Transport of vitamins, nucleosides, and related molecules (Homo sapiens)

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22-24, 34, 42934, 10162132711, 25, 3712, 14, 30, 3172, 61, 321322, 27, 2921, 331920328, 38185836, 4128, 389274015, 3515, 3517, 3926albuminbile salt and acid cholate bile salts 6xSLC35D1 lysosomal lumencytosolbile salts and acids Golgi lumenalbumincholate bile salt complex endoplasmic reticulum lumenligands of SLC28A3PAPStaurochenodeoxycholate GDP-ManNa+UMPligands of SLC29A3SLCO2B1 substratesSLC35B4SLC35A3SLC29A3UDP-GlcAPGT substratesGMPSLCO4C1UDP-GlcNAcPGT substratesThyroid hormone transporting SLCOsSLC35D1 SLC29A2T3/T4 hormonesLong chain fatty acidscholate bile saltsSLC35D2UMPSLC35B4ligands of SLC29A3SLCO1B1UDP-GlcNAcGDP-ManAc-CoAGDP-FucDIGXCMP-SA6xSLC35D1SLCO2A1vitamins transported by SMVTSLC28A3SLCO3A1 substratesSLCO3A1 substratesSLC35A1ligands of SLC28A2SLC29A1UMPALBligands of SLC29A1SLCO1B3ligands of SLC29A2SLC35A2Na+Na+T3/T4 hormonesligands of SLC29A4ALBCMP-SAligands of SLC28A2Long chain fatty acidsSLCO2B1 substratesGDP-FucSLCO2B1taurocholate Na+UDP-XylPAPSAc-CoAUDP-xylalbumincholate bile salt complextaurocholate bile salts and acids UDP-Gal transporter substratesSLC35C1ALB UDP-sugarsUDP-GlcAUMPchenodeoxycholate ALB vitamins transported by SMVTUDP-GlcNAcNa+SLCO1A2FATP1/4/6CMPUDP-GlcNAcGMPligands of SLC29A1UDP-sugarsSLC28A1UMPDIGXSLC35B2,3CMPcholate glycocholate ligands of SLC29A4SLC5A6SLC29A4Na+SLC28A2ligands of SLC28A3SLCO3A1-1ligands of SLC28A1SLC33A1UMPUDP-Gal transporter substratesligands of SLC29A2ligands of SLC28A1albuminbile salt and acid glycocholate 181333926


Description

This pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=425397

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Bibliography

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  20. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H.; ''Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.''; PubMed Europe PMC Scholia
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  22. Newman LE, Zhou CJ, Mudigonda S, Mattheyses AL, Paradies E, Marobbio CM, Kahn RA.; ''The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.''; PubMed Europe PMC Scholia
  23. Lu R, Kanai N, Bao Y, Schuster VL.; ''Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT).''; PubMed Europe PMC Scholia
  24. Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B.; ''Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.''; PubMed Europe PMC Scholia
  25. Crawford CR, Patel DH, Naeve C, Belt JA.; ''Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line.''; PubMed Europe PMC Scholia
  26. Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD.; ''Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1).''; PubMed Europe PMC Scholia
  27. Martinez-Duncker I, Dupré T, Piller V, Piller F, Candelier JJ, Trichet C, Tchernia G, Oriol R, Mollicone R.; ''Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter.''; PubMed Europe PMC Scholia
  28. Ashikov A, Routier F, Fuhlrott J, Helmus Y, Wild M, Gerardy-Schahn R, Bakker H.; ''The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.''; PubMed Europe PMC Scholia
  29. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ.; ''Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.''; PubMed Europe PMC Scholia
  30. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ.; ''Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.''; PubMed Europe PMC Scholia
  31. Miura N, Ishida N, Hoshino M, Yamauchi M, Hara T, Ayusawa D, Kawakita M.; ''Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.''; PubMed Europe PMC Scholia
  32. Ishida N, Kuba T, Aoki K, Miyatake S, Kawakita M, Sanai Y.; ''Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.''; PubMed Europe PMC Scholia
  33. Handford M, Rodriguez-Furlán C, Orellana A.; ''Nucleotide-sugar transporters: structure, function and roles in vivo.''; PubMed Europe PMC Scholia
  34. Bailey LK, Campbell LJ, Evetts KA, Littlefield K, Rajendra E, Nietlispach D, Owen D, Mott HR.; ''The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function.''; PubMed Europe PMC Scholia
  35. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A.; ''Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.''; PubMed Europe PMC Scholia
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  37. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T.; ''Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.''; PubMed Europe PMC Scholia
  38. Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD, Baldwin SA.; ''Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.''; PubMed Europe PMC Scholia
  39. Muraoka M, Kawakita M, Ishida N.; ''Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity.''; PubMed Europe PMC Scholia
  40. Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V.; ''Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter.''; PubMed Europe PMC Scholia
  41. Stahl A, Hirsch DJ, Gimeno RE, Punreddy S, Ge P, Watson N, Patel S, Kotler M, Raimondi A, Tartaglia LA, Lodish HF.; ''Identification of the major intestinal fatty acid transport protein.''; PubMed Europe PMC Scholia
  42. Kamiyama S, Sasaki N, Goda E, Ui-Tei K, Saigo K, Narimatsu H, Jigami Y, Kannagi R, Irimura T, Nishihara S.; ''Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.''; PubMed Europe PMC Scholia
  43. Ozeran JD, Westley J, Schwartz NB.; ''Identification and partial purification of PAPS translocase.''; PubMed Europe PMC Scholia
  44. Kamiyama S, Suda T, Ueda R, Suzuki M, Okubo R, Kikuchi N, Chiba Y, Goto S, Toyoda H, Saigo K, Watanabe M, Narimatsu H, Jigami Y, Nishihara S.; ''Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter.''; PubMed Europe PMC Scholia
  45. Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.; ''Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.''; PubMed Europe PMC Scholia
  46. Lübke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Körner C.; ''Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.''; PubMed Europe PMC Scholia
  47. Klingenberg M.; ''Molecular aspects of the adenine nucleotide carrier from mitochondria.''; PubMed Europe PMC Scholia
  48. Visser WE, Philp NJ, van Dijk TB, Klootwijk W, Friesema EC, Jansen J, Beesley PW, Ianculescu AG, Visser TJ.; ''Evidence for a homodimeric structure of human monocarboxylate transporter 8.''; PubMed Europe PMC Scholia
  49. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B.; ''Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.''; PubMed Europe PMC Scholia
  50. Ritzel MW, Ng AM, Yao SY, Graham K, Loewen SK, Smith KM, Ritzel RG, Mowles DA, Carpenter P, Chen XZ, Karpinski E, Hyde RJ, Baldwin SA, Cass CE, Young JD.; ''Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).''; PubMed Europe PMC Scholia
  51. Duee ED, Vignais PV.; ''[Exchange between extra- and intramitochondrial adenine nucleotides].''; PubMed Europe PMC Scholia
  52. De Marcos Lousa C, Trézéguet V, Dianoux AC, Brandolin G, Lauquin GJ.; ''The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.''; PubMed Europe PMC Scholia
  53. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM.; ''Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.''; PubMed Europe PMC Scholia
  54. Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Wallace DC.; ''A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed.''; PubMed Europe PMC Scholia
  55. Ishida N, Miura N, Yoshioka S, Kawakita M.; ''Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.''; PubMed Europe PMC Scholia
  56. Nabokina SM, Subramanian VS, Said HM.; ''Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter.''; PubMed Europe PMC Scholia
  57. Zhang T, Li S, Zhang Y, Zhong C, Lai Z, Ding J.; ''Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.''; PubMed Europe PMC Scholia
  58. Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA.; ''FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells.''; PubMed Europe PMC Scholia
  59. Flower DR, North AC, Attwood TK.; ''Structure and sequence relationships in the lipocalins and related proteins.''; PubMed Europe PMC Scholia
  60. Hagenbuch B, Meier PJ.; ''Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.''; PubMed Europe PMC Scholia
  61. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T.; ''Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.''; PubMed Europe PMC Scholia
  62. Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD.; ''Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.''; PubMed Europe PMC Scholia
  63. Pfaff E, Klingenberg M, Heldt HW.; ''Unspecific permeation and specific exchange of adenine nucleotides in liver mitochondria.''; PubMed Europe PMC Scholia
  64. Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD.; ''Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
114879view16:39, 25 January 2021ReactomeTeamReactome version 75
113325view11:39, 2 November 2020ReactomeTeamReactome version 74
112536view15:50, 9 October 2020ReactomeTeamReactome version 73
101449view11:32, 1 November 2018ReactomeTeamreactome version 66
100987view21:10, 31 October 2018ReactomeTeamreactome version 65
100523view19:44, 31 October 2018ReactomeTeamreactome version 64
100070view16:28, 31 October 2018ReactomeTeamreactome version 63
99621view15:00, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99228view12:44, 31 October 2018ReactomeTeamreactome version 62
94041view13:53, 16 August 2017ReactomeTeamreactome version 61
93665view11:30, 9 August 2017ReactomeTeamreactome version 61
86787view09:26, 11 July 2016ReactomeTeamreactome version 56
83207view10:22, 18 November 2015ReactomeTeamVersion54
81588view13:07, 21 August 2015ReactomeTeamVersion53
77048view08:34, 17 July 2014ReactomeTeamFixed remaining interactions
76753view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76078view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75788view11:31, 10 June 2014ReactomeTeamReactome 48 Update
75138view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74785view08:52, 30 April 2014ReactomeTeamReactome46
45060view19:59, 6 October 2011KhanspersOntology Term : 'transport pathway' added !
42152view22:00, 4 March 2011MaintBotAutomatic update
39963view05:58, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6xSLC35D1ComplexREACT_7361 (Reactome)
ALB ProteinP02768 (Uniprot-TrEMBL)
ALBProteinP02768 (Uniprot-TrEMBL)
Ac-CoAMetaboliteCHEBI:15351 (ChEBI)
CMP-SAMetaboliteCHEBI:16556 (ChEBI)
CMPMetaboliteCHEBI:17361 (ChEBI)
DIGXMetaboliteCHEBI:4551 (ChEBI)
FATP1/4/6REACT_24174 (Reactome)
GDP-FucMetaboliteCHEBI:17009 (ChEBI)
GDP-ManMetaboliteCHEBI:15820 (ChEBI)
GMPMetaboliteCHEBI:17345 (ChEBI)
Long chain fatty acidsMetaboliteREACT_24406 (Reactome)
Long chain fatty acidsMetaboliteREACT_24650 (Reactome)
Na+MetaboliteCHEBI:29101 (ChEBI)
PAPSMetaboliteCHEBI:17980 (ChEBI)
PGT substratesMetaboliteREACT_24629 (Reactome)
PGT substratesMetaboliteREACT_24713 (Reactome)
SLC28A1ProteinO00337 (Uniprot-TrEMBL)
SLC28A2ProteinO43868 (Uniprot-TrEMBL)
SLC28A3ProteinQ9HAS3 (Uniprot-TrEMBL)
SLC29A1ProteinQ99808 (Uniprot-TrEMBL)
SLC29A2ProteinQ14542 (Uniprot-TrEMBL)
SLC29A3ProteinQ9BZD2 (Uniprot-TrEMBL)
SLC29A4ProteinQ7RTT9 (Uniprot-TrEMBL)
SLC33A1ProteinO00400 (Uniprot-TrEMBL)
SLC35A1ProteinP78382 (Uniprot-TrEMBL)
SLC35A2ProteinP78381 (Uniprot-TrEMBL)
SLC35A3ProteinQ9Y2D2 (Uniprot-TrEMBL)
SLC35B2,3ProteinREACT_164729 (Reactome)
SLC35B4ProteinQ969S0 (Uniprot-TrEMBL)
SLC35C1ProteinQ96A29 (Uniprot-TrEMBL)
SLC35D1 ProteinQ9NTN3 (Uniprot-TrEMBL)
SLC35D2ProteinQ76EJ3 (Uniprot-TrEMBL)
SLC5A6ProteinQ9Y289 (Uniprot-TrEMBL)
SLCO1A2ProteinP46721 (Uniprot-TrEMBL)
SLCO1B1ProteinQ9Y6L6 (Uniprot-TrEMBL)
SLCO1B3ProteinQ9NPD5 (Uniprot-TrEMBL)
SLCO2A1ProteinQ92959 (Uniprot-TrEMBL)
SLCO2B1 substratesMetaboliteREACT_24278 (Reactome)
SLCO2B1 substratesMetaboliteREACT_24748 (Reactome)
SLCO2B1ProteinO94956 (Uniprot-TrEMBL)
SLCO3A1 substratesProteinREACT_24656 (Reactome)
SLCO3A1 substratesMetaboliteREACT_24849 (Reactome)
SLCO3A1-1ProteinQ9UIG8-1 (Uniprot-TrEMBL)
SLCO4C1ProteinQ6ZQN7 (Uniprot-TrEMBL)
T3/T4 hormonesMetaboliteREACT_24262 (Reactome)
T3/T4 hormonesMetaboliteREACT_24702 (Reactome)
Thyroid hormone transporting SLCOsProteinREACT_24523 (Reactome)
UDP-Gal transporter substratesMetaboliteREACT_22450 (Reactome)
UDP-Gal transporter substratesMetaboliteREACT_22484 (Reactome)
UDP-GlcAMetaboliteCHEBI:17200 (ChEBI)
UDP-GlcNAcMetaboliteCHEBI:16264 (ChEBI)
UDP-XylMetaboliteCHEBI:16082 (ChEBI)
UDP-sugarsMetaboliteREACT_23127 (Reactome)
UDP-sugarsMetaboliteREACT_23247 (Reactome)
UDP-xylMetaboliteCHEBI:16082 (ChEBI)
UMPMetaboliteCHEBI:16695 (ChEBI)
albumin bile salt and acid ComplexREACT_10829 (Reactome)
albumin cholate bile salt complexComplexREACT_10265 (Reactome)
bile salts and acids MetaboliteREACT_10444 (Reactome)
chenodeoxycholate MetaboliteCHEBI:16755 (ChEBI)
cholate MetaboliteCHEBI:16359 (ChEBI)
cholate bile saltsMetaboliteREACT_10246 (Reactome)
glycocholate MetaboliteCHEBI:17687 (ChEBI)
ligands of SLC28A1MetaboliteREACT_8051 (Reactome)
ligands of SLC28A1MetaboliteREACT_8344 (Reactome)
ligands of SLC28A2MetaboliteREACT_8398 (Reactome)
ligands of SLC28A2MetaboliteREACT_8955 (Reactome)
ligands of SLC28A3MetaboliteREACT_8379 (Reactome)
ligands of SLC28A3MetaboliteREACT_8767 (Reactome)
ligands of SLC29A1MetaboliteREACT_8358 (Reactome)
ligands of SLC29A1MetaboliteREACT_8580 (Reactome)
ligands of SLC29A2MetaboliteREACT_8574 (Reactome)
ligands of SLC29A2MetaboliteREACT_8842 (Reactome)
ligands of SLC29A3MetaboliteREACT_22517 (Reactome)
ligands of SLC29A3MetaboliteREACT_22952 (Reactome)
ligands of SLC29A4MetaboliteREACT_23205 (Reactome)
ligands of SLC29A4MetaboliteREACT_23305 (Reactome)
taurochenodeoxycholate MetaboliteCHEBI:9407 (ChEBI)
taurocholate MetaboliteCHEBI:28865 (ChEBI)
vitamins transported by SMVTMetaboliteREACT_22987 (Reactome)
vitamins transported by SMVTMetaboliteREACT_23003 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
6xSLC35D1REACT_6892 (Reactome)
ALBArrowREACT_10072 (Reactome)
ALBArrowREACT_10091 (Reactome)
ALBArrowREACT_10124 (Reactome)
CMP-SAArrowREACT_22111 (Reactome)
CMP-SAREACT_22111 (Reactome)
CMPArrowREACT_22111 (Reactome)
CMPREACT_22111 (Reactome)
FATP1/4/6REACT_23817 (Reactome)
GDP-ManArrowREACT_22122 (Reactome)
GDP-ManREACT_22122 (Reactome)
GMPArrowREACT_22122 (Reactome)
GMPREACT_22122 (Reactome)
Na+ArrowREACT_1504 (Reactome)
Na+ArrowREACT_2011 (Reactome)
Na+ArrowREACT_22320 (Reactome)
Na+ArrowREACT_714 (Reactome)
Na+REACT_1504 (Reactome)
Na+REACT_2011 (Reactome)
Na+REACT_22320 (Reactome)
Na+REACT_714 (Reactome)
REACT_10072 (Reactome) A molecule of extracellular bile salt (glyco- or taurocholate or taurochenodeoxycholate) or bile acid (cholate or chenodeoxycholate) is transported into the cytosol, mediated by OATP-A (SLCO1A2) in the plasma membrane. Bile salts and acids exist in the blood as complexes with serum albumin, and their uptake by OATP-A must involve disruption of this complex, but the molecular mechanism coupling release of a bile salt or acid from albumin to its uptake by OATP-A is unknown. In the body, OATP-A is expressed only at low levels on the basolateral surfaces of hepatocytes and may play only a minor role in the uptake of bile salts and acids by the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).
REACT_10091 (Reactome) A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-C (SLCO1B1) in the plasma membrane. Glyco- and taurocholate exist in the blood as complexes with serum albumin, and its uptake by OATP-C must involve disruption of this complex, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-C is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glyco- and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).
REACT_10124 (Reactome) A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).
REACT_1054 (Reactome) The plasma membrane-associated protein SLC29A1 mediates the reversible transport of one molecule of adenosine, cytosine, guanosine, inosine, thymidine, or uridine from the extracellular space to the cytosol.
REACT_1268 (Reactome) The plasma membrane-associated protein SLC29A2 mediates the reversible transport of one molecule of adenine, adenosine, cytidine, cytosine, guanine, guanosine, hypoxanthine, inosine, thymidine, thymine, uracil, or uridine from the cytosol to the extracellular space.
REACT_1504 (Reactome) The plasma membrane-associated protein SLC28A3 mediates the transport of one molecule of adenosine, cytidine, guanosine, inosine, thymidine, or uridine, and two sodium ions, from the extracellular space to the cytosol.
REACT_2011 (Reactome) The plasma membrane-associated protein SLC28A2 mediates the transport of one molecule of adenosine, guanosine, inosine, or uridine, and one sodium ion, from the extracellular space to the cytosol.
REACT_22111 (Reactome) The human gene SLC35A1 encodes the CMP-sialic acid transporter which mediates the antiport of CMP-sialic acid into the Golgi lumen in exchange for CMP (Ishida N et al, 1996). Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F). CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation (Martinez-Duncker I et al, 2005).
REACT_22122 (Reactome) The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the antiport of GDP-mannose into the Golgi lumen in exchange for GMP (Suda T et al, 2004; Ishida N et al, 2005).
REACT_22160 (Reactome) The human gene SLC35A3 encodes the UDP-GlcNAc transporter (Ishida N et al, 1999). It is ubiquitously expressed and resides on the Golgi membrane where it transports UDP- N-acetylglucosamine (GlcNAc) into the Golgi lumen in exchange for UMP.
REACT_22188 (Reactome) The human gene SLC29A4 encodes the equilibrative nucleoside transporter 4 (ENT4). It is ubiquitously expressed and mediates the reversible transport of the nucleoside adenosine at acidic pH (this transport is absent at pH 7.4) (Barnes K et al, 2006). ENT4 has also been shown to mediate the transport of biogenic amines such as serotonin, dopamine, norepinephrine and epinephrine. For this reason, ENT4 is also known as the plasma membrane monoamine transporter (PMAT) (Engel K et al, 2004).
REACT_22212 (Reactome) The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. ENT3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin SA et al, 2005). Defects in SLC29A3 are the cause of H syndrome, an autosomal recessive disorder(Molho-Pessach V et al, 2008).
REACT_22226 (Reactome) The human gene SLC33A1 encodes acetyl-CoA transporter AT1 (Kanamori A et al, 1997).Acetyl-CoA is transported to the lumen of the Golgi apparatus, where it serves as the substrate of acetyltransferases that modify the sialyl residues of gangliosides and glycoproteins. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) which is a neurodegenerative disorder (Lin P et al, 2008).
REACT_22255 (Reactome) The human gene SLC35B2 encodes the adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPST1) (Ozeran et al. 1996, Kamiyama et al. 2003). In human tissues, PAPST1 is highly expressed in the placenta and pancreas and present at lower levels in the colon and heart. The human gene SLC35B3 encodes a human PAPS transporter gene that is closely related to PAPST1. Called PAPST2, it is predominantly expressed in the colon (Kamiyama et al. 2006).
REACT_22259 (Reactome) The human gene SLC35C1 encodes the GDP-fucose transporter FUCT1. It resides on the Golgi membrane and mediates the transport of UDP-fucose into the Golgi lumen. Defects in SLC35C1 causes the congenital disorder of glycosylation type 2C, also known as leukocyte adhesion deficiency type II (LAD2) (Lubke T et al, 2001).
REACT_22287 (Reactome) The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars such as UDP-GlcNAc and UDP-glucose into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).
REACT_22299 (Reactome) The human gene SLC35A2 encodes the UDP-galactose transporter (Miura N et al, 1996). It is located on the Golgi membrane and mediates the antiport of UDP-Gal into the Golgi lumen in exchange for UMP. This transporter is also known to transport UDP-N-acetylgalactosamine (UDP-GalNAc) in the same way as UDP-Gal (Segawa H et al, 2002).
REACT_22300 (Reactome) The human gene SLC35B4 encodes the bifunctional UDP-xylose and UDP-N-acetylglucosamine transporter YEA4. YEA4 resides on the Golgi membrane and mediates the influx of UDP-xylose into the lumen (Ashikov A et al, 2005).
REACT_22315 (Reactome) The human gene SLC29A4 encodes the equilibrative nucleoside transporter 4 (ENT4). It is ubiquitously expressed and mediates the reversible transport of the nucleoside adenosine at acidic pH (this transport is absent at pH 7.4) (Barnes K et al, 2006). ENT4 has also been shown to mediate the transport of biogenic amines such as serotonin, dopamine, norepinephrine and epinephrine. For this reason, ENT4 is also known as the plasma membrane monoamine transporter (PMAT) (Engel K et al, 2004).
REACT_22320 (Reactome) Biotin (vitamin H or B7) is a water-soluble B-complex vitamin. Biotin is a cofactor in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis. D-Pantothoate (vitamin B5), is a water-soluble vitamin needed to form coenzyme-A (CoA), and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats. Lipoic acid is an organosulfur compound, the R-enantiomer of which is an essential cofactor for many enzyme complexes.

The human SLC5A6 encodes the Na+-dependent multivitamin transporter SMVT (Prasad PD et al, 1999; Wang H et al, 1999). SMVT co-transports these vitamins/cofactors into cells with Na+ ions electrogenically.
REACT_22323 (Reactome) The human gene SLC35B4 encodes the bifunctional UDP-xylose and UDP-N-acetylglucosamine transporter YEA4. YEA4 resides on the Golgi membrane and mediates the influx of UDP-N-acetylglucosamine into the lumen (Ashikov A et al, 2005).
REACT_22395 (Reactome) The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. ENT3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin SA et al, 2005). Defects in SLC29A3 are the cause of H syndrome, an autosomal recessive disorder(Molho-Pessach V et al, 2008).
REACT_23779 (Reactome) The human gene SLCO2A1 encodes prostaglandin transporter PGT. It is ubiquitously expressed and can transport PGD2, PGE1, PGE2 and PGF2A (Lu R et al, 1996).
REACT_23817 (Reactome) Of the six fatty acid transporter proteins (FATP) characterized, only three have been shown to mediate the influx into cells of long chain fatty acids (LCFAs); FATP1, 4 and 6. They have been shown to transport the prototypical LCFA oleic acid (OLEA) but are believed to be able to transport LCFAs with chain lengths longer than 10 carbons. FATP1 is highly expressed in adipose tissue and muscle (Hatch GM et al, 2002). FATP4 is the major intestinal LCFA transporter (Fitscher BA et al, 1998; Stahl A et al, 1999). FATP6 is localized to cardiac myocytes (Gimeno RE et al, 2003).
REACT_23822 (Reactome) The human gene SLCO3A1 encodes the organic anion transporting polypeptide D. Several variants are expressed but isoform 1 is ubiquitous and can transport a range of substrates including the prostaglandins E1 and E2, thyroxine and vasopressin (AVP) (Huber RD et al, 2007).
REACT_23829 (Reactome) SLCO2B1 (formerly OATP-B) is abundantly expressed in human liver, where it is localized at the basolateral membrane of hepatocytes. It has a narrow substrate range, able to transport bromosulphophthalein (BSP), estrone-3-sulphate and dehydroepiandrosterone-sulphate (DHEAS) (Kullak-Ublick GA et al, 2001).
REACT_23909 (Reactome) Digoxin is a commonly prescribed drug for the treatment of heart failure. It is mainly eliminated from the body by the kidneys. Human SLCO4C1 (formerly OATP-H) is the first member of the organic anion transporting polypeptide (OATP) family expressed in human kidney. It is found on the baolateral membrane of the nephron and is thought to be the first step of the transport of digoxin into urine (Mikkaichi T et al, 2004).
REACT_23913 (Reactome) Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thryoid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara K et al, 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe T et al, 1999; Hsiang B et al, 1999). SLCO4A1 (formerly OATP-E) is mainly expressed in peripheral tissue and has a broad substrate specificty (Tamai I et al, 2000). SLCO1C1 (formerly OATP-F) is highly expressed in brain and is also a high affinity thyroid hormone transporter (Pizzagalli F et al, 2002).
REACT_6892 (Reactome) The human gene SLC35D1 encodes the UDP-glucuronic acid transporter which transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen (Muraoka et al. 2001).
REACT_714 (Reactome) The plasma membrane-associated protein SLC28A1 mediates the transport of one molecule of 2'-deoxyadenosine, adenosine, cytidine, thymidine, or uridine, and one sodium ion, from the extracellular space to the cytosol.
REACT_806 (Reactome) The plasma membrane-associated protein SLC29A1 mediates the reversible transport of one molecule of adenosine, guanosine, inosine, or uridine from the cytosol to the extracellular space.
REACT_958 (Reactome) The plasma membrane-associated protein SLC29A2 mediates the reversible transport of one molecule of adenine, adenosine, cytidine, cytosine, guanine, guanosine, hypoxanthine, inosine, thymidine, thymine, uracil, or uridine from the extracellular space to the cytosol.
SLC28A1REACT_714 (Reactome)
SLC28A2REACT_2011 (Reactome)
SLC28A3REACT_1504 (Reactome)
SLC29A1REACT_1054 (Reactome)
SLC29A1REACT_806 (Reactome)
SLC29A2REACT_1268 (Reactome)
SLC29A2REACT_958 (Reactome)
SLC29A3REACT_22212 (Reactome)
SLC29A3REACT_22395 (Reactome)
SLC29A4REACT_22188 (Reactome)
SLC29A4REACT_22315 (Reactome)
SLC33A1REACT_22226 (Reactome)
SLC35A1REACT_22111 (Reactome)
SLC35A2REACT_22299 (Reactome)
SLC35A3REACT_22160 (Reactome)
SLC35B2,3REACT_22255 (Reactome)
SLC35B4REACT_22300 (Reactome)
SLC35B4REACT_22323 (Reactome)
SLC35C1REACT_22259 (Reactome)
SLC35D2REACT_22122 (Reactome)
SLC35D2REACT_22287 (Reactome)
SLC5A6REACT_22320 (Reactome)
SLCO1A2REACT_10072 (Reactome)
SLCO1B1REACT_10091 (Reactome)
SLCO1B3REACT_10124 (Reactome)
SLCO2A1REACT_23779 (Reactome)
SLCO2B1REACT_23829 (Reactome)
SLCO3A1-1REACT_23822 (Reactome)
SLCO4C1REACT_23909 (Reactome)
Thyroid hormone transporting SLCOsREACT_23913 (Reactome)
UDP-Gal transporter substratesArrowREACT_22299 (Reactome)
UDP-Gal transporter substratesREACT_22299 (Reactome)
UDP-GlcAArrowREACT_6892 (Reactome)
UDP-GlcAREACT_6892 (Reactome)
UDP-GlcNAcArrowREACT_22160 (Reactome)
UDP-GlcNAcArrowREACT_6892 (Reactome)
UDP-GlcNAcREACT_22160 (Reactome)
UDP-GlcNAcREACT_6892 (Reactome)
UDP-sugarsArrowREACT_22287 (Reactome)
UDP-sugarsREACT_22287 (Reactome)
UMPArrowREACT_22160 (Reactome)
UMPArrowREACT_22287 (Reactome)
UMPArrowREACT_22299 (Reactome)
UMPREACT_22160 (Reactome)
UMPREACT_22287 (Reactome)
UMPREACT_22299 (Reactome)
bile salts and acids ArrowREACT_10072 (Reactome)
cholate bile saltsArrowREACT_10091 (Reactome)
cholate bile saltsArrowREACT_10124 (Reactome)
ligands of SLC28A1ArrowREACT_714 (Reactome)
ligands of SLC28A1REACT_714 (Reactome)
ligands of SLC28A2ArrowREACT_2011 (Reactome)
ligands of SLC28A2REACT_2011 (Reactome)
ligands of SLC28A3ArrowREACT_1504 (Reactome)
ligands of SLC28A3REACT_1504 (Reactome)
vitamins transported by SMVTArrowREACT_22320 (Reactome)
vitamins transported by SMVTREACT_22320 (Reactome)
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