Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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19, 32, 383151716253371135, 1424119374, 225, 215, 15, 19, 21203585, 106, 19, 21, 2221285, 19, 21-23, 295, 195, 19, 212155, 6, 19, 213430312, 5, 12, 19, 22...5, 17, 2126212121SREBF1A,2 SREBP1A/2NF-YSP1MVK gene SREBP1A/2NF-YSP1DHCR7 gene SREBF1A,2 NF-Y SREBF1A,1C,2 cleaved by S2P SREBF1A,2 NF-Y SREBF1A,2 SREBP1A/2MVD gene Coactivators of PPARalpha SREBP1A/1C Dimer SREBP1A/1CNF-YSP1FASN gene SREBP1A/2LSS gene SREBP1A/2 Dimer NF-Y SREBP1A/2NF-YSP1GGPS1 gene SREBP1A/2NF-YHMGCR gene Coactivators of PPARalpha NF-Y SREBP1A/1CNF-YGPAM gene SREBP1A/1C/2 Dimer SREBP1A/2SQLE gene SREBP1A/2 Dimer PPARARXRA Coactivator Complex SREBP1A/1C/2 Dimer Activated PPARARXRA Heterodimer NF-Y SREBP1A/1C/2NF-YTM7SF2 gene mitochondrial outer membraneSREBP1A/1C/2 Dimer SREBP1A/2 Dimer NF-Y SREBP1A/1C Dimer SREBP1A/1C Dimer NF-Y nucleoplasmSREBF1A,2 SREBP1A/2 Dimer Ligands of PPARA Ligands of PPARA SREBF1A,2 SREBP1A/2 Dimer cytosolSREBF1A,2 PPARARXRA Coactivator Complex NF-Y SREBP1A/2 Dimer SREBP1A/2NF-YSP1IDI1 gene NF-Y SREBP1A/1C/2ELOVL6 gene SREBP1A/1C Dimer SREBP1A/1C/2 Dimer NF-Y NF-Y NF-Y SREBF1A,C SREBP1A/2 Dimer SREBF1A,2 Activated PPARARXRA Heterodimer SREBF1A,1C,2 cleaved by S2P SREBP1A/1C/2 Dimer SREBP1A/2 Dimer Coactivators of PPARalpha Activated PPARARXRA Heterodimer SREBF1A,1C,2 cleaved by S2P SREBF1A,1C,2 cleaved by S2P NF-Y SREBF1A,1C,2 cleaved by S2P SREBP1A/1C/2NF-YFDPS gene PPARA Fatty Acid Complex SREBF1A,C PPARA Fatty Acid Complex NF-Y NF-Y SREBP1A/1C/2 Dimer PPARARXRA Coactivator Complex SREBP1A/2NF-YSC5DL gene SREBP1A/1CACACA gene SREBP1A/1C/2NF-YSP1FDFT1 gene NF-Y PPARA Fatty Acid Complex SREBP1A/1C/2NF-YHMGCS1 gene SREBP1A/2 Dimer SREBP1A/1CACACB gene NF-Y SREBF1A,C SREBF1A,C SREBP1A/2NF-YSP1PMVK gene SREBP1A/2 Dimer SREBF1A,2 SREBF1A,1C,2 cleaved by S2P SREBF1A,C SREBP1A/1C Dimer SREBF1A,2 SREBF1A,2 SREBF1A,2 SREBP1A/2NF-YSP1CYP51A1 gene SREBP1A/2 Dimer Ligands of PPARA SREBP1A/2 Dimer endoplasmic reticulum membraneSREBP1A/2 DimerSREBF1-1SREBP1A/2NF-YSC5DL geneSREBP1A/1C/2ELOVL6 geneACACANFYC NCOA6 SREBF2SREBF1-3 SREBF2MVDSREBF2SREBF2HELZ2 TM7SF2NCOA1 SQLE geneNFYC AA HELZ2 ALA HMGCS1 genePMVK gene RXRA NCOA6 HMGCS1 gene SREBF1-1NFYB CYP51A1ALA NCOA1 ALA SREBF1-3 NFYC NFYB SREBP1A/1CNF-YGPAM geneSP1SREBP1A/2NF-YSP1MVK geneNFYB NFYA SREBF2NFYA HMGCS1GGPS1 geneSREBF1-1SREBF2ACACB gene SREBP1A/1CNF-YSP1FASN geneSREBF2NFYC Palm SREBP1A/2MVD geneNFYC SREBF2FDFT1 gene NFYB SMARCD3 SREBF1-3 NFYB NF-YTGS1 SREBF1-1SREBF1-1PMVK genePPARARXRA Coactivator ComplexSREBF2CYP51A1 geneAA SP1FDPS gene FASNSREBP1A/2NF-YHMGCR geneCHD9 NFYA RXRA IDI1 gene SREBF1-1NFYB SP1MED1 SREBP1A/1CACACB geneGPAMIDI1NFYC SP1CREBBPACACBSREBF1-1NFYB SP1NFYC SMARCD3 PMVKNCOA2 SREBF1-1CARM1SREBF1-1FDFT1 geneSREBF2SREBP1A/2NF-YSP1PMVK geneSREBP1A/2NF-YSP1GGPS1 geneMED1 NCOA6 SREBF2NFYA NFYA SREBP1A/2NF-YSP1CYP51A1 geneNFYB NFYC ACACA geneSREBF1-3 SREBF1-3 TGS1 LINA SREBF1-1SREBF1-1EPA HMGCR-1GGPS1 gene TBL1X SREBP1A/1CACACA geneNFYA NFYB PPARA NFYC ELOVL6LSSDHCR7 gene DHCR7ELOVL6 gene SP1SREBP1A/1C/2NF-YSP1FDFT1 geneNFYC SREBP1A/1C/2NF-YTM7SF2 geneNFYC HMGCR gene NFYA LSS geneTM7SF2 gene NFYB NFYA NFYA NFYC SREBF2SREBP1A/2NF-YSP1DHCR7 geneCYP51A1 gene SREBF2SREBF1-3 SREBF1-1CARM1TBL1X AA NFYB NFYA FDPS geneNFYA NFYA TBL1XR1 NFYC SREBF1-1NFYC ACACA gene CHD9 PPARA SREBF1-1SREBF1-3 NFYC SREBP1A/2LSS geneSQLE gene LSS gene SREBF1-1NFYB SREBF1-3 NFYB SREBF2SC5DL gene SREBP1A/1C/2NF-YHMGCS1 geneSC5DL geneACACB geneSP1GPAM geneEPA NFYB MVKDHCR7 geneNCOA1 Palm TGS1 TBL1XR1 SREBF1-3 MVD gene NFYA RXRA SREBF1-1PPARARXRA Coactivator ComplexSREBP1A/1C/2 DimerNCOA2 SREBF2FASN gene NFYB SREBF1-1CARM1CREBBPSREBP1A/2SQLE geneSREBF1-3 SREBF1-1SREBF2SC5DNFYC SREBP1A/1C/2NF-YFDPS genePPARA NFYA EPA SREBF1-1FDFT1IDI1 geneSREBF2NF-YGGPS1CHD9 HELZ2 PPARARXRA Coactivator ComplexFASN geneLINA NFYA NFYC SREBP1A/1C DimerMVK geneSMARCD3 MED1 NFYB MVK gene SQLELINA SREBF1-1TM7SF2 geneSREBF1-1SREBP1A/2NF-YSP1IDI1 genePalm SREBF2SREBF1-1NFYA SP1FDPSSP1TBL1X SP1NFYB NCOA2 SREBF1-3 CREBBPMVD geneHMGCR geneGPAM gene SREBF1-1NFYA TBL1XR1 SP1ELOVL6 gene21212118211814, 17, 21, 292112, 2121212121212121


Description

After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2426168

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Bibliography

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  1. Jiang G, McKenzie TL, Conrad DG, Shechter I.; ''Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.''; PubMed Europe PMC Scholia
  2. Magaña MM, Lin SS, Dooley KA, Osborne TF.; ''Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins.''; PubMed Europe PMC Scholia
  3. Horton JD, Goldstein JL, Brown MS.; ''SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.''; PubMed Europe PMC Scholia
  4. Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M.; ''Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.''; PubMed Europe PMC Scholia
  5. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B.; ''DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.''; PubMed Europe PMC Scholia
  6. Li J, Ding SF, Habib NA, Fermor BF, Wood CB, Gilmour RS.; ''Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.''; PubMed Europe PMC Scholia
  7. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ.; ''Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.''; PubMed Europe PMC Scholia
  8. Bennett MK, Lopez JM, Sanchez HB, Osborne TF.; ''Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways.''; PubMed Europe PMC Scholia
  9. Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N.; ''Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.''; PubMed Europe PMC Scholia
  10. Chambliss KL, Slaughter CA, Schreiner R, Hoffmann GF, Gibson KM.; ''Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.''; PubMed Europe PMC Scholia
  11. Toth MJ, Huwyler L.; ''Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase.''; PubMed Europe PMC Scholia
  12. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ.; ''Human fatty acid synthase: properties and molecular cloning.''; PubMed Europe PMC Scholia
  13. Wilkin DJ, Kutsunai SY, Edwards PA.; ''Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.''; PubMed Europe PMC Scholia
  14. Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ.; ''Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.''; PubMed Europe PMC Scholia
  15. Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.; ''Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.''; PubMed Europe PMC Scholia
  16. Choi WI, Jeon BN, Park H, Yoo JY, Kim YS, Koh DI, Kim MH, Kim YR, Lee CE, Kim KS, Osborne TF, Hur MW.; ''Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).''; PubMed Europe PMC Scholia
  17. Xuan JW, Kowalski J, Chambers AF, Denhardt DT.; ''A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase.''; PubMed Europe PMC Scholia
  18. Pai JT, Guryev O, Brown MS, Goldstein JL.; ''Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins.''; PubMed Europe PMC Scholia
  19. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.; ''Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.''; PubMed Europe PMC Scholia
  20. Tabor DE, Kim JB, Spiegelman BM, Edwards PA.; ''Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.''; PubMed Europe PMC Scholia
  21. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A.; ''ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.''; PubMed Europe PMC Scholia
  22. Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR.; ''Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells.''; PubMed Europe PMC Scholia
  23. Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E.; ''Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.''; PubMed Europe PMC Scholia
  24. Inoue J, Sato R, Maeda M.; ''Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase.''; PubMed Europe PMC Scholia
  25. Ericsson J, Jackson SM, Edwards PA.; ''Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene.''; PubMed Europe PMC Scholia
  26. Vock C, Döring F, Nitz I.; ''Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.''; PubMed Europe PMC Scholia
  27. Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF.; ''A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.''; PubMed Europe PMC Scholia
  28. Bené H, Lasky D, Ntambi JM.; ''Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol.''; PubMed Europe PMC Scholia
  29. Lu B, Jiang YJ, Kim P, Moser A, Elias PM, Grunfeld C, Feingold KR.; ''Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis.''; PubMed Europe PMC Scholia
  30. Wassif CA, Maslen C, Kachilele-Linjewile S, Lin D, Linck LM, Connor WE, Steiner RD, Porter FD.; ''Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome.''; PubMed Europe PMC Scholia
  31. Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T.; ''SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase.''; PubMed Europe PMC Scholia
  32. Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y.; ''Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase.''; PubMed Europe PMC Scholia
  33. Weber LW, Boll M, Stampfl A.; ''Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins.''; PubMed Europe PMC Scholia
  34. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD.; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; PubMed Europe PMC Scholia
  35. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.; ''Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.''; PubMed Europe PMC Scholia
  36. Schiavoni G, Bennati AM, Castelli M, Della Fazia MA, Beccari T, Servillo G, Roberti R.; ''Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box.''; PubMed Europe PMC Scholia
  37. Oh SY, Park SK, Kim JW, Ahn YH, Park SW, Kim KS.; ''Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.''; PubMed Europe PMC Scholia
  38. Nakamura Y, Sakakibara J, Izumi T, Shibata A, Ono T.; ''Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells.''; PubMed Europe PMC Scholia
  39. Harada N, Fujimoto E, Okuyama M, Sakaue H, Nakaya Y.; ''Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.''; PubMed Europe PMC Scholia
  40. Párraga A, Bellsolell L, Ferré-D'Amaré AR, Burley SK.; ''Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.''; PubMed Europe PMC Scholia
  41. Xiong S, Chirala SS, Wakil SJ.; ''Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites.''; PubMed Europe PMC Scholia
  42. Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F.; ''SREBP transcription factors: master regulators of lipid homeostasis.''; PubMed Europe PMC Scholia
  43. Wang M, Yang F, Zhang X, Zhao H, Wang Q, Pan Y.; ''Comparative analysis of MTF-1 binding sites between human and mouse.''; PubMed Europe PMC Scholia
  44. Zhao Y, Yu L, Gao J, Fu Q, Hua Y, Zhang H, Zhao S.; ''cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase.''; PubMed Europe PMC Scholia
  45. Strömstedt M, Rozman D, Waterman MR.; ''The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123263view09:02, 9 July 2022EgonwIt was there twice
123261view08:50, 9 July 2022EgonwReplaced an old Ensembl identifier
114667view16:13, 25 January 2021ReactomeTeamReactome version 75
114381view12:04, 9 January 2021EgonwUpdated Ensembl identifier
113058view10:58, 2 November 2020ReactomeTeamReactome version 74
112290view15:12, 9 October 2020ReactomeTeamReactome version 73
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA MetaboliteCHEBI:15843 (ChEBI)
ACACA gene ProteinENSG00000132142 (ENSEMBL)
ACACA geneENSG00000132142 (ENSEMBL)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (ENSEMBL)
ACACB geneENSG00000076555 (ENSEMBL)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBPProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000067064 (ENSEMBL)
CYP51A1 geneENSG00000067064 (ENSEMBL)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene ProteinENSG00000172893 (ENSEMBL)
DHCR7 geneENSG00000172893 (ENSEMBL)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (ENSEMBL)
ELOVL6 geneENSG00000170522 (ENSEMBL)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
FASN gene ProteinENSG00000169710 (ENSEMBL)
FASN geneENSG00000169710 (ENSEMBL)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (ENSEMBL)
FDFT1 geneENSG00000079459 (ENSEMBL)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (ENSEMBL)
FDPS geneENSG00000160752 (ENSEMBL)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (ENSEMBL)
GGPS1 geneENSG00000152904 (ENSEMBL)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (ENSEMBL)
GPAM geneENSG00000119927 (ENSEMBL)
GPAMProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (ENSEMBL)
HMGCR geneENSG00000113161 (ENSEMBL)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (ENSEMBL)
HMGCS1 geneENSG00000112972 (ENSEMBL)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (ENSEMBL)
IDI1 geneENSG00000067064 (ENSEMBL)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
LSS gene ProteinENSG00000160285 (ENSEMBL)
LSS geneENSG00000160285 (ENSEMBL)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MVD gene ProteinENSG00000167508 (ENSEMBL)
MVD geneENSG00000167508 (ENSEMBL)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (ENSEMBL)
MVK geneENSG00000110921 (ENSEMBL)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexREACT_26721 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene ProteinENSG00000163344 (ENSEMBL)
PMVK geneENSG00000163344 (ENSEMBL)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
Palm MetaboliteCHEBI:15756 (ChEBI)
RXRA ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (ENSEMBL)
SC5DL geneENSG00000109929 (ENSEMBL)
SC5DProteinO75845 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
SQLE gene ProteinENSG00000104549 (ENSEMBL)
SQLE geneENSG00000104549 (ENSEMBL)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1-1ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A/1C ACACA geneComplexREACT_148537 (Reactome)
SREBP1A/1C ACACB geneComplexREACT_148190 (Reactome)
SREBP1A/1C

NF-Y

GPAM gene		ComplexREACT_148505 (Reactome)
SREBP1A/1C

NF-Y SP1

FASN gene		ComplexREACT_116518 (Reactome)
SREBP1A/1C DimerComplexREACT_148003 (Reactome)
SREBP1A/1C/2 ELOVL6 geneComplexREACT_148436 (Reactome)
SREBP1A/1C/2

NF-Y

FDPS gene		ComplexREACT_148195 (Reactome)
SREBP1A/1C/2

NF-Y

HMGCS1 gene		ComplexREACT_148333 (Reactome)
SREBP1A/1C/2

NF-Y SP1

FDFT1 gene		ComplexREACT_148107 (Reactome)
SREBP1A/1C/2

NF-Y

TM7SF2 gene		ComplexREACT_148435 (Reactome)
SREBP1A/1C/2 DimerComplexREACT_117119 (Reactome)
SREBP1A/2 LSS geneComplexREACT_148445 (Reactome)
SREBP1A/2 MVD geneComplexREACT_148564 (Reactome)
SREBP1A/2

NF-Y

HMGCR gene		ComplexREACT_148301 (Reactome)
SREBP1A/2

NF-Y

SC5DL gene		ComplexREACT_148446 (Reactome)
SREBP1A/2

NF-Y SP1

CYP51A1 gene		ComplexREACT_148151 (Reactome)
SREBP1A/2

NF-Y SP1

DHCR7 gene		ComplexREACT_148543 (Reactome)
SREBP1A/2

NF-Y SP1

GGPS1 gene		ComplexREACT_147937 (Reactome)
SREBP1A/2

NF-Y SP1

IDI1 gene		ComplexREACT_148432 (Reactome)
SREBP1A/2

NF-Y SP1

MVK gene		ComplexREACT_148095 (Reactome)
SREBP1A/2

NF-Y SP1

PMVK gene		ComplexREACT_148481 (Reactome)
SREBP1A/2 SQLE geneComplexREACT_148275 (Reactome)
SREBP1A/2 DimerComplexREACT_119740 (Reactome)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
TM7SF2 gene ProteinENSG00000149809 (ENSEMBL)
TM7SF2 geneENSG00000149809 (ENSEMBL)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ACACA geneREACT_147714 (Reactome)
ACACB geneREACT_147803 (Reactome)
CYP51A1 geneREACT_147786 (Reactome)
DHCR7 geneREACT_147715 (Reactome)
ELOVL6 geneREACT_147877 (Reactome)
FASN geneREACT_147842 (Reactome)
FDFT1 geneREACT_147835 (Reactome)
FDPS geneREACT_147735 (Reactome)
GGPS1 geneREACT_147815 (Reactome)
GPAM geneREACT_147903 (Reactome)
HMGCR geneREACT_147894 (Reactome)
HMGCS1 geneREACT_147710 (Reactome)
IDI1 geneREACT_147783 (Reactome)
LSS geneREACT_147766 (Reactome)
MVD geneREACT_147898 (Reactome)
MVK geneREACT_147804 (Reactome)
NF-YREACT_147699 (Reactome)
NF-YREACT_147710 (Reactome)
NF-YREACT_147715 (Reactome)
NF-YREACT_147735 (Reactome)
NF-YREACT_147752 (Reactome)
NF-YREACT_147783 (Reactome)
NF-YREACT_147786 (Reactome)
NF-YREACT_147804 (Reactome)
NF-YREACT_147815 (Reactome)
NF-YREACT_147835 (Reactome)
NF-YREACT_147842 (Reactome)
NF-YREACT_147859 (Reactome)
NF-YREACT_147861 (Reactome)
NF-YREACT_147894 (Reactome)
NF-YREACT_147903 (Reactome)
PMVK geneREACT_147861 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_115739 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_115945 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_115997 (Reactome)
REACT_115739 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115784 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115945 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115997 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147699 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
REACT_147710 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
REACT_147714 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
REACT_147715 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
REACT_147725 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147728 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147735 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
REACT_147743 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147752 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
REACT_147766 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
REACT_147771 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147783 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
REACT_147786 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
REACT_147803 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
REACT_147804 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
REACT_147807 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147810 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147815 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
REACT_147816 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147826 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147835 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
REACT_147842 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
REACT_147844 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147859 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
REACT_147861 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
REACT_147863 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147864 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147875 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147877 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
REACT_147880 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147888 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147894 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
REACT_147898 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
REACT_147899 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147902 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147903 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
SC5DL geneREACT_147859 (Reactome)
SP1REACT_147715 (Reactome)
SP1REACT_147783 (Reactome)
SP1REACT_147786 (Reactome)
SP1REACT_147803 (Reactome)
SP1REACT_147804 (Reactome)
SP1REACT_147815 (Reactome)
SP1REACT_147835 (Reactome)
SP1REACT_147842 (Reactome)
SP1REACT_147861 (Reactome)
SQLE geneREACT_147752 (Reactome)
SREBP1A/1C ACACA geneArrowREACT_147816 (Reactome)
SREBP1A/1C ACACB geneArrowREACT_147743 (Reactome)
SREBP1A/1C

NF-Y

GPAM gene		ArrowREACT_147810 (Reactome)
SREBP1A/1C

NF-Y SP1

FASN gene		ArrowREACT_115784 (Reactome)
SREBP1A/1C DimerREACT_147714 (Reactome)
SREBP1A/1C DimerREACT_147803 (Reactome)
SREBP1A/1C DimerREACT_147842 (Reactome)
SREBP1A/1C DimerREACT_147903 (Reactome)
SREBP1A/1C/2 ELOVL6 geneArrowREACT_147888 (Reactome)
SREBP1A/1C/2

NF-Y

FDPS gene		ArrowREACT_147807 (Reactome)
SREBP1A/1C/2

NF-Y

HMGCS1 gene		ArrowREACT_115739 (Reactome)
SREBP1A/1C/2

NF-Y SP1

FDFT1 gene		ArrowREACT_115945 (Reactome)
SREBP1A/1C/2

NF-Y

TM7SF2 gene		ArrowREACT_147728 (Reactome)
SREBP1A/1C/2 DimerREACT_147699 (Reactome)
SREBP1A/1C/2 DimerREACT_147710 (Reactome)
SREBP1A/1C/2 DimerREACT_147735 (Reactome)
SREBP1A/1C/2 DimerREACT_147835 (Reactome)
SREBP1A/1C/2 DimerREACT_147877 (Reactome)
SREBP1A/2 LSS geneArrowREACT_147844 (Reactome)
SREBP1A/2 MVD geneArrowREACT_147863 (Reactome)
SREBP1A/2

NF-Y

HMGCR gene		ArrowREACT_115997 (Reactome)
SREBP1A/2

NF-Y

SC5DL gene		ArrowREACT_147875 (Reactome)
SREBP1A/2

NF-Y SP1

CYP51A1 gene		ArrowREACT_147899 (Reactome)
SREBP1A/2

NF-Y SP1

DHCR7 gene		ArrowREACT_147864 (Reactome)
SREBP1A/2

NF-Y SP1

GGPS1 gene		ArrowREACT_147826 (Reactome)
SREBP1A/2

NF-Y SP1

IDI1 gene		ArrowREACT_147880 (Reactome)
SREBP1A/2

NF-Y SP1

MVK gene		ArrowREACT_147902 (Reactome)
SREBP1A/2

NF-Y SP1

PMVK gene		ArrowREACT_147771 (Reactome)
SREBP1A/2 SQLE geneArrowREACT_147725 (Reactome)
SREBP1A/2 DimerREACT_147715 (Reactome)
SREBP1A/2 DimerREACT_147752 (Reactome)
SREBP1A/2 DimerREACT_147766 (Reactome)
SREBP1A/2 DimerREACT_147783 (Reactome)
SREBP1A/2 DimerREACT_147786 (Reactome)
SREBP1A/2 DimerREACT_147804 (Reactome)
SREBP1A/2 DimerREACT_147815 (Reactome)
SREBP1A/2 DimerREACT_147859 (Reactome)
SREBP1A/2 DimerREACT_147861 (Reactome)
SREBP1A/2 DimerREACT_147894 (Reactome)
SREBP1A/2 DimerREACT_147898 (Reactome)
TM7SF2 geneREACT_147699 (Reactome)
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