Presynaptic depolarization and calcium channel opening (Homo sapiens)

Wikipathways-description 

The action potential travels down the axon and reaches the pre-synaptic terminal depolarizing the membrane in the pre-synaptic terminal. The depolarization causes the voltage-gated Ca2+ channels to open allowing the influx of Ca2+ that signals the release of neurotransmitter into the synaptic cleft.

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=112308

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Bibliography

1. Diriong S, Lory P, Williams ME, Ellis SB, Harpold MM, Taviaux S.; ''Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.''; PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	114658	view	16:12, 25 January 2021	ReactomeTeam	Reactome version 75
	113106	view	11:16, 2 November 2020	ReactomeTeam	Reactome version 74
	112340	view	15:26, 9 October 2020	ReactomeTeam	Reactome version 73
	101240	view	11:13, 1 November 2018	ReactomeTeam	reactome version 66
	100779	view	20:40, 31 October 2018	ReactomeTeam	reactome version 65
	100322	view	19:17, 31 October 2018	ReactomeTeam	reactome version 64
	99867	view	16:00, 31 October 2018	ReactomeTeam	reactome version 63
	99424	view	14:36, 31 October 2018	ReactomeTeam	reactome version 62 (2nd attempt)
	99107	view	12:39, 31 October 2018	ReactomeTeam	reactome version 62
	94505	view	09:21, 14 September 2017	Mkutmon	reactome version 61
	86351	view	09:15, 11 July 2016	ReactomeTeam	reactome version 56
	83053	view	09:47, 18 November 2015	ReactomeTeam	Version54
	81360	view	12:53, 21 August 2015	ReactomeTeam	Version53
	76829	view	08:05, 17 July 2014	ReactomeTeam	Fixed remaining interactions
	76533	view	11:50, 16 July 2014	ReactomeTeam	Fixed remaining interactions
	75866	view	09:51, 11 June 2014	ReactomeTeam	Re-fixing comment source
	75566	view	10:36, 10 June 2014	ReactomeTeam	Reactome 48 Update
	74921	view	13:44, 8 May 2014	Anwesha	Fixing comment source for displaying WikiPathways description
	74565	view	08:36, 30 April 2014	ReactomeTeam	Reactome46
	68994	view	17:44, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	45188	view	10:00, 7 October 2011	MartijnVanIersel	Ontology Term : 'neuron-to-neuron signaling pathways' added !
	42023	view	21:51, 4 March 2011	MaintBot	Automatic update
	39826	view	05:51, 21 January 2011	MaintBot	New pathway

External references

DataNodes

Name	Type	Database reference	Comment
Ca2+	Metabolite	CHEBI:29108 (ChEBI)
Voltage Gated Ca2+ Channel		REACT_12910 (Reactome)

Annotated Interactions

Source	Target	Type	Database reference	Comment
			REACT_12594 (Reactome)	Ca2+ influx from the extracellular space into the presynaptic neuron through the Voltage Gated Ca2+ Channels (VGCC), is dependant on the arrival of an action potential at the synaptic bulb. The vesicle fusion and subsequent release of glutamate into the synapse is triggered by this influx of Ca2+. The VGCCs involved here could be of the N, P/Q or R type. Hyperpolarization of the cell membrane due to KIR3 potassium channel activity inhibits this influx of Ca2+.
Voltage Gated Ca2+ Channel			REACT_12594 (Reactome)