Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)

From WikiPathways

Revision as of 11:23, 10 June 2014 by ReactomeTeam (Talk | contribs)
Jump to: navigation, search
8, 143, 1511, 154, 84, 86, 9, 1318, 145, 164, 8U12 snRNP CF I post exon ligation complex TFIIF Cap Binding Complex capped, methylated pre-mRNACBC Complex U5 snRNP RNA Polymerase II capped pre-mRNACBCRNA Pol II snRNP Sm core complex Cap Binding Complex Mature SLBP independent Histone mRNAeIF4E complex SF3B snRNP Sm core complex capped, methylated pre-mRNACBC Complex U2 snRNP Spliceosomal E Complex Cleavage and Polyadenylation Complex U5 snRNP U6 snRNP U5 snRNP SF3B 3' end cleaved, ligated exon containing complex snRNP Sm core complex U2 snRNP Magoh-Y14 complex TFIIF TFIIF SF3A snRNP Sm core complex RNA Polymerase II holoenzyme complex snRNP Sm core complex Magoh-Y14 complex lariat containing 5'-end cleaved mRNACBC complex Cleavage and Polyadenylation Complex U5 snRNP Cleavage and Polyadenylation Complex capped, methylated pre-mRNACBC Complex Magoh-Y14 complex SF3B U4 ATAC snRNP U1 snRNP U5 snRNP SF3B SF3A Magoh-Y14 complex RNA Polymerase II holoenzyme complex RNA Polymerase II holoenzyme complex TFIIF TFIIF U11 snRNP U6 snRNP Nup107 Complex Mature Intronless Transcript Derived Histone mRNATAPAly/Ref Complex RNA Polymerase II CF II Mature intronless transcript derived Histone mRNASLBPeIF4E Complex Cap Binding Complex hnRNP proteins RNA polymerase II CF II U2 snRNP Cap Binding Complex snRNP Sm core complex CPSF U6 ATAC snRNP U2 snRNP RNA Polymerase II holoenzyme complex snRNP Sm core complex Cap Binding Complex capped, methylated pre-mRNACBC Complex U12 snRNP Cleavage and Polyadenylation Complex U4 ATACU5U6 ATAC Complex snRNP Sm core complex Spliceosomal Active C Complex U12 snRNP TFIIF U5 snRNP U11 snRNP RNA Polymerase II holoenzyme complex U5 snRNP Mature intronless derived mRNA complex U6 ATAC snRNP CF II CF II RNA Polymerase II RNA Polymerase II CF I SF3A CF I capped, methylated pre-mRNACBC Complex snRNP Sm core complex Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complex ATAC C Complex with lariat containing 5'-end cleaved mRNA U5 snRNP CF II cytosolMagoh-Y14 complex snRNP Sm core complex snRNP Sm core complex RNA Polymerase II holoenzyme complex snRNP Sm core complex U1 snRNP Cap Binding Complex Magoh-Y14 complex Nup107 Complex CF I U5 snRNP RNA polymerase II Cap Binding Complex EJC complex CstF SF3B Spliceosomal E Complex Cap Binding Complex RNA Polymerase II RNA Polymerase II holoenzyme complex CF I CF II pre-EJC complex RNA polymerase II Spliceosomal A Complex capped, methylated pre-mRNPCBC complex U1 snRNP 3'-polyadenylated, capped mRNA complex CPSF U4 snRNP U4U5U6 trisnRNP complex RNA Polymerase II CstF Mature Intronless Transcript Derived mRNAeIF4E Complex Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complex Mature mRNP Complex U12 snRNP CstF pre-EJC complex TFIIF Cap Binding Complex capped, methylated pre-mRNACBC Complex U4 snRNP Nucleoplasmic mature intronless derived mRNATAPAly/Ref complex TFIIF Nuclear Pore Complex snRNP Sm core complex RNA Polymerase II holoenzyme complex U11 snRNP SF3B Cap Binding Complex SF3A RNA Polymerase II holoenzyme complex RNA Polymerase II holoenzyme complex RNA Polymerase II holoenzyme complex Cap Binding Complex RNA Polymerase II RNA Polymerase II CPSF pre-EJC complex CF II U6 snRNP Nup62 Complex Magoh-Y14 complex CF II lariat containing 5'-end cleaved mRNACBC complex SF3B RNA Polymerase II holoenzyme complex U2 snRNP snRNP Sm core complex U4 ATACU5U6 ATAC Complex SF3A CstF ATAC A Complex snRNP Sm core complex Mature Intronless Transcript Derived Histone mRNATAPAly/Ref complex U4 ATAC snRNP RNA Polymerase II holoenzyme complex U1 snRNP CPSF Cap Binding Complex EJC complex CPSF CPSF Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complex snRNP Sm core complex capped, methylated pre-mRNACBC Complex ATAC A Complex SF3B Magoh-Y14 complex RNA Polymerase II Spliceosomal A Complex U2 snRNP TAP3'-polyadenylated, capped mRNA complex Export Receptor bound mature mRNA Complex Cap Binding Complex SF3B U6 ATAC snRNP TFIIF capped, methylated pre-mRNACBC Complex Ligated exon containing complex Mature intronless derived mRNATAPAly/Ref complex U12 snRNP Export Receptor bound mature mRNA Complex RNA Polymerase II holoenzyme complex TFIIF Cleavage and Polyadenylation Complex Cap Binding Complex mRNA 3'-end cleavage factor snRNP Sm core complex Spliceosomal Intermediate C Complex U6 snRNP pre-EJC complex CF I snRNP Sm core complex CF I U4 ATAC snRNP CPSF Cap Binding Complex CstF U4 ATAC snRNPU6 ATAC snRNP U2 snRNP Cleavage and Polyadenylation Complex RNA Polymerase II Nuclear Pore Complex EJC complex hnRNP proteins capped, methylated pre-mRNACBC Complex U1 snRNP U4 ATAC snRNPU6 ATAC snRNP Nup62 Complex U6 snRNP snRNP Sm core complex SF3B ATAC B Complex U5 snRNP CPSF U11 snRNP Spliceosomal B Complex U5 snRNP Exon Junction Complex SF3A Cap Binding Complex SF3A capped, methylated pre-mRNACBC Complex RNA polymerase II SF3A TFIIF Cap Binding Complex CF I U4 snRNP CstF RNA Polymerase II Cap Binding Complex TFIIF capped, methylated pre-mRNACBC Complex U4 snRNPU6 snRNP complex Cap Binding Complex Mature Intronless transcript derived Histone mRNASLBPCBP80CBP20 SF3B pre-EJC complex Cap Binding Complex U6 snRNP ATAC C Complex U11 snRNP CstF RNA Polymerase II holoenzyme complex RNA Polymerase II holoenzyme complex CstF U4 snRNPU6 snRNP complex TFIIF U6 ATAC snRNP EJC complex nucleoplasmMature intronless transcript derived Histone pre-mRNACBC complex snRNP Sm core complex Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complex CF I Cap Binding Complex CPSF CPSF Cap Binding Complex mRNA capped, methylated pre-mRNACBC Complex RNA Polymerase II U6 ATAC snRNP TFIIF Cap Binding Complex SF3B 3'-polyadenylated, capped mRNA complex SF3B Magoh-Y14 complex Cap Binding Complex Spliceosomal E Complex intron-containing complex snRNP Sm core complex U6 snRNP U5 snRNP CF II CPSF TFIIF pre-EJC complex TFIIF RNA Polymerase II U2 snRNP Cap Binding Complex snRNP Sm core complex NFX.1 hPrp18ALYREF Cap Binding Complex HNRNPH1POLR2C CPSF3 PAPOLAPOLR2L CSTF3 POLR2B PTBP1 HNRNPUL1 POLR2I HNRNPA0 HNRNPL NXF1EFTUD2 HNRNPK NXF1SRSF4 SNRPF GTF2F22xMe-SNRPB POLR2DSRSF3 NUDT21 POLR2K CCAR1 CD2BP2 NUP160 YBX1 HNRNPFPRPF8 NUP210 CCAR1 DHX38 SRSF2 ALYREFGTF2F2UPF3B PTBP1 SRSF6 SNRPA SRSF7 SF3A3 PRPF4 SNRPE PAPOLAPOLR2J RBM5 Export Receptor bound mature mRNA ComplexCD2BP2 SRSF11 PABPN1 DHX38 HNRNPR POLR2DDHX38 HNRNPFPOLR2H SNRPB2 EIF4EPOLR2FALYREF NFX.1 HNRNPH1U6 snRNA POLR2DHNRNPD HNRNPUL1 PCF11 SNRNP40 POLR2A CPSF1 U6 snRNA SNRPE AAAS TXNL4A POLR2I U4U5U6 trisnRNP complexSF3B1 POLR2G ALYREFHNRNPM CSTF3 NUP133 SRSF6 SRSF4 RNPS1 SNRPD2 SRSF7 Exon Junction ComplexHNRNPU SUGP1 CPSF2 DHX9 2xMe-SNRPD1 SNRPD2 NUDT21 NFX.1 POLR2H NCBP2 CLP1 EFTUD2 POM121 ATAC B ComplexSpliceosomal E ComplexSF3B2 NFX.1 HNRNPC HNRNPM SF3A2 POLR2H SRSF3 SRSF1 MAGOH SNRPE SRSF7 2xMe-SNRPD1 mRNA 3'-end cleavage factorPOLR2B SMC2 HNRNPA1HNRNPH2 HNRNPA1 SNRNP200 POLR2C HNRNPM NUP98-5 SRSF1 DHX9 CF IUPF3B HNRNPR SNRPA METTL3 POM121 2xMe-SNRPD3 SF3A1 2xMe-SNRPD1 YBX1 GTF2F1NHP2L1 LSM2 2xMe-SNRPD1 POLR2B NCBP2 HNRNPC PRPF8 2xMe-SNRPD1 GTF2F1DNAJC8POLR2C EFTUD2 POLR2DCstFPOLR2K SF3A3 PRPF4 POLR2L CSTF2SNRPF HNRNPUL1 NCBP2 SF3B14 CPSF2 POLR2A HNRNPA0 POLR2A ALYREF Mature SLBP independent Histone mRNAeIF4E complex2xMe-SNRPD3 SRSF6 SNRPD2 DHX38CDC40GTF2F2U5 snRNA SRSF7POLR2L SNRPG TXNL4A SRSF1 ALYREF POLR2J GTF2F2SUGP1 SF3B2 SNRPD2 RANBP2 U12 snRNPU2AF2 GTF2F2SNRPF SF3B3 DHX9 SNRNP200 NCBP2 CPSF1 NXF1POLR2DPOLR2B SF3A1 2xMe-SNRPD1 SRSF4 PRPF4 PCBP1 SRSF5 SNRPF POLR2C U6 snRNA NUP50 SRSF1 PRPF6 POLR2FPCBP2 NCBP1 U6 snRNA 2xMe-SNRPB CSTF2SMC1A DHX38 RNPS1 POLR2G SF3B2 HNRNPC SNRPF CSTF3 POLR2E RBMXPOLR2G SNRPF SNRPD2 LSM2 HNRNPR SNRPG NHP2L1 EIF4ESMC1A2xMe-SNRPD3 NCBP1 POLR2B U2 snRNA RANBP2 NUP188U2 snRNA 2xMe-SNRPB SNRPF PHF5ANUP205PRPF8 2xMe-SNRPD3 SRSF4 GTF2F2PRPF8 PCBP1 NCBP2 SNRPD2 PCF11 NUP85 SRSF9 DDX23 2xMe-SNRPD3 SNRPG SRSF5 SRSF6 MAGOH 3'-polyadenylated, capped mRNA complexU1 snRNA ALYREF SNRPB2 TXNL4A PCBP1 SF3B1 RBM5 2xMe-SNRPB SF3B4 NUP50 ATAC C ComplexSUGP1 SUGP1 POLR2K SRSF1U6 ATAC snRNPCSTF3 SRSF1 NCBP2 NUP62 2xMe-SNRPD3 DNAJC8SRSF2 SF3B2 GTF2F2NCBP2 NHP2L1 NUP93 U2AF2 EFTUD2 SF3A1 NCBP1 CPSF2 RNPS1 POLR2C SMC1A HNRNPA1 NFX.1SRSF2 SRSF11 SRSF2 SNRPF NUP43 HNRNPA2B1 NUDT21 NCBP2 SNRNP70 SNRPG U4 snRNA PCBP1POLR2DSNRPD2 POLR2J HNRNPUL1 SNRPA1 SRSF5 SF3B2 2xMe-SNRPB SRRM1 SF3B2 POLR2K CPSF3 GTF2F2U5 snRNA HNRNPUL1 CPSFPOLR2H U2 snRNPPOLR2B SUGP1LSM2 HNRNPH2 SRRM1PCF11 SF3B5 POLR2C POLR2I CPSF2 SNRPA1 CPSF1 POLR2H Spliceosomal A ComplexGTF2F22xMe-SNRPD3 ASR2BSF3B3 PCF11 CSTF1 POLR2K U11 snRNPPOLR2I SNRPD2 POLR2E HNRNPL PCF11 POLR2K NHP2L1 PHF5APOLR2E SNRPE HNRNPK SRSF3SF3A3 Mature intronless derived mRNATAPAly/Ref complexFUS TXNL4A Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexSF3B4 SRSF9 PAPOLAPOLR2FNUP85 UPF3B SRSF4 PRPF8 NCBP1 SRSF1 SRSF1 SNRPF HNRNPH2CSTF2RBMXNCBP2 NCBP1 POLR2K 2xMe-SNRPD1 SNRNP40 SNRPF 2xMe-SNRPD1 U5 snRNA PTBP1SF3A2 CPSF1 SRSF3 NCBP2 YBX1 SNRPG SRRM1 SNRPF SF3B14 U1 snRNPSRSF9 NHP2L1 intron-containing complex2xMe-SNRPD3 RNPS1 TXNL4A CLP1 HNRNPH1GTF2F1POLR2E ALYREF SNRPG HuR /3 RRM proteinPOLR2L CD2BP2 NXF1SF3B3 SRSF2 U1 snRNA NCBP2 CPSF2 PHF5AFUS POLR2B POLR2A NUP160 POLR2G POLR2FMAGOH POLR2E SNRPA1 SNRPA1 PCBP1 CPSF3 SRSF6 POLR2L EFTUD2 HNRNPD U5 snRNA SRSF5 CPSF2 RBM8A HNRNPA0 RNPS1U5 snRNPNUP214 hPrp19RBM5 SNRPG SRSF7 LSM2 2xMe-SNRPB SRSF9 SNRNP200 SF3B5 LSM2 HNRNPU U4 ATAC snRNPSRSF6 CD2BP2SNRPG 2xMe-SNRPD1 SNRPG SRSF5 NUP205HNRNPR RBMXSF3B2 DHX38 2xMe-SNRPD3 SMC1A SNRPA CPSF7 PHF5ACstFLSM2 2xMe-SNRPD1 SRSF6 U4 snRNPHNRNPU PRPF6 SRSF6 GTF2F1p68 DEAH protein2xMe-SNRPD3 PCBP2 NUPL1-2 HNRNPRSNRPA 2xMe-SNRPB PAPOLAPOLR2G POLR2J SF3B5 HNRNPA3 SF3B4 POLR2I SRRM1 SNRPE CSTF1 CDC40 SNRNP40 SNRPG SF3B14 ALYREF GTF2F1POLR2B PAPOLAPTBP1 SF3B5 NUDT21 NXF1SRSF2 POLR2G RBM8A TXNL4A POLR2B POLR2FHNRNPA2B1 HNRNPH2 ALYREF CDC40 SNRPG HNRNPR EFTUD2 SF3B2 SF3B14 SRSF7 POLR2L HNRNPH1CPSF7 PRPF8 SF3A3 RNPS1 POLR2A POLR2A SNRPA SNRPA1 POLR2E SRRM1 SF3B1 RNPS1 U6 snRNA SRSF5 CSTF2POLR2H HNRNPKNUP155 SLBP SMC1A POLR2A 2xMe-SNRPB POLR2L SF3A2 HNRNPA1 SF3B5 POLR2E 2xMe-SNRPD3 GTF2F12xMe-SNRPB FUS RBMXMAGOH POLR2J SF3B3 AAAS GTF2F2U5 snRNA CD2BP2 HNRNPA0 SNRNP70 Mature intronless derived mRNA complex2xMe-SNRPB SNRPE SF3B14 U2AF1 ALYREF HNRNPUL1 POLR2J SRSF11 HNRNPH1SNRNP200 PRPF6 POLR2C POLR2K HNRNPF2xMe-SNRPD3 POLR2DPOLR2H SF3B14 2xMe-SNRPD3 NCBP2 HNRNPH2 SRSF2 SNRPD2 U1 snRNA POLR2H YBX1 NFAR-2 proteinNCBP2 POLR2K SRSF7 HNRNPFDNAJC8SNRPA1 EIF4E SF3B1 TXNL4A NXF1PCF11 SF3B5 SRSF2 CLP1 SNRPE NCBP1 ALYREF CDC40 RNPS1 HNRNPDSRSF6 2xMe-SNRPD3 POLR2G CD2BP2 NHP2L1 2xMe-SNRPD1 SEH1L-2 SRSF2 Nuclear Pore Complex SNRNP40 SRSF6 p-S5-POLR2A CPSF3 SRSF7 MAGOH NCBP2 Cleavage and Polyadenylation ComplexYBX1 NCBP2 SRRM1 SNRPE SNRNP200 HNRNPK 2xMe-SNRPB POLR2FSRSF4SF3B1 SNRNP200 POLR2C SNRPG SNRPG CPSF1 2xMe-SNRPD1 CPSF7 SUGP1 GTF2F1EFTUD2 NCBP2 SRRM1HNRNPH1SNRPG SNRPE POLR2I HNRNPA3 POLR2K CPSF2 POLR2I U2AF1 RBM8A HNRNPL SRSF7 PHF5AHNRNPH2 POLR2C SNRNP40 HNRNPU CPSFU2AF1 PRPF4 SF3B2 SRSF11 CPSF2 SF3B1 POLR2E NUP155 POLR2B SF3B14 POLR2E GTF2F2SNRPF HNRNPD SNRPE CPSF7 2xMe-SNRPD3 POLR2C NHP2L1 EFTUD2 CC1.3 protein /3 RRM, RSDDX23 POLR2K RNPS1 2xMe-SNRPB SF3A1 2xMe-SNRPD1 POLR2K CLP1 SRSF9 SNRNP40 2xMe-SNRPB PABPN1 SF3B14 CSTF1 SF3B4 CSTF2DDX23 HNRNPR SNRPD2 HNRNPH1SF3B1 Mature Intronless Transcript Derived mRNAeIF4E ComplexCSTF1 SRSF1 SNRPF HNRNPM POLR2H CPSF3 SLBP NHP2L1 SRRM1 HNRNPD SNRNP200 POLR2G NUP93 POLR2DEFTUD2 NFX.1 SRSF7 U2 snRNA NUP37 SF3B5 CDC40 SNRPE NCBP1 SNRPG Mature intronless transcript derived Histone pre-mRNACBC complexMAGOH POLR2DEFTUD2 U2AF2 SF3B4 POLR2J Mature intronless transcript derived Histone mRNASLBPTAPAly/Ref complexGTF2F1U2AF1 NUPL2 2xMe-SNRPD1 PABPN1SNRPE SNRPD2 SF3B3 HNRNPA1 Mature mRNP ComplexPCF11 NCBP1 RNA polymerase II POLR2FCPSF3 POLR2E NXF1SF3A1 SRSF9 Mature Intronless Transcript Derived Histone mRNATAPAly/Ref ComplexHNRNPL DNAJC8SNRPB2 Nucleoplasmic mature intronless derived mRNATAPAly/Ref complexSRSF4 HNRNPH2 RNPS1 2xMe-SNRPB CSTF3 DNAJC8CLP1 PCBP1 NXF1HNRNPU FUS HNRNPM DDX23 p-S5-POLR2A U2 snRNA SNRPF CDC40 ALYREF PRPF8 NCBP1 POLR2G NCBP2 CLP1 U2AF2 NCBP1 NUP214 SF3B1 POLR2L RBM8A SNRPF ALYREF RBMXSRSF6 CDC40 U2AF1 POLR2I NUP54 ALYREF 3' end cleaved, ligated exon containing complexHNRNPA3 HNRNPMPOLR2D2xMe-SNRPB SF3B2 SF3B2 SNRPD2 DDX23 SNRPD2 CF IINCBP1 2xMe-SNRPD3 HNRNPK POLR2H UPF3B HNRNPL 2xMe-SNRPD1 CPSF1 PCBP2 GTF2F2NCBP2 CPSF1 SF3B4 HNRNPFPOLR2H SRSF52xMe-SNRPD3 SNRPD2 MAGOH U4 snRNA SRSF1 PRPF8 U2 snRNA UPF3BPOLR2L POLR2FSRSF7 SNRPG Spliceosomal Active C ComplexNUP37 FUS POLR2G HNRNPL HNRNPU GTF2F1SNRNP40 SLBP EIF4E POLR2A POLR2C SRSF4 U6 snRNA 2xMe-SNRPD3 SNRNP70 CPSF1 Mature intronless transcript derived Histone mRNASLBPeIF4E ComplexDDX23 ALYREF RBMXSNRPF HNRNPK CPSF7 HNRNPM SNRPG 2xMe-SNRPB NUDT21 ALYREF POLR2DNUP35 HNRNPCNFX.1 SRSF11 POLR2I SNRNP40 HNRNPA3 DHX9 POLR2H POLR2A U5 snRNA POLR2J POLR2J SF3A1 U5 snRNA CF IDHX9 SNRNP200 SRSF3 U6 snRNA SF3A3 SRSF3 SRSF9 PCBP1 SRRM1 SF3B5 HNRNPL CCAR1 NCBP1 SNRPF SRSF7 SRSF1 PCBP1 TXNL4A SRSF4 LSM2 PABPN1 GTF2F2HNRNPD DDX23 PAPOLANCBP1 NCBP1 NCBP1 U5 snRNA CSTF2HNRNPA0PRPF6 SNRPE U2 snRNA SF3A3 SNRPE SNRNP40 SRSF5 POLR2I DDX23 CD2BP2 POLR2J SF3B1 CDC40 SMC1A YBX1 SRSF4 SF3B3 RBM8A U2AF1 SEH1L-2 LSM2 Mature Intronless transcript derived Histone mRNASLBPCBP80CBP20SRSF2 NUDT21 U2AF2RBMXSF3B3 NCBP2 POLR2L PRPF4 NUDT21 SRSF2 POLR2I PCBP2 U4 snRNA SRRM1 ALYREF SRSF9 NUDT21 Spliceosomal B ComplexNup45 POLR2FDHX38 2xMe-SNRPB GTF2F2SNRPA1 SNRPD2 CSTF1 SF3A2 PCBP2 POLR2L DHX38 CSTF1 FUS SNRPF DHX9 SRSF2 SF3B3 NXF1SNRPE POLR2C 2xMe-SNRPD3 LSM2 PABPN1HNRNPR CSTF1 TXNL4A NHP2L1 NCBP1 CPSF2 CPSF1 POLR2H SUGP1 CCAR1 SF3B4 LSM2 NCBP2 SRSF1 SF3A2 RNPS1 TXNL4A SF3B5 NFX.1 SRSF9 GTF2F1EIF4E POLR2G HNRNPA2B1 PRPF6 POLR2B HNRNPU NUDT21 mRNA U2AF1 RBM5 U1 snRNA POLR2I PCBP2 ALYREF POLR2I NCBP1 SF3A1 DDX23 SRSF11 HNRNPA1 Mature Intronless Transcript Derived Histone mRNATAPAly/Ref complexHNRNPC CPSF1 U5 snRNA CLP1 GTF2F1SRSF7 PRPF4 PRPF8 CSTF1 SNRPD2 2xMe-SNRPD1 Ligated exon containing complexATAC C Complex with lariat containing 5'-end cleaved mRNAHNRNPK SNRPA1 NXF1POLR2DSRSF5 HNRNPA0 2xMe-SNRPD1 SRSF1 POLR2J DHX9 NCBP1 CSTF2POLR2J RBM8A SMC1A SRSF1 2xMe-SNRPB SNRPG CPSF2 POLR2G SNRPD2 ALYREF POLR2B HNRNPLHNRNPA3 CD2BP2 GTF2F1SMC1A SF3B4 GTF2F1SRSF6 NCBP2 HNRNPUL1 p-S5-POLR2A SRSF6 SRSF9 POLR2DSNRPB2 ALYREFDHX38 NFX.1 CCAR1 SNRNP200 U4 ATACU5U6 ATAC ComplexSF3B5 SRRM1 U2AF2 UPF3B HNRNPK SF3B14 NUPL1-2 SNRPD2 NFX.1 POLR2E NCBP2 HNRNPA2B1 POLR2C SRSF2 NUP188UPF3B POLR2G RBM8A SNRPE SF3B14 SF3A3 POLR2J POLR2L NUP210 SNRPE SNRPE POLR2I FUS NUP88 CPSF3 SRSF2POLR2FRAE1 LSM2 TPR SF3A2 HNRNPH1SNRPB2 SNRPB2 HNRNPFHNRNPA1 CSTF3 POLR2B RAE1 POLR2FHNRNPM SRSF7 U2AF2 UBA, Tudor - FLJ21007SNRPG TAP3'-polyadenylated, capped mRNA complexDHX9 CPSF7 PRPF6 PABPN1 SF3B2 POLR2DHNRNPC CCAR1 PTBP1 PCF11 TXNL4A HNRNPD CPSF7 PRPF4 SF3B5 SRSF3 SMC1A CPSF1 POLR2FPRPF6 POLR2I SF3B1 NCBP1 SRSF11 SRSF11 PCBP2DDX23 HNRNPC NUP107 HNRNPA2B1 2xMe-SNRPB SNRPB2 SF3B14 NUP133 SRSF2 SRSF1 PRPF6 POLR2I CPSF3 SRRM1 PRPF8 POLR2F2xMe-SNRPB MAGOH HNRNPH1RBM8A Spliceosomal Intermediate C ComplexU2AF1HNRNPA1 CPSF3 U5 snRNA 2xMe-SNRPD1 p-S5-POLR2A SNRNP40 PHF5APOLR2A POLR2E POLR2FGTF2F1CSTF3 GTF2F2EFTUD2 SF3B4 U2AF2 SF3B4 NUP153 SRSF2 post exon ligation complexU2 snRNA NCBP1 SNRNP200 DHX38 SRSF9 PTBP1 PCBP1 SF3B4 DHX38 SRSF1 2xMe-SNRPD1 SRSF3 CCAR1 SF3B14 CD2BP2 SNRPD2 PRPF4 SF3B3 Magoh-Y14 complexNCBP1 SF3B3 SRSF6 CLP1 SF3B4 U2AF1 PRPF8 SRSF11 NUP153 SF3B3 SF3B1 PABPN1 SUGP1 POLR2DHNRNPA0 SF3A2 SNRNP70 CF IISF3A3 RBMXU2AF2 NCBP2SUGP1 HNRNPUL1 YBX1 SLBP HNRNPH2 POLR2C SF3B1 CPSF7 HNRNPA0 DDX23 ATAC A ComplexRBM5NFX.1 POLR2B NUP88 HNRNPH2 capped, methylated pre-mRNPCBC complexPRPF6 POLR2E SNRPE SF3B5 SNRPD2 SNRNP200 SRSF2 SRSF3 CLP1 U2AF1 NFX.1 PHF5ASRSF5 HNRNPD POLR2K POLR2A POLR2A U2AF2 PRPF6 UPF3B YBX1POLR2G U5 snRNA SNRPD2 HNRNPUL1FUS RBMXPOLR2H PCBP2 SF3A2 PHF5ATPR CPSF3 SRSF5 SRSF3 PAPOLAPAPOLASRSF11NHP2L1 U2AF1 POLR2K U5 snRNA PCF11 RBM5 NCBP2 NCBP2 YBX1 NUP98-5 SNRNP70 SRSF3 CCAR1RBM8A HNRNPFSNRPF NHP2L1 ALYREF NUPL2 SRSF7 CDC40 HNRNPL POLR2E DNAJC8SF3B1 NXF1NUP54 Nup45 POLR2E POLR2L SNRNP40 capped, methylated pre-mRNACBC ComplexPRPF6 HNRNPUTXNL4A PABPN1 CPSF3 SNRPE CCAR1 POLR2C POLR2J POLR2J HNRNPR POLR2B HNRNPA2B1 NUP43 RBM5 PRPF6 NHP2L1 SNRPG ALYREF2xMe-SNRPD3 HNRNPA0 2xMe-SNRPD3 CSTF2HNRNPFPOLR2K GTF2F1SRSF3 NUP107 EFTUD2 SRSF9POLR2C HNRNPA3 NFX.1 EIF4ERNPS1 UPF3B POLR2K EIF4E SRRM1 NXF1RNPS1 HNRNPA3 PCBP2 RNPS1 GTF2F2HNRNPA3SF3B3 SNRPG SF3B3 POLR2L DnaJ hom. NP_055602SRSF4 LSM2 SNRPB2 PTBP1 POLR2G POLR2FUPF3B MAGOH SRRM1 HNRNPA2B1 CSTF3 HNRNPK PTBP1 SF3B5 Nuclear Pore Complex SNRPF SNRPF POLR2FHNRNPFhPrp22Export Receptor bound mature mRNA ComplexU2AF2 PABPN1 HNRNPM HNRNPU NCBP2 POLR2E DDX23 SF3B14 SRSF7 NUP62 PTBP1 HNRNPC capped pre-mRNACBCRNA Pol II SNRNP40 SNRPG SNRNP200 POLR2B FUSPRPF8 SRSF1 ATPDNAJC8POLR2J 2xMe-SNRPB DNAJC8NHP2L1 NUP35 POLR2G SNRPF NCBP1 NCBP1 SF3B4 2xMe-SNRPD1 hPrp5NCBP1 CPSF2 SNRPE SRRM1 CDC40 POLR2L NFX.1 SRSF7 CDC40 DHX9SF3A1 2xMe-SNRPB SRSF5 U2AF2 NCBP1HNRNPA2B1POLR2H 2xMe-SNRPD1 HNRNPD CPSF7 U1 snRNA NXF1RBM5 SRSF6 HNRNPA3 SRSF11 U2AF1 hSLU7HNRNPC SRSF6 GTF2F1Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNPCBC complexNFX.1 U1 snRNPPOLR2DRBM5 NCBP2 SF3B2 U2 snRNA NCBP1 HNRNPA2B1 SNRPD2 PAPOLANXF1SNRPE SRSF6hPrp43CPSFhTra2NXF12xMe-SNRPD1 2xMe-SNRPD3 HNRNPA1 NCBP1 POLR2H POLR2L RNPS1 27, 10, 127, 10, 12


Description

No description

Comments

Wikipathways-description 
Co-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per gene, which cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. Thus the time that it takes for pol II to synthesize each intron defines a minimal time and distance along the gene in which splicing factors can be recruited. The time that it takes for pol II to reach the end of the gene defines the maximal time in which splicing could occur co-transcriptionally. Thus, the kinetics of transcription can affect the kinetics of splicing.Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm.

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=72203

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Hutten S, Kehlenbach RH.; ''CRM1-mediated nuclear export: to the pore and beyond.''; PubMed Europe PMC Scholia
  2. Lévesque L, Guzik B, Guan T, Coyle J, Black BE, Rekosh D, Hammarskjöld ML, Paschal BM.; ''RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex.''; PubMed Europe PMC Scholia
  3. Coltri P, Effenberger K, Chalkley RJ, Burlingame AL, Jurica MS.; ''Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.''; PubMed Europe PMC Scholia
  4. Zhou Z, Licklider LJ, Gygi SP, Reed R.; ''Comprehensive proteomic analysis of the human spliceosome.''; PubMed Europe PMC Scholia
  5. Le Hir H, Izaurralde E, Maquat LE, Moore MJ.; ''The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.''; PubMed Europe PMC Scholia
  6. Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J.; ''SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.''; PubMed Europe PMC Scholia
  7. Ajuh P, Sleeman J, Chusainow J, Lamond AI.; ''A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.''; PubMed Europe PMC Scholia
  8. Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, Lührmann R, Stelzl U.; ''Dynamic protein-protein interaction wiring of the human spliceosome.''; PubMed Europe PMC Scholia
  9. Pikielny CW, Bindereif A, Green MR.; ''In vitro reconstitution of snRNPs: a reconstituted U4/U6 snRNP participates in splicing complex formation.''; PubMed Europe PMC Scholia
  10. Kataoka N, Dreyfuss G.; ''A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex.''; PubMed Europe PMC Scholia
  11. Hung ML, Hautbergue GM, Snijders AP, Dickman MJ, Wilson SA.; ''Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.''; PubMed Europe PMC Scholia
  12. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ.; ''Proteomic analysis of the mammalian nuclear pore complex.''; PubMed Europe PMC Scholia
  13. Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E, Bork P.; ''Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins.''; PubMed Europe PMC Scholia
  14. Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R.; ''Molecular architecture of the human Prp19/CDC5L complex.''; PubMed Europe PMC Scholia
  15. Moore CL, Sharp PA.; ''Accurate cleavage and polyadenylation of exogenous RNA substrate.''; PubMed Europe PMC Scholia
  16. Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA.; ''The SRm160/300 splicing coactivator subunits.''; PubMed Europe PMC Scholia
  17. Le Hir H, Gatfield D, Izaurralde E, Moore MJ.; ''The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.''; PubMed Europe PMC Scholia
  18. Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C.; ''A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.''; PubMed Europe PMC Scholia
  19. Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM.; ''Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.''; PubMed Europe PMC Scholia
  20. Lindtner S, Felber BK, Kjems J.; ''An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element.''; PubMed Europe PMC Scholia
  21. Katahira J, Straesser K, Saiwaki T, Yoneda Y, Hurt E.; ''Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling.''; PubMed Europe PMC Scholia
  22. Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, Chang X, Cheng H.; ''Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.''; PubMed Europe PMC Scholia
  23. Ilagan JO, Chalkley RJ, Burlingame AL, Jurica MS.; ''Rearrangements within human spliceosomes captured after exon ligation.''; PubMed Europe PMC Scholia
  24. Makarov EM, Owen N, Bottrill A, Makarova OV.; ''Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs.''; PubMed Europe PMC Scholia
  25. Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMed Europe PMC Scholia
  26. Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, Adhikari S, Shi Y, Lv Y, Chen YS, Zhao X, Li A, Yang Y, Dahal U, Lou XM, Liu X, Huang J, Yuan WP, Zhu XF, Cheng T, Zhao YL, Wang X, Rendtlew Danielsen JM, Liu F, Yang YG.; ''Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.''; PubMed Europe PMC Scholia
  27. Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E, Reed R.; ''The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans.''; PubMed Europe PMC Scholia
  28. Cheng H, Dufu K, Lee CS, Hsu JL, Dias A, Reed R.; ''Human mRNA export machinery recruited to the 5' end of mRNA.''; PubMed Europe PMC Scholia
  29. Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.; ''The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression.''; PubMed Europe PMC Scholia
  30. Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, Lührmann R.; ''Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.''; PubMed Europe PMC Scholia
  31. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R.; ''Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.''; PubMed Europe PMC Scholia
  32. Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-Ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, Hacohen N, Zhang F, Carr SA, Lander ES, Regev A.; ''Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites.''; PubMed Europe PMC Scholia
  33. Wu Q, Krainer AR.; ''AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.''; PubMed Europe PMC Scholia
  34. Carmody SR, Wente SR.; ''mRNA nuclear export at a glance.''; PubMed Europe PMC Scholia
  35. Valadkhan S, Manley JL.; ''Splicing-related catalysis by protein-free snRNAs.''; PubMed Europe PMC Scholia
  36. Kabachinski G, Schwartz TU.; ''The nuclear pore complex--structure and function at a glance.''; PubMed Europe PMC Scholia
  37. Lévesque L, Bor YC, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld ML, Paschal BM.; ''Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.''; PubMed Europe PMC Scholia
  38. Ruskin B, Krainer AR, Maniatis T, Green MR.; ''Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro.''; PubMed Europe PMC Scholia
  39. Bessonov S, Anokhina M, Krasauskas A, Golas MM, Sander B, Will CL, Urlaub H, Stark H, Lührmann R.; ''Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis.''; PubMed Europe PMC Scholia
  40. Lamond AI, Konarska MM, Grabowski PJ, Sharp PA.; ''Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.''; PubMed Europe PMC Scholia
  41. Teng IF, Wilson SA.; ''Mapping interactions between mRNA export factors in living cells.''; PubMed Europe PMC Scholia
  42. Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMed Europe PMC Scholia
  43. Culjkovic-Kraljacic B, Borden KL.; ''Aiding and abetting cancer: mRNA export and the nuclear pore.''; PubMed Europe PMC Scholia
  44. Shepard J, Reick M, Olson S, Graveley BR.; ''Characterization of U2AF(6), a splicing factor related to U2AF(35).''; PubMed Europe PMC Scholia
  45. Charlesworth A, Meijer HA, de Moor CH.; ''Specificity factors in cytoplasmic polyadenylation.''; PubMed Europe PMC Scholia
  46. Rappsilber J, Ryder U, Lamond AI, Mann M.; ''Large-scale proteomic analysis of the human spliceosome.''; PubMed Europe PMC Scholia
  47. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI.; ''Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.''; PubMed Europe PMC Scholia
  48. Brahms H, Meheus L, de Brabandere V, Fischer U, Lührmann R.; ''Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.''; PubMed Europe PMC Scholia
  49. Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, Cullen BR.; ''Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes.''; PubMed Europe PMC Scholia
  50. Wagner S, Chiosea S, Ivshina M, Nickerson JA.; ''In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.''; PubMed Europe PMC Scholia
  51. Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMed Europe PMC Scholia
  52. Erkmann JA, Kutay U.; ''Nuclear export of mRNA: from the site of transcription to the cytoplasm.''; PubMed Europe PMC Scholia
  53. Kang Y, Bogerd HP, Yang J, Cullen BR.; ''Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor.''; PubMed Europe PMC Scholia
  54. Watkins JL, Murphy R, Emtage JL, Wente SR.; ''The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.''; PubMed Europe PMC Scholia
  55. Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E.; ''Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.''; PubMed Europe PMC Scholia
  56. Meinel DM, Burkert-Kautzsch C, Kieser A, O'Duibhir E, Siebert M, Mayer A, Cramer P, Söding J, Holstege FC, Sträßer K.; ''Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II.''; PubMed Europe PMC Scholia
  57. Lin-Moshier Y, Sebastian PJ, Higgins L, Sampson ND, Hewitt JE, Marchant JS.; ''Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.''; PubMed Europe PMC Scholia
  58. Viphakone N, Cumberbatch MG, Livingstone MJ, Heath PR, Dickman MJ, Catto JW, Wilson SA.; ''Luzp4 defines a new mRNA export pathway in cancer cells.''; PubMed Europe PMC Scholia
  59. Valadkhan S, Mohammadi A, Wachtel C, Manley JL.; ''Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.''; PubMed Europe PMC Scholia
  60. Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M.; ''Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.''; PubMed Europe PMC Scholia
  61. Kang Y, Cullen BR.; ''The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.''; PubMed Europe PMC Scholia
  62. Madan V, Kanojia D, Li J, Okamoto R, Sato-Otsubo A, Kohlmann A, Sanada M, Grossmann V, Sundaresan J, Shiraishi Y, Miyano S, Thol F, Ganser A, Yang H, Haferlach T, Ogawa S, Koeffler HP.; ''Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.''; PubMed Europe PMC Scholia
  63. Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R.; ''The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export.''; PubMed Europe PMC Scholia
  64. Hautbergue GM, Hung ML, Golovanov AP, Lian LY, Wilson SA.; ''Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.''; PubMed Europe PMC Scholia
  65. Hastings ML, Krainer AR.; ''Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.''; PubMed Europe PMC Scholia
  66. Golovanov AP, Hautbergue GM, Tintaru AM, Lian LY, Wilson SA.; ''The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.''; PubMed Europe PMC Scholia
  67. Deckert J, Hartmuth K, Boehringer D, Behzadnia N, Will CL, Kastner B, Stark H, Urlaub H, Lührmann R.; ''Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.''; PubMed Europe PMC Scholia
  68. Yoshimoto R, Kataoka N, Okawa K, Ohno M.; ''Isolation and characterization of post-splicing lariat-intron complexes.''; PubMed Europe PMC Scholia
  69. Box JA, Bunch JT, Tang W, Baumann P.; ''Spliceosomal cleavage generates the 3' end of telomerase RNA.''; PubMed Europe PMC Scholia
  70. Johnson SA, Kim H, Erickson B, Bentley DL.; ''The export factor Yra1 modulates mRNA 3' end processing.''; PubMed Europe PMC Scholia
  71. Bachi A, Braun IC, Rodrigues JP, Panté N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, Izaurralde E.; ''The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.''; PubMed Europe PMC Scholia
  72. Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt E.; ''TREX is a conserved complex coupling transcription with messenger RNA export.''; PubMed Europe PMC Scholia
  73. Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA.; ''Chtop is a component of the dynamic TREX mRNA export complex.''; PubMed Europe PMC Scholia
  74. Fontoura BM, Blobel G, Matunis MJ.; ''A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.''; PubMed Europe PMC Scholia
  75. Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ.; ''Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.''; PubMed Europe PMC Scholia
  76. Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain JC, Krämer A.; ''Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.''; PubMed Europe PMC Scholia
  77. Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL.; ''Molecular architecture of the human pre-mRNA 3' processing complex.''; PubMed Europe PMC Scholia
  78. Takagaki Y, Manley JL.; ''Complex protein interactions within the human polyadenylation machinery identify a novel component.''; PubMed Europe PMC Scholia
  79. Kreivi JP, Lamond AI.; ''RNA splicing: unexpected spliceosome diversity.''; PubMed Europe PMC Scholia
  80. Katahira J.; ''Nuclear export of messenger RNA.''; PubMed Europe PMC Scholia
  81. Rougemaille M, Dieppois G, Kisseleva-Romanova E, Gudipati RK, Lemoine S, Blugeon C, Boulay J, Jensen TH, Stutz F, Devaux F, Libri D.; ''THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.''; PubMed Europe PMC Scholia
  82. Luna R, Rondón AG, Aguilera A.; ''New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.''; PubMed Europe PMC Scholia
  83. Zaric B, Chami M, Rémigy H, Engel A, Ballmer-Hofer K, Winkler FK, Kambach C.; ''Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function.''; PubMed Europe PMC Scholia
  84. Zhao J, Hyman L, Moore C.; ''Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.''; PubMed Europe PMC Scholia
  85. Lejeune F, Ishigaki Y, Li X, Maquat LE.; ''The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.''; PubMed Europe PMC Scholia
  86. Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, Seraphin B, Rio MC, Tomasetto C.; ''Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.''; PubMed Europe PMC Scholia
  87. Daguenet E, Baguet A, Degot S, Schmidt U, Alpy F, Wendling C, Spiegelhalter C, Kessler P, Rio MC, Le Hir H, Bertrand E, Tomasetto C.; ''Perispeckles are major assembly sites for the exon junction core complex.''; PubMed Europe PMC Scholia
  88. Braun IC, Herold A, Rode M, Conti E, Izaurralde E.; ''Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.''; PubMed Europe PMC Scholia
  89. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R.; ''Recruitment of the human TREX complex to mRNA during splicing.''; PubMed Europe PMC Scholia
  90. Harris ME, Böhni R, Schneiderman MH, Ramamurthy L, Schümperli D, Marzluff WF.; ''Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.''; PubMed Europe PMC Scholia
  91. Hautbergue GM, Hung ML, Walsh MJ, Snijders AP, Chang CT, Jones R, Ponting CP, Dickman MJ, Wilson SA.; ''UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA.''; PubMed Europe PMC Scholia
  92. Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjöld ML.; ''NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.''; PubMed Europe PMC Scholia
  93. von Moeller H, Lerner R, Ricciardi A, Basquin C, Marzluff WF, Conti E.; ''Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.''; PubMed Europe PMC Scholia
  94. Dreyfuss G, Matunis MJ, Piñol-Roma S, Burd CG.; ''hnRNP proteins and the biogenesis of mRNA.''; PubMed Europe PMC Scholia
  95. Rondón AG, Jimeno S, García-Rubio M, Aguilera A.; ''Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.''; PubMed Europe PMC Scholia
  96. Steckelberg AL, Boehm V, Gromadzka AM, Gehring NH.; ''CWC22 connects pre-mRNA splicing and exon junction complex assembly.''; PubMed Europe PMC Scholia
  97. Gencheva M, Kato M, Newo AN, Lin RJ.; ''Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing.''; PubMed Europe PMC Scholia
  98. Dufu K, Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, Reed R.; ''ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex.''; PubMed Europe PMC Scholia
  99. Lin DH, Stuwe T, Schilbach S, Rundlet EJ, Perriches T, Mobbs G, Fan Y, Thierbach K, Huber FM, Collins LN, Davenport AM, Jeon YE, Hoelz A.; ''Architecture of the symmetric core of the nuclear pore.''; PubMed Europe PMC Scholia
  100. Hartmuth K, Urlaub H, Vornlocher HP, Will CL, Gentzel M, Wilm M, Lührmann R.; ''Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.''; PubMed Europe PMC Scholia
  101. Grzybowska EA.; ''Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing.''; PubMed Europe PMC Scholia
  102. Yao C, Choi EA, Weng L, Xie X, Wan J, Xing Y, Moresco JJ, Tu PG, Yates JR, Shi Y.; ''Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing.''; PubMed Europe PMC Scholia
  103. Reichert VL, Le Hir H, Jurica MS, Moore MJ.; ''5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.''; PubMed Europe PMC Scholia
  104. Katahira J, Strässer K, Podtelejnikov A, Mann M, Jung JU, Hurt E.; ''The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human.''; PubMed Europe PMC Scholia
  105. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W.; ''Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.''; PubMed Europe PMC Scholia
  106. Wente SR, Rout MP.; ''The nuclear pore complex and nuclear transport.''; PubMed Europe PMC Scholia
  107. Viphakone N, Hautbergue GM, Walsh M, Chang CT, Holland A, Folco EG, Reed R, Wilson SA.; ''TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.''; PubMed Europe PMC Scholia
  108. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R.; ''The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.''; PubMed Europe PMC Scholia
  109. Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M.; ''Molecular architecture of the inner ring scaffold of the human nuclear pore complex.''; PubMed Europe PMC Scholia
  110. Behzadnia N, Golas MM, Hartmuth K, Sander B, Kastner B, Deckert J, Dube P, Will CL, Urlaub H, Stark H, Lührmann R.; ''Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.''; PubMed Europe PMC Scholia
  111. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E.; ''TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.''; PubMed Europe PMC Scholia
  112. Taniguchi I, Ohno M.; ''ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.''; PubMed Europe PMC Scholia
  113. Kota KP, Wagner SR, Huerta E, Underwood JM, Nickerson JA.; ''Binding of ATP to UAP56 is necessary for mRNA export.''; PubMed Europe PMC Scholia
  114. Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA.; ''Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors.''; PubMed Europe PMC Scholia
  115. Shen H, Zheng X, Luecke S, Green MR.; ''The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.''; PubMed Europe PMC Scholia
  116. Wahle E, Rüegsegger U.; ''3'-End processing of pre-mRNA in eukaryotes.''; PubMed Europe PMC Scholia
  117. Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E.; ''TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.''; PubMed Europe PMC Scholia
  118. Bessonov S, Anokhina M, Will CL, Urlaub H, Lührmann R.; ''Isolation of an active step I spliceosome and composition of its RNP core.''; PubMed Europe PMC Scholia
  119. Singh J, Sikand K, Conrad H, Will CL, Komar AA, Shukla GC.; ''U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115088view17:03, 25 January 2021ReactomeTeamReactome version 75
113530view12:00, 2 November 2020ReactomeTeamReactome version 74
112728view16:13, 9 October 2020ReactomeTeamReactome version 73
101644view11:51, 1 November 2018ReactomeTeamreactome version 66
101180view21:38, 31 October 2018ReactomeTeamreactome version 65
100706view20:10, 31 October 2018ReactomeTeamreactome version 64
100256view16:56, 31 October 2018ReactomeTeamreactome version 63
99809view15:20, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93917view13:44, 16 August 2017ReactomeTeamreactome version 61
93494view11:25, 9 August 2017ReactomeTeamreactome version 61
88115view10:05, 26 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
86590view09:21, 11 July 2016ReactomeTeamreactome version 56
83367view11:01, 18 November 2015ReactomeTeamVersion54
81532view13:04, 21 August 2015ReactomeTeamVersion53
77003view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76708view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76034view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75743view11:23, 10 June 2014ReactomeTeamReactome 48 Update
75093view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74829view10:05, 30 April 2014ReactomeTeamReactome46
74740view08:49, 30 April 2014ReactomeTeamReactome46
42105view21:57, 4 March 2011MaintBotAutomatic update
39915view05:56, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2xMe-SNRPB ProteinP14678 (Uniprot-TrEMBL)
2xMe-SNRPD1 ProteinP62314 (Uniprot-TrEMBL)
2xMe-SNRPD3 ProteinP62318 (Uniprot-TrEMBL)
3' end cleaved, ligated exon containing complexComplexREACT_3092 (Reactome)
3'-polyadenylated, capped mRNA complexComplexREACT_5827 (Reactome)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
ALYREF ProteinQ86V81 (Uniprot-TrEMBL)
ALYREFProteinQ86V81 (Uniprot-TrEMBL)
ASR2BREACT_5122 (Reactome)
ATAC A ComplexComplexREACT_4037 (Reactome)
ATAC B ComplexComplexREACT_5095 (Reactome)
ATAC C Complex with lariat containing 5'-end cleaved mRNAComplexREACT_5134 (Reactome)
ATAC C ComplexComplexREACT_4626 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
CC1.3 protein /3 RRM, RSREACT_4848 (Reactome)
CCAR1 ProteinQ8IX12 (Uniprot-TrEMBL)
CCAR1ProteinQ8IX12 (Uniprot-TrEMBL)
CD2BP2 ProteinO95400 (Uniprot-TrEMBL)
CD2BP2ProteinO95400 (Uniprot-TrEMBL)
CDC40 ProteinO60508 (Uniprot-TrEMBL)
CDC40ProteinO60508 (Uniprot-TrEMBL)
CF IIComplexREACT_3772 (Reactome)
CF IComplexREACT_4896 (Reactome)
CLP1 ProteinQ92989 (Uniprot-TrEMBL)
CPSF1 ProteinQ10570 (Uniprot-TrEMBL)
CPSF2 ProteinQ9P2I0 (Uniprot-TrEMBL)
CPSF3 ProteinQ9UKF6 (Uniprot-TrEMBL)
CPSF7 ProteinQ8N684 (Uniprot-TrEMBL)
CPSFComplexREACT_4530 (Reactome)
CSTF1 ProteinQ05048 (Uniprot-TrEMBL)
CSTF2ProteinP33240 (Uniprot-TrEMBL)
CSTF3 ProteinQ12996 (Uniprot-TrEMBL)
Cap Binding Complex ComplexREACT_3884 (Reactome)
Cleavage and Polyadenylation ComplexComplexREACT_3144 (Reactome)
CstFComplexREACT_3503 (Reactome)
DDX23 ProteinQ9BUQ8 (Uniprot-TrEMBL)
DHX38 ProteinQ92620 (Uniprot-TrEMBL)
DHX38ProteinQ92620 (Uniprot-TrEMBL)
DHX9 ProteinQ08211 (Uniprot-TrEMBL)
DHX9ProteinQ08211 (Uniprot-TrEMBL)
DNAJC8ProteinO75937 (Uniprot-TrEMBL)
DnaJ hom. NP_055602REACT_4415 (Reactome)
EFTUD2 ProteinQ15029 (Uniprot-TrEMBL)
EIF4E ProteinP06730 (Uniprot-TrEMBL)
EIF4EProteinP06730 (Uniprot-TrEMBL)
Exon Junction ComplexComplexREACT_2984 (Reactome)
Export Receptor bound mature mRNA ComplexComplexREACT_2455 (Reactome)
Export Receptor bound mature mRNA ComplexComplexREACT_2624 (Reactome)
FUS ProteinP35637 (Uniprot-TrEMBL)
FUSProteinP35637 (Uniprot-TrEMBL)
GTF2F1ProteinP35269 (Uniprot-TrEMBL)
GTF2F2ProteinP13984 (Uniprot-TrEMBL)
HNRNPA0 ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA0ProteinQ13151 (Uniprot-TrEMBL)
HNRNPA1 ProteinP09651 (Uniprot-TrEMBL)
HNRNPA1ProteinP09651 (Uniprot-TrEMBL)
HNRNPA2B1 ProteinP22626 (Uniprot-TrEMBL)
HNRNPA2B1ProteinP22626 (Uniprot-TrEMBL)
HNRNPA3 ProteinP51991 (Uniprot-TrEMBL)
HNRNPA3ProteinP51991 (Uniprot-TrEMBL)
HNRNPC ProteinP07910 (Uniprot-TrEMBL)
HNRNPCProteinP07910 (Uniprot-TrEMBL)
HNRNPD ProteinQ14103 (Uniprot-TrEMBL)
HNRNPDProteinQ14103 (Uniprot-TrEMBL)
HNRNPFProteinP52597 (Uniprot-TrEMBL)
HNRNPH1ProteinP31943 (Uniprot-TrEMBL)
HNRNPH2 ProteinP55795 (Uniprot-TrEMBL)
HNRNPH2ProteinP55795 (Uniprot-TrEMBL)
HNRNPK ProteinP61978 (Uniprot-TrEMBL)
HNRNPKProteinP61978 (Uniprot-TrEMBL)
HNRNPL ProteinP14866 (Uniprot-TrEMBL)
HNRNPLProteinP14866 (Uniprot-TrEMBL)
HNRNPM ProteinP52272 (Uniprot-TrEMBL)
HNRNPMProteinP52272 (Uniprot-TrEMBL)
HNRNPR ProteinO43390 (Uniprot-TrEMBL)
HNRNPRProteinO43390 (Uniprot-TrEMBL)
HNRNPU ProteinQ00839 (Uniprot-TrEMBL)
HNRNPUL1 ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUL1ProteinQ9BUJ2 (Uniprot-TrEMBL)
HNRNPUProteinQ00839 (Uniprot-TrEMBL)
HuR /3 RRM proteinREACT_5767 (Reactome)
LSM2 ProteinQ9Y333 (Uniprot-TrEMBL)
Ligated exon containing complexComplexREACT_5472 (Reactome)
MAGOH ProteinP61326 (Uniprot-TrEMBL)
METTL3 ProteinQ86U44 (Uniprot-TrEMBL)
Magoh-Y14 complexComplexREACT_5524 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref Complex		ComplexREACT_4560 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref complex		ComplexREACT_5697 (Reactome)
Mature Intronless Transcript Derived mRNA eIF4E ComplexComplexREACT_3252 (Reactome)
Mature Intronless transcript derived Histone mRNA

SLBP CBP80

CBP20		ComplexREACT_3802 (Reactome)
Mature SLBP independent Histone mRNA eIF4E complexComplexREACT_3452 (Reactome)
Mature intronless derived mRNA

TAP

Aly/Ref complex		ComplexREACT_4662 (Reactome)
Mature intronless derived mRNA complexComplexREACT_4047 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		ComplexREACT_2791 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		ComplexREACT_3824 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP

eIF4E Complex		ComplexREACT_2270 (Reactome)
Mature intronless transcript derived Histone pre-mRNA CBC complexComplexREACT_5592 (Reactome)
Mature mRNP ComplexComplexREACT_4851 (Reactome)
NCBP1 ProteinQ09161 (Uniprot-TrEMBL)
NCBP1ProteinQ09161 (Uniprot-TrEMBL)
NCBP2 ProteinP52298 (Uniprot-TrEMBL)
NCBP2ProteinP52298 (Uniprot-TrEMBL)
NFAR-2 proteinREACT_4072 (Reactome)
NFX.1 ProteinO43831 (Uniprot-TrEMBL)
NFX.1ProteinO43831 (Uniprot-TrEMBL)
NHP2L1 ProteinP55769 (Uniprot-TrEMBL)
NUDT21 ProteinO43809 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
NXF1ProteinQ9UBU9 (Uniprot-TrEMBL)
Nuclear Pore Complex ComplexREACT_5542 (Reactome)
Nucleoplasmic mature intronless derived mRNA

TAP

Aly/Ref complex		ComplexREACT_4247 (Reactome)
Nup45 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
PABPN1 ProteinQ86U42 (Uniprot-TrEMBL)
PABPN1ProteinQ86U42 (Uniprot-TrEMBL)
PAPOLAProteinP51003 (Uniprot-TrEMBL)
PCBP1 ProteinQ15365 (Uniprot-TrEMBL)
PCBP1ProteinQ15365 (Uniprot-TrEMBL)
PCBP2 ProteinQ15366 (Uniprot-TrEMBL)
PCBP2ProteinQ15366 (Uniprot-TrEMBL)
PCF11 ProteinO94913 (Uniprot-TrEMBL)
PHF5AProteinQ7RTV0 (Uniprot-TrEMBL)
POLR2A ProteinP24928 (Uniprot-TrEMBL)
POLR2B ProteinP30876 (Uniprot-TrEMBL)
POLR2C ProteinP19387 (Uniprot-TrEMBL)
POLR2DProteinO15514 (Uniprot-TrEMBL)
POLR2E ProteinP19388 (Uniprot-TrEMBL)
POLR2FProteinP61218 (Uniprot-TrEMBL)
POLR2G ProteinP62487 (Uniprot-TrEMBL)
POLR2H ProteinP52434 (Uniprot-TrEMBL)
POLR2I ProteinP36954 (Uniprot-TrEMBL)
POLR2J ProteinP52435 (Uniprot-TrEMBL)
POLR2K ProteinP53803 (Uniprot-TrEMBL)
POLR2L ProteinP62875 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
PRPF4 ProteinO43172 (Uniprot-TrEMBL)
PRPF6 ProteinO94906 (Uniprot-TrEMBL)
PRPF8 ProteinQ6P2Q9 (Uniprot-TrEMBL)
PTBP1 ProteinP26599 (Uniprot-TrEMBL)
PTBP1ProteinP26599 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RBM5 ProteinP52756 (Uniprot-TrEMBL)
RBM5ProteinP52756 (Uniprot-TrEMBL)
RBM8A ProteinQ9Y5S9 (Uniprot-TrEMBL)
RBMXProteinP38159 (Uniprot-TrEMBL)
RNA polymerase II ComplexREACT_4593 (Reactome)
RNPS1 ProteinQ15287 (Uniprot-TrEMBL)
RNPS1ProteinQ15287 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SF3A1 ProteinQ15459 (Uniprot-TrEMBL)
SF3A2 ProteinQ15428 (Uniprot-TrEMBL)
SF3A3 ProteinQ12874 (Uniprot-TrEMBL)
SF3B1 ProteinO75533 (Uniprot-TrEMBL)
SF3B14 ProteinQ9Y3B4 (Uniprot-TrEMBL)
SF3B2 ProteinQ13435 (Uniprot-TrEMBL)
SF3B3 ProteinQ15393 (Uniprot-TrEMBL)
SF3B4 ProteinQ15427 (Uniprot-TrEMBL)
SF3B5 ProteinQ9BWJ5 (Uniprot-TrEMBL)
SLBP ProteinQ14493 (Uniprot-TrEMBL)
SMC1A ProteinQ14683 (Uniprot-TrEMBL)
SMC1AProteinQ14683 (Uniprot-TrEMBL)
SMC2 REACT_2529 (Reactome)
SNRNP200 ProteinO75643 (Uniprot-TrEMBL)
SNRNP40 ProteinQ96DI7 (Uniprot-TrEMBL)
SNRNP70 ProteinP08621 (Uniprot-TrEMBL)
SNRPA ProteinP09012 (Uniprot-TrEMBL)
SNRPA1 ProteinP09661 (Uniprot-TrEMBL)
SNRPB2 ProteinP08579 (Uniprot-TrEMBL)
SNRPD2 ProteinP62316 (Uniprot-TrEMBL)
SNRPE ProteinP62304 (Uniprot-TrEMBL)
SNRPF ProteinP62306 (Uniprot-TrEMBL)
SNRPG ProteinP62308 (Uniprot-TrEMBL)
SRRM1 ProteinQ8IYB3 (Uniprot-TrEMBL)
SRRM1ProteinQ8IYB3 (Uniprot-TrEMBL)
SRSF1 ProteinQ07955 (Uniprot-TrEMBL)
SRSF11 ProteinQ05519 (Uniprot-TrEMBL)
SRSF11ProteinQ05519 (Uniprot-TrEMBL)
SRSF1ProteinQ07955 (Uniprot-TrEMBL)
SRSF2 ProteinQ01130 (Uniprot-TrEMBL)
SRSF2ProteinQ01130 (Uniprot-TrEMBL)
SRSF3 ProteinP84103 (Uniprot-TrEMBL)
SRSF3ProteinP84103 (Uniprot-TrEMBL)
SRSF4 ProteinQ08170 (Uniprot-TrEMBL)
SRSF4ProteinQ08170 (Uniprot-TrEMBL)
SRSF5 ProteinQ13243 (Uniprot-TrEMBL)
SRSF5ProteinQ13243 (Uniprot-TrEMBL)
SRSF6 ProteinQ13247 (Uniprot-TrEMBL)
SRSF6ProteinQ13247 (Uniprot-TrEMBL)
SRSF7 ProteinQ16629 (Uniprot-TrEMBL)
SRSF7ProteinQ16629 (Uniprot-TrEMBL)
SRSF9 ProteinQ13242 (Uniprot-TrEMBL)
SRSF9ProteinQ13242 (Uniprot-TrEMBL)
SUGP1 ProteinQ8IWZ8 (Uniprot-TrEMBL)
SUGP1ProteinQ8IWZ8 (Uniprot-TrEMBL)
Spliceosomal A ComplexComplexREACT_4512 (Reactome)
Spliceosomal Active C ComplexComplexREACT_2680 (Reactome)
Spliceosomal B ComplexComplexREACT_3078 (Reactome)
Spliceosomal E ComplexComplexREACT_4545 (Reactome)
Spliceosomal Intermediate C ComplexComplexREACT_5473 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP CBC complexComplexREACT_5191 (Reactome)
TAP 3'-polyadenylated, capped mRNA complexComplexREACT_4136 (Reactome)
TPR ProteinP12270 (Uniprot-TrEMBL)
TXNL4A ProteinP83876 (Uniprot-TrEMBL)
U1 snRNA ProteinV00590 (EMBL)
U1 snRNPComplexREACT_2910 (Reactome) The U1 snRNP is a particle consisting of the U1 snRNA and Sm core plus unique snRNP polypeptides. The U1-specific polypeptides are 70K, A, and C. The Sm core polypeptides are B, B', D1, D2, D3, E, F, G. The Sm core is a heteroheptamer in the shape of a donut, containing either B or B', which are almost identical to each other.
U11 snRNPComplexREACT_5751 (Reactome)
U12 snRNPComplexREACT_3595 (Reactome)
U2 snRNA ProteinX59360 (EMBL)
U2 snRNPComplexREACT_3715 (Reactome)
U2AF1 ProteinQ01081 (Uniprot-TrEMBL)
U2AF1ProteinQ01081 (Uniprot-TrEMBL)
U2AF2 ProteinP26368 (Uniprot-TrEMBL)
U2AF2ProteinP26368 (Uniprot-TrEMBL)
U4

U5

U6 trisnRNP complex		ComplexREACT_5066 (Reactome)
U4 ATAC

U5

U6 ATAC Complex		ComplexREACT_4539 (Reactome)
U4 ATAC snRNPComplexREACT_5266 (Reactome)
U4 snRNA ProteinX59361 (EMBL)
U4 snRNPComplexREACT_4877 (Reactome)
U5 snRNA ProteinX04293 (EMBL)
U5 snRNPComplexREACT_2482 (Reactome)
U6 ATAC snRNPComplexREACT_3135 (Reactome)
U6 snRNA ProteinX59362 (EMBL)
UBA, Tudor - FLJ21007REACT_3970 (Reactome)
UPF3B ProteinQ9BZI7 (Uniprot-TrEMBL)
UPF3BProteinQ9BZI7 (Uniprot-TrEMBL)
YBX1 ProteinP67809 (Uniprot-TrEMBL)
YBX1ProteinP67809 (Uniprot-TrEMBL)
capped pre-mRNA

CBC

RNA Pol II 		ComplexREACT_3243 (Reactome)
capped, methylated pre-mRNA CBC ComplexComplexREACT_3634 (Reactome)
capped, methylated pre-mRNP CBC complexComplexREACT_2736 (Reactome)
hPrp18REACT_3085 (Reactome)
hPrp19REACT_3274 (Reactome)
hPrp22REACT_3038 (Reactome)
hPrp43REACT_5171 (Reactome)
hPrp5REACT_3263 (Reactome)
hSLU7REACT_5157 (Reactome)
hTra2REACT_4242 (Reactome)
intron-containing complexComplexREACT_3239 (Reactome)
mRNA 3'-end cleavage factorComplexREACT_2642 (Reactome)
mRNA ComplexREACT_3236 (Reactome)
p-S5-POLR2A ProteinP24928 (Uniprot-TrEMBL)
p68 DEAH proteinREACT_4900 (Reactome)
post exon ligation complexComplexREACT_5793 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3' end cleaved, ligated exon containing complexArrowREACT_1914 (Reactome)
3' end cleaved, ligated exon containing complexREACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complexArrowREACT_1162 (Reactome)
3'-polyadenylated, capped mRNA complexREACT_53 (Reactome)
ALYREFArrowREACT_1044 (Reactome)
ALYREFArrowREACT_1228 (Reactome)
ALYREFArrowREACT_1334 (Reactome)
ALYREFArrowREACT_1356 (Reactome)
ALYREFREACT_1604 (Reactome)
ALYREFREACT_1897 (Reactome)
ALYREFREACT_222 (Reactome)
ALYREFREACT_696 (Reactome)
ASR2BREACT_222 (Reactome)
ATAC A ComplexREACT_1253 (Reactome)
ATAC C ComplexArrowREACT_1615 (Reactome)
ATPREACT_1162 (Reactome)
CC1.3 protein /3 RRM, RSREACT_222 (Reactome)
CCAR1REACT_222 (Reactome)
CD2BP2REACT_222 (Reactome)
CDC40ArrowREACT_138 (Reactome)
CDC40REACT_788 (Reactome)
CF IArrowREACT_1914 (Reactome)
CF IIArrowREACT_1914 (Reactome)
CF IIREACT_1184 (Reactome)
CF IREACT_1184 (Reactome)
CPSFArrowREACT_1162 (Reactome)
CPSFArrowREACT_1897 (Reactome)
CPSFREACT_1184 (Reactome)
Cap Binding Complex ArrowREACT_1897 (Reactome)
Cap Binding Complex ArrowREACT_696 (Reactome)
Cleavage and Polyadenylation ComplexREACT_625 (Reactome)
CstFArrowREACT_1914 (Reactome)
CstFREACT_1184 (Reactome)
DHX38ArrowREACT_138 (Reactome)
DHX38REACT_788 (Reactome)
DHX9REACT_222 (Reactome)
DNAJC8REACT_788 (Reactome)
DnaJ hom. NP_055602REACT_222 (Reactome)
EIF4EREACT_1044 (Reactome)
EIF4EREACT_1228 (Reactome)
EIF4EREACT_1334 (Reactome)
EIF4EREACT_1356 (Reactome)
Export Receptor bound mature mRNA ComplexArrowREACT_138 (Reactome)
Export Receptor bound mature mRNA ComplexREACT_1228 (Reactome)
FUSREACT_222 (Reactome)
HNRNPA0ArrowREACT_1331 (Reactome)
HNRNPA0REACT_1877 (Reactome)
HNRNPA1ArrowREACT_1331 (Reactome)
HNRNPA1REACT_1877 (Reactome)
HNRNPA2B1ArrowREACT_1331 (Reactome)
HNRNPA2B1REACT_1877 (Reactome)
HNRNPA3ArrowREACT_1331 (Reactome)
HNRNPA3REACT_1877 (Reactome)
HNRNPCArrowREACT_1331 (Reactome)
HNRNPCREACT_1877 (Reactome)
HNRNPDArrowREACT_1331 (Reactome)
HNRNPDREACT_1877 (Reactome)
HNRNPFArrowREACT_1331 (Reactome)
HNRNPFREACT_1877 (Reactome)
HNRNPH1ArrowREACT_1331 (Reactome)
HNRNPH1REACT_1877 (Reactome)
HNRNPH2ArrowREACT_1331 (Reactome)
HNRNPH2REACT_1877 (Reactome)
HNRNPKArrowREACT_1331 (Reactome)
HNRNPKREACT_1877 (Reactome)
HNRNPLArrowREACT_1331 (Reactome)
HNRNPLREACT_1877 (Reactome)
HNRNPMArrowREACT_1331 (Reactome)
HNRNPMREACT_1877 (Reactome)
HNRNPRArrowREACT_1331 (Reactome)
HNRNPRREACT_1877 (Reactome)
HNRNPUArrowREACT_1331 (Reactome)
HNRNPUL1REACT_222 (Reactome)
HNRNPUREACT_1877 (Reactome)
HuR /3 RRM proteinREACT_222 (Reactome)
Ligated exon containing complexArrowREACT_1331 (Reactome)
Magoh-Y14 complexREACT_774 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref Complex		REACT_1356 (Reactome)
Mature Intronless Transcript Derived Histone mRNA

TAP

Aly/Ref complex		ArrowREACT_696 (Reactome)
Mature Intronless Transcript Derived mRNA eIF4E ComplexArrowREACT_1334 (Reactome)
Mature Intronless transcript derived Histone mRNA

SLBP CBP80

CBP20		REACT_1604 (Reactome)
Mature SLBP independent Histone mRNA eIF4E complexArrowREACT_1356 (Reactome)
Mature intronless derived mRNA

TAP

Aly/Ref complex		REACT_1334 (Reactome)
Mature intronless derived mRNA complexREACT_1897 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		ArrowREACT_1604 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP TAP

Aly/Ref complex		REACT_1044 (Reactome)
Mature intronless transcript derived Histone mRNA

SLBP

eIF4E Complex		ArrowREACT_1044 (Reactome)
Mature intronless transcript derived Histone pre-mRNA CBC complexREACT_696 (Reactome)
Mature mRNP ComplexArrowREACT_1228 (Reactome)
NCBP1ArrowREACT_1604 (Reactome)
NCBP2ArrowREACT_1604 (Reactome)
NFAR-2 proteinREACT_222 (Reactome)
NFX.1REACT_222 (Reactome)
NXF1ArrowREACT_1044 (Reactome)
NXF1ArrowREACT_1228 (Reactome)
NXF1ArrowREACT_1334 (Reactome)
NXF1ArrowREACT_1356 (Reactome)
NXF1REACT_1604 (Reactome)
NXF1REACT_1897 (Reactome)
NXF1REACT_53 (Reactome)
NXF1REACT_696 (Reactome)
Nuclear Pore Complex ArrowREACT_1004 (Reactome)
Nuclear Pore Complex ArrowREACT_1044 (Reactome)
Nuclear Pore Complex ArrowREACT_1228 (Reactome)
Nuclear Pore Complex ArrowREACT_1334 (Reactome)
Nuclear Pore Complex ArrowREACT_1356 (Reactome)
Nuclear Pore Complex ArrowREACT_138 (Reactome)
Nuclear Pore Complex ArrowREACT_1604 (Reactome)
Nuclear Pore Complex ArrowREACT_1799 (Reactome)
Nuclear Pore Complex ArrowREACT_1897 (Reactome)
Nuclear Pore Complex ArrowREACT_2104 (Reactome)
Nuclear Pore Complex ArrowREACT_696 (Reactome)
Nuclear Pore Complex ArrowREACT_904 (Reactome)
Nucleoplasmic mature intronless derived mRNA

TAP

Aly/Ref complex		ArrowREACT_1897 (Reactome)
PABPN1ArrowREACT_1162 (Reactome)
PABPN1REACT_1184 (Reactome)
PAPOLAArrowREACT_1162 (Reactome)
PAPOLAREACT_1162 (Reactome)
PAPOLAREACT_1184 (Reactome)
PCBP1ArrowREACT_1331 (Reactome)
PCBP1REACT_1877 (Reactome)
PCBP2ArrowREACT_1331 (Reactome)
PCBP2REACT_1877 (Reactome)
PTBP1ArrowREACT_1331 (Reactome)
PTBP1REACT_1877 (Reactome)
RBM5REACT_222 (Reactome)
RBMXArrowREACT_1331 (Reactome)
RBMXREACT_1877 (Reactome)
REACT_1004 (Reactome) The nucleoplasmic 3' polyadenylated, capped intronless mRNA and TAP are transported through the NPC to the cyotplasmic side of the pore.
REACT_1044 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
REACT_1162 (Reactome) The upstream fragment generated by 3' cleavage of the pre-mRNA receives a poly(A) tail of approximately 250 AMP residues in a reaction depending on the AAUAAA sequence 10 to 30 nucleotides upstream of the 3' end. Polyadenylation is carried out by three proteins: Poly(A) polymerase carries the catalytic activity. The enzyme has no specificity for any particular RNA sequence, and it also has a very low affinity for the RNA.

Under physiological conditions, the activity of poly(A) polymerase thus depends on two auxiliary factors, both of which bind to specific RNA sequences and recruit the enzyme by a direct contact. One of these proteins is the heterotetrameric CPSF, which binds the AAUAAA sequence and is also essential for 3' cleavage. The second is the nuclear poly(A) binding protein (PABPN1), which binds the growing poly(A) tails once this has reached a length of about ten nucleotides. Stimulation of poly(A) polymerase by both proteins is synergistic and results in processive elongation of the RNA, i.e. the polymerase adds AMP residues without dissociating from the RNA. The processive reaction is terminated when the tail has reached a length of about 250 nucleotides.

REACT_1184 (Reactome)
REACT_1228 (Reactome) At the beginning of this reaction, 1 molecule of 'eIF4E', and 1 molecule of 'Export Receptor bound mature mRNA Complex' are present. At the end of this reaction, 1 molecule of 'THOC4(Aly/Ref)', 1 molecule of 'Mature mRNP Complex', 1 molecule of 'SRm160', and 1 molecule of 'TAP' are present.

This reaction takes place in the 'cytoplasm'.

REACT_1253 (Reactome) The U4atac/U6atac enters the spliceosome and U6atac snRNA forms base pairing interactions with the 5' ss and also forms base pairing interactions with U12 and U4atac is partially displaced. U5 snRNP, the only snRNP common to both the major and minor splicing pathways, also joins the spliceosome to form the B complex and interacts with nucleotides within the 3' end of the exon flanking the 5' ss.
REACT_1331 (Reactome) The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.
REACT_1334 (Reactome) The cytoplasmic 3' polyadenylated, capped intronless mRNA and TAP are released from the NPC into the cytosol. Cytosolic TAP will be recycled to the nucleous, while the 3' polyadenylated, capped intronless mRNA is bound by eIF4E and destined for translation.
REACT_1356 (Reactome) At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm.
REACT_138 (Reactome) At the beginning of this reaction, 1 molecule of 'TAP:3'-polyadenylated, capped mRNA complex' is present. At the end of this reaction, 1 molecule of 'SRp55', 1 molecule of 'U2AF 65 kDa subunit', 1 molecule of 'SR9 / SRp30', 1 molecule of 'hTra2', 1 molecule of 'hPrp16', 1 molecule of 'SR 11/ p54', 1 molecule of 'hPrp22', 1 molecule of 'SRp40', 1 molecule of 'hPrp17', 1 molecule of 'SF2/ASF/SFRS1', 1 molecule of 'hSLU7', 1 molecule of 'Export Receptor bound mature mRNA Complex', 1 molecule of 'U2AF 35 kDa subunit', 1 molecule of 'SR2 / SC35', 1 molecule of 'hPrp43', 1 molecule of 'SRp20', 1 molecule of 'SR7/ 9G8 protein', 1 molecule of 'hPrp18', and 1 molecule of 'SR4 / SRp75' are present.

This reaction takes place in the 'nucleoplasm'.

REACT_1494 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present. At the end of this reaction, 1 molecule of 'U6 ATAC snRNP', 1 molecule of 'post exon ligation complex', 1 molecule of 'U12 snRNP', 1 molecule of 'U11 snRNP', and 1 molecule of 'U5 snRNP' are present.

This reaction takes place in the 'nucleus'.

REACT_1554 (Reactome) The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.
REACT_1604 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The stemloop and SLBP enhance the rate of transport of histone mRNAs in Xenopus oocytes, but are not essential for transport
REACT_1615 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC B Complex' is present. At the end of this reaction, 1 molecule of 'U4 ATAC snRNP', and 1 molecule of 'ATAC C Complex' are present.

This reaction takes place in the 'nucleus'.

REACT_1720 (Reactome) In addition to the methylation of the 5'-cap, there is methylation of internal nucleotides in the mRNA. This methylation can occur in translated and untranslated regions. One to three methyl groups have been seen per mRNA molecule, but methylation is non-stoichiometric. The most frequent methylation observed is at the N6 position of adenosine. The function of mRNA internal methylation, if any, is unknown.
REACT_1799 (Reactome) Once the transport complex is fully assembled the mature mRNA can be translocated from the nucleoplasm to the cytoplasm. The assembled complex starts at the nucleoplasmic basket, travels through the pore, and ends it journey at the cytoplasmic face of the nuclear pore complex.
REACT_1877 (Reactome) After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.
REACT_1897 (Reactome) The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm.
REACT_1914 (Reactome) Endonucleolytic cleavage separates the pre-mRNA into an upstream fragment destined to become the mature mRNA, and a downstream fragment that is rapidly degraded. Cleavage depends on two signals in the RNA, a highly conserved hexanucleotide, AAUAAA, 10 to 30 nucleotides upstream of the cleavage site, and a poorly conserved GU- or U-rich downstream element. Additional sequences, often upstream of AAUAAA, can enhance the efficiency of the reaction. Cleavage occurs most often after a CA dinucleotide. A single gene can have more than one 3' processing site.

Cleavage is preceded by the assembly of a large processing complex, the composition of which is poorly defined. ATP, but not its hydrolysis, is required for assembly. Cleavage at the 3'-end of mRNAs depends on a number of protein factors. CPSF, a heterotetramer, binds specifically to the AAUAAA sequence. The heterotrimer CstF binds the downstream element. CF I, which appears to be composed of two subunits, one of several related larger polypeptides and a common smaller one, also binds RNA, but with unknown specificity. RNA recognition by these proteins is cooperative. Cleavage also requires CF II, composed of at least two subunits, and poly(A) polymerase, the enzyme synthesizing the poly(A) tail in the second step of the reaction. The polypeptide catalyzing the hydrolysis of the phosphodiester bond remains to be identified.

Cleavage produces a 3'-OH on the upstream fragment and a 5'-phosphate on the downstream fragment. At some unknown point after cleavage, the downstream RNA fragment, CstF, CF I and CF II are thought to be released, whereas CPSF and poly(A) polymerase remain to carry out polyadenylation.

REACT_1935 (Reactome) In the first catalytic step of mRNA splicing, the 2' OH group of the bulged A at the branch site performs a nucleophilic attack on the 5' splice site phosphodiester bond, resulting in cleavage of the bond between the 5' exon and the 5' end of the intron, and formation of a new bond between the 5' end of the intron and the branch site A. This results in a lariat-shaped intermediate, with the intron still attached to the 3' exon. The branch site A has a 2'-5' phosphodiester bond with the G at the beginning of the intron, in addition to the usual 5'-3' and 3'-5'phosphodiester bonds.
REACT_2104 (Reactome) In this reaction, 1 molecule of 'Export Receptor bound mature mRNA Complex' is translocated from nucleoplasm to cytosol.

This reaction takes place in the 'nuclear envelope'.

REACT_222 (Reactome) Pre-mRNA transcripts become rapidly associated with many RNA-binding proteins, including hnRNP proteins, cap-binding proteins, SR proteins, etc; in the test tube this binding does not require splice sites or ATP. The E complex, or early complex, is the first detectable functional intermediate in spliceosome assembly in vitro. It is an ATP-independent complex. When a functional 5' splice site is present, it is bound by the U1 snRNP. The splicing factor U2AF (65 and 35 kDa subunits) binds to the polypyrimidine tract (Y)n and the AG dinucleotide at the 3' splice site, respectively. SF1/mBBP binds to the branch site. Binding of many of these factors is cooperative; e.g., SR proteins and U2AF apparently interact with each other, facilitating their binding to the pre-mRNA. In the presence of ATP, the E complex is converted to the first ATP-dependent spliceosomal complex, namely the A complex.
REACT_2241 (Reactome) At the beginning of this reaction, 1 molecule of 'ATAC C Complex' is present. At the end of this reaction, 1 molecule of 'ATAC C Complex with lariat containing 5'-end cleaved mRNA' is present.

This reaction takes place in the 'nucleus'.

REACT_48 (Reactome) The formation of the B complex is ATP-dependent, and both the 5' and 3' splice sites are essential for B complex assembly. The U4 and U6 snRNPS are extensively base-paired, and this U4:U6 complex associates with the U5 snRNP to form a tri-snRNP particle. This tri-snRNP particle then binds to the spliceosomal A complex, to form the spliceosomal B complex.
REACT_53 (Reactome) Aly/Ref recruits TAP to the Exon Junction Complex. This makes the mRNP complex ready for export to the cytoplasm.
REACT_625 (Reactome) The spliceosomal C complex is a very short-lived intermediate; the splicing intermediates are rapidly converted to splicing products. Also, the spliced products are released very rapidly, and no complex containing both the splicing products has been isolated. Conversion of the spliceosomal B complex to the spliceosomal C complex requires ATP. The extensive base-pairing between the U4 and U6 snRNAs is disrupted during the formation of the C complex, which is thought to require helicase-type activity associated with the DEAD box factors.
REACT_696 (Reactome) Histone mRNAs are exported by a mechanism that requires TAP, the key factor requires for transport of polyadenylated mRNAs. How TAP is recruited to the histone mRNAs is not known, but it is clear that transport can occur in the absence of either the stemloop or of SLBP. The mature transcript docks at the NPC, in the course of transport CBC will be lost from the mRNA cap, and remain in the nucleous.
REACT_774 (Reactome) At the beginning of this reaction, 1 molecule of 'Magoh-Y14 complex', and 1 molecule of 'Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex' are present. At the end of this reaction, 1 molecule of 'Exon Junction Complex' is present.

This reaction takes place in the 'nucleoplasm'.

REACT_788 (Reactome) The A complex is the first ATP-dependent complex in spliceosome assembly. U2AF recruits the U2 snRNP to bind to the branch site in the E complex in an ATP-dependent fashion, to form the A complex. The U2 snRNA base-pairs with the branch site, causing the branch-site adenosine to bulge out, which later positions it for nucleophilic attack at the 5' splice site. The A complex serves as a substrate for formation of the B complex.
REACT_864 (Reactome) U12-type AT-AC introns are distinguished from the major U2-type introns by the consensus sequences of their highly conserved splicing signals. U12 introns have the 5' ss consensus sequence (G/A)TATCCTTT, the branchpoint sequence TTTCCTTAACT and the 3' ss (C/T)AG. Initial recognition of AT-AC introns involves interaction of U12 snRNP with the branch-point sequence and U11 with the 5' ss. Unlike the major splicing pathway, U11 and U12 are in a complex and interact with the pre-mRNA simultaneously, binding in an ATP-dependent manner as a di-snRNP complex and likely bridging the 5' ss and 3' ss region.

Twenty proteins have been identified in the U11/U12 di-snRNP complex including the snRNP Sm proteins B’, B, D3, D2, D1, E, F, and G which are identical to the major splicing pathway Sm proteins. A U2 snRNP core protein complex, SF3b is also found in the U11/U12 di-snRNP, including p14, a protein that interacts with the branchpoint adenosine.

SR proteins are required for formation of A complex in AT-AC splicing. The same SR proteins involved in splicing of the major introns are also active in splicing of AT-AC introns, though, as in the major pathway, there is substrate specificity.

REACT_904 (Reactome) The mature SLBP independent intronless histone mRNA is transported through the nucler pore to the cytoplasmic side.
RNA polymerase II ArrowREACT_1331 (Reactome)
RNPS1REACT_222 (Reactome)
SMC1AREACT_222 (Reactome)
SMC2 REACT_222 (Reactome)
SRRM1ArrowREACT_1228 (Reactome)
SRRM1REACT_222 (Reactome)
SRSF11ArrowREACT_138 (Reactome)
SRSF11REACT_788 (Reactome)
SRSF1ArrowREACT_138 (Reactome)
SRSF1REACT_222 (Reactome)
SRSF1REACT_864 (Reactome)
SRSF2ArrowREACT_138 (Reactome)
SRSF2REACT_222 (Reactome)
SRSF2REACT_864 (Reactome)
SRSF3ArrowREACT_138 (Reactome)
SRSF3REACT_222 (Reactome)
SRSF4ArrowREACT_138 (Reactome)
SRSF4REACT_788 (Reactome)
SRSF5ArrowREACT_138 (Reactome)
SRSF5REACT_222 (Reactome)
SRSF6ArrowREACT_138 (Reactome)
SRSF6REACT_222 (Reactome)
SRSF6REACT_864 (Reactome)
SRSF7ArrowREACT_138 (Reactome)
SRSF7REACT_222 (Reactome)
SRSF7REACT_864 (Reactome)
SRSF9ArrowREACT_138 (Reactome)
SRSF9REACT_222 (Reactome)
SUGP1REACT_222 (Reactome)
Spliceosomal A ComplexREACT_48 (Reactome)
Spliceosomal Active C ComplexREACT_1935 (Reactome)
Spliceosomal B ComplexREACT_625 (Reactome)
Spliceosomal E ComplexREACT_788 (Reactome)
Spliceosomal Intermediate C ComplexArrowREACT_625 (Reactome)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP CBC complexREACT_774 (Reactome)
U1 snRNPArrowREACT_625 (Reactome)
U1 snRNPREACT_222 (Reactome)
U11 snRNPArrowREACT_1494 (Reactome)
U11 snRNPREACT_864 (Reactome)
U12 snRNPArrowREACT_1494 (Reactome)
U12 snRNPREACT_864 (Reactome)
U2 snRNPREACT_788 (Reactome)
U2AF1ArrowREACT_138 (Reactome)
U2AF1REACT_222 (Reactome)
U2AF2ArrowREACT_138 (Reactome)
U2AF2REACT_222 (Reactome)
U4

U5

U6 trisnRNP complex		REACT_48 (Reactome)
U4 ATAC

U5

U6 ATAC Complex		REACT_1253 (Reactome)
U4 ATAC snRNPArrowREACT_1615 (Reactome)
U4 snRNPArrowREACT_625 (Reactome)
U5 snRNPArrowREACT_1494 (Reactome)
U6 ATAC snRNPArrowREACT_1494 (Reactome)
UBA, Tudor - FLJ21007REACT_222 (Reactome)
UPF3BREACT_1935 (Reactome)
YBX1REACT_222 (Reactome)
capped, methylated pre-mRNA CBC ComplexREACT_1877 (Reactome)
capped, methylated pre-mRNA CBC ComplexREACT_864 (Reactome)
capped, methylated pre-mRNP CBC complexREACT_222 (Reactome)
hPrp18ArrowREACT_138 (Reactome)
hPrp19REACT_222 (Reactome)
hPrp22ArrowREACT_138 (Reactome)
hPrp43ArrowREACT_138 (Reactome)
hPrp5REACT_788 (Reactome)
hSLU7ArrowREACT_138 (Reactome)
hTra2ArrowREACT_138 (Reactome)
hTra2REACT_788 (Reactome)
intron-containing complexArrowREACT_1331 (Reactome)
mRNA 3'-end cleavage factorREACT_1914 (Reactome)
mRNA REACT_1720 (Reactome)
p68 DEAH proteinREACT_222 (Reactome)
post exon ligation complexArrowREACT_1494 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1889"
Personal tools