Nucleosome assembly (Homo sapiens)

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1, 3, 4, 6, 9...1, 2, 8, 941, 3, 6, 10Centromeric ChromatinCENPH-I Mis18 Complex Centromeric Chromatin New CENPA NucleosomeMis18HJURP Complex RSF Complex Centromeric ChromatinCENPH-I Complex Centromeric ChromatinCENPH-I Complex Mis18 Complex Mis18 Complex Centromeric ChromatinCENPH-I Complex Centromeric ChromatinCENPH-I Complex HJURPCENPA Complex RSF Complex Centromeric ChromatinCENPH-IMis18HJURPCENPA Complex HJURPCENPA Complex CENPAH4 Tetramer Centromeric ChromatinCENPH-I Mis18 Complex Centromeric ChromatinCENPH-ICentromeric NucleosomeRSF Complex CENPAH4 Tetramer Centromeric ChromatinCENPH-I Complex HJURP Complex Centromeric Nucleosome Mis18 Complex Centromeric Nucleosome Mis18 Complex CENPA CENPQ MIS18BP1 CENPI CENPK RBBP7 CENPP CENPA CENPQ OIP5 CENPK RBBP7 HJURPCENPA ComplexCENPH Centromeric ChromatinCENPH-IMis18HJURPCENPA ComplexCENPI OIP5 RBBP4 RBBP4 MLF1IP CENPO CENPN CASC5 MLF1IP ITGB3BP RUVBL1 RBBP4 Mis18 ComplexCENPO RBBP4 ITGB3BP CENPA RBBP7 CENPP RSF ComplexMIS18A CASC5 ITGB3BP CENPP CASC5 NPM1 CENPN Centromeric ChromatinCENPH-I ComplexMIS18BP1 RBBP4 HIST1H4A OIP5 CENPO CENPQ HIST1H4A CASC5 CENPH MIS18A RUVBL1 CENPH NPM1 RSF1 MLF1IP Histone H2ACENPQ SMARCA5 CENPO MLF1IP CENPN MLF1IP HJURP CENPI HIST1H4A CENPI HJURP CENPK RUVBL1 OIP5 Centromeric ChromatinCENPH-ICentromeric NucleosomeRSF ComplexSMARCA5 HJURP MIS18BP1 CENPK CENPN CENPH CENPA CENPH MIS18A HIST1H4A CENPK Centromeric ChromatinCENPH-I Mis18 ComplexCENPP ITGB3BP NPM1 CENPO RSF1 MIS18A CENPI CENPP RBBP7 CENPN Centromeric Chromatin New CENPA NucleosomeMis18HJURP ComplexMIS18BP1 CASC5 ITGB3BP CENPQ Histone H2B3, 5, 6, 107, 91, 4-6, 9...44, 51, 53, 6, 101


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Wikipathways-description 
The formation of centromeric chromatin assembly outside the context of DNA replication involves the assembly of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A).

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=774815

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Bibliography

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  1. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW.; ''The human CENP-A centromeric nucleosome-associated complex.''; PubMed Europe PMC Scholia
  2. Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW.; ''Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.''; PubMed Europe PMC Scholia
  3. Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K.; ''Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.''; PubMed Europe PMC Scholia
  4. Mellone BG, Zhang W, Karpen GH.; ''Frodos found: Behold the CENP-a "Ring" bearers.''; PubMed Europe PMC Scholia
  5. Barnhart MC, Kuich PH, Stellfox ME, Ward JA, Bassett EA, Black BE, Foltz DR.; ''HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore.''; PubMed Europe PMC Scholia
  6. Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G.; ''HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.''; PubMed Europe PMC Scholia
  7. Shuaib M, Ouararhni K, Dimitrov S, Hamiche A.; ''HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres.''; PubMed Europe PMC Scholia
  8. Perpelescu M, Nozaki N, Obuse C, Yang H, Yoda K.; ''Active establishment of centromeric CENP-A chromatin by RSF complex.''; PubMed Europe PMC Scholia
  9. Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF.; ''Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.''; PubMed Europe PMC Scholia
  10. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T.; ''The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.''; PubMed Europe PMC Scholia
  11. Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M.; ''Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.''; PubMed Europe PMC Scholia
  12. Hayashi T, Fujita Y, Iwasaki O, Adachi Y, Takahashi K, Yanagida M.; ''Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.''; PubMed Europe PMC Scholia
  13. Maddox PS, Hyndman F, Monen J, Oegema K, Desai A.; ''Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.''; PubMed Europe PMC Scholia
  14. Carroll CW, Milks KJ, Straight AF.; ''Dual recognition of CENP-A nucleosomes is required for centromere assembly.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114914view16:43, 25 January 2021ReactomeTeamReactome version 75
113359view11:43, 2 November 2020ReactomeTeamReactome version 74
112568view15:53, 9 October 2020ReactomeTeamReactome version 73
101481view11:34, 1 November 2018ReactomeTeamreactome version 66
101019view21:14, 31 October 2018ReactomeTeamreactome version 65
100554view19:48, 31 October 2018ReactomeTeamreactome version 64
100102view16:33, 31 October 2018ReactomeTeamreactome version 63
99652view15:04, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99254view12:45, 31 October 2018ReactomeTeamreactome version 62
93942view13:46, 16 August 2017ReactomeTeamreactome version 61
93736view13:24, 16 August 2017ReactomeTeamreactome version 61
93531view11:26, 9 August 2017ReactomeTeamreactome version 61
88075view09:01, 26 July 2016RyanmillerOntology Term : 'pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis' added !
88074view08:59, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86631view09:22, 11 July 2016ReactomeTeamreactome version 56
83051view09:47, 18 November 2015ReactomeTeamVersion54
81357view12:53, 21 August 2015ReactomeTeamVersion53
76826view08:05, 17 July 2014ReactomeTeamFixed remaining interactions
76530view11:50, 16 July 2014ReactomeTeamFixed remaining interactions
75863view09:51, 11 June 2014ReactomeTeamRe-fixing comment source
75563view10:36, 10 June 2014ReactomeTeamReactome 48 Update
74918view13:44, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74562view08:36, 30 April 2014ReactomeTeamReactome46
68940view17:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
42092view21:56, 4 March 2011MaintBotAutomatic update
39900view05:55, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CASC5 ProteinQ8NG31 (Uniprot-TrEMBL)
CENPA ProteinP49450 (Uniprot-TrEMBL)
CENPH ProteinQ9H3R5 (Uniprot-TrEMBL)
CENPI ProteinQ92674 (Uniprot-TrEMBL)
CENPK ProteinQ9BS16 (Uniprot-TrEMBL)
CENPN ProteinQ96H22 (Uniprot-TrEMBL)
CENPO ProteinQ9BU64 (Uniprot-TrEMBL)
CENPP ProteinQ6IPU0 (Uniprot-TrEMBL)
CENPQ ProteinQ7L2Z9 (Uniprot-TrEMBL)
Centromeric Chromatin 
New CENPA Nucleosome

Mis18

HJURP Complex		ComplexREACT_23327 (Reactome)
Centromeric Chromatin

CENPH-I

Mis18 Complex		ComplexREACT_22736 (Reactome) The Mis18 complex binds the centromere in late telophase/early G1 phase. The mechanism of interaction between the Mis18 complex and the centromeric core is unknown.
Centromeric Chromatin

CENPH-I Centromeric Nucleosome

RSF Complex		ComplexREACT_23201 (Reactome)
Centromeric Chromatin

CENPH-I Mis18 HJURP

CENPA Complex		ComplexREACT_23362 (Reactome)
Centromeric Chromatin CENPH-I ComplexComplexREACT_22632 (Reactome) The mechanism of interaction between the CENPH-I Complex and the centromeric nucleosome (containing CENPA) is unknown. The CENH-I complex is observed to interact with the centromeric core throughout the cell cycle.
HIST1H4A ProteinP62805 (Uniprot-TrEMBL)
HJURP CENPA ComplexComplexREACT_22554 (Reactome)
HJURP ProteinQ8NCD3 (Uniprot-TrEMBL)
Histone H2AProteinREACT_8447 (Reactome)
Histone H2BProteinREACT_8092 (Reactome)
ITGB3BP ProteinQ13352 (Uniprot-TrEMBL)
MIS18A ProteinQ9NYP9 (Uniprot-TrEMBL)
MIS18BP1 ProteinQ6P0N0 (Uniprot-TrEMBL)
MLF1IP ProteinQ71F23 (Uniprot-TrEMBL)
Mis18 ComplexComplexREACT_22768 (Reactome)
NPM1 ProteinP06748 (Uniprot-TrEMBL)
OIP5 ProteinO43482 (Uniprot-TrEMBL)
RBBP4 ProteinQ09028 (Uniprot-TrEMBL)
RBBP7 ProteinQ16576 (Uniprot-TrEMBL)
RSF ComplexComplexREACT_22664 (Reactome)
RSF1 ProteinQ96T23 (Uniprot-TrEMBL)
RUVBL1 ProteinQ9Y265 (Uniprot-TrEMBL)
SMARCA5 ProteinO60264 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
Centromeric Chromatin

CENPH-I

Mis18 Complex		REACT_22146 (Reactome)
Centromeric Chromatin

CENPH-I Centromeric Nucleosome

RSF Complex		REACT_22185 (Reactome)
Centromeric Chromatin

CENPH-I Mis18 HJURP

CENPA Complex		REACT_22217 (Reactome)
Centromeric Chromatin CENPH-I ComplexREACT_22169 (Reactome)
HJURP CENPA ComplexREACT_22146 (Reactome)
Histone H2AREACT_22185 (Reactome)
Histone H2BREACT_22185 (Reactome)
Mis18 ComplexREACT_22169 (Reactome)
REACT_22146 (Reactome) The HJURP complex binds free, newly synthesized CENPA-H4 tetramers. A direct interaction occurs between HJURP and CENPA. The CATD domain of CENPA is sufficient for the interaction. The complex then localizes to the centromere in early G1 phase. HJURP is required for deposition of new CENPA-containing nucleosomes.
REACT_22169 (Reactome) The Mis18 complex (containing Mis18-alpha, Mis18-beta, Mis18BP1, RBap46, and RbAp48) transiently binds the centromere in late anaphase-telophase to early G1. The mechanism by which the Mis18 complex binds the centromere is unknown. The Mis18 complex is required for deposition of new CENPA-containing nucleosomes at the centromere. The CENPH-I complex is constitutively associated with centromeres and is required for deposition of new CENPA-containing nucleosomes.
REACT_22185 (Reactome) A new centromeric nucleosome containing histone H2A, histone H2B, histone H4, and CENPA is deposited at the centromere in late telophase/early G1 phase. The exact mechanism by which the new CENPA-containing nucleosome is transferred to DNA is unknown. HJURP directly binds newly synthesized CENPA before deposition. The Mis18 and HJURP complexes are required for deposition of newly synthesized CENPA-containing nucleosomes. The exact stoichiometries and interactions of the complexes are unknown.
REACT_22217 (Reactome) The RSF complex binds the centromere in mid-G1 phase after deposition of new CENPA-containing nucleosomes has occurred. The RSF complex is required for stable incorporation of the previously deposited CENPA-containing nucleosomes.
RSF ComplexREACT_22217 (Reactome)
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