Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none cytosolnucleoplasmcapped pre-mRNACBCRNA Pol IICap Binding ComplexRNA Polymerase IIRNA polymerase IIRNA Polymerase II holoenzyme complexTFIIFcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFmRNAcapped, methylated pre-mRNPCBC complexcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU1 snRNPsnRNP Sm core complexSpliceosomal E ComplexU1 snRNPsnRNP Sm core complexcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU2 snRNPsnRNP Sm core complexSF3ASF3BSpliceosomal A ComplexSpliceosomal E ComplexU1 snRNPsnRNP Sm core complexcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU2 snRNPSF3ASF3BU4U5U6 trisnRNP complexU4 snRNPU6 snRNP complexU4 snRNPU6 snRNPsnRNP Sm core complexU5 snRNPSpliceosomal B ComplexU4 snRNPU6 snRNP complexU4 snRNPU6 snRNPsnRNP Sm core complexSpliceosomal A ComplexSpliceosomal E ComplexU1 snRNPcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU2 snRNPSF3ASF3BU5 snRNPCleavage and Polyadenylation ComplexCPSFCstFCF ICF IISpliceosomal Intermediate C ComplexU2 snRNPsnRNP Sm core complexSF3ASF3BU5 snRNPU6 snRNPCleavage and Polyadenylation ComplexCPSFCstFCF ICF IIcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFhnRNP proteinsU4 snRNPU1 snRNPsnRNP Sm core complexSpliceosomal Active C ComplexU2 snRNPsnRNP Sm core complexSF3ASF3BU5 snRNPU6 snRNPCleavage and Polyadenylation ComplexCPSFCstFCF ICF IIcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFhnRNP proteinsSpliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complexU2 snRNPsnRNP Sm core complexSF3ASF3BU5 snRNPU6 snRNPCleavage and Polyadenylation ComplexCPSFCstFCF ICF IIlariat containing 5'-end cleaved mRNACBC complexCap Binding ComplexRNA polymerase IIRNA Polymerase II holoenzyme complexTFIIFpre-EJC complexMagoh-Y14 complexExon Junction ComplexSpliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complexU2 snRNPsnRNP Sm core complexSF3ASF3BU5 snRNPU6 snRNPCleavage and Polyadenylation ComplexCPSFCstFCF ICF IIlariat containing 5'-end cleaved mRNACBC complexCap Binding ComplexRNA polymerase IIRNA Polymerase II holoenzyme complexTFIIFpre-EJC complexMagoh-Y14 complexLigated exon containing complexCap Binding ComplexCleavage and Polyadenylation ComplexCPSFCstFCF ICF IIEJC complexpre-EJC complexMagoh-Y14 complexRNA polymerase IIRNA Polymerase II holoenzyme complexTFIIFintron-containing complexU2 snRNPsnRNP Sm core complexSF3ASF3BU5 snRNPU6 snRNPU12 snRNPsnRNP Sm core complexSF3BU11 snRNPsnRNP Sm core complexATAC A Complexcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU11 snRNPsnRNP Sm core complexU12 snRNPSF3BU4 ATACU5U6 ATAC ComplexU5 snRNPsnRNP Sm core complexU4 ATAC snRNPU6 ATAC snRNPU4 ATAC snRNPU6 ATAC snRNPATAC B ComplexATAC A Complexcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU11 snRNPsnRNP Sm core complexU12 snRNPSF3BU4 ATACU5U6 ATAC ComplexU5 snRNPU4 ATAC snRNPU6 ATAC snRNPU4 ATAC snRNPU6 ATAC snRNPU4 ATAC snRNPsnRNP Sm core complexATAC C ComplexU11 snRNPsnRNP Sm core complexU12 snRNPSF3Bcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU5 snRNPU6 ATAC snRNPATAC C Complex with lariat containing 5'-end cleaved mRNAU11 snRNPsnRNP Sm core complexU12 snRNPSF3BU5 snRNPU6 ATAC snRNPcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFpost exon ligation complexcapped, methylated pre-mRNACBC ComplexCap Binding ComplexRNA Polymerase IIRNA Polymerase II holoenzyme complexTFIIFU5 snRNPsnRNP Sm core complexU6 ATAC snRNPsnRNP Sm core complex3' end cleaved, ligated exon containing complexCap Binding ComplexCPSFEJC complexpre-EJC complexMagoh-Y14 complexCF IICstFCF ImRNA 3'-end cleavage factorCF ICF II3'-polyadenylated, capped mRNA complexCap Binding ComplexEJC complexpre-EJC complexMagoh-Y14 complexCPSFTAP3'-polyadenylated, capped mRNA complex3'-polyadenylated, capped mRNA complexCap Binding ComplexEJC complexpre-EJC complexMagoh-Y14 complexExport Receptor bound mature mRNA ComplexMagoh-Y14 complexCap Binding ComplexNuclear Pore ComplexNup107 ComplexNup62 ComplexExport Receptor bound mature mRNA ComplexMagoh-Y14 complexCap Binding ComplexMature mRNP ComplexMagoh-Y14 complexCap Binding ComplexCPSFCstFCF IICF IMature Intronless transcript derived Histone mRNASLBPCBP80CBP20Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexMature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexMature intronless transcript derived Histone mRNASLBPeIF4E ComplexMature intronless transcript derived Histone pre-mRNACBC complexCap Binding ComplexMature Intronless Transcript Derived Histone mRNATAPAly/Ref complexCap Binding ComplexNuclear Pore ComplexNup107 ComplexNup62 ComplexMature Intronless Transcript Derived Histone mRNATAPAly/Ref ComplexMature SLBP independent Histone mRNAeIF4E complexMature intronless derived mRNA complexCPSFCap Binding ComplexNucleoplasmic mature intronless derived mRNATAPAly/Ref complexCPSFMature intronless derived mRNATAPAly/Ref complexMature Intronless Transcript Derived mRNAeIF4E Complexcapped pre-mRNACBCRNA Pol IIcapped, methylated pre-mRNACBC ComplexmRNAHNRNPUHNRNPA2B1HNRNPA1HNRNPFPCBP2HNRNPDHNRNPH2HNRNPMPTBP1HNRNPCHNRNPKPCBP1HNRNPLHNRNPA0HNRNPA3HNRNPH1RBMXHNRNPRcapped, methylated pre-mRNPCBC complexUBA, Tudor - FLJ21007RBM5HNRNPUL1YBX1FUSHuR /3 RRM proteinhPrp19SUGP1CD2BP2SRSF9CC1.3 protein /3 RRM, RSSMC1AU1 snRNPSRRM1DnaJ hom. NP_055602RNPS1SRSF6DHX9SRSF7NFX.1ASR2BCCAR1SRSF2SMC2SRSF1U2AF1ALYREFSRSF5NFAR-2 proteinp68 DEAH proteinSRSF3U2AF2Spliceosomal E ComplexU2 snRNPhPrp5DHX38DNAJC8CDC40hTra2SRSF11SRSF4Spliceosomal A ComplexU4U5U6 trisnRNP complexSpliceosomal B ComplexCleavage and Polyadenylation ComplexSpliceosomal Intermediate C ComplexU4 snRNPU1 snRNPSpliceosomal Active C ComplexUPF3BSpliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complexMagoh-Y14 complexExon Junction ComplexLigated exon containing complexRNA polymerase IIintron-containing complexU12 snRNPU11 snRNPATAC A ComplexU4 ATACU5U6 ATAC ComplexATAC B ComplexU4 ATAC snRNPATAC C ComplexATAC C Complex with lariat containing 5'-end cleaved mRNApost exon ligation complexU5 snRNPU6 ATAC snRNP3' end cleaved, ligated exon containing complexCF IICstFCF ImRNA 3'-end cleavage factorATP3'-polyadenylated, capped mRNA complexPABPN1PAPOLACPSFNXF1TAP3'-polyadenylated, capped mRNA complexhSLU7hPrp18hPrp22Export Receptor bound mature mRNA ComplexhPrp43Nuclear Pore ComplexExport Receptor bound mature mRNA ComplexEIF4EALYREFNXF1Mature mRNP ComplexSRRM1PABPN1CPSFPAPOLACstFCF IICF IMature Intronless transcript derived Histone mRNASLBPCBP80CBP20NCBP2Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexNCBP1NXF1Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexMature intronless transcript derived Histone mRNASLBPeIF4E ComplexMature intronless transcript derived Histone pre-mRNACBC complexMature Intronless Transcript Derived Histone mRNATAPAly/Ref complexCap Binding ComplexNXF1ALYREFEIF4ENuclear Pore ComplexMature Intronless Transcript Derived Histone mRNATAPAly/Ref ComplexMature SLBP independent Histone mRNAeIF4E complexMature intronless derived mRNA complexNucleoplasmic mature intronless derived mRNATAPAly/Ref complexNXF1CPSFMature intronless derived mRNATAPAly/Ref complexMature Intronless Transcript Derived mRNAeIF4E ComplexEIF4ENXF1ALYREFNCBP2NCBP1p-S5-POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2METTL3PCBP1PCBP2PTBP1HNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUNCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2U1 snRNASNRNP70SNRPASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3U1 snRNASNRNP70SNRPASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3U2AF1U2AF2SRSF2SRSF7SRSF9SRSF5SRSF6SRSF1SRSF3DHX9FUSYBX1SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUHNRNPUL1ALYREFSRRM1RNPS1NFX.1NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2PCBP1PCBP2PTBP1U2 snRNASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14U1 snRNASNRNP70SNRPASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3U2AF1U2AF2SRSF2SRSF7SRSF9SRSF5SRSF6SRSF1SRSF3DHX9FUSYBX1SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUHNRNPUL1ALYREFSRRM1RNPS1NFX.1NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2PCBP1PCBP2PTBP1U2 snRNASNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14SRSF4SRSF11DHX38CDC40DNAJC8U4 snRNANHP2L1PRPF4U6 snRNALSM2SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200PRPF8U4 snRNANHP2L1PRPF4U6 snRNALSM2SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3U1 snRNASNRNP70SNRPAU2AF1U2AF2SRSF2SRSF7SRSF9SRSF5SRSF6SRSF1SRSF3DHX9FUSYBX1SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUHNRNPUL1ALYREFSRRM1RNPS1NFX.1NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2PCBP1PCBP2PTBP1U2 snRNASNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14SRSF4SRSF11DHX38CDC40DNAJC8U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200PRPF8CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3PAPOLAPABPN1NUDT21CPSF7CLP1PCF11U2 snRNASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8U6 snRNAPRPF4U2AF2U2AF1CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3PAPOLAPABPN1NUDT21CPSF7CLP1PCF11SRSF1SRSF2SRSF4SRSF7SRSF9SRSF11SRSF3SRSF5SRSF6DHX38CDC40YBX1FUSDNAJC8DHX9SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPUL1ALYREFSRRM1RNPS1NFX.1NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2HNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUPCBP1PCBP2PTBP1U4 snRNANHP2L1PRPF4U1 snRNASNRNP70SNRPASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3U2 snRNASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8U6 snRNAPRPF4U2AF2U2AF1CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3PAPOLAPABPN1NUDT21CPSF7CLP1PCF11SRSF1SRSF2SRSF4SRSF7SRSF9SRSF11SRSF3SRSF5SRSF6DHX38CDC40YBX1FUSDNAJC8DHX9SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPUL1ALYREFSRRM1RNPS1NFX.1NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2HNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUPCBP1PCBP2PTBP1HNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUU2 snRNASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8U6 snRNAPRPF4U2AF1U2AF2CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3PAPOLAPABPN1NUDT21CPSF7CLP1PCF11SRSF1SRSF4SRSF6SRSF5SRSF7SRSF2SRSF3SRSF9DHX38SRSF11CDC40YBX1FUSDNAJC8DHX9SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPUL1PCBP1PCBP2PTBP1NCBP2NCBP1p-S5-POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2UPF3BNFX.1SRRM1RNPS1ALYREFMAGOHRBM8AHNRNPA0HNRNPA1HNRNPA2B1HNRNPA3HNRNPCHNRNPDHNRNPFRBMXHNRNPH1HNRNPH2HNRNPKHNRNPLHNRNPMHNRNPRHNRNPUU2 snRNASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8U6 snRNAPRPF4U2AF1U2AF2CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3PAPOLAPABPN1NUDT21CPSF7CLP1PCF11SRSF1SRSF4SRSF6SRSF5SRSF7SRSF2SRSF3SRSF9DHX38SRSF11CDC40YBX1FUSDNAJC8DHX9SUGP1CCAR1RBM5CD2BP2SMC1AHNRNPUL1PCBP1PCBP2PTBP1NCBP2NCBP1p-S5-POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2UPF3BNFX.1SRRM1RNPS1ALYREFMAGOHRBM8ANCBP2NCBP1CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3PAPOLAPABPN1NUDT21CPSF7CLP1PCF11SRSF1SRSF2SRSF4SRSF7SRSF9SRSF11SRSF3SRSF5SRSF6DHX38CDC40U2AF1U2AF2UPF3BNFX.1SRRM1RNPS1ALYREFMAGOHRBM8Ap-S5-POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2U2 snRNASNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPA1SNRPB2SF3A1SF3A2SF3A3SF3B1SF3B2SF3B3SF3B4SF3B5PHF5ASF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8U6 snRNAPRPF4YBX1FUSDNAJC8DHX9RBM5SMC1ACD2BP2SUGP1CCAR1HNRNPUL1SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SF3B1SF3B2SF3B3SF3B4SF3B5SF3B14SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SRSF6SRSF2SRSF7SRSF1SF3B1SF3B2SF3B3SF3B4SF3B5SF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3PRPF8NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SRSF6SRSF2SRSF7SRSF1SF3B1SF3B2SF3B3SF3B4SF3B5SF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SF3B1SF3B2SF3B3SF3B4SF3B5SF3B14NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2SRSF2SRSF7SRSF6SRSF1U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3SF3B1SF3B2SF3B3SF3B4SF3B5SF3B14U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2PRPF8SRSF1SRSF2SRSF7SRSF6NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2SRSF1SRSF2SRSF7SRSF6NCBP2NCBP1POLR2APOLR2JPOLR2IPOLR2BPOLR2DPOLR2GPOLR2CPOLR2HPOLR2KPOLR2EPOLR2FPOLR2LGTF2F1GTF2F2U5 snRNATXNL4ASNRNP40DDX23PRPF6EFTUD2SNRNP200NHP2L1LSM2SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3PRPF8SNRPD2SNRPESNRPFSNRPG2xMe-SNRPB2xMe-SNRPD12xMe-SNRPD3NCBP2NCBP1SRSF1SRSF11SRSF2SRSF4SRSF7SRSF9SRSF3SRSF5SRSF6DHX38CDC40U2AF1U2AF2CPSF1CPSF2CPSF3PABPN1PAPOLAUPF3BNFX.1SRRM1RNPS1ALYREFMAGOHRBM8ACLP1PCF11CSTF1CSTF2CSTF3NUDT21CPSF7NUDT21CPSF7CLP1PCF11SRSF1SRSF4SRSF7SRSF2SRSF11SRSF6SRSF5SRSF3DHX38CDC40U2AF1U2AF2NCBP2NCBP1SRSF9UPF3BNFX.1SRRM1RNPS1ALYREFMAGOHRBM8ACPSF1CPSF2CPSF3NXF1SRSF1SRSF4SRSF7SRSF2SRSF11SRSF6SRSF5SRSF3DHX38CDC40U2AF1U2AF2NCBP2NCBP1SRSF9UPF3BNFX.1SRRM1RNPS1ALYREFMAGOHRBM8AALYREFUPF3BSRRM1RNPS1NFX.1NXF1MAGOHRBM8ANCBP2NCBP1NUP160NUP133NUP107NUP98-5NUP37NUP62NUPL1-2NUP54Nup45AAASNUP210NUPL2NUP153NUP155NUP188NUP205NUP214NUP35RANBP2NUP43NUP50NUP85NUP88NUP93POM121RAE1TPRSEH1L-2ALYREFUPF3BSRRM1RNPS1NFX.1NXF1RBM8AMAGOHNCBP2NCBP1EIF4ENFX.1RNPS1UPF3BRBM8AMAGOHNCBP2NCBP1CPSF1CPSF2CPSF3CSTF1CSTF2CSTF3CLP1PCF11NUDT21CPSF7SLBPNCBP1NCBP2SLBPNXF1ALYREFSLBPNXF1ALYREFSLBPEIF4ENCBP2NCBP1NXF1ALYREFNCBP2NCBP1NUP160NUP133NUP107NUP98-5NUP37NUP62NUPL1-2NUP54Nup45AAASNUP210NUPL2NUP153NUP155NUP188NUP205NUP214NUP35RANBP2NUP43NUP50NUP85NUP88NUP93POM121RAE1TPRSEH1L-2NXF1ALYREFEIF4ECPSF1CPSF2CPSF3NCBP2NCBP1NXF1ALYREFCPSF1CPSF2CPSF3NXF1ALYREFEIF4EName: Processing of Capped Intron-Containing Pre-mRNAOrganism: Homo sapiens


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Co-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per gene, which cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. Thus the time that it takes for pol II to synthesize each intron defines a minimal time and distance along the gene in which splicing factors can be recruited. The time that it takes for pol II to reach the end of the gene defines the maximal time in which splicing could occur co-transcriptionally. Thus, the kinetics of transcription can affect the kinetics of splicing.Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm.

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Bibliography

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  101. Grzybowska EA.; ''Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.''; PubMed Europe PMC Scholia
  102. Yao C, Choi EA, Weng L, Xie X, Wan J, Xing Y, Moresco JJ, Tu PG, Yates JR, Shi Y.; ''Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.''; PubMed Europe PMC Scholia
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  104. Katahira J, Strässer K, Podtelejnikov A, Mann M, Jung JU, Hurt E.; ''The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.''; PubMed Europe PMC Scholia
  105. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W.; ''Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.''; PubMed Europe PMC Scholia
  106. Wente SR, Rout MP.; ''The nuclear pore complex and nuclear transport.''; PubMed Europe PMC Scholia
  107. Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA.; ''TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.''; PubMed Europe PMC Scholia
  108. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R.; ''The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.''; PubMed Europe PMC Scholia
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  111. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E.; ''TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.''; PubMed Europe PMC Scholia
  112. Taniguchi I, Ohno M.; ''ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.''; PubMed Europe PMC Scholia
  113. Kota KP, Wagner SR, Huerta E, Underwood JM, Nickerson JA.; ''Binding of ATP to UAP56 is necessary for mRNA export.''; PubMed Europe PMC Scholia
  114. Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA.; ''Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors.''; PubMed Europe PMC Scholia
  115. Shen H, Zheng X, Luecke S, Green MR.; ''The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.''; PubMed Europe PMC Scholia
  116. Wahle E, Rüegsegger U.; ''3'-End processing of pre-mRNA in eukaryotes.''; PubMed Europe PMC Scholia
  117. Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E.; ''TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.''; PubMed Europe PMC Scholia
  118. Bessonov S, Anokhina M, Will CL, Urlaub H, Lührmann R.; ''Isolation of an active step I spliceosome and composition of its RNP core.''; PubMed Europe PMC Scholia
  119. Singh J, Sikand K, Conrad H, Will CL, Komar AA, Shukla GC.; ''U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.''; PubMed Europe PMC Scholia

History

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115088
Reactome
view17:03, 25 January 2021ReactomeTeamReactome version 75
113530view12:00, 2 November 2020ReactomeTeamReactome version 74
112728view16:13, 9 October 2020ReactomeTeamReactome version 73
101644view11:51, 1 November 2018ReactomeTeamreactome version 66
101180view21:38, 31 October 2018ReactomeTeamreactome version 65
100706view20:10, 31 October 2018ReactomeTeamreactome version 64
100256view16:56, 31 October 2018ReactomeTeamreactome version 63
99809view15:20, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93917view13:44, 16 August 2017ReactomeTeamreactome version 61
93494view11:25, 9 August 2017ReactomeTeamreactome version 61
88115view10:05, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86590view09:21, 11 July 2016ReactomeTeamreactome version 56
83367view11:01, 18 November 2015ReactomeTeamVersion54
81532view13:04, 21 August 2015ReactomeTeamVersion53
77003view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76708view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76034view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75743view11:23, 10 June 2014ReactomeTeamReactome 48 Update
75093view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74829view10:05, 30 April 2014ReactomeTeamReactome46
74740view08:49, 30 April 2014ReactomeTeamReactome46
42105view21:57, 4 March 2011MaintBotAutomatic update
39915view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2xMe-SNRPB ProteinP14678 (Uniprot-TrEMBL)
2xMe-SNRPD1 ProteinP62314 (Uniprot-TrEMBL)
2xMe-SNRPD3 ProteinP62318 (Uniprot-TrEMBL)
3' end cleaved, ligated exon containing complexComplexREACT_3092 (Reactome)
3'-polyadenylated, capped mRNA complexComplexREACT_5827 (Reactome)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
ALYREF ProteinQ86V81 (Uniprot-TrEMBL)
ALYREFProteinQ86V81 (Uniprot-TrEMBL)
ASR2BREACT_5122 (Reactome)
ATAC A ComplexComplexREACT_4037 (Reactome)
ATAC B ComplexComplexREACT_5095 (Reactome)
ATAC C Complex with lariat containing 5'-end cleaved mRNAComplexREACT_5134 (Reactome)
ATAC C ComplexComplexREACT_4626 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
CC1.3 protein /3 RRM, RSREACT_4848 (Reactome)
CCAR1 ProteinQ8IX12 (Uniprot-TrEMBL)
CCAR1ProteinQ8IX12 (Uniprot-TrEMBL)
CD2BP2 ProteinO95400 (Uniprot-TrEMBL)
CD2BP2ProteinO95400 (Uniprot-TrEMBL)
CDC40 ProteinO60508 (Uniprot-TrEMBL)
CDC40ProteinO60508 (Uniprot-TrEMBL)
CF IIComplexREACT_3772 (Reactome)
CF IComplexREACT_4896 (Reactome)
CLP1 ProteinQ92989 (Uniprot-TrEMBL)
CPSF1 ProteinQ10570 (Uniprot-TrEMBL)
CPSF2 ProteinQ9P2I0 (Uniprot-TrEMBL)
CPSF3 ProteinQ9UKF6 (Uniprot-TrEMBL)
CPSF7 ProteinQ8N684 (Uniprot-TrEMBL)
CPSFComplexREACT_4530 (Reactome)
CSTF1 ProteinQ05048 (Uniprot-TrEMBL)
CSTF2ProteinP33240 (Uniprot-TrEMBL)
CSTF3 ProteinQ12996 (Uniprot-TrEMBL)
Cap Binding Complex ComplexREACT_3884 (Reactome)
Cleavage and Polyadenylation ComplexComplexREACT_3144 (Reactome)
CstFComplexREACT_3503 (Reactome)
DDX23 ProteinQ9BUQ8 (Uniprot-TrEMBL)
DHX38 ProteinQ92620 (Uniprot-TrEMBL)
DHX38ProteinQ92620 (Uniprot-TrEMBL)
DHX9 ProteinQ08211 (Uniprot-TrEMBL)
DHX9ProteinQ08211 (Uniprot-TrEMBL)
DNAJC8ProteinO75937 (Uniprot-TrEMBL)
DnaJ hom. NP_055602REACT_4415 (Reactome)
EFTUD2 ProteinQ15029 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
Exon Junction ComplexComplexREACT_2984 (Reactome)
Export Receptor bound mature mRNA ComplexComplexREACT_2455 (Reactome)
Export Receptor bound mature mRNA ComplexComplexREACT_2624 (Reactome)
FUS ProteinP35637 (Uniprot-TrEMBL)
FUSProteinP35637 (Uniprot-TrEMBL)
GTF2F1ProteinP35269 (Uniprot-TrEMBL)
GTF2F2ProteinP13984 (Uniprot-TrEMBL)
HNRNPA0 ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA0ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA1 ProteinP09651 (Uniprot-TrEMBL)
HNRNPA1ProteinP09651 (Uniprot-TrEMBL)
HNRNPA2B1 ProteinP22626 (Uniprot-TrEMBL)
HNRNPA2B1ProteinP22626 (Uniprot-TrEMBL)
HNRNPA3 ProteinP51991 (Uniprot-TrEMBL)
HNRNPA3ProteinP51991 (Uniprot-TrEMBL)
HNRNPC ProteinP07910 (Uniprot-TrEMBL)
HNRNPCProteinP07910 (Uniprot-TrEMBL)
HNRNPD ProteinQ14103 (Uniprot-TrEMBL)
HNRNPDProteinQ14103 (Uniprot-TrEMBL)
HNRNPFProteinP52597 (Uniprot-TrEMBL)
HNRNPH1ProteinP31943 (Uniprot-TrEMBL)
HNRNPH2 ProteinP55795 (Uniprot-TrEMBL)
HNRNPH2ProteinP55795 (Uniprot-TrEMBL)
HNRNPK ProteinP61978 (Uniprot-TrEMBL)
HNRNPKProteinP61978 (Uniprot-TrEMBL)
HNRNPL ProteinP14866 (Uniprot-TrEMBL)
HNRNPLProteinP14866 (Uniprot-TrEMBL)
HNRNPM ProteinP52272 (Uniprot-TrEMBL)
HNRNPMProteinP52272 (Uniprot-TrEMBL)
HNRNPR ProteinO43390 (Uniprot-TrEMBL)
HNRNPRProteinO43390 (Uniprot-TrEMBL)
HNRNPU ProteinQ00839 (Uniprot-TrEMBL)
HNRNPUL1 ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUL1ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUProteinQ00839 (Uniprot-TrEMBL)
HuR /3 RRM proteinREACT_5767 (Reactome)
LSM2 ProteinQ9Y333 (Uniprot-TrEMBL)
Ligated exon containing complexComplexREACT_5472 (Reactome)
MAGOH ProteinP61326 (Uniprot-TrEMBL)
METTL3 ProteinQ86U44 (Uniprot-TrEMBL)
Magoh-Y14 complexComplexREACT_5524 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref Complex
ComplexREACT_4560 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref complex
ComplexREACT_5697 (Reactome)
Mature Intronless Transcript Derived mRNA eIF4E ComplexComplexREACT_3252 (Reactome)
Mature Intronless transcript derived Histone mRNA

SLBP CBP80

CBP20
ComplexREACT_3802 (Reactome)
Mature SLBP independent Histone mRNA eIF4E complexComplexREACT_3452 (Reactome)
Mature intronless derived mRNA

TAP

Aly/Ref complex
ComplexREACT_4662 (Reactome)
Mature intronless derived mRNA complexComplexREACT_4047 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex
ComplexREACT_2791 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex
ComplexREACT_3824 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP

eIF4E Complex
ComplexREACT_2270 (Reactome)
Mature intronless transcript derived Histone pre-mRNA CBC complexComplexREACT_5592 (Reactome)
Mature mRNP ComplexComplexREACT_4851 (Reactome)
NCBP1 ProteinQ09161 (Uniprot-TrEMBL)
NCBP1ProteinQ09161 (Uniprot-TrEMBL)
NCBP2 ProteinP52298 (Uniprot-TrEMBL)
NCBP2ProteinP52298 (Uniprot-TrEMBL)
NFAR-2 proteinREACT_4072 (Reactome)
NFX.1 ProteinO43831 (Uniprot-TrEMBL)
NFX.1ProteinO43831 (Uniprot-TrEMBL)
NHP2L1 ProteinP55769 (Uniprot-TrEMBL)
NUDT21 ProteinO43809 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
NXF1ProteinQ9UBU9 (Uniprot-TrEMBL)
Nuclear Pore Complex ComplexREACT_5542 (Reactome)
Nucleoplasmic mature intronless derived mRNA

TAP

Aly/Ref complex
ComplexREACT_4247 (Reactome)
Nup45 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
PABPN1 ProteinQ86U42 (Uniprot-TrEMBL)
PABPN1ProteinQ86U42 (Uniprot-TrEMBL)
PAPOLAProteinP51003 (Uniprot-TrEMBL)
PCBP1 ProteinQ15365 (Uniprot-TrEMBL)
PCBP1ProteinQ15365 (Uniprot-TrEMBL)
PCBP2 ProteinQ15366 (Uniprot-TrEMBL)
PCBP2ProteinQ15366 (Uniprot-TrEMBL)
PCF11 ProteinO94913 (Uniprot-TrEMBL)
PHF5AProteinQ7RTV0 (Uniprot-TrEMBL)
POLR2A ProteinP24928 (Uniprot-TrEMBL)
POLR2B ProteinP30876 (Uniprot-TrEMBL)
POLR2C ProteinP19387 (Uniprot-TrEMBL)
POLR2DProteinO15514 (Uniprot-TrEMBL)
POLR2E ProteinP19388 (Uniprot-TrEMBL)
POLR2FProteinP61218 (Uniprot-TrEMBL)
POLR2G ProteinP62487 (Uniprot-TrEMBL)
POLR2H ProteinP52434 (Uniprot-TrEMBL)
POLR2I ProteinP36954 (Uniprot-TrEMBL)
POLR2J ProteinP52435 (Uniprot-TrEMBL)
POLR2K ProteinP53803 (Uniprot-TrEMBL)
POLR2L ProteinP62875 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
PRPF4 ProteinO43172 (Uniprot-TrEMBL)
PRPF6 ProteinO94906 (Uniprot-TrEMBL)
PRPF8 ProteinQ6P2Q9 (Uniprot-TrEMBL)
PTBP1 ProteinP26599 (Uniprot-TrEMBL)
PTBP1ProteinP26599 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RBM5 ProteinP52756 (Uniprot-TrEMBL)
RBM5ProteinP52756 (Uniprot-TrEMBL)
RBM8A ProteinQ9Y5S9 (Uniprot-TrEMBL)
RBMXProteinP38159 (Uniprot-TrEMBL)
RNA polymerase II ComplexREACT_4593 (Reactome)
RNPS1 ProteinQ15287 (Uniprot-TrEMBL)
RNPS1ProteinQ15287 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SF3A1 ProteinQ15459 (Uniprot-TrEMBL)
SF3A2 ProteinQ15428 (Uniprot-TrEMBL)
SF3A3 ProteinQ12874 (Uniprot-TrEMBL)
SF3B1 ProteinO75533 (Uniprot-TrEMBL)
SF3B14 ProteinQ9Y3B4 (Uniprot-TrEMBL)
SF3B2 ProteinQ13435 (Uniprot-TrEMBL)
SF3B3 ProteinQ15393 (Uniprot-TrEMBL)
SF3B4 ProteinQ15427 (Uniprot-TrEMBL)
SF3B5 ProteinQ9BWJ5 (Uniprot-TrEMBL)
SLBP ProteinQ14493 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC1AProteinQ14683 (Uniprot-TrEMBL)
SMC2 REACT_2529 (Reactome)
SNRNP200 ProteinO75643 (Uniprot-TrEMBL)
SNRNP40 ProteinQ96DI7 (Uniprot-TrEMBL)
SNRNP70 ProteinP08621 (Uniprot-TrEMBL)
SNRPA ProteinP09012 (Uniprot-TrEMBL)
SNRPA1 ProteinP09661 (Uniprot-TrEMBL)
SNRPB2 ProteinP08579 (Uniprot-TrEMBL)
SNRPD2 ProteinP62316 (Uniprot-TrEMBL)
SNRPE ProteinP62304 (Uniprot-TrEMBL)
SNRPF ProteinP62306 (Uniprot-TrEMBL)
SNRPG ProteinP62308 (Uniprot-TrEMBL)
SRRM1 ProteinQ8IYB3 (Uniprot-TrEMBL)
SRRM1ProteinQ8IYB3 (Uniprot-TrEMBL)
SRSF1 ProteinQ07955 (Uniprot-TrEMBL)
SRSF11 ProteinQ05519 (Uniprot-TrEMBL)
SRSF11ProteinQ05519 (Uniprot-TrEMBL)
SRSF1ProteinQ07955 (Uniprot-TrEMBL)
SRSF2 ProteinQ01130 (Uniprot-TrEMBL)
SRSF2ProteinQ01130 (Uniprot-TrEMBL)
SRSF3 ProteinP84103 (Uniprot-TrEMBL)
SRSF3ProteinP84103 (Uniprot-TrEMBL)
SRSF4 ProteinQ08170 (Uniprot-TrEMBL)
SRSF4ProteinQ08170 (Uniprot-TrEMBL)
SRSF5 ProteinQ13243 (Uniprot-TrEMBL)
SRSF5ProteinQ13243 (Uniprot-TrEMBL)
SRSF6 ProteinQ13247 (Uniprot-TrEMBL)
SRSF6ProteinQ13247 (Uniprot-TrEMBL)
SRSF7 ProteinQ16629 (Uniprot-TrEMBL)
SRSF7ProteinQ16629 (Uniprot-TrEMBL)
SRSF9 ProteinQ13242 (Uniprot-TrEMBL)
SRSF9ProteinQ13242 (Uniprot-TrEMBL)
SUGP1 ProteinQ8IWZ8 (Uniprot-TrEMBL)
SUGP1ProteinQ8IWZ8 (Uniprot-TrEMBL)
Spliceosomal A ComplexComplexREACT_4512 (Reactome)
Spliceosomal Active C ComplexComplexREACT_2680 (Reactome)
Spliceosomal B ComplexComplexREACT_3078 (Reactome)
Spliceosomal E ComplexComplexREACT_4545 (Reactome)
Spliceosomal Intermediate C ComplexComplexREACT_5473 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP CBC complexComplexREACT_5191 (Reactome)
TAP 3'-polyadenylated, capped mRNA complexComplexREACT_4136 (Reactome)
TPR ProteinP12270 (Uniprot-TrEMBL)
TXNL4A ProteinP83876 (Uniprot-TrEMBL)
U1 snRNA ProteinV00590 (EMBL)
U1 snRNPComplexREACT_2910 (Reactome) The U1 snRNP is a particle consisting of the U1 snRNA and Sm core plus unique snRNP polypeptides. The U1-specific polypeptides are 70K, A, and C. The Sm core polypeptides are B, B', D1, D2, D3, E, F, G. The Sm core is a heteroheptamer in the shape of a donut, containing either B or B', which are almost identical to each other.
U11 snRNPComplexREACT_5751 (Reactome)
U12 snRNPComplexREACT_3595 (Reactome)
U2 snRNA ProteinX59360 (EMBL)
U2 snRNPComplexREACT_3715 (Reactome)
U2AF1 ProteinQ01081 (Uniprot-TrEMBL)
U2AF1ProteinQ01081 (Uniprot-TrEMBL)
U2AF2 ProteinP26368 (Uniprot-TrEMBL)
U2AF2ProteinP26368 (Uniprot-TrEMBL)
U4

U5

U6 trisnRNP complex
ComplexREACT_5066 (Reactome)
U4 ATAC

U5

U6 ATAC Complex
ComplexREACT_4539 (Reactome)
U4 ATAC snRNPComplexREACT_5266 (Reactome)
U4 snRNA ProteinX59361 (EMBL)
U4 snRNPComplexREACT_4877 (Reactome)
U5 snRNA ProteinX04293 (EMBL)
U5 snRNPComplexREACT_2482 (Reactome)
U6 ATAC snRNPComplexREACT_3135 (Reactome)
U6 snRNA ProteinX59362 (EMBL)
UBA, Tudor - FLJ21007REACT_3970 (Reactome)
UPF3B ProteinQ9BZI7 (Uniprot-TrEMBL)
UPF3BProteinQ9BZI7 (Uniprot-TrEMBL)
YBX1 ProteinP67809 (Uniprot-TrEMBL)
YBX1ProteinP67809 (Uniprot-TrEMBL)
capped pre-mRNA

CBC

RNA Pol II
ComplexREACT_3243 (Reactome)
capped, methylated pre-mRNA CBC ComplexComplexREACT_3634 (Reactome)
capped, methylated pre-mRNP CBC complexComplexREACT_2736 (Reactome)
hPrp18REACT_3085 (Reactome)
hPrp19REACT_3274 (Reactome)
hPrp22REACT_3038 (Reactome)
hPrp43REACT_5171 (Reactome)
hPrp5REACT_3263 (Reactome)
hSLU7REACT_5157 (Reactome)
hTra2REACT_4242 (Reactome)
intron-containing complexComplexREACT_3239 (Reactome)
mRNA 3'-end cleavage factorComplexREACT_2642 (Reactome)
mRNA ComplexREACT_3236 (Reactome)
p-S5-POLR2A ProteinP24928 (Uniprot-TrEMBL)
p68 DEAH proteinREACT_4900 (Reactome)
post exon ligation complexComplexREACT_5793 (Reactome)

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
3' end cleaved, ligated exon containing complexArrowREACT_1914 (Reactome)
3' end cleaved, ligated exon containing complexREACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complexArrowREACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complexREACT_53 (Reactome)
ALYREFArrowREACT_1044 (Reactome)
ALYREFArrowREACT_1228 (Reactome)
ALYREFArrowREACT_1334 (Reactome)
ALYREFArrowREACT_1356 (Reactome)
ALYREFREACT_1604 (Reactome)
ALYREFREACT_1897 (Reactome)
ALYREFREACT_222 (Reactome)
ALYREFREACT_696 (Reactome)
ASR2BREACT_222 (Reactome)
ATAC A ComplexREACT_1253 (Reactome)
ATAC C ComplexArrowREACT_1615 (Reactome)
ATPREACT_1162 (Reactome)
CC1.3 protein /3 RRM, RSREACT_222 (Reactome)
CCAR1REACT_222 (Reactome)
CD2BP2REACT_222 (Reactome)
CDC40ArrowREACT_138 (Reactome)
CDC40REACT_788 (Reactome)
CF IArrowREACT_1914 (Reactome)
CF IIArrowREACT_1914 (Reactome)
CF IIREACT_1184 (Reactome)
CF IREACT_1184 (Reactome)
CPSFArrowREACT_1162 (Reactome)
CPSFArrowREACT_1897 (Reactome)
CPSFREACT_1184 (Reactome)
Cap Binding Complex ArrowREACT_1897 (Reactome)
Cap Binding Complex ArrowREACT_696 (Reactome)
Cleavage and Polyadenylation ComplexREACT_625 (Reactome)
CstFArrowREACT_1914 (Reactome)
CstFREACT_1184 (Reactome)
DHX38ArrowREACT_138 (Reactome)
DHX38REACT_788 (Reactome)
DHX9REACT_222 (Reactome)
DNAJC8REACT_788 (Reactome)
DnaJ hom. NP_055602REACT_222 (Reactome)
EIF4EREACT_1044 (Reactome)
EIF4EREACT_1228 (Reactome)
EIF4EREACT_1334 (Reactome)
EIF4EREACT_1356 (Reactome)
Export Receptor bound mature mRNA ComplexArrowREACT_138 (Reactome)
Export Receptor bound mature mRNA ComplexREACT_1228 (Reactome)
FUSREACT_222 (Reactome)
HNRNPA0ArrowREACT_1331 (Reactome)
HNRNPA0REACT_1877 (Reactome)
HNRNPA1ArrowREACT_1331 (Reactome)
HNRNPA1REACT_1877 (Reactome)
HNRNPA2B1ArrowREACT_1331 (Reactome)
HNRNPA2B1REACT_1877 (Reactome)
HNRNPA3ArrowREACT_1331 (Reactome)
HNRNPA3REACT_1877 (Reactome)
HNRNPCArrowREACT_1331 (Reactome)
HNRNPCREACT_1877 (Reactome)
HNRNPDArrowREACT_1331 (Reactome)
HNRNPDREACT_1877 (Reactome)
HNRNPFArrowREACT_1331 (Reactome)
HNRNPFREACT_1877 (Reactome)
HNRNPH1ArrowREACT_1331 (Reactome)
HNRNPH1REACT_1877 (Reactome)
HNRNPH2ArrowREACT_1331 (Reactome)
HNRNPH2REACT_1877 (Reactome)
HNRNPKArrowREACT_1331 (Reactome)
HNRNPKREACT_1877 (Reactome)
HNRNPLArrowREACT_1331 (Reactome)
HNRNPLREACT_1877 (Reactome)
HNRNPMArrowREACT_1331 (Reactome)
HNRNPMREACT_1877 (Reactome)
HNRNPRArrowREACT_1331 (Reactome)
HNRNPRREACT_1877 (Reactome)
HNRNPUArrowREACT_1331 (Reactome)
HNRNPUL1REACT_222 (Reactome)
HNRNPUREACT_1877 (Reactome)
HuR /3 RRM proteinREACT_222 (Reactome)
Ligated exon containing complexArrowREACT_1331 (Reactome)
Magoh-Y14 complexREACT_774 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref Complex
REACT_1356 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref complex
ArrowREACT_696 (Reactome)
Mature Intronless Transcript Derived mRNA eIF4E ComplexArrowREACT_1334 (Reactome)
Mature Intronless transcript derived Histone mRNA

SLBP CBP80

CBP20
REACT_1604 (Reactome)
Mature SLBP independent Histone mRNA eIF4E complexArrowREACT_1356 (Reactome)
Mature intronless derived mRNA

TAP

Aly/Ref complex
REACT_1334 (Reactome)
Mature intronless derived mRNA complexREACT_1897 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex
ArrowREACT_1604 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex
REACT_1044 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP

eIF4E Complex
ArrowREACT_1044 (Reactome)
Mature intronless transcript derived Histone pre-mRNA CBC complexREACT_696 (Reactome)
Mature mRNP ComplexArrowREACT_1228 (Reactome)
NCBP1ArrowREACT_1604 (Reactome)
NCBP2ArrowREACT_1604 (Reactome)
NFAR-2 proteinREACT_222 (Reactome)
NFX.1REACT_222 (Reactome)
NXF1ArrowREACT_1044 (Reactome)
NXF1ArrowREACT_1228 (Reactome)
NXF1ArrowREACT_1334 (Reactome)
NXF1ArrowREACT_1356 (Reactome)
NXF1REACT_1604 (Reactome)
NXF1REACT_1897 (Reactome)
NXF1REACT_53 (Reactome)
NXF1REACT_696 (Reactome)
Nuclear Pore Complex ArrowREACT_1004 (Reactome)
Nuclear Pore Complex ArrowREACT_1044 (Reactome)
Nuclear Pore Complex ArrowREACT_1228 (Reactome)
Nuclear Pore Complex ArrowREACT_1334 (Reactome)
Nuclear Pore Complex ArrowREACT_1356 (Reactome)
Nuclear Pore Complex ArrowREACT_138 (Reactome)
Nuclear Pore Complex ArrowREACT_1604 (Reactome)
Nuclear Pore Complex ArrowREACT_1799 (Reactome)
Nuclear Pore Complex ArrowREACT_1897 (Reactome)
Nuclear Pore Complex ArrowREACT_2104 (Reactome)
Nuclear Pore Complex ArrowREACT_696 (Reactome)
Nuclear Pore Complex ArrowREACT_904 (Reactome)
Nucleoplasmic mature intronless derived mRNA

TAP

Aly/Ref complex
ArrowREACT_1897 (Reactome)
PABPN1ArrowREACT_1162 (Reactome)
PABPN1REACT_1184 (Reactome)
PAPOLAArrowREACT_1162 (Reactome)
PAPOLAREACT_1184 (Reactome)
PAPOLAmim-catalysisREACT_1162 (Reactome)
PCBP1ArrowREACT_1331 (Reactome)
PCBP1REACT_1877 (Reactome)
PCBP2ArrowREACT_1331 (Reactome)
PCBP2REACT_1877 (Reactome)
PTBP1ArrowREACT_1331 (Reactome)
PTBP1REACT_1877 (Reactome)
RBM5REACT_222 (Reactome)
RBMXArrowREACT_1331 (Reactome)
RBMXREACT_1877 (Reactome)
REACT_1004 (Reactome) The nucleoplasmic 3' polyadenylated, capped intronless mRNA and TAP are transported through the NPC to the cyotplasmic side of the pore.
REACT_1044 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
REACT_1162 (Reactome) The upstream fragment generated by 3' cleavage of the pre-mRNA receives a poly(A) tail of approximately 250 AMP residues in a reaction depending on the AAUAAA sequence 10 to 30 nucleotides upstream of the 3' end. Polyadenylation is carried out by three proteins: Poly(A) polymerase carries the catalytic activity. The enzyme has no specificity for any particular RNA sequence, and it also has a very low affinity for the RNA.

Under physiological conditions, the activity of poly(A) polymerase thus depends on two auxiliary factors, both of which bind to specific RNA sequences and recruit the enzyme by a direct contact. One of these proteins is the heterotetrameric CPSF, which binds the AAUAAA sequence and is also essential for 3' cleavage. The second is the nuclear poly(A) binding protein (PABPN1), which binds the growing poly(A) tails once this has reached a length of about ten nucleotides. Stimulation of poly(A) polymerase by both proteins is synergistic and results in processive elongation of the RNA, i.e. the polymerase adds AMP residues without dissociating from the RNA. The processive reaction is terminated when the tail has reached a length of about 250 nucleotides.

REACT_1184 (Reactome)
REACT_1228 (Reactome) At the beginning of this reaction, 1 molecule of 'eIF4E', and 1 molecule of 'Export Receptor bound mature mRNA Complex' are present. At the end of this reaction, 1 molecule of 'THOC4(Aly/Ref)', 1 molecule of 'Mature mRNP Complex', 1 molecule of 'SRm160', and 1 molecule of 'TAP' are present.

This reaction takes place in the 'cytoplasm'.

REACT_1253 (Reactome) The U4atac/U6atac enters the spliceosome and U6atac snRNA forms base pairing interactions with the 5' ss and also forms base pairing interactions with U12 and U4atac is partially displaced. U5 snRNP, the only snRNP common to both the major and minor splicing pathways, also joins the spliceosome to form the B complex and interacts with nucleotides within the 3' end of the exon flanking the 5' ss.
REACT_1331 (Reactome) The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.
REACT_1334 (Reactome) The cytoplasmic 3' polyadenylated, capped intronless mRNA and TAP are released from the NPC into the cytosol. Cytosolic TAP will be recycled to the nucleous, while the 3' polyadenylated, capped intronless mRNA is bound by eIF4E and destined for translation.
REACT_1356 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
REACT_138 (Reactome) At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present.

This reaction takes place in the 'nucleoplasm'.

REACT_1494 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present. At the end of this reaction, 1 molecule of 'U6 ATAC snRNP', 1 molecule of 'post exon ligation complex', 1 molecule of 'U12 snRNP', 1 molecule of 'U11 snRNP', and 1 molecule of 'U5 snRNP' are present.

This reaction takes place in the 'nucleus'.

REACT_1554 (Reactome) The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.
REACT_1604 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The stemloop and SLBP enhance the rate of transport of histone mRNAs in Xenopus oocytes, but are not essential for transport
REACT_1615 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC B Complex' is present. At the end of this reaction, 1 molecule of 'U4 ATAC snRNP', and 1 molecule of 'ATAC C Complex' are present.

This reaction takes place in the 'nucleus'.

REACT_1720 (Reactome) In addition to the methylation of the 5'-cap, there is methylation of internal nucleotides in the mRNA. This methylation can occur in translated and untranslated regions. One to three methyl groups have been seen per mRNA molecule, but methylation is non-stoichiometric. The most frequent methylation observed is at the N6 position of adenosine. The function of mRNA internal methylation, if any, is unknown.
REACT_1799 (Reactome) Once the transport complex is fully assembled the mature mRNA can be translocated from the nucleoplasm to the cytoplasm. The assembled complex starts at the nucleoplasmic basket, travels through the pore, and ends it journey at the cytoplasmic face of the nuclear pore complex.
REACT_1877 (Reactome) After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.
REACT_1897 (Reactome) The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm.
REACT_1914 (Reactome) Endonucleolytic cleavage separates the pre-mRNA into an upstream fragment destined to become the mature mRNA, and a downstream fragment that is rapidly degraded. Cleavage depends on two signals in the RNA, a highly conserved hexanucleotide, AAUAAA, 10 to 30 nucleotides upstream of the cleavage site, and a poorly conserved GU- or U-rich downstream element. Additional sequences, often upstream of AAUAAA, can enhance the efficiency of the reaction. Cleavage occurs most often after a CA dinucleotide. A single gene can have more than one 3' processing site.

Cleavage is preceded by the assembly of a large processing complex, the composition of which is poorly defined. ATP, but not its hydrolysis, is required for assembly. Cleavage at the 3'-end of mRNAs depends on a number of protein factors. CPSF, a heterotetramer, binds specifically to the AAUAAA sequence. The heterotrimer CstF binds the downstream element. CF I, which appears to be composed of two subunits, one of several related larger polypeptides and a common smaller one, also binds RNA, but with unknown specificity. RNA recognition by these proteins is cooperative. Cleavage also requires CF II, composed of at least two subunits, and poly(A) polymerase, the enzyme synthesizing the poly(A) tail in the second step of the reaction. The polypeptide catalyzing the hydrolysis of the phosphodiester bond remains to be identified.

Cleavage produces a 3'-OH on the upstream fragment and a 5'-phosphate on the downstream fragment. At some unknown point after cleavage, the downstream RNA fragment, CstF, CF I and CF II are thought to be released, whereas CPSF and poly(A) polymerase remain to carry out polyadenylation.

REACT_1935 (Reactome) In the first catalytic step of mRNA splicing, the 2' OH group of the bulged A at the branch site performs a nucleophilic attack on the 5' splice site phosphodiester bond, resulting in cleavage of the bond between the 5' exon and the 5' end of the intron, and formation of a new bond between the 5' end of the intron and the branch site A. This results in a lariat-shaped intermediate, with the intron still attached to the 3' exon. The branch site A has a 2'-5' phosphodiester bond with the G at the beginning of the intron, in addition to the usual 5'-3' and 3'-5'phosphodiester bonds.
REACT_2104 (Reactome) In this reaction, 1 molecule of 'Export Receptor bound mature mRNA Complex' is translocated from nucleoplasm to cytosol.

This reaction takes place in the 'nuclear envelope'.

REACT_222 (Reactome) Pre-mRNA transcripts become rapidly associated with many RNA-binding proteins, including hnRNP proteins, cap-binding proteins, SR proteins, etc; in the test tube this binding does not require splice sites or ATP. The E complex, or early complex, is the first detectable functional intermediate in spliceosome assembly in vitro. It is an ATP-independent complex. When a functional 5' splice site is present, it is bound by the U1 snRNP. The splicing factor U2AF (65 and 35 kDa subunits) binds to the polypyrimidine tract (Y)n and the AG dinucleotide at the 3' splice site, respectively. SF1/mBBP binds to the branch site. Binding of many of these factors is cooperative; e.g., SR proteins and U2AF apparently interact with each other, facilitating their binding to the pre-mRNA. In the presence of ATP, the E complex is converted to the first ATP-dependent spliceosomal complex, namely the A complex.
REACT_2241 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex' is present. At the end of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present.

This reaction takes place in the 'nucleus'.

REACT_48 (Reactome) The formation of the B complex is ATP-dependent, and both the 5' and 3' splice sites are essential for B complex assembly. The U4 and U6 snRNPS are extensively base-paired, and this U4:U6 complex associates with the U5 snRNP to form a tri-snRNP particle. This tri-snRNP particle then binds to the spliceosomal A complex, to form the spliceosomal B complex.
REACT_53 (Reactome) Aly/Ref recruits TAP to the Exon Junction Complex. This makes the mRNP complex ready for export to the cytoplasm.
REACT_625 (Reactome) The spliceosomal C complex is a very short-lived intermediate; the splicing intermediates are rapidly converted to splicing products. Also, the spliced products are released very rapidly, and no complex containing both the splicing products has been isolated. Conversion of the spliceosomal B complex to the spliceosomal C complex requires ATP. The extensive base-pairing between the U4 and U6 snRNAs is disrupted during the formation of the C complex, which is thought to require helicase-type activity associated with the DEAD box factors.
REACT_696 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The mature transcript docks at the NPC, in the course of transport CBC will be lost from the mRNA cap, and remain in the nucleous.
REACT_774 (Reactome) At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

REACT_788 (Reactome) The A complex is the first ATP-dependent complex in spliceosome assembly. U2AF recruits the U2 snRNP to bind to the branch site in the E complex in an ATP-dependent fashion, to form the A complex. The U2 snRNA base-pairs with the branch site, causing the branch-site adenosine to bulge out, which later positions it for nucleophilic attack at the 5' splice site. The A complex serves as a substrate for formation of the B complex.
REACT_864 (Reactome) U12-type AT-AC introns are distinguished from the major U2-type introns by the consensus sequences of their highly conserved splicing signals. U12 introns have the 5' ss consensus sequence (G/A)TATCCTTT, the branchpoint sequence TTTCCTTAACT and the 3' ss (C/T)AG. Initial recognition of AT-AC introns involves interaction of U12 snRNP with the branch-point sequence and U11 with the 5' ss. Unlike the major splicing pathway, U11 and U12 are in a complex and interact with the pre-mRNA simultaneously, binding in an ATP-dependent manner as a di-snRNP complex and likely bridging the 5' ss and 3' ss region.

Twenty proteins have been identified in the U11/U12 di-snRNP complex including the snRNP Sm proteins B’, B, D3, D2, D1, E, F, and G which are identical to the major splicing pathway Sm proteins. A U2 snRNP core protein complex, SF3b is also found in the U11/U12 di-snRNP, including p14, a protein that interacts with the branchpoint adenosine.

SR proteins are required for formation of A complex in AT-AC splicing. The same SR proteins involved in splicing of the major introns are also active in splicing of AT-AC introns, though, as in the major pathway, there is substrate specificity.

REACT_904 (Reactome) The mature SLBP independent intronless histone mRNA is transported through the nucler pore to the cytoplasmic side.
RNA polymerase II ArrowREACT_1331 (Reactome)
RNPS1REACT_222 (Reactome)
SMC1AREACT_222 (Reactome)
SMC2 REACT_222 (Reactome)
SRRM1ArrowREACT_1228 (Reactome)
SRRM1REACT_222 (Reactome)
SRSF11ArrowREACT_138 (Reactome)
SRSF11REACT_788 (Reactome)
SRSF1ArrowREACT_138 (Reactome)
SRSF1REACT_222 (Reactome)
SRSF1REACT_864 (Reactome)
SRSF2ArrowREACT_138 (Reactome)
SRSF2REACT_222 (Reactome)
SRSF2REACT_864 (Reactome)
SRSF3ArrowREACT_138 (Reactome)
SRSF3REACT_222 (Reactome)
SRSF4ArrowREACT_138 (Reactome)
SRSF4REACT_788 (Reactome)
SRSF5ArrowREACT_138 (Reactome)
SRSF5REACT_222 (Reactome)
SRSF6ArrowREACT_138 (Reactome)
SRSF6REACT_222 (Reactome)
SRSF6REACT_864 (Reactome)
SRSF7ArrowREACT_138 (Reactome)
SRSF7REACT_222 (Reactome)
SRSF7REACT_864 (Reactome)
SRSF9ArrowREACT_138 (Reactome)
SRSF9REACT_222 (Reactome)
SUGP1REACT_222 (Reactome)
Spliceosomal A ComplexREACT_48 (Reactome)
Spliceosomal Active C ComplexREACT_1935 (Reactome)
Spliceosomal B ComplexREACT_625 (Reactome)
Spliceosomal E ComplexREACT_788 (Reactome)
Spliceosomal Intermediate C ComplexArrowREACT_625 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP CBC complexREACT_774 (Reactome)
U1 snRNPArrowREACT_625 (Reactome)
U1 snRNPREACT_222 (Reactome)
U11 snRNPArrowREACT_1494 (Reactome)
U11 snRNPREACT_864 (Reactome)
U12 snRNPArrowREACT_1494 (Reactome)
U12 snRNPREACT_864 (Reactome)
U2 snRNPREACT_788 (Reactome)
U2AF1ArrowREACT_138 (Reactome)
U2AF1REACT_222 (Reactome)
U2AF2ArrowREACT_138 (Reactome)
U2AF2REACT_222 (Reactome)
U4

U5

U6 trisnRNP complex
REACT_48 (Reactome)
U4 ATAC

U5

U6 ATAC Complex
REACT_1253 (Reactome)
U4 ATAC snRNPArrowREACT_1615 (Reactome)
U4 snRNPArrowREACT_625 (Reactome)
U5 snRNPArrowREACT_1494 (Reactome)
U6 ATAC snRNPArrowREACT_1494 (Reactome)
UBA, Tudor - FLJ21007REACT_222 (Reactome)
UPF3BREACT_1935 (Reactome)
YBX1REACT_222 (Reactome)
capped, methylated pre-mRNA CBC ComplexREACT_1877 (Reactome)
capped, methylated pre-mRNA CBC ComplexREACT_864 (Reactome)
capped, methylated pre-mRNP CBC complexREACT_222 (Reactome)
hPrp18ArrowREACT_138 (Reactome)
hPrp19REACT_222 (Reactome)
hPrp22ArrowREACT_138 (Reactome)
hPrp43ArrowREACT_138 (Reactome)
hPrp5REACT_788 (Reactome)
hSLU7ArrowREACT_138 (Reactome)
hTra2ArrowREACT_138 (Reactome)
hTra2REACT_788 (Reactome)
intron-containing complexArrowREACT_1331 (Reactome)
mRNA 3'-end cleavage factormim-catalysisREACT_1914 (Reactome)
mRNA mim-catalysisREACT_1720 (Reactome)
p68 DEAH proteinREACT_222 (Reactome)
post exon ligation complexArrowREACT_1494 (Reactome)
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