP Sm core complex Mature mRNP Complex CF I capped, methylated pre-mRNACBC Complex CPSF RNA Polymerase II CstF capped, methylated pre-mRNACBC Complex U4 ATACU5U6 ATAC Complex snRNP Sm core complex CstF SF3A Cleavage and Polyadenylation Complex U11 snRNP CPSF TFIIF Magoh-Y14 complex U4 snRNP Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complex Mature Intronless Transcript Derived mRNAeIF4E Complex 3'-polyadenylated, capped mRNA complex U2 snRNP Cap Binding Complex snRNP Sm core complex U1 snRNP RNA Polymerase II holoenzyme complex TFIIF Spliceosomal A Complex CF I Mature intronless transcript derived Histone pre-mRNACBC complex CPSF U2 snRNP CPSF U4 snRNPU6 snRNP complex SF3B U5 snRNP Cap Binding Complex U12 snRNP U2 snRNP Cap Binding Complex U5 snRNP snRNP Sm core complex RNA Polymerase II holoenzyme complex Magoh-Y14 complex Nuclear Pore Complex U6 ATAC snRNP SF3B Mature intronless transcript derived Histone mRNASLBPeIF4E Complex U2 snRNP lariat containing 5'-end cleaved mRNACBC complex lariat containing 5'-end cleaved mRNACBC complex U2 snRNP RNA Polymerase II TFIIF capped, methylated pre-mRNACBC Complex Cap Binding Complex U11 snRNP pre-EJC complex snRNP Sm core complex Magoh-Y14 complex CPSF CF II post exon ligation complex Cap Binding Complex SF3B U12 snRNP CF I RNA Polymerase II RNA Polymerase II holoenzyme complex nucleoplasmSF3A Cap Binding Complex SF3B Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complex U5 snRNP hnRNP proteins EJC complex MAGOH UPF3B NCBP2 ALYREFHNRNPM POLR2FPAPOLACLP1 PCBP2 CPSF7 POLR2H HNRNPA1 NFX.1 POLR2C HNRNPC PCBP1 Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexPRPF8 HNRNPU ALYREF SRSF6 2xMe-SNRPD3 YBX1SNRPB2 POLR2K CDC40 SRSF1 GTF2F1HNRNPA0 HNRNPA2B1 NUP37 CD2BP2 HNRNPK SNRPF NUP188HNRNPUL1 DNAJC8SRSF3 NFX.1 U2 snRNA NXF1POLR2J SF3B1 SNRPG POLR2A SF3B4 SNRPE 2xMe-SNRPD1 CLP1 POLR2G CCAR1 RNPS1 SRRM1 DNAJC8PCF11 TXNL4A PTBP1 POLR2K CPSF1 HNRNPK POLR2L SF3B1 EIF4E SNRPD2 hPrp18POLR2J HNRNPM DNAJC8POLR2K HNRNPH2 NFX.1 SRSF7 SNRNP200 POLR2DCSTF2CPSF1 2xMe-SNRPD1 NUP155 EFTUD2 POLR2C U6 snRNA SF3B5 POLR2E SRSF3SNRPD2 SRSF4mRNA 3'-end cleavage factorNUP62 SNRNP40 SRSF2 MAGOH 2xMe-SNRPB SRSF1 HNRNPA3 UPF3BSNRPD2 CSTF3 SUGP1 NCBP1 2xMe-SNRPB Spliceosomal Intermediate C ComplexMAGOH POLR2L POLR2I SRSF6 U4 snRNA Mature Intronless Transcript Derived Histone mRNATAPAly/Ref ComplexPOLR2J SNRPD2 PHF5ANCBP2 HNRNPH1ALYREF SF3B3 POLR2L SUGP1 YBX1 NCBP1 2xMe-SNRPD1 Spliceosomal A ComplexSRSF5 SF3A1 PCF11 POLR2H SRSF5HNRNPH2HNRNPR HNRNPD CPSF2 POLR2FPCBP2 NUP54 YBX1 CCAR1 NUDT21 ALYREF SNRPE SNRPG HNRNPFExport Receptor bound mature mRNA ComplexNCBP1 SF3B2 NCBP2 RBM5 HNRNPUL1SNRPF SNRPG SRSF2 POLR2H NFX.1 HNRNPH1CPSF3 SF3A1 SNRPF RBM5 POLR2FPRPF8 POLR2K CF IIGTF2F1SF3B4 CPSF2 SNRPE NUDT21 2xMe-SNRPD3 NFX.1 POLR2I DDX23 UPF3B POLR2DHNRNPC POLR2DNXF1CPSF2 DDX23 FUS 2xMe-SNRPB POLR2A PRPF6 SRSF2RBM5SRSF6 EFTUD2 SF3B4 CLP1 POLR2G SNRPG SMC1A SF3B14 2xMe-SNRPB NUP88 SNRPG SRSF5 SRSF7 2xMe-SNRPD3 SF3B14 CD2BP2 U6 snRNA NUP160 CSTF2EIF4EPOLR2K POLR2H SF3B2 NCBP1 SRSF3 DHX9 HNRNPA1 U2AF1 2xMe-SNRPD3 POLR2FCPSF1 POM121 SRSF9 Cleavage and Polyadenylation ComplexPCBP1 SNRPB2 POLR2B SNRPF U6 ATAC snRNPNUDT21 HNRNPA3 NCBP2 RNA polymerase II POLR2E PHF5AHNRNPH12xMe-SNRPD3 CPSF7 GTF2F2HNRNPL POLR2E 2xMe-SNRPD3 2xMe-SNRPB U2AF1 SRRM1 ATAC C ComplexPRPF4 SNRPA SF3B4 SRSF4 POLR2H SNRPG NUP88 RANBP2 SNRPG SNRPB2 2xMe-SNRPD3 DHX38 NUP43 SNRPF SF3A2 SRSF2 SRSF1 U2AF1 SNRPA1 POLR2I 2xMe-SNRPB CSTF3 RAE1 SRSF6 NHP2L1 SF3B4 SRRM1YBX1 CDC40 CPSFSRSF2 SNRPE NCBP2 SF3B1 EFTUD2 NCBP1 SF3B5 PCBP1 SNRPB2 NCBP1 POM121 SNRPG SMC1A SMC1A GTF2F1NFAR-2 proteinSNRPG CPSF7 SRSF11 ALYREF AAAS SRSF7 RBM5 SF3B2 SF3B14 SNRNP40 CPSFPRPF4 SEH1L-2 UPF3B PRPF8 SF3B2 POLR2B CSTF3 PABPN1POLR2FHNRNPUL1 HNRNPD SMC2 SRSF11 DHX38 U5 snRNA 2xMe-SNRPD3 NUP93 HNRNPFSRSF1 POLR2I SNRPF SNRPA1 LSM2 HNRNPH1POLR2K 2xMe-SNRPB POLR2G SNRPF SF3A3 DHX9 SF3B14 U2 snRNA RBM8A SF3B14 GTF2F1PAPOLAHNRNPA3 PRPF6 NFX.1 NXF1POLR2L SNRPF POLR2H SMC1AYBX1 HNRNPR CPSF2 SRSF7 POLR2A POLR2FPOLR2C CSTF3 SF3A3 NCBP1 POLR2L SNRPD2 RNPS1 SF3A2 SRSF1SF3B14 SRSF7 PABPN1 GTF2F1SNRPG POLR2C 2xMe-SNRPB GTF2F2HNRNPUL1 Mature Intronless transcript derived Histone mRNASLBPCBP80CBP20GTF2F1SNRPD2 SNRNP40 GTF2F22xMe-SNRPD1 HNRNPU SNRNP70 SF3B4 EIF4E CCAR1 EFTUD2 Mature intronless transcript derived Histone mRNASLBPeIF4E ComplexhPrp5DHX38 CLP1 intron-containing complexRAE1 NXF1SRSF5 FUS CPSF1 YBX1 SRSF7 2xMe-SNRPD3 HNRNPKNUDT21 HNRNPL NFX.1 POLR2B GTF2F1SNRPD2 SNRNP200 2xMe-SNRPD3 SRSF2 PRPF6 HNRNPLSF3B3 NXF1U2AF2 POLR2I CD2BP2 SNRPA1 RBM8A 2xMe-SNRPD3 DDX23 SNRPD2 YBX1 SNRPD2 SNRPF SNRPE Ligated exon containing complexEFTUD2 SRSF4 HNRNPM SRSF6 GTF2F2PAPOLASF3B1 U1 snRNA SRSF9PCBP2 PCBP2 SRSF2 SF3B14 SRSF11 SNRPE ALYREF CSTF3 DHX38 RBM5 POLR2H POLR2DNUP37 POLR2E HNRNPA0 PCF11 GTF2F2SF3A3 SF3A3 U2 snRNA PAPOLAFUS NFX.1 PRPF8 HNRNPH2 PRPF6 DHX9 CSTF3 CstFHNRNPC NFX.1DDX23 NUP50 CC1.3 protein /3 RRM, RSALYREF SNRPA1 SRSF5 U2AF1 NCBP2 SRSF6 U4 ATAC snRNPTXNL4A SNRPG RNPS1 SNRPG FUS U1 snRNPSNRPA1 RNPS1U2AF1 SRSF9 NUP43 SNRPE HNRNPL PHF5AFUS SF3B4 HNRNPA3 SNRPG CLP1 DNAJC8CF IU2AF2 SF3B3 SRSF3 U1 snRNPSNRPF LSM2 U2AF2 SRRM1 U1 snRNA SF3A2 HNRNPA2B1 NUP210 PTBP1 SRSF7 SF3B2 CPSF3 POLR2E POLR2G TXNL4A RBMXU5 snRNA POLR2C RBM8A 2xMe-SNRPD1 PABPN1 CPSF2 SNRNP200 ATAC A ComplexSNRNP40 CPSF2 HNRNPUPOLR2H CLP1 PRPF4 SRSF11 NCBP1 CPSF1 SRSF11 POLR2E POLR2I EFTUD2 POLR2H SNRPD2 HNRNPFHNRNPR NFX.1 DHX9 U1 snRNA POLR2A CPSF1 PHF5ADDX23 DHX38 PCBP2 PCBP1 SRSF2 SRSF6 SF3B4 NCBP2 POLR2DPOLR2DSNRPG SF3A3 GTF2F2MAGOH SF3B5 POLR2A SNRPF U2AF1 CPSF7 POLR2L HNRNPA3NUP35 NCBP1 PTBP1 POLR2DSRSF2 HNRNPA1 SF3B3 HNRNPD TXNL4A GTF2F2SF3A2 NCBP1 U2AF2 RBM5 HNRNPL hPrp22POLR2G U11 snRNPNUP155 U2 snRNPPRPF6 SRRM1 HNRNPC SNRPF NCBP2 SNRPB2 2xMe-SNRPD1 CDC40 SRSF9 NFX.1 NCBP2 POLR2G DNAJC8HNRNPM NHP2L1 Spliceosomal B ComplexPOLR2FGTF2F1HNRNPK SF3A2 POLR2K POLR2L DDX23 SRSF1 NXF1HNRNPR SRSF3 2xMe-SNRPB SNRPE POLR2L SUGP1 Spliceosomal E ComplexPOLR2I GTF2F1SRSF1 HNRNPK RBM5 SF3A3 RBM8A SF3B5 EFTUD2 NUP160 SRSF5 SNRNP40 SRSF6 SRSF4 2xMe-SNRPD1 POLR2B CPSF1 NCBP1 POLR2A HNRNPCPOLR2J SRSF1 POLR2E HNRNPA2B1 SNRPD2 SF3A1 SRRM1 SRSF6 NUP98-5 SNRNP200 FUS POLR2DSRSF1 TXNL4A ALYREFSRSF2 CSTF1 SUGP1 POLR2I NCBP1 2xMe-SNRPD1 U6 snRNA HNRNPU ATAC B ComplexUBA, Tudor - FLJ21007SNRPA SF3B5 ATAC C Complex with lariat containing 5'-end cleaved mRNAPOLR2FU2AF1 PRPF8 CSTF2SNRPA SRSF2 SMC1A SRSF2 PRPF8 NXF1DHX9HNRNPM SNRPA1 2xMe-SNRPD1 POLR2C RBMXGTF2F1CSTF3 POLR2C SRRM1 Export Receptor bound mature mRNA ComplexU2 snRNA SRSF5 SNRNP40 HNRNPR POLR2FSNRNP200 SNRPF Mature intronless derived mRNATAPAly/Ref complexSRSF9 SNRPA PHF5AU5 snRNA ALYREF SF3B5 GTF2F2NUP35 POLR2H DDX23 GTF2F2SNRPG 2xMe-SNRPD3 HNRNPH2 2xMe-SNRPD1 3'-polyadenylated, capped mRNA complexSRSF1 POLR2FPRPF4 SNRPD2 SNRNP70 NHP2L1 GTF2F1hSLU7U2AF2 SF3B2 SF3A1 GTF2F1SRSF4 SRSF3 SNRNP200 SNRPB2 PCF11 CDC40 NUDT21 SRSF4 NUDT21 PRPF8 PTBP1 2xMe-SNRPB HNRNPM SF3B5 ALYREFPABPN1 NCBP2 2xMe-SNRPD3 PCBP2 POLR2L PAPOLAMature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexSNRNP70 RBM8A HNRNPH2 U6 snRNA POLR2E SEH1L-2 POLR2K PRPF8 POLR2J POLR2A SNRPG Nup45 SNRNP40 DHX9 2xMe-SNRPD1 POLR2B SNRPA1 NXF1HNRNPA1 POLR2K SNRPD2 CSTF1 SNRPD2 POLR2G NCBP1SRRM1 SRSF9 NUP205SF3B3 CPSF3 2xMe-SNRPD1 2xMe-SNRPB U5 snRNA HNRNPD UPF3B SNRPE NXF1POLR2B post exon ligation complexPAPOLAGTF2F2SRSF4 SF3B2 SRSF6 EIF4E PCBP1 DDX23 SF3B1 CPSFDNAJC8HNRNPR POLR2A SNRPD2 CPSF7 RBM5 SRSF1 Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complexNCBP1 RNPS1 CCAR1 ALYREF NHP2L1 POLR2DSNRPG 2xMe-SNRPD3 DHX9 Exon Junction ComplexPRPF4 CSTF1 POLR2E POLR2I SNRPD2 PABPN1 POLR2B NUP50 SF3B5 METTL3 Nuclear Pore Complex 2xMe-SNRPD3 NXF1PCBP2 SRSF3 NCBP1 CSTF1 POLR2C NUPL2 NCBP2 SRSF11 RBMXPCBP1POLR2K SF3B2 PHF5APHF5A2xMe-SNRPB NHP2L1 2xMe-SNRPB NUDT21 POLR2B POLR2A HNRNPU POLR2L ALYREF NCBP2 SF3A1 CstFSNRPD2 U2 snRNA EIF4EPAPOLAU5 snRNA HNRNPK POLR2L U2AF2SNRPE 2xMe-SNRPB POLR2J U1 snRNA SRSF9 SNRPF SNRPG HNRNPA2B1 U2 snRNA mRNA SRSF5 3' end cleaved, ligated exon containing complexSNRPF Nup45 CCAR1 POLR2E HNRNPUL1 POLR2J HNRNPA2B1 SNRNP200 SLBP Mature Intronless Transcript Derived Histone mRNATAPAly/Ref complexPOLR2DPOLR2FSRSF6 CPSF1 SNRPF SNRPF CSTF2NCBP2 NHP2L1 NCBP2 HNRNPL 2xMe-SNRPD3 HNRNPU SRSF4 NCBP1 SRSF6 SRSF2 SRSF1 NCBP2 POLR2K NUP85 HNRNPA0Magoh-Y14 complexSRSF9 POLR2C SNRNP200 RBMXCCAR1 POLR2L POLR2DPRPF6 POLR2G POLR2G SF3B2 PRPF6 SLBP CD2BP2 SRSF1 CDC40 CPSF1 SF3B4 CDC40 SRSF3 NCBP1 NCBP1 TXNL4A HNRNPUL1 HNRNPUL1 POLR2B 2xMe-SNRPD3 SF3B3 SRSF7 U4 snRNA EFTUD2 DNAJC8SRSF7 SRRM1 SNRPE HNRNPH2 NHP2L1 CLP1 POLR2B SRRM1 NUP133 PRPF6 NUDT21 HNRNPRLSM2 2xMe-SNRPD1 SF3A2 SF3B4 2xMe-SNRPD1 SNRNP200 DHX9 POLR2C NHP2L1 U12 snRNPPOLR2G SF3B5 SNRNP40 RNPS1 CD2BP2 SRSF3 SF3B14 EIF4ECPSF3 Mature SLBP independent Histone mRNAeIF4E complexSNRPG NCBP2SF3B2 CPSF7 SNRPA HNRNPL U4 ATACU5U6 ATAC ComplexPOLR2I SRSF7 CPSF2 SRSF1 NCBP1 POLR2C p-S5-POLR2A LSM2 MAGOH NCBP2 SRSF3 ATPU6 snRNA NUP153 HNRNPA0 U4 snRNA DnaJ hom. NP_055602HNRNPA2B1SF3A3 2xMe-SNRPB PABPN1 SF3B3 NHP2L1 NCBP2 DNAJC8PABPN1 RBM5 2xMe-SNRPD3 CCAR1 SRSF6 NCBP2 CPSF3 2xMe-SNRPD1 POLR2FSRSF6SNRPE CPSF2 SRRM1 CLP1 EFTUD2 PRPF4 Mature mRNP ComplexCSTF1 CSTF2POLR2L SMC1A HNRNPUL1 TXNL4A SNRPE POLR2I SRSF7 SF3B3 POLR2A EFTUD2 TXNL4A MAGOH RNPS1 PTBP1 POLR2E HNRNPFLSM2 POLR2H U4 snRNPSRSF1 HNRNPA1CPSF3 ALYREF SNRPE POLR2C SNRPB2 SLBP POLR2C POLR2B SF3B2 PRPF8 DHX38 HNRNPD NCBP2 HNRNPH1TAP3'-polyadenylated, capped mRNA complexPRPF6 SRSF6 PTBP1 SF3B3 CPSF2 U2AF2 PABPN1 2xMe-SNRPB SRSF7 CPSF2 SNRPG HNRNPU SF3A3 EIF4E POLR2K YBX1 HNRNPC SNRPD2 NCBP2 POLR2G CD2BP2 SLBP NUDT21 POLR2G CPSF1 RNPS1 DDX23 SNRPB2 PRPF8 NXF1POLR2E 2xMe-SNRPB p-S5-POLR2A POLR2H RBMXRBMXPCBP2 SNRPF PTBP1 SRSF4 TXNL4A SF3B1 POLR2I NCBP2 POLR2DFUS YBX1 POLR2K SF3B1 NUP133 NCBP2 MAGOH SNRPE SNRPE DDX23 DHX38NCBP1 SRSF5 ALYREF HNRNPU DDX23 NUP210 2xMe-SNRPB NCBP2 GTF2F2POLR2I HNRNPFPOLR2FSRSF11 RANBP2 NCBP1 POLR2E CPSF1 2xMe-SNRPD1 SNRPF SF3B4 POLR2G SRSF1 NUP1882xMe-SNRPD1 2xMe-SNRPD1 POLR2C SMC1A TPR PAPOLAALYREFSRSF2 ALYREF U2AF2 UPF3B SF3B3 HNRNPM SF3B1 SF3B1 HNRNPK HNRNPD CF IPOLR2H NXF1PCBP1 ALYREF DHX38 NCBP1 SRSF5 FUSU5 snRNA SRSF7 CD2BP2 NCBP2 LSM2 PCF11 SF3B14 POLR2K HNRNPH1HNRNPA0 HNRNPA3 SRSF4 EFTUD2 HNRNPH2 SRSF2 SNRPE TXNL4A CDC40 HNRNPA3 CSTF2capped, methylated pre-mRNACBC ComplexLSM2 POLR2C SF3B5 POLR2B DHX38 DHX38 PTBP1NHP2L1 HNRNPH1NUPL1-2 HNRNPFTXNL4A SF3B1 CDC40NUP62 SRSF3 SRSF11 LSM2 POLR2C NFX.1 RBM8A U2AF2 UPF3B p-S5-POLR2A SNRNP70 hPrp43HNRNPM HNRNPA2B1 SNRPF p68 DEAH proteinHNRNPD CSTF2PRPF6 SF3A1 POLR2DSNRNP200 SNRNP40 POLR2DGTF2F2PCBP1 PTBP1 CPSF7 RNPS1 PRPF8 U5 snRNA CPSF3 U5 snRNA NUP214 SRSF11 SRSF6 SF3A2 POLR2B U6 snRNA FUS RNPS1 SF3A1 SNRPA1 U5 snRNA UPF3B SF3B4 SF3B3 CDC40 HNRNPUL1 DDX23 HNRNPA2B1 2xMe-SNRPB CPSF2 SF3B14 HNRNPA0 Cap Binding Complex SF3B14 CDC40 CPSF7 U5 snRNA CPSF3 POLR2A DHX38 NUP214 SF3B14 SF3B5 PCF11 SMC1A POLR2K HNRNPC SF3B3 SRSF2 CSTF1 SF3B4 HNRNPL CPSF3 ALYREF SMC1A NFX.1 SUGP1 NXF1HNRNPR POLR2FSF3B5 U2 snRNA HNRNPC NHP2L1 POLR2J HuR /3 RRM proteinPOLR2J POLR2H TPR HNRNPR HNRNPA0 LSM2 GTF2F22xMe-SNRPD1 SRSF11 2xMe-SNRPB U6 snRNA NCBP1 U2AF2 CSTF2SRSF9 POLR2J SNRNP40 U2AF1 HNRNPH2 GTF2F1POLR2DPOLR2DRNPS1 LSM2 ALYREF SUGP1POLR2E PRPF6 2xMe-SNRPB hPrp19CCAR1 HNRNPL POLR2L p-S5-POLR2A SF3B3 SNRNP40 ALYREF NXF1SRSF9 SUGP1 CLP1 RNPS1 SNRNP70 PRPF4 POLR2J SRSF9 GTF2F1PRPF6 SRSF5 HNRNPA1 POLR2I SRSF11POLR2I SUGP1 NUP54 SNRPF CDC40 U2AF1SRRM1HNRNPK 2xMe-SNRPD3 SRSF2 Mature intronless transcript derived Histone pre-mRNACBC complexNUP205SRSF6 NFX.1 U2 snRNA GTF2F2PRPF4 SF3B5 Mature intronless derived mRNA complexNUPL2 NUP153 GTF2F2NFX.1 SNRNP200 POLR2J LSM2 PCBP2EFTUD2 PCF11 Mature Intronless Transcript Derived mRNAeIF4E Complex2xMe-SNRPD1 HNRNPA0 POLR2FPOLR2G POLR2G SRRM1 POLR2H HNRNPFNUP93 HNRNPA1 LSM2 SNRPD2 Spliceosomal Active C ComplexU2AF1 HNRNPC SRSF7 PCF11 HNRNPK GTF2F1HNRNPA2B1 SUGP1 NUPL1-2 PRPF8 U1 snRNA POLR2FRBMXMAGOH NUP107 POLR2A ALYREF GTF2F1CPSF3 NCBP1 RBM8A RBMXHNRNPA0 CF IIHNRNPA3 capped, methylated pre-mRNPCBC complexU5 snRNA SF3B1 SF3B14 SNRPE SRSF7SRSF3 SNRPG SF3B1 SNRPE POLR2E UPF3B ALYREF PABPN1RBM8A HNRNPFCPSF7 HNRNPU POLR2J SNRPE NUP98-5 2xMe-SNRPD3 2xMe-SNRPD3 U5 snRNPHNRNPMSRRM1 RNPS1 CSTF1 PCF11 SNRPD2 RNPS1 CPSF3 GTF2F2NHP2L1 POLR2J SRSF5 AAAS SF3A1 HNRNPH1SNRNP200 SF3B1 SNRPE POLR2H CD2BP2U2AF1 SRSF9 SRSF7 CD2BP2 POLR2G SF3B2 SNRPF NUP85 capped pre-mRNACBCRNA Pol II NCBP2 POLR2E 2xMe-SNRPD3 POLR2B POLR2B TXNL4A SRSF7 hTra2POLR2B Nucleoplasmic mature intronless derived mRNATAPAly/Ref complex2xMe-SNRPD1 NCBP1 NHP2L1 HNRNPA1 MAGOH SRSF1 DHX9 CCAR1SF3B2 NCBP2 U2AF1 UPF3B NXF1HNRNPDPOLR2L SNRPE HNRNPH2 SRSF4 U2AF2 NCBP1 HNRNPA1 U2AF2 RBMXU4U5U6 trisnRNP complexCSTF1 ALYREF HNRNPH1POLR2J SNRPD2 HNRNPA3 POLR2J SNRPD2 POLR2K PCBP1 POLR2I PHF5ASNRPG SRRM1 HNRNPF2xMe-SNRPB CSTF3 NCBP1 2xMe-SNRPD1 ASR2BNUP107 PAPOLARNPS1 SNRNP40 SF3A2 HNRNPD Nuclear Pore Complex POLR2L U5 snRNA RBM8A 41, 12, 131, 12, 13


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Co-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per gene, which cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. Thus the time that it takes for pol II to synthesize each intron defines a minimal time and distance along the gene in which splicing factors can be recruited. The time that it takes for pol II to reach the end of the gene defines the maximal time in which splicing could occur co-transcriptionally. Thus, the kinetics of transcription can affect the kinetics of splicing.Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm.

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Bibliography

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  1. Hutten S, Kehlenbach RH.; ''CRM1-mediated nuclear export: to the pore and beyond.''; PubMed Europe PMC Scholia
  2. Lévesque L, Guzik B, Guan T, Coyle J, Black BE, Rekosh D, Hammarskjöld ML, Paschal BM.; ''RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex.''; PubMed Europe PMC Scholia
  3. Coltri P, Effenberger K, Chalkley RJ, Burlingame AL, Jurica MS.; ''Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.''; PubMed Europe PMC Scholia
  4. Zhou Z, Licklider LJ, Gygi SP, Reed R.; ''Comprehensive proteomic analysis of the human spliceosome.''; PubMed Europe PMC Scholia
  5. Le Hir H, Izaurralde E, Maquat LE, Moore MJ.; ''The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.''; PubMed Europe PMC Scholia
  6. Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J.; ''SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.''; PubMed Europe PMC Scholia
  7. Ajuh P, Sleeman J, Chusainow J, Lamond AI.; ''A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.''; PubMed Europe PMC Scholia
  8. Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, Lührmann R, Stelzl U.; ''Dynamic protein-protein interaction wiring of the human spliceosome.''; PubMed Europe PMC Scholia
  9. Pikielny CW, Bindereif A, Green MR.; ''In vitro reconstitution of snRNPs: a reconstituted U4/U6 snRNP participates in splicing complex formation.''; PubMed Europe PMC Scholia
  10. Kataoka N, Dreyfuss G.; ''A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex.''; PubMed Europe PMC Scholia
  11. Hung ML, Hautbergue GM, Snijders AP, Dickman MJ, Wilson SA.; ''Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.''; PubMed Europe PMC Scholia
  12. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ.; ''Proteomic analysis of the mammalian nuclear pore complex.''; PubMed Europe PMC Scholia
  13. Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E, Bork P.; ''Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins.''; PubMed Europe PMC Scholia
  14. Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R.; ''Molecular architecture of the human Prp19/CDC5L complex.''; PubMed Europe PMC Scholia
  15. Moore CL, Sharp PA.; ''Accurate cleavage and polyadenylation of exogenous RNA substrate.''; PubMed Europe PMC Scholia
  16. Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA.; ''The SRm160/300 splicing coactivator subunits.''; PubMed Europe PMC Scholia
  17. Le Hir H, Gatfield D, Izaurralde E, Moore MJ.; ''The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.''; PubMed Europe PMC Scholia
  18. Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C.; ''A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.''; PubMed Europe PMC Scholia
  19. Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM.; ''Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.''; PubMed Europe PMC Scholia
  20. Lindtner S, Felber BK, Kjems J.; ''An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element.''; PubMed Europe PMC Scholia
  21. Katahira J, Straesser K, Saiwaki T, Yoneda Y, Hurt E.; ''Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling.''; PubMed Europe PMC Scholia
  22. Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, Chang X, Cheng H.; ''Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.''; PubMed Europe PMC Scholia
  23. Ilagan JO, Chalkley RJ, Burlingame AL, Jurica MS.; ''Rearrangements within human spliceosomes captured after exon ligation.''; PubMed Europe PMC Scholia
  24. Makarov EM, Owen N, Bottrill A, Makarova OV.; ''Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs.''; PubMed Europe PMC Scholia
  25. Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMed Europe PMC Scholia
  26. Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, Adhikari S, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Dahal U, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang X, Rendtlew Danielsen JM, Liu F, Yang YG.; ''Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.''; PubMed Europe PMC Scholia
  27. Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E, Reed R.; ''The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans.''; PubMed Europe PMC Scholia
  28. Cheng H, Dufu K, Lee CS, Hsu JL, Dias A, Reed R.; ''Human mRNA export machinery recruited to the 5' end of mRNA.''; PubMed Europe PMC Scholia
  29. Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.; ''The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.''; PubMed Europe PMC Scholia
  30. Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, Lührmann R.; ''Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.''; PubMed Europe PMC Scholia
  31. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R.; ''Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.''; PubMed Europe PMC Scholia
  32. Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, Hacohen N, Zhang F, Carr SA, Lander ES, Regev A.; ''Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.''; PubMed Europe PMC Scholia
  33. Wu Q, Krainer AR.; ''AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.''; PubMed Europe PMC Scholia
  34. Carmody SR, Wente SR.; ''mRNA nuclear export at a glance.''; PubMed Europe PMC Scholia
  35. Valadkhan S, Manley JL.; ''Splicing-related catalysis by protein-free snRNAs.''; PubMed Europe PMC Scholia
  36. Kabachinski G, Schwartz TU.; ''The nuclear pore complex--structure and function at a glance.''; PubMed Europe PMC Scholia
  37. Lévesque L, Bor YC, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld ML, Paschal BM.; ''Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.''; PubMed Europe PMC Scholia
  38. Ruskin B, Krainer AR, Maniatis T, Green MR.; ''Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro.''; PubMed Europe PMC Scholia
  39. Bessonov S, Anokhina M, Krasauskas A, Golas MM, Sander B, Will CL, Urlaub H, Stark H, Lührmann R.; ''Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.''; PubMed Europe PMC Scholia
  40. Lamond AI, Konarska MM, Grabowski PJ, Sharp PA.; ''Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.''; PubMed Europe PMC Scholia
  41. Teng IF, Wilson SA.; ''Mapping interactions between mRNA export factors in living cells.''; PubMed Europe PMC Scholia
  42. Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMed Europe PMC Scholia
  43. Culjkovic-Kraljacic B, Borden KL.; ''Aiding and abetting cancer: mRNA export and the nuclear pore.''; PubMed Europe PMC Scholia
  44. Shepard J, Reick M, Olson S, Graveley BR.; ''Characterization of U2AF(6), a splicing factor related to U2AF(35).''; PubMed Europe PMC Scholia
  45. Charlesworth A, Meijer HA, de Moor CH.; ''Specificity factors in cytoplasmic polyadenylation.''; PubMed Europe PMC Scholia
  46. Rappsilber J, Ryder U, Lamond AI, Mann M.; ''Large-scale proteomic analysis of the human spliceosome.''; PubMed Europe PMC Scholia
  47. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI.; ''Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.''; PubMed Europe PMC Scholia
  48. Brahms H, Meheus L, de Brabandere V, Fischer U, Lührmann R.; ''Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.''; PubMed Europe PMC Scholia
  49. Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, Cullen BR.; ''Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.''; PubMed Europe PMC Scholia
  50. Wagner S, Chiosea S, Ivshina M, Nickerson JA.; ''In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.''; PubMed Europe PMC Scholia
  51. Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMed Europe PMC Scholia
  52. Erkmann JA, Kutay U.; ''Nuclear export of mRNA: from the site of transcription to the cytoplasm.''; PubMed Europe PMC Scholia
  53. Kang Y, Bogerd HP, Yang J, Cullen BR.; ''Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor.''; PubMed Europe PMC Scholia
  54. Watkins JL, Murphy R, Emtage JL, Wente SR.; ''The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.''; PubMed Europe PMC Scholia
  55. Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E.; ''Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.''; PubMed Europe PMC Scholia
  56. Meinel DM, Burkert-Kautzsch C, Kieser A, O'Duibhir E, Siebert M, Mayer A, Cramer P, Söding J, Holstege FC, Sträßer K.; ''Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.''; PubMed Europe PMC Scholia
  57. Lin-Moshier Y, Sebastian PJ, Higgins L, Sampson ND, Hewitt JE, Marchant JS.; ''Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.''; PubMed Europe PMC Scholia
  58. Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA.; ''Luzp4 defines a new mRNA export pathway in cancer cells.''; PubMed Europe PMC Scholia
  59. Valadkhan S, Mohammadi A, Wachtel C, Manley JL.; ''Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.''; PubMed Europe PMC Scholia
  60. Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M.; ''Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.''; PubMed Europe PMC Scholia
  61. Kang Y, Cullen BR.; ''The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.''; PubMed Europe PMC Scholia
  62. Madan V, Kanojia D, Li J, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Miyano S, Thol F, Ganser A, Yang H, Haferlach T, Ogawa S, Koeffler HP.; ''Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.''; PubMed Europe PMC Scholia
  63. Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R.; ''The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export.''; PubMed Europe PMC Scholia
  64. Hautbergue GM, Hung ML, Golovanov AP, Lian LY, Wilson SA.; ''Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.''; PubMed Europe PMC Scholia
  65. Hastings ML, Krainer AR.; ''Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.''; PubMed Europe PMC Scholia
  66. Golovanov AP, Hautbergue GM, Tintaru AM, Lian LY, Wilson SA.; ''The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.''; PubMed Europe PMC Scholia
  67. Deckert J, Hartmuth K, Boehringer D, Behzadnia N, Will CL, Kastner B, Stark H, Urlaub H, Lührmann R.; ''Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.''; PubMed Europe PMC Scholia
  68. Yoshimoto R, Kataoka N, Okawa K, Ohno M.; ''Isolation and characterization of post-splicing lariat-intron complexes.''; PubMed Europe PMC Scholia
  69. Box JA, Bunch JT, Tang W, Baumann P.; ''Spliceosomal cleavage generates the 3' end of telomerase RNA.''; PubMed Europe PMC Scholia
  70. Johnson SA, Kim H, Erickson B, Bentley DL.; ''The export factor Yra1 modulates mRNA 3' end processing.''; PubMed Europe PMC Scholia
  71. Bachi A, Braun IC, Rodrigues JP, Panté N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, Izaurralde E.; ''The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.''; PubMed Europe PMC Scholia
  72. Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt E.; ''TREX is a conserved complex coupling transcription with messenger RNA export.''; PubMed Europe PMC Scholia
  73. Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA.; ''Chtop is a component of the dynamic TREX mRNA export complex.''; PubMed Europe PMC Scholia
  74. Fontoura BM, Blobel G, Matunis MJ.; ''A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.''; PubMed Europe PMC Scholia
  75. Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ.; ''Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.''; PubMed Europe PMC Scholia
  76. Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain JC, Krämer A.; ''Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.''; PubMed Europe PMC Scholia
  77. Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL.; ''Molecular architecture of the human pre-mRNA 3' processing complex.''; PubMed Europe PMC Scholia
  78. Takagaki Y, Manley JL.; ''Complex protein interactions within the human polyadenylation machinery identify a novel component.''; PubMed Europe PMC Scholia
  79. Kreivi JP, Lamond AI.; ''RNA splicing: unexpected spliceosome diversity.''; PubMed Europe PMC Scholia
  80. Katahira J.; ''Nuclear export of messenger RNA.''; PubMed Europe PMC Scholia
  81. Rougemaille M, Dieppois G, Kisseleva-Romanova E, Gudipati RK, Lemoine S, Blugeon C, Boulay J, Jensen TH, Stutz F, Devaux F, Libri D.; ''THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.''; PubMed Europe PMC Scholia
  82. Luna R, Rondón AG, Aguilera A.; ''New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.''; PubMed Europe PMC Scholia
  83. Zaric B, Chami M, Rémigy H, Engel A, Ballmer-Hofer K, Winkler FK, Kambach C.; ''Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function.''; PubMed Europe PMC Scholia
  84. Zhao J, Hyman L, Moore C.; ''Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.''; PubMed Europe PMC Scholia
  85. Lejeune F, Ishigaki Y, Li X, Maquat LE.; ''The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.''; PubMed Europe PMC Scholia
  86. Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, Seraphin B, Rio MC, Tomasetto C.; ''Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.''; PubMed Europe PMC Scholia
  87. Daguenet E, Baguet A, Degot S, Schmidt U, Alpy F, Wendling C, Spiegelhalter C, Kessler P, Rio MC, Le Hir H, Bertrand E, Tomasetto C.; ''Perispeckles are major assembly sites for the exon junction core complex.''; PubMed Europe PMC Scholia
  88. Braun IC, Herold A, Rode M, Conti E, Izaurralde E.; ''Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.''; PubMed Europe PMC Scholia
  89. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R.; ''Recruitment of the human TREX complex to mRNA during splicing.''; PubMed Europe PMC Scholia
  90. Harris ME, Böhni R, Schneiderman MH, Ramamurthy L, Schümperli D, Marzluff WF.; ''Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.''; PubMed Europe PMC Scholia
  91. Hautbergue GM, Hung ML, Walsh MJ, Snijders AP, Chang CT, Jones R, Ponting CP, Dickman MJ, Wilson SA.; ''UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.''; PubMed Europe PMC Scholia
  92. Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjöld ML.; ''NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.''; PubMed Europe PMC Scholia
  93. von Moeller H, Lerner R, Ricciardi A, Basquin C, Marzluff WF, Conti E.; ''Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.''; PubMed Europe PMC Scholia
  94. Dreyfuss G, Matunis MJ, Piñol-Roma S, Burd CG.; ''hnRNP proteins and the biogenesis of mRNA.''; PubMed Europe PMC Scholia
  95. Rondón AG, Jimeno S, García-Rubio M, Aguilera A.; ''Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.''; PubMed Europe PMC Scholia
  96. Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH.; ''CWC22 connects pre-mRNA splicing and exon junction complex assembly.''; PubMed Europe PMC Scholia
  97. Gencheva M, Kato M, Newo AN, Lin RJ.; ''Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing.''; PubMed Europe PMC Scholia
  98. Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, Reed R.; ''ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.''; PubMed Europe PMC Scholia
  99. Lin DH, Stuwe T, Schilbach S, Rundlet EJ, Perriches T, Mobbs G, Fan Y, Thierbach K, Huber FM, Collins LN, Davenport AM, Jeon YE, Hoelz A.; ''Architecture of the symmetric core of the nuclear pore.''; PubMed Europe PMC Scholia
  100. Hartmuth K, Urlaub H, Vornlocher HP, Will CL, Gentzel M, Wilm M, Lührmann R.; ''Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.''; PubMed Europe PMC Scholia
  101. Grzybowska EA.; ''Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.''; PubMed Europe PMC Scholia
  102. Yao C, Choi EA, Weng L, Xie X, Wan J, Xing Y, Moresco JJ, Tu PG, Yates JR, Shi Y.; ''Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.''; PubMed Europe PMC Scholia
  103. Reichert VL, Le Hir H, Jurica MS, Moore MJ.; ''5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.''; PubMed Europe PMC Scholia
  104. Katahira J, Strässer K, Podtelejnikov A, Mann M, Jung JU, Hurt E.; ''The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.''; PubMed Europe PMC Scholia
  105. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W.; ''Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.''; PubMed Europe PMC Scholia
  106. Wente SR, Rout MP.; ''The nuclear pore complex and nuclear transport.''; PubMed Europe PMC Scholia
  107. Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA.; ''TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.''; PubMed Europe PMC Scholia
  108. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R.; ''The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.''; PubMed Europe PMC Scholia
  109. Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M.; ''Molecular architecture of the inner ring scaffold of the human nuclear pore complex.''; PubMed Europe PMC Scholia
  110. Behzadnia N, Golas MM, Hartmuth K, Sander B, Kastner B, Deckert J, Dube P, Will CL, Urlaub H, Stark H, Lührmann R.; ''Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.''; PubMed Europe PMC Scholia
  111. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E.; ''TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.''; PubMed Europe PMC Scholia
  112. Taniguchi I, Ohno M.; ''ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.''; PubMed Europe PMC Scholia
  113. Kota KP, Wagner SR, Huerta E, Underwood JM, Nickerson JA.; ''Binding of ATP to UAP56 is necessary for mRNA export.''; PubMed Europe PMC Scholia
  114. Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA.; ''Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors.''; PubMed Europe PMC Scholia
  115. Shen H, Zheng X, Luecke S, Green MR.; ''The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.''; PubMed Europe PMC Scholia
  116. Wahle E, Rüegsegger U.; ''3'-End processing of pre-mRNA in eukaryotes.''; PubMed Europe PMC Scholia
  117. Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E.; ''TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.''; PubMed Europe PMC Scholia
  118. Bessonov S, Anokhina M, Will CL, Urlaub H, Lührmann R.; ''Isolation of an active step I spliceosome and composition of its RNP core.''; PubMed Europe PMC Scholia
  119. Singh J, Sikand K, Conrad H, Will CL, Komar AA, Shukla GC.; ''U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115088view17:03, 25 January 2021ReactomeTeamReactome version 75
113530view12:00, 2 November 2020ReactomeTeamReactome version 74
112728view16:13, 9 October 2020ReactomeTeamReactome version 73
101644view11:51, 1 November 2018ReactomeTeamreactome version 66
101180view21:38, 31 October 2018ReactomeTeamreactome version 65
100706view20:10, 31 October 2018ReactomeTeamreactome version 64
100256view16:56, 31 October 2018ReactomeTeamreactome version 63
99809view15:20, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93917view13:44, 16 August 2017ReactomeTeamreactome version 61
93494view11:25, 9 August 2017ReactomeTeamreactome version 61
88115view10:05, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86590view09:21, 11 July 2016ReactomeTeamreactome version 56
83367view11:01, 18 November 2015ReactomeTeamVersion54
81532view13:04, 21 August 2015ReactomeTeamVersion53
77003view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76708view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76034view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75743view11:23, 10 June 2014ReactomeTeamReactome 48 Update
75093view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74829view10:05, 30 April 2014ReactomeTeamReactome46
74740view08:49, 30 April 2014ReactomeTeamReactome46
42105view21:57, 4 March 2011MaintBotAutomatic update
39915view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2xMe-SNRPB ProteinP14678 (Uniprot-TrEMBL)
2xMe-SNRPD1 ProteinP62314 (Uniprot-TrEMBL)
2xMe-SNRPD3 ProteinP62318 (Uniprot-TrEMBL)
3' end cleaved, ligated exon containing complexComplexREACT_3092 (Reactome)
3'-polyadenylated, capped mRNA complexComplexREACT_5827 (Reactome)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
ALYREF ProteinQ86V81 (Uniprot-TrEMBL)
ALYREFProteinQ86V81 (Uniprot-TrEMBL)
ASR2BREACT_5122 (Reactome)
ATAC A ComplexComplexREACT_4037 (Reactome)
ATAC B ComplexComplexREACT_5095 (Reactome)
ATAC C Complex with lariat containing 5'-end cleaved mRNAComplexREACT_5134 (Reactome)
ATAC C ComplexComplexREACT_4626 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
CC1.3 protein /3 RRM, RSREACT_4848 (Reactome)
CCAR1 ProteinQ8IX12 (Uniprot-TrEMBL)
CCAR1ProteinQ8IX12 (Uniprot-TrEMBL)
CD2BP2 ProteinO95400 (Uniprot-TrEMBL)
CD2BP2ProteinO95400 (Uniprot-TrEMBL)
CDC40 ProteinO60508 (Uniprot-TrEMBL)
CDC40ProteinO60508 (Uniprot-TrEMBL)
CF IIComplexREACT_3772 (Reactome)
CF IComplexREACT_4896 (Reactome)
CLP1 ProteinQ92989 (Uniprot-TrEMBL)
CPSF1 ProteinQ10570 (Uniprot-TrEMBL)
CPSF2 ProteinQ9P2I0 (Uniprot-TrEMBL)
CPSF3 ProteinQ9UKF6 (Uniprot-TrEMBL)
CPSF7 ProteinQ8N684 (Uniprot-TrEMBL)
CPSFComplexREACT_4530 (Reactome)
CSTF1 ProteinQ05048 (Uniprot-TrEMBL)
CSTF2ProteinP33240 (Uniprot-TrEMBL)
CSTF3 ProteinQ12996 (Uniprot-TrEMBL)
Cap Binding Complex ComplexREACT_3884 (Reactome)
Cleavage and Polyadenylation ComplexComplexREACT_3144 (Reactome)
CstFComplexREACT_3503 (Reactome)
DDX23 ProteinQ9BUQ8 (Uniprot-TrEMBL)
DHX38 ProteinQ92620 (Uniprot-TrEMBL)
DHX38ProteinQ92620 (Uniprot-TrEMBL)
DHX9 ProteinQ08211 (Uniprot-TrEMBL)
DHX9ProteinQ08211 (Uniprot-TrEMBL)
DNAJC8ProteinO75937 (Uniprot-TrEMBL)
DnaJ hom. NP_055602REACT_4415 (Reactome)
EFTUD2 ProteinQ15029 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
Exon Junction ComplexComplexREACT_2984 (Reactome)
Export Receptor bound mature mRNA ComplexComplexREACT_2455 (Reactome)
Export Receptor bound mature mRNA ComplexComplexREACT_2624 (Reactome)
FUS ProteinP35637 (Uniprot-TrEMBL)
FUSProteinP35637 (Uniprot-TrEMBL)
GTF2F1ProteinP35269 (Uniprot-TrEMBL)
GTF2F2ProteinP13984 (Uniprot-TrEMBL)
HNRNPA0 ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA0ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA1 ProteinP09651 (Uniprot-TrEMBL)
HNRNPA1ProteinP09651 (Uniprot-TrEMBL)
HNRNPA2B1 ProteinP22626 (Uniprot-TrEMBL)
HNRNPA2B1ProteinP22626 (Uniprot-TrEMBL)
HNRNPA3 ProteinP51991 (Uniprot-TrEMBL)
HNRNPA3ProteinP51991 (Uniprot-TrEMBL)
HNRNPC ProteinP07910 (Uniprot-TrEMBL)
HNRNPCProteinP07910 (Uniprot-TrEMBL)
HNRNPD ProteinQ14103 (Uniprot-TrEMBL)
HNRNPDProteinQ14103 (Uniprot-TrEMBL)
HNRNPFProteinP52597 (Uniprot-TrEMBL)
HNRNPH1ProteinP31943 (Uniprot-TrEMBL)
HNRNPH2 ProteinP55795 (Uniprot-TrEMBL)
HNRNPH2ProteinP55795 (Uniprot-TrEMBL)
HNRNPK ProteinP61978 (Uniprot-TrEMBL)
HNRNPKProteinP61978 (Uniprot-TrEMBL)
HNRNPL ProteinP14866 (Uniprot-TrEMBL)
HNRNPLProteinP14866 (Uniprot-TrEMBL)
HNRNPM ProteinP52272 (Uniprot-TrEMBL)
HNRNPMProteinP52272 (Uniprot-TrEMBL)
HNRNPR ProteinO43390 (Uniprot-TrEMBL)
HNRNPRProteinO43390 (Uniprot-TrEMBL)
HNRNPU ProteinQ00839 (Uniprot-TrEMBL)
HNRNPUL1 ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUL1ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUProteinQ00839 (Uniprot-TrEMBL)
HuR /3 RRM proteinREACT_5767 (Reactome)
LSM2 ProteinQ9Y333 (Uniprot-TrEMBL)
Ligated exon containing complexComplexREACT_5472 (Reactome)
MAGOH ProteinP61326 (Uniprot-TrEMBL)
METTL3 ProteinQ86U44 (Uniprot-TrEMBL)
Magoh-Y14 complexComplexREACT_5524 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref Complex		ComplexREACT_4560 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref complex		ComplexREACT_5697 (Reactome)
Mature Intronless Transcript Derived mRNA eIF4E ComplexComplexREACT_3252 (Reactome)
Mature Intronless transcript derived Histone mRNA

SLBP CBP80

CBP20		ComplexREACT_3802 (Reactome)
Mature SLBP independent Histone mRNA eIF4E complexComplexREACT_3452 (Reactome)
Mature intronless derived mRNA

TAP

Aly/Ref complex		ComplexREACT_4662 (Reactome)
Mature intronless derived mRNA complexComplexREACT_4047 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		ComplexREACT_2791 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		ComplexREACT_3824 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP

eIF4E Complex		ComplexREACT_2270 (Reactome)
Mature intronless transcript derived Histone pre-mRNA CBC complexComplexREACT_5592 (Reactome)
Mature mRNP ComplexComplexREACT_4851 (Reactome)
NCBP1 ProteinQ09161 (Uniprot-TrEMBL)
NCBP1ProteinQ09161 (Uniprot-TrEMBL)
NCBP2 ProteinP52298 (Uniprot-TrEMBL)
NCBP2ProteinP52298 (Uniprot-TrEMBL)
NFAR-2 proteinREACT_4072 (Reactome)
NFX.1 ProteinO43831 (Uniprot-TrEMBL)
NFX.1ProteinO43831 (Uniprot-TrEMBL)
NHP2L1 ProteinP55769 (Uniprot-TrEMBL)
NUDT21 ProteinO43809 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
NXF1ProteinQ9UBU9 (Uniprot-TrEMBL)
Nuclear Pore Complex ComplexREACT_5542 (Reactome)
Nucleoplasmic mature intronless derived mRNA

TAP

Aly/Ref complex		ComplexREACT_4247 (Reactome)
Nup45 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
PABPN1 ProteinQ86U42 (Uniprot-TrEMBL)
PABPN1ProteinQ86U42 (Uniprot-TrEMBL)
PAPOLAProteinP51003 (Uniprot-TrEMBL)
PCBP1 ProteinQ15365 (Uniprot-TrEMBL)
PCBP1ProteinQ15365 (Uniprot-TrEMBL)
PCBP2 ProteinQ15366 (Uniprot-TrEMBL)
PCBP2ProteinQ15366 (Uniprot-TrEMBL)
PCF11 ProteinO94913 (Uniprot-TrEMBL)
PHF5AProteinQ7RTV0 (Uniprot-TrEMBL)
POLR2A ProteinP24928 (Uniprot-TrEMBL)
POLR2B ProteinP30876 (Uniprot-TrEMBL)
POLR2C ProteinP19387 (Uniprot-TrEMBL)
POLR2DProteinO15514 (Uniprot-TrEMBL)
POLR2E ProteinP19388 (Uniprot-TrEMBL)
POLR2FProteinP61218 (Uniprot-TrEMBL)
POLR2G ProteinP62487 (Uniprot-TrEMBL)
POLR2H ProteinP52434 (Uniprot-TrEMBL)
POLR2I ProteinP36954 (Uniprot-TrEMBL)
POLR2J ProteinP52435 (Uniprot-TrEMBL)
POLR2K ProteinP53803 (Uniprot-TrEMBL)
POLR2L ProteinP62875 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
PRPF4 ProteinO43172 (Uniprot-TrEMBL)
PRPF6 ProteinO94906 (Uniprot-TrEMBL)
PRPF8 ProteinQ6P2Q9 (Uniprot-TrEMBL)
PTBP1 ProteinP26599 (Uniprot-TrEMBL)
PTBP1ProteinP26599 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RBM5 ProteinP52756 (Uniprot-TrEMBL)
RBM5ProteinP52756 (Uniprot-TrEMBL)
RBM8A ProteinQ9Y5S9 (Uniprot-TrEMBL)
RBMXProteinP38159 (Uniprot-TrEMBL)
RNA polymerase II ComplexREACT_4593 (Reactome)
RNPS1 ProteinQ15287 (Uniprot-TrEMBL)
RNPS1ProteinQ15287 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SF3A1 ProteinQ15459 (Uniprot-TrEMBL)
SF3A2 ProteinQ15428 (Uniprot-TrEMBL)
SF3A3 ProteinQ12874 (Uniprot-TrEMBL)
SF3B1 ProteinO75533 (Uniprot-TrEMBL)
SF3B14 ProteinQ9Y3B4 (Uniprot-TrEMBL)
SF3B2 ProteinQ13435 (Uniprot-TrEMBL)
SF3B3 ProteinQ15393 (Uniprot-TrEMBL)
SF3B4 ProteinQ15427 (Uniprot-TrEMBL)
SF3B5 ProteinQ9BWJ5 (Uniprot-TrEMBL)
SLBP ProteinQ14493 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC1AProteinQ14683 (Uniprot-TrEMBL)
SMC2 REACT_2529 (Reactome)
SNRNP200 ProteinO75643 (Uniprot-TrEMBL)
SNRNP40 ProteinQ96DI7 (Uniprot-TrEMBL)
SNRNP70 ProteinP08621 (Uniprot-TrEMBL)
SNRPA ProteinP09012 (Uniprot-TrEMBL)
SNRPA1 ProteinP09661 (Uniprot-TrEMBL)
SNRPB2 ProteinP08579 (Uniprot-TrEMBL)
SNRPD2 ProteinP62316 (Uniprot-TrEMBL)
SNRPE ProteinP62304 (Uniprot-TrEMBL)
SNRPF ProteinP62306 (Uniprot-TrEMBL)
SNRPG ProteinP62308 (Uniprot-TrEMBL)
SRRM1 ProteinQ8IYB3 (Uniprot-TrEMBL)
SRRM1ProteinQ8IYB3 (Uniprot-TrEMBL)
SRSF1 ProteinQ07955 (Uniprot-TrEMBL)
SRSF11 ProteinQ05519 (Uniprot-TrEMBL)
SRSF11ProteinQ05519 (Uniprot-TrEMBL)
SRSF1ProteinQ07955 (Uniprot-TrEMBL)
SRSF2 ProteinQ01130 (Uniprot-TrEMBL)
SRSF2ProteinQ01130 (Uniprot-TrEMBL)
SRSF3 ProteinP84103 (Uniprot-TrEMBL)
SRSF3ProteinP84103 (Uniprot-TrEMBL)
SRSF4 ProteinQ08170 (Uniprot-TrEMBL)
SRSF4ProteinQ08170 (Uniprot-TrEMBL)
SRSF5 ProteinQ13243 (Uniprot-TrEMBL)
SRSF5ProteinQ13243 (Uniprot-TrEMBL)
SRSF6 ProteinQ13247 (Uniprot-TrEMBL)
SRSF6ProteinQ13247 (Uniprot-TrEMBL)
SRSF7 ProteinQ16629 (Uniprot-TrEMBL)
SRSF7ProteinQ16629 (Uniprot-TrEMBL)
SRSF9 ProteinQ13242 (Uniprot-TrEMBL)
SRSF9ProteinQ13242 (Uniprot-TrEMBL)
SUGP1 ProteinQ8IWZ8 (Uniprot-TrEMBL)
SUGP1ProteinQ8IWZ8 (Uniprot-TrEMBL)
Spliceosomal A ComplexComplexREACT_4512 (Reactome)
Spliceosomal Active C ComplexComplexREACT_2680 (Reactome)
Spliceosomal B ComplexComplexREACT_3078 (Reactome)
Spliceosomal E ComplexComplexREACT_4545 (Reactome)
Spliceosomal Intermediate C ComplexComplexREACT_5473 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP CBC complexComplexREACT_5191 (Reactome)
TAP 3'-polyadenylated, capped mRNA complexComplexREACT_4136 (Reactome)
TPR ProteinP12270 (Uniprot-TrEMBL)
TXNL4A ProteinP83876 (Uniprot-TrEMBL)
U1 snRNA ProteinV00590 (EMBL)
U1 snRNPComplexREACT_2910 (Reactome) The U1 snRNP is a particle consisting of the U1 snRNA and Sm core plus unique snRNP polypeptides. The U1-specific polypeptides are 70K, A, and C. The Sm core polypeptides are B, B', D1, D2, D3, E, F, G. The Sm core is a heteroheptamer in the shape of a donut, containing either B or B', which are almost identical to each other.
U11 snRNPComplexREACT_5751 (Reactome)
U12 snRNPComplexREACT_3595 (Reactome)
U2 snRNA ProteinX59360 (EMBL)
U2 snRNPComplexREACT_3715 (Reactome)
U2AF1 ProteinQ01081 (Uniprot-TrEMBL)
U2AF1ProteinQ01081 (Uniprot-TrEMBL)
U2AF2 ProteinP26368 (Uniprot-TrEMBL)
U2AF2ProteinP26368 (Uniprot-TrEMBL)
U4

U5

U6 trisnRNP complex		ComplexREACT_5066 (Reactome)
U4 ATAC

U5

U6 ATAC Complex		ComplexREACT_4539 (Reactome)
U4 ATAC snRNPComplexREACT_5266 (Reactome)
U4 snRNA ProteinX59361 (EMBL)
U4 snRNPComplexREACT_4877 (Reactome)
U5 snRNA ProteinX04293 (EMBL)
U5 snRNPComplexREACT_2482 (Reactome)
U6 ATAC snRNPComplexREACT_3135 (Reactome)
U6 snRNA ProteinX59362 (EMBL)
UBA, Tudor - FLJ21007REACT_3970 (Reactome)
UPF3B ProteinQ9BZI7 (Uniprot-TrEMBL)
UPF3BProteinQ9BZI7 (Uniprot-TrEMBL)
YBX1 ProteinP67809 (Uniprot-TrEMBL)
YBX1ProteinP67809 (Uniprot-TrEMBL)
capped pre-mRNA

CBC

RNA Pol II 		ComplexREACT_3243 (Reactome)
capped, methylated pre-mRNA CBC ComplexComplexREACT_3634 (Reactome)
capped, methylated pre-mRNP CBC complexComplexREACT_2736 (Reactome)
hPrp18REACT_3085 (Reactome)
hPrp19REACT_3274 (Reactome)
hPrp22REACT_3038 (Reactome)
hPrp43REACT_5171 (Reactome)
hPrp5REACT_3263 (Reactome)
hSLU7REACT_5157 (Reactome)
hTra2REACT_4242 (Reactome)
intron-containing complexComplexREACT_3239 (Reactome)
mRNA 3'-end cleavage factorComplexREACT_2642 (Reactome)
mRNA ComplexREACT_3236 (Reactome)
p-S5-POLR2A ProteinP24928 (Uniprot-TrEMBL)
p68 DEAH proteinREACT_4900 (Reactome)
post exon ligation complexComplexREACT_5793 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3' end cleaved, ligated exon containing complexArrowREACT_1914 (Reactome)
3' end cleaved, ligated exon containing complexREACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complexArrowREACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complexREACT_53 (Reactome)
ALYREFArrowREACT_1044 (Reactome)
ALYREFArrowREACT_1228 (Reactome)
ALYREFArrowREACT_1334 (Reactome)
ALYREFArrowREACT_1356 (Reactome)
ALYREFREACT_1604 (Reactome)
ALYREFREACT_1897 (Reactome)
ALYREFREACT_222 (Reactome)
ALYREFREACT_696 (Reactome)
ASR2BREACT_222 (Reactome)
ATAC A ComplexREACT_1253 (Reactome)
ATAC C ComplexArrowREACT_1615 (Reactome)
ATPREACT_1162 (Reactome)
CC1.3 protein /3 RRM, RSREACT_222 (Reactome)
CCAR1REACT_222 (Reactome)
CD2BP2REACT_222 (Reactome)
CDC40ArrowREACT_138 (Reactome)
CDC40REACT_788 (Reactome)
CF IArrowREACT_1914 (Reactome)
CF IIArrowREACT_1914 (Reactome)
CF IIREACT_1184 (Reactome)
CF IREACT_1184 (Reactome)
CPSFArrowREACT_1162 (Reactome)
CPSFArrowREACT_1897 (Reactome)
CPSFREACT_1184 (Reactome)
Cap Binding Complex ArrowREACT_1897 (Reactome)
Cap Binding Complex ArrowREACT_696 (Reactome)
Cleavage and Polyadenylation ComplexREACT_625 (Reactome)
CstFArrowREACT_1914 (Reactome)
CstFREACT_1184 (Reactome)
DHX38ArrowREACT_138 (Reactome)
DHX38REACT_788 (Reactome)
DHX9REACT_222 (Reactome)
DNAJC8REACT_788 (Reactome)
DnaJ hom. NP_055602REACT_222 (Reactome)
EIF4EREACT_1044 (Reactome)
EIF4EREACT_1228 (Reactome)
EIF4EREACT_1334 (Reactome)
EIF4EREACT_1356 (Reactome)
Export Receptor bound mature mRNA ComplexArrowREACT_138 (Reactome)
Export Receptor bound mature mRNA ComplexREACT_1228 (Reactome)
FUSREACT_222 (Reactome)
HNRNPA0ArrowREACT_1331 (Reactome)
HNRNPA0REACT_1877 (Reactome)
HNRNPA1ArrowREACT_1331 (Reactome)
HNRNPA1REACT_1877 (Reactome)
HNRNPA2B1ArrowREACT_1331 (Reactome)
HNRNPA2B1REACT_1877 (Reactome)
HNRNPA3ArrowREACT_1331 (Reactome)
HNRNPA3REACT_1877 (Reactome)
HNRNPCArrowREACT_1331 (Reactome)
HNRNPCREACT_1877 (Reactome)
HNRNPDArrowREACT_1331 (Reactome)
HNRNPDREACT_1877 (Reactome)
HNRNPFArrowREACT_1331 (Reactome)
HNRNPFREACT_1877 (Reactome)
HNRNPH1ArrowREACT_1331 (Reactome)
HNRNPH1REACT_1877 (Reactome)
HNRNPH2ArrowREACT_1331 (Reactome)
HNRNPH2REACT_1877 (Reactome)
HNRNPKArrowREACT_1331 (Reactome)
HNRNPKREACT_1877 (Reactome)
HNRNPLArrowREACT_1331 (Reactome)
HNRNPLREACT_1877 (Reactome)
HNRNPMArrowREACT_1331 (Reactome)
HNRNPMREACT_1877 (Reactome)
HNRNPRArrowREACT_1331 (Reactome)
HNRNPRREACT_1877 (Reactome)
HNRNPUArrowREACT_1331 (Reactome)
HNRNPUL1REACT_222 (Reactome)
HNRNPUREACT_1877 (Reactome)
HuR /3 RRM proteinREACT_222 (Reactome)
Ligated exon containing complexArrowREACT_1331 (Reactome)
Magoh-Y14 complexREACT_774 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref Complex		REACT_1356 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref complex		ArrowREACT_696 (Reactome)
Mature Intronless Transcript Derived mRNA eIF4E ComplexArrowREACT_1334 (Reactome)
Mature Intronless transcript derived Histone mRNA

SLBP CBP80

CBP20		REACT_1604 (Reactome)
Mature SLBP independent Histone mRNA eIF4E complexArrowREACT_1356 (Reactome)
Mature intronless derived mRNA

TAP

Aly/Ref complex		REACT_1334 (Reactome)
Mature intronless derived mRNA complexREACT_1897 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		ArrowREACT_1604 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		REACT_1044 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP

eIF4E Complex		ArrowREACT_1044 (Reactome)
Mature intronless transcript derived Histone pre-mRNA CBC complexREACT_696 (Reactome)
Mature mRNP ComplexArrowREACT_1228 (Reactome)
NCBP1ArrowREACT_1604 (Reactome)
NCBP2ArrowREACT_1604 (Reactome)
NFAR-2 proteinREACT_222 (Reactome)
NFX.1REACT_222 (Reactome)
NXF1ArrowREACT_1044 (Reactome)
NXF1ArrowREACT_1228 (Reactome)
NXF1ArrowREACT_1334 (Reactome)
NXF1ArrowREACT_1356 (Reactome)
NXF1REACT_1604 (Reactome)
NXF1REACT_1897 (Reactome)
NXF1REACT_53 (Reactome)
NXF1REACT_696 (Reactome)
Nuclear Pore Complex ArrowREACT_1004 (Reactome)
Nuclear Pore Complex ArrowREACT_1044 (Reactome)
Nuclear Pore Complex ArrowREACT_1228 (Reactome)
Nuclear Pore Complex ArrowREACT_1334 (Reactome)
Nuclear Pore Complex ArrowREACT_1356 (Reactome)
Nuclear Pore Complex ArrowREACT_138 (Reactome)
Nuclear Pore Complex ArrowREACT_1604 (Reactome)
Nuclear Pore Complex ArrowREACT_1799 (Reactome)
Nuclear Pore Complex ArrowREACT_1897 (Reactome)
Nuclear Pore Complex ArrowREACT_2104 (Reactome)
Nuclear Pore Complex ArrowREACT_696 (Reactome)
Nuclear Pore Complex ArrowREACT_904 (Reactome)
Nucleoplasmic mature intronless derived mRNA

TAP

Aly/Ref complex		ArrowREACT_1897 (Reactome)
PABPN1ArrowREACT_1162 (Reactome)
PABPN1REACT_1184 (Reactome)
PAPOLAArrowREACT_1162 (Reactome)
PAPOLAREACT_1184 (Reactome)
PAPOLAmim-catalysisREACT_1162 (Reactome)
PCBP1ArrowREACT_1331 (Reactome)
PCBP1REACT_1877 (Reactome)
PCBP2ArrowREACT_1331 (Reactome)
PCBP2REACT_1877 (Reactome)
PTBP1ArrowREACT_1331 (Reactome)
PTBP1REACT_1877 (Reactome)
RBM5REACT_222 (Reactome)
RBMXArrowREACT_1331 (Reactome)
RBMXREACT_1877 (Reactome)
REACT_1004 (Reactome) The nucleoplasmic 3' polyadenylated, capped intronless mRNA and TAP are transported through the NPC to the cyotplasmic side of the pore.
REACT_1044 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
REACT_1162 (Reactome) The upstream fragment generated by 3' cleavage of the pre-mRNA receives a poly(A) tail of approximately 250 AMP residues in a reaction depending on the AAUAAA sequence 10 to 30 nucleotides upstream of the 3' end. Polyadenylation is carried out by three proteins: Poly(A) polymerase carries the catalytic activity. The enzyme has no specificity for any particular RNA sequence, and it also has a very low affinity for the RNA.

Under physiological conditions, the activity of poly(A) polymerase thus depends on two auxiliary factors, both of which bind to specific RNA sequences and recruit the enzyme by a direct contact. One of these proteins is the heterotetrameric CPSF, which binds the AAUAAA sequence and is also essential for 3' cleavage. The second is the nuclear poly(A) binding protein (PABPN1), which binds the growing poly(A) tails once this has reached a length of about ten nucleotides. Stimulation of poly(A) polymerase by both proteins is synergistic and results in processive elongation of the RNA, i.e. the polymerase adds AMP residues without dissociating from the RNA. The processive reaction is terminated when the tail has reached a length of about 250 nucleotides.

REACT_1184 (Reactome)
REACT_1228 (Reactome) At the beginning of this reaction, 1 molecule of 'eIF4E', and 1 molecule of 'Export Receptor bound mature mRNA Complex' are present. At the end of this reaction, 1 molecule of 'THOC4(Aly/Ref)', 1 molecule of 'Mature mRNP Complex', 1 molecule of 'SRm160', and 1 molecule of 'TAP' are present.

This reaction takes place in the 'cytoplasm'.

REACT_1253 (Reactome) The U4atac/U6atac enters the spliceosome and U6atac snRNA forms base pairing interactions with the 5' ss and also forms base pairing interactions with U12 and U4atac is partially displaced. U5 snRNP, the only snRNP common to both the major and minor splicing pathways, also joins the spliceosome to form the B complex and interacts with nucleotides within the 3' end of the exon flanking the 5' ss.
REACT_1331 (Reactome) The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.
REACT_1334 (Reactome) The cytoplasmic 3' polyadenylated, capped intronless mRNA and TAP are released from the NPC into the cytosol. Cytosolic TAP will be recycled to the nucleous, while the 3' polyadenylated, capped intronless mRNA is bound by eIF4E and destined for translation.
REACT_1356 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
REACT_138 (Reactome) At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present.

This reaction takes place in the 'nucleoplasm'.

REACT_1494 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present. At the end of this reaction, 1 molecule of 'U6 ATAC snRNP', 1 molecule of 'post exon ligation complex', 1 molecule of 'U12 snRNP', 1 molecule of 'U11 snRNP', and 1 molecule of 'U5 snRNP' are present.

This reaction takes place in the 'nucleus'.

REACT_1554 (Reactome) The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.
REACT_1604 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The stemloop and SLBP enhance the rate of transport of histone mRNAs in Xenopus oocytes, but are not essential for transport
REACT_1615 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC B Complex' is present. At the end of this reaction, 1 molecule of 'U4 ATAC snRNP', and 1 molecule of 'ATAC C Complex' are present.

This reaction takes place in the 'nucleus'.

REACT_1720 (Reactome) In addition to the methylation of the 5'-cap, there is methylation of internal nucleotides in the mRNA. This methylation can occur in translated and untranslated regions. One to three methyl groups have been seen per mRNA molecule, but methylation is non-stoichiometric. The most frequent methylation observed is at the N6 position of adenosine. The function of mRNA internal methylation, if any, is unknown.
REACT_1799 (Reactome) Once the transport complex is fully assembled the mature mRNA can be translocated from the nucleoplasm to the cytoplasm. The assembled complex starts at the nucleoplasmic basket, travels through the pore, and ends it journey at the cytoplasmic face of the nuclear pore complex.
REACT_1877 (Reactome) After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.
REACT_1897 (Reactome) The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm.
REACT_1914 (Reactome) Endonucleolytic cleavage separates the pre-mRNA into an upstream fragment destined to become the mature mRNA, and a downstream fragment that is rapidly degraded. Cleavage depends on two signals in the RNA, a highly conserved hexanucleotide, AAUAAA, 10 to 30 nucleotides upstream of the cleavage site, and a poorly conserved GU- or U-rich downstream element. Additional sequences, often upstream of AAUAAA, can enhance the efficiency of the reaction. Cleavage occurs most often after a CA dinucleotide. A single gene can have more than one 3' processing site.

Cleavage is preceded by the assembly of a large processing complex, the composition of which is poorly defined. ATP, but not its hydrolysis, is required for assembly. Cleavage at the 3'-end of mRNAs depends on a number of protein factors. CPSF, a heterotetramer, binds specifically to the AAUAAA sequence. The heterotrimer CstF binds the downstream element. CF I, which appears to be composed of two subunits, one of several related larger polypeptides and a common smaller one, also binds RNA, but with unknown specificity. RNA recognition by these proteins is cooperative. Cleavage also requires CF II, composed of at least two subunits, and poly(A) polymerase, the enzyme synthesizing the poly(A) tail in the second step of the reaction. The polypeptide catalyzing the hydrolysis of the phosphodiester bond remains to be identified.

Cleavage produces a 3'-OH on the upstream fragment and a 5'-phosphate on the downstream fragment. At some unknown point after cleavage, the downstream RNA fragment, CstF, CF I and CF II are thought to be released, whereas CPSF and poly(A) polymerase remain to carry out polyadenylation.

REACT_1935 (Reactome) In the first catalytic step of mRNA splicing, the 2' OH group of the bulged A at the branch site performs a nucleophilic attack on the 5' splice site phosphodiester bond, resulting in cleavage of the bond between the 5' exon and the 5' end of the intron, and formation of a new bond between the 5' end of the intron and the branch site A. This results in a lariat-shaped intermediate, with the intron still attached to the 3' exon. The branch site A has a 2'-5' phosphodiester bond with the G at the beginning of the intron, in addition to the usual 5'-3' and 3'-5'phosphodiester bonds.
REACT_2104 (Reactome) In this reaction, 1 molecule of 'Export Receptor bound mature mRNA Complex' is translocated from nucleoplasm to cytosol.

This reaction takes place in the 'nuclear envelope'.

REACT_222 (Reactome) Pre-mRNA transcripts become rapidly associated with many RNA-binding proteins, including hnRNP proteins, cap-binding proteins, SR proteins, etc; in the test tube this binding does not require splice sites or ATP. The E complex, or early complex, is the first detectable functional intermediate in spliceosome assembly in vitro. It is an ATP-independent complex. When a functional 5' splice site is present, it is bound by the U1 snRNP. The splicing factor U2AF (65 and 35 kDa subunits) binds to the polypyrimidine tract (Y)n and the AG dinucleotide at the 3' splice site, respectively. SF1/mBBP binds to the branch site. Binding of many of these factors is cooperative; e.g., SR proteins and U2AF apparently interact with each other, facilitating their binding to the pre-mRNA. In the presence of ATP, the E complex is converted to the first ATP-dependent spliceosomal complex, namely the A complex.
REACT_2241 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex' is present. At the end of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present.

This reaction takes place in the 'nucleus'.

REACT_48 (Reactome) The formation of the B complex is ATP-dependent, and both the 5' and 3' splice sites are essential for B complex assembly. The U4 and U6 snRNPS are extensively base-paired, and this U4:U6 complex associates with the U5 snRNP to form a tri-snRNP particle. This tri-snRNP particle then binds to the spliceosomal A complex, to form the spliceosomal B complex.
REACT_53 (Reactome) Aly/Ref recruits TAP to the Exon Junction Complex. This makes the mRNP complex ready for export to the cytoplasm.
REACT_625 (Reactome) The spliceosomal C complex is a very short-lived intermediate; the splicing intermediates are rapidly converted to splicing products. Also, the spliced products are released very rapidly, and no complex containing both the splicing products has been isolated. Conversion of the spliceosomal B complex to the spliceosomal C complex requires ATP. The extensive base-pairing between the U4 and U6 snRNAs is disrupted during the formation of the C complex, which is thought to require helicase-type activity associated with the DEAD box factors.
REACT_696 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The mature transcript docks at the NPC, in the course of transport CBC will be lost from the mRNA cap, and remain in the nucleous.
REACT_774 (Reactome) At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

REACT_788 (Reactome) The A complex is the first ATP-dependent complex in spliceosome assembly. U2AF recruits the U2 snRNP to bind to the branch site in the E complex in an ATP-dependent fashion, to form the A complex. The U2 snRNA base-pairs with the branch site, causing the branch-site adenosine to bulge out, which later positions it for nucleophilic attack at the 5' splice site. The A complex serves as a substrate for formation of the B complex.
REACT_864 (Reactome) U12-type AT-AC introns are distinguished from the major U2-type introns by the consensus sequences of their highly conserved splicing signals. U12 introns have the 5' ss consensus sequence (G/A)TATCCTTT, the branchpoint sequence TTTCCTTAACT and the 3' ss (C/T)AG. Initial recognition of AT-AC introns involves interaction of U12 snRNP with the branch-point sequence and U11 with the 5' ss. Unlike the major splicing pathway, U11 and U12 are in a complex and interact with the pre-mRNA simultaneously, binding in an ATP-dependent manner as a di-snRNP complex and likely bridging the 5' ss and 3' ss region.

Twenty proteins have been identified in the U11/U12 di-snRNP complex including the snRNP Sm proteins B’, B, D3, D2, D1, E, F, and G which are identical to the major splicing pathway Sm proteins. A U2 snRNP core protein complex, SF3b is also found in the U11/U12 di-snRNP, including p14, a protein that interacts with the branchpoint adenosine.

SR proteins are required for formation of A complex in AT-AC splicing. The same SR proteins involved in splicing of the major introns are also active in splicing of AT-AC introns, though, as in the major pathway, there is substrate specificity.

REACT_904 (Reactome) The mature SLBP independent intronless histone mRNA is transported through the nucler pore to the cytoplasmic side.
RNA polymerase II ArrowREACT_1331 (Reactome)
RNPS1REACT_222 (Reactome)
SMC1AREACT_222 (Reactome)
SMC2 REACT_222 (Reactome)
SRRM1ArrowREACT_1228 (Reactome)
SRRM1REACT_222 (Reactome)
SRSF11ArrowREACT_138 (Reactome)
SRSF11REACT_788 (Reactome)
SRSF1ArrowREACT_138 (Reactome)
SRSF1REACT_222 (Reactome)
SRSF1REACT_864 (Reactome)
SRSF2ArrowREACT_138 (Reactome)
SRSF2REACT_222 (Reactome)
SRSF2REACT_864 (Reactome)
SRSF3ArrowREACT_138 (Reactome)
SRSF3REACT_222 (Reactome)
SRSF4ArrowREACT_138 (Reactome)
SRSF4REACT_788 (Reactome)
SRSF5ArrowREACT_138 (Reactome)
SRSF5REACT_222 (Reactome)
SRSF6ArrowREACT_138 (Reactome)
SRSF6REACT_222 (Reactome)
SRSF6REACT_864 (Reactome)
SRSF7ArrowREACT_138 (Reactome)
SRSF7REACT_222 (Reactome)
SRSF7REACT_864 (Reactome)
SRSF9ArrowREACT_138 (Reactome)
SRSF9REACT_222 (Reactome)
SUGP1REACT_222 (Reactome)
Spliceosomal A ComplexREACT_48 (Reactome)
Spliceosomal Active C ComplexREACT_1935 (Reactome)
Spliceosomal B ComplexREACT_625 (Reactome)
Spliceosomal E ComplexREACT_788 (Reactome)
Spliceosomal Intermediate C ComplexArrowREACT_625 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP CBC complexREACT_774 (Reactome)
U1 snRNPArrowREACT_625 (Reactome)
U1 snRNPREACT_222 (Reactome)
U11 snRNPArrowREACT_1494 (Reactome)
U11 snRNPREACT_864 (Reactome)
U12 snRNPArrowREACT_1494 (Reactome)
U12 snRNPREACT_864 (Reactome)
U2 snRNPREACT_788 (Reactome)
U2AF1ArrowREACT_138 (Reactome)
U2AF1REACT_222 (Reactome)
U2AF2ArrowREACT_138 (Reactome)
U2AF2REACT_222 (Reactome)
U4

U5

U6 trisnRNP complex		REACT_48 (Reactome)
U4 ATAC

U5

U6 ATAC Complex		REACT_1253 (Reactome)
U4 ATAC snRNPArrowREACT_1615 (Reactome)
U4 snRNPArrowREACT_625 (Reactome)
U5 snRNPArrowREACT_1494 (Reactome)
U6 ATAC snRNPArrowREACT_1494 (Reactome)
UBA, Tudor - FLJ21007REACT_222 (Reactome)
UPF3BREACT_1935 (Reactome)
YBX1REACT_222 (Reactome)
capped, methylated pre-mRNA CBC ComplexREACT_1877 (Reactome)
capped, methylated pre-mRNA CBC ComplexREACT_864 (Reactome)
capped, methylated pre-mRNP CBC complexREACT_222 (Reactome)
hPrp18ArrowREACT_138 (Reactome)
hPrp19REACT_222 (Reactome)
hPrp22ArrowREACT_138 (Reactome)
hPrp43ArrowREACT_138 (Reactome)
hPrp5REACT_788 (Reactome)
hSLU7ArrowREACT_138 (Reactome)
hTra2ArrowREACT_138 (Reactome)
hTra2REACT_788 (Reactome)
intron-containing complexArrowREACT_1331 (Reactome)
mRNA 3'-end cleavage factormim-catalysisREACT_1914 (Reactome)
mRNA mim-catalysisREACT_1720 (Reactome)
p68 DEAH proteinREACT_222 (Reactome)
post exon ligation complexArrowREACT_1494 (Reactome)
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