Oxidative damage response (Mus musculus)

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GSHCell survivalC3aActivator of Cell DeathC3b/4b, C3b, C3dC4aC5aMitochondrial pathwayOxidative stressROSInhibitor of Cell DeathCell lysis and clearanceC3-convertaseApoptosisC4b/2aLiver regenerationNf-kB pathwayMuscle contraction,Chemotaxis,Phagocyte recruitment,Inflammation etcStressAdaptive response in liverProteasomeComplement activationFormation of apoptotic bodiesC3b(classical pathway)DNA replicationInduction of antioxidant genesROSMembrane lysis complexC1sCdc42Tnfrsf1bC1rC1qaPcnaMapk12C5r1Bag4HcCasp9Cdkn1aCr1C1qbApaf1C3ar1C1qgCr2Mapk13Cdkn1cC4Traf1CyctTnfNfkb1Bcl2Map3k9Mapk14Cdkn1bTraf3Traf6BadTraf2TtrapTnk2CycsMap2k6Bak1Casp3Gadd45aC2Map3k1


Description

This pathway shows how tissue is damaged when oxegen levels are not balanced and become too high.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
126385view10:08, 26 April 2023EgonwLicense is CCZero
120957view10:40, 3 February 2022EgonwMade three pathways clickable
117039view14:12, 16 May 2021EweitzModified title
90720view20:45, 13 December 2016KhanspersModified description
90169view14:17, 20 October 2016Mkutmonfix unconnected lines
79337view12:13, 21 March 2015EgonwReplaced a batch of gene names with their Entrez gene IDs.
78428view10:26, 7 January 2015MaintBotadded missing graphIds
75225view18:12, 12 May 2014Khanspersadded pathway nodes
75223view17:54, 12 May 2014Khanspersfixed label and most xrefs
69181view18:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67560view11:26, 26 June 2013DdiglesOntology Term : 'oxidative stress response pathways' added !
43789view21:45, 27 July 2011Samuel SklarModified description
43788view21:41, 27 July 2011Samuel SklarSpecify description
41370view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
36318view17:55, 19 March 2010MaintBotModified categories
36313view22:19, 18 March 2010MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf1GeneProduct11783 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
Bag4GeneProduct67384 (Entrez Gene)
Bak1GeneProduct12018 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
C1qaGeneProductC1QA (Entrez Gene)
C1qbGeneProductC1QB (Entrez Gene)
C1qgGeneProductC1QG (Other)
C1rGeneProductC1R (Entrez Gene)
C1sGeneProductC1S (Entrez Gene)
C2GeneProduct12263 (Entrez Gene)
C3ar1GeneProduct12267 (Entrez Gene)
C4GeneProduct12268 (Entrez Gene)
C5r1GeneProductC5R1 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Cr1GeneProductCR1 (Entrez Gene)
Cr2GeneProduct12902 (Entrez Gene)
CycsGeneProduct13063 (Entrez Gene) Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1
CyctGeneProduct13067 (Entrez Gene)
Gadd45aGeneProduct13197 (Entrez Gene)
HcGeneProduct15139 (Entrez Gene)
Map2k6GeneProduct26398 (Entrez Gene) Xbp1,Mapk10,Klhl8,Mapk10
Map3k1GeneProduct26401 (Entrez Gene)
Map3k9GeneProduct338372 (Entrez Gene)
Mapk12GeneProduct18037 (Entrez Gene)
Mapk13GeneProduct26415 (Entrez Gene)
Mapk14GeneProduct26414 (Entrez Gene) Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1
Nfkb1GeneProduct18033 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
Tnfrsf1bGeneProduct21938 (Entrez Gene)
Tnk2GeneProduct51789 (Entrez Gene)
Traf1GeneProduct22029 (Entrez Gene)
Traf2GeneProduct22030 (Entrez Gene)
Traf3GeneProduct22031 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)
TtrapGeneProductTTRAP (Entrez Gene)

Annotated Interactions

No annotated interactions

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