Host Interactions of HIV factors (Homo sapiens)

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302836927494, 3612, 446, 29172013084211, 25, 45409373349132718, 4341303263042272731, 40, 41134992812, 224230291712, 14, 1610, 212, 19, 24, 32, 46...3817497, 26Nef:class I MHCcomplex:AP-1:PACS-1Complex [earlyendosome membrane]class I MHC complex[Golgi membrane]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]Ran GTPase:GDP[cytosol]Cul5-SCF complex[cytosol]AP-2 Complex[cytosol]Vpr:importin-alphacomplex [cytosol]CD4:Nef:AP-2Complex:v-ATPaseComplex [plasmamembrane]class I MHC complex[early endosomemembrane]Fyn:Nef Complex[cytosol]APOBEC3G:Vif:Cul5:SCFcomplex [cytosol]Nuclear Pore Complex(NPC) [nuclearenvelope]AP-1 Complex[cytosol]Rev:Importin-beta:B23[nucleoplasm]class I MHC complex[Golgi membrane]Ran-GTP[nucleoplasm]Nup107 Complex[nuclear envelope]AP-1 Complex[cytosol]mitochondrial matrixnucleoporin-associatedRev:Importin-beta:B23complex [nuclearenvelope]RT [cytosol]Ran-GTP[nucleoplasm]Cul5-SCF complex[cytosol]Ub [cytosol]class I MHC complex[Golgi membrane]IN bound to sticky3' ends of viral DNAin PIC [cytosol]RanBP1:Ran-GTP:CRM1:Rev-boundmRNA complex[cytosol]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]CD4:Vpu:beta-TrCP_1:Skp1complex [endoplasmicreticulum membrane]viral DNA with 3'sticky ends[cytosol]viral DNA with 3'sticky ends[cytosol]APOBEC3G:Vif:Cul5:SCFcomplex [cytosol]Nup107 Complex[nuclear envelope]Crm1:Ran GTPase:GTP[cytosol]Nef:class I MHCcomplex:Ap-1:PACS-1Complex [Golgimembrane]Nup107 Complex[nuclear envelope]APOBEC3G:RTC withdeaminated minussssDNA:tRNAprimer:RNA template[cytosol]Rev multimer-boundHIV-1 mRNA[nucleoplasm]multi-ubiquitinatedAPOBEC3G:Vif:Cul5:SCFcomplex [cytosol]AP-2 Complex[cytosol]Matrix [cytosol]CD4:Vpu:beta-TrCP_1[endoplasmicreticulum membrane]Rev-bound HIV-1 mRNA[nucleoplasm]CD8:Nef:AP-2Complex:v-ATPaseComplex [plasmamembrane]AP-2 Complex[cytosol]CD28:Nef:Clathrin-coatedPit Adapter ProteinComplex [plasmamembrane]Vif:APOBEC3G complex[cytosol]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]Tat:P-TEFb(CyclinT1:Cdk9) complex[nucleoplasm]APOBEC3G [cytosol]cytosolRev-bound HIV-1 mRNA[nucleoplasm]Ran:GTP [cytosol]Rev-bound HIV-1 mRNA[nucleoplasm]InternalizedCD8:Nef:Clathrin-CoatedPit AdapterProtein:v-ATPase[early endosomemembrane]Golgi lumenP-TEFb(CyclinT1:Cdk9) complex[nucleoplasm]Rev multimer-boundHIV-1 mRNA:CRM1complex[nucleoplasm]Nef:class I MHCcomplex [Golgimembrane]Vif:Cul5:SCF complex[cytosol]Importin-beta:RanGTP complex[nucleoplasm]Nup62 Complex[nuclear envelope]Nuclear Pore Complex(NPC) [nuclearenvelope]PIC anchored to theNPC [nuclearenvelope]Importin beta-1:Revmultimer complex[nucleoplasm]Importin beta-1:Revmultimer complex[cytosol]AP-2 Complex[cytosol]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]RT [cytosol]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTP[nucleoplasm]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTP:NPC[nuclear envelope]Matrix [cytosol]Importin beta-1:Revmultimer complex[nucleoplasm]AP-1 mu [cytosol]RTC with minussssDNA containingdeaminated Cresidues:tRNAprimer:RNA template[cytosol]Rev-bound HIV-1 mRNA[nucleoplasm]endoplasmic reticulum lumenIN bound to sticky3' ends of viral DNAin PIC [cytosol]Nef:CD28 Complex[plasma membrane]Hck-1:Nef [cytosol]Nup62 Complex[nuclear envelope]P-TEFb(CyclinT1:Cdk9) complex[nucleoplasm]26S proteasome[cytosol]AP-1 sigma [cytosol]CD28:Nef:Clathrin-coatedPit Adapter Protein[cytosol]APOBEC3G [cytosol]CD4:Vpu complex[endoplasmicreticulum membrane]APOBEC3G:RTC withminus sssDNA:tRNAprimer:RNA template[cytosol]Ran-GTP[nucleoplasm]IN bound to sticky3' ends of viral DNA[cytosol]Rev-bound HIV-1 mRNA[nucleoplasm]CD4:Lck Complex[plasma membrane]AP-1 Complex[cytosol]DOCK2:ELMO1:RAC1:NefComplex [cytosol]Nef:T cell Receptorzeta:Lipid Raft: Pak2 Complex [plasmamembrane]nucleoplasmRan-GTP[nucleoplasm]AP-1 sigma [cytosol]Ub [cytosol]Ran-GDP[nucleoplasm]RT [cytosol]IN bound to sticky3' ends of viral DNAin PIC [cytosol]InternalizedCD4:Nef:Clathrin-CoatedPit AdapterProtein:v-ATPase[early endosomemembrane]p6 protein [cytosol]AP-2 Complex[cytosol]p6 protein [cytosol]CD4:Vpu complex[endoplasmicreticulum membrane]Matrix [cytosol]CD4:Vpu complex[endoplasmicreticulum membrane]CD8:Nef Complex[plasma membrane]IN bound to sticky3' ends of viral DNAin PIC [cytosol]CD4:Vpu:beta-TrCP_1[endoplasmicreticulum membrane]APOBEC3G [cytosol]Nup107 Complex[nuclear envelope]Lck:Nef [cytosol]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTP[cytosol]Ran-GTP[nucleoplasm]APOBEC3G:HIV-1PIC[cytosol]Vpu:beta-TrCP1:Skp1complex [endoplasmicreticulum membrane]early endosome membraneminus sssDNA:RNAtemplate:tRNA primer[cytosol]Rev:Importin-beta:B23[nucleoplasm]Rev multimer-boundHIV-1 mRNA:CRM1complex[nucleoplasm]Rev:importin-beta:B23:Ran-GTPcomplex[nucleoplasm]p6 protein [cytosol]AP-1 mu [cytosol]AP-2 Complex[cytosol]APOBEC3G [cytosol]Cul5-SCF complex[cytosol]ADP/ATP translocasemonomer (generic)[mitochondrial innermembrane]Rev:Importin-beta:NPM1[cytosol]mitochondrial intermembrane spacep6 protein [cytosol]APOBEC3G [cytosol]CD4:Vpu:beta-TrCP_1[endoplasmicreticulum membrane]Nuclear Pore Complex(NPC) [nuclearenvelope]ANT1:Vpr complex[mitochondrial innermembrane]Arf1:Nef:endosomalCD4 [early endosomemembrane]IN bound to sticky3' ends of viral DNA[cytosol]Importin beta-1:Revmultimer complex[cytosol]early endosome membraneRan:GTP [cytosol]Ran-GTP[nucleoplasm]AP-1 sigma [cytosol]CD4:Vpu:beta-TrCP_1:Skp1complex [endoplasmicreticulum membrane]Rev-bound HIV-1 mRNA[cytosol]Rev:Importin-beta:NPM1[cytosol]Rev multimer-boundHIV-1 mRNA[nucleoplasm]CD4:Nef Complex[plasma membrane]Crm1:Ran GTPase:GTP[cytosol]p6 protein [cytosol]minus sssDNAcontainingdeaminated Cresidues:RNAtemplate:tRNA primer[cytosol]26S proteasome[cytosol]RTC with minussssDNA:tRNAprimer:RNA template[cytosol]Vif:APOBEC3G complex[cytosol]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]Rev-bound HIV-1 mRNA[cytosol]p6 protein [cytosol]Matrix [cytosol]Vif:APOBEC3G complex[cytosol]Rev multimer-boundHIV-1 mRNA[nucleoplasm]p6 protein [cytosol]Adaptor proteincomplex 2 (AP-2)large adaptins[cytosol]AP-1 mu [cytosol]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTP[cytosol]Rev multimer-boundHIV-1 mRNA[nucleoplasm]IN bound to sticky3' ends of viral DNA[cytosol]multiubiquitinatedCD4:Vpu:beta-TrCP_1:Skp1complex [endoplasmicreticulum membrane]AP-2 Complex[cytosol]Nef:CD28 Complex[plasma membrane]Nuclear Pore Complex(NPC) [nuclearenvelope]Rev multimer-boundHIV-1 mRNA [cytosol]APOBEC3G [cytosol]viral DNA with 3'sticky ends[cytosol]viral DNA with 3'sticky ends[cytosol]Matrix [cytosol]Nup62 Complex[nuclear envelope]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTP[nucleoplasm]Rev multimer-boundHIV-1 mRNA [cytosol]Matrix [cytosol]Ran:GTP [cytosol]CD4:Nef Complex[plasma membrane]RTC with minussssDNA:tRNAprimer:RNA template[cytosol]Nup62 Complex[nuclear envelope]CD4:Vpu complex[endoplasmicreticulum membrane]minus sssDNA:RNAtemplate:tRNA primer[cytosol]IN bound to sticky3' ends of viral DNA[cytosol]Cul5-SCF complex[cytosol]Rev multimer-boundHIV-1 mRNA:CRM1complex[nucleoplasm]Matrix [cytosol]CD8:Nef Complex[plasma membrane]Importin beta-1:Revmultimer complex[cytosol]Ran-GTPmyristoylated NefProtein(UniProt:P04601)[cytosol]NUPL2 [cytosol]Importin-beta:RanGTP complexTCEB1 [cytosol]PSMB5 [cytosol]PSIP1 [cytosol]PACS1(2-963)RAE1 [nuclearenvelope]SEH1L-2 [nuclearenvelope]UBA52(1-76)[cytosol]PSMA3 [cytosol]CUL5 [cytosol]Nup45 [nuclearenvelope]UBC(533-608)[cytosol]POM121 [nuclearenvelope]KPNA1myristoylated NefProtein(UniProt:P04601)[cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]UBB(1-76) [cytosol]RBX1 [cytosol]26S proteasomeNUP98-5 [nuclearenvelope]NUP155 [nuclearenvelope]p6 (P04585) protein[cytosol]AP1G1 [cytosol]ATP6V1HArf1:Nef:endosomalCD4SKP1myristoylated NefProtein(UniProt:P04601)[cytosol]MA (P04591) protein[cytosol]NUPL1-2 [nuclearenvelope]VIF (P69723) protein[cytosol]ADP/ATP translocasemonomer (generic)ATP6V1H [cytosol]PSMA7(2-248)[cytosol]VIF (P69723) protein[cytosol]CD4 [early endosome]IN (Integrase)(P04585) protein[cytosol]RPS27A(1-76)[cytosol]KPNB1 [nucleoplasm]PSMD2 [cytosol]REV (P04618) protein[cytosol]AP2A2(1-939)[cytosol]VPU (P05919)[endoplasmicreticulum membrane]APOBEC3G:RTC withdeaminated minussssDNA:tRNAprimer:RNA templateNUP155 [nuclearenvelope]POM121 [nuclearenvelope]NUP98-5 [nuclearenvelope]AP1S1 [cytosol]AP1B1 [cytosol]AP2M1 [cytosol]AP2A1 [cytosol]NUP54 [nuclearenvelope]PSMC1(2-440)[cytosol]HIV-1 mRNA[nucleoplasm]RanBP1:Ran-GTP:CRM1:Rev-boundmRNA complexMA (P04591) protein[cytosol]CD4 [early endosome]REV (P04618) protein[cytosol]NUP210 [nuclearenvelope]ATP6V1H [plasmamembrane]PPIA [cytosol]p6 (P04591) protein[cytosol]Nef:class I MHCcomplex:Ap-1:PACS-1ComplexPSIP1 [cytosol]PSMD11 [cytosol]HLA class Ihistocompatibilityantigen, A-2 alphachain [Golgimembrane]PSMD1 [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]UBC(457-532)[cytosol]AAAS [nuclearenvelope]UBC(229-304)[cytosol]PSIP1 [cytosol]p51 (RT) [cytosol]H2OBTRC [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]NUPL1-2 [nuclearenvelope]NUP188(2-1749)[nuclear envelope]HIV-1 mRNAVPU (P05919) protein[cytosol]UBC(153-228)[cytosol]RCC1PSME2 [cytosol]RANBP2 [cytosol]PSMB2 [cytosol]XPO1 [nucleoplasm]Rev:importin-beta:B23:Ran-GTPcomplexCDK9 [nucleoplasm]MA (P04585) protein[cytosol]RAE1 [nuclearenvelope]MA (P04585) protein[cytosol]p6 (P04591) protein[cytosol]IN (Integrase)(P04585) protein[cytosol]AP1M2(2-423)[cytosol]REV (P04618) protein[cytosol]NUP188(2-1749)[nuclear envelope]AP-2 ComplexTCEB2 [cytosol]VPU (P05919) protein[cytosol]DOCK2AP2A2(1-939)[cytosol]B2M(21-119) [earlyendosome membrane]PSMB2 [cytosol]SEH1L-2 [nuclearenvelope]MA (P04591) protein[cytosol]APOBEC3G-3 [cytosol]PAK2(1-524) [plasmamembrane]HLA class Ihistocompatibilityantigen, A-2 alphachain [earlyendosome membrane]CUL5 [cytosol]NUP155 [nuclearenvelope]AP1G1 [cytosol]Reversetranscriptase/ribonucleaseH [cytosol]PSMB4 [cytosol]NUP153 [nucleoplasm]KPNA1 [cytosol]HLA class Ihistocompatibilityantigen, A-2 alphachain [Golgimembrane]CD8B [plasmamembrane]RBX1 [cytosol]NUP153 [nucleoplasm]ATP6V1H [plasmamembrane]MA (P04591) protein[cytosol]RANGAP1XPO1 [cytosol]NUP133 [nuclearenvelope]Hck-1:NefSKP1 [cytosol]AP2A1 [cytosol]IN (Integrase)(P04585) protein[cytosol]CD4:Vpu:beta-TrCP_1VIF (P69723) protein[cytosol]AP1M2(2-423)[cytosol]NUP188(2-1749)[nuclear envelope]InternalizedCD4:Nef:Clathrin-CoatedPit AdapterProtein:v-ATPaseREV (P04618) protein[nucleoplasm]AP2M1 [cytosol]ELMO1HCK(2-526)PSMF1(2-271)[cytosol]HMGA1 [cytosol]p6 (P04591) protein[cytosol]NUP88 [cytosol]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTPVPR (P69726) proteinp6 (P04585) protein[cytosol]PSMA8 [cytosol]RAN [nucleoplasm]NUP37 [nuclearenvelope]CD28 [plasmamembrane]NUP62 [nuclearenvelope]MA (P04585) protein[cytosol]FYN(2-537)CDK9 [nucleoplasm]NUP107 [nuclearenvelope]NUP107 [nuclearenvelope]PSMD1 [cytosol]BTRC [cytosol]REV (P04618) protein[cytosol]PSMA1 [cytosol]Rev-multimerNUP85 [nuclearenvelope]NUP214 [cytosol]KPNB1 [nucleoplasm]PSMD3 [cytosol]PSMD4(2-377)[cytosol]AP2A2(1-939)[cytosol]AP2M1 [cytosol]MA (P04591) protein[cytosol]NUP155 [nuclearenvelope]PSMC2 [cytosol]UBC(77-152)[cytosol]XPO1 [nucleoplasm]RAC1-1HIV-1 mRNA[nucleoplasm]PSMD12 [cytosol]AP1M1 [cytosol]UBB(77-152)[cytosol]NUP210 [nuclearenvelope]PSMD10 [cytosol]RTC with minussssDNA:tRNAprimer:RNA templateInternalizedCD8:Nef:Clathrin-CoatedPit AdapterProtein:v-ATPaseVPR (P69726) protein[cytosol]AP2S1 [cytosol]VIF (P69723) protein[cytosol]AP2A1 [cytosol]REV (P04618) protein[nucleoplasm]PSMC5 [cytosol]myristoylated NefProtein(UniProt:P04601)PSME3 [cytosol]AP2A1 [cytosol]NPM1RAN [nucleoplasm]RAC1-1 [cytosol]PSMB4 [cytosol]UBB(153-228)[cytosol]NUP133 [nuclearenvelope]HIV-1 mRNA [cytosol]PSME1 [cytosol]XPO1 [nucleoplasm]UBB(153-228)[cytosol]Fyn:Nef Complexp6 (P04591) protein[cytosol]HMGA1 [cytosol]PSMB3 [cytosol]PSMA3 [cytosol]Nef:class I MHCcomplexNUP88 [cytosol]GTP [nucleoplasm]AP2A2(1-939)[cytosol]SKP1 [cytosol]NUPL2 [cytosol]REV (P04618) protein[cytosol]AP2B1 [cytosol]p51 (RT) [cytosol]Cul5-SCF complexNup45 [nuclearenvelope]Vpr:importin-alphacomplexPSMB5 [cytosol]VIF (P69723) protein[cytosol]NPM1 [cytosol]RANBP2 [cytosol]NH3NUP160 [nuclearenvelope]NUP88 [cytosol]VPU (P05919) protein[cytosol]AP2B1 [cytosol]Reversetranscriptase/ribonucleaseH [cytosol]AP2B1 [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]UBC(305-380)[cytosol]AAAS [nuclearenvelope]AAAS [nuclearenvelope]PSMC6(2-389)[cytosol]PPIA [cytosol]PSMB6 [cytosol]PPIA [cytosol]RBX1 [cytosol]PSMD14 [cytosol]CD4REV (P04618) protein[cytosol]REV (P04618) protein[nucleoplasm]NUP93 [nuclearenvelope]VPU (P05919)[endoplasmicreticulum membrane]CD247-1 [plasmamembrane]FYN(2-537) [cytosol]GDPNUP43 [nuclearenvelope]AP-1 ComplexNUP37 [nuclearenvelope]VPU (P05919) protein[cytosol]p6 (P04585) protein[cytosol]NUPL2 [cytosol]APOBEC3G-3 [cytosol]NUP214 [cytosol]VPR (P69726) protein[nucleoplasm]VPU (P05919) protein[cytosol]UBC(457-532)[cytosol]PAK2(1-524)CCNT1 [nucleoplasm]NUP50 [nucleoplasm]IN (Integrase)(P04585) protein[cytosol]Rev-bound HIV-1 mRNANUP210 [nuclearenvelope]NPM1 [nucleoplasm]ATP6V1HAP2A2(1-939)[cytosol]VIF (P69723) protein[cytosol]PSMB6 [cytosol]RANBP1(2-201)[nuclear envelope]class I MHC complexUBC(381-456)[cytosol]AP1S2 [cytosol]UBC(609-684)[cytosol]NUP62 [nuclearenvelope]PACS1(2-963)[cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]NUP160 [nuclearenvelope]PSMA5 [cytosol]ARF1(2-181)[cytosol]TCEB1 [cytosol]TPR [nucleoplasm]BTRC [cytosol]PSMA5 [cytosol]AP1S3 [cytosol]PSMB1 [cytosol]RAE1 [nuclearenvelope]CUL5 [cytosol]Ubmyristoylated NefProtein(UniProt:P04601)PSMA6 [cytosol]ELMO1 [cytosol]Ran-GDPNPM1PSMB8 [cytosol]GTPAP1S3 [cytosol]PSME1 [cytosol]AP-2 ComplexRan GTPase:GDPVPU (P05919) protein[cytosol]HMGA1 [cytosol]NUP153 [nucleoplasm]CD4BANF1 [cytosol]NUP133 [nuclearenvelope]PSMA6 [cytosol]Nef:CD28 Complexmyristoylated NefProtein(UniProt:P04601)[cytosol]AP1B1 [cytosol]RAN [nucleoplasm]Tat (P04608)[nucleoplasm]Vif:Cul5:SCF complexAP2A1 [cytosol]PSMA4 [cytosol]Vif:APOBEC3G complexCD4 [endoplasmicreticulum membrane]UBB(77-152)[cytosol]UBA52(1-76)[cytosol]VPR (P69726) protein[cytosol]NUP54 [nuclearenvelope]REV (P04618) proteinXPO1Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTPmulti-ubiquitinatedAPOBEC3G:Vif:Cul5:SCFcomplexCD4 [endoplasmicreticulum membrane]TPR [nucleoplasm]CD4:Vpu:beta-TrCP_1:Skp1complexCD4:Nef:AP-2Complex:v-ATPaseComplexPSMD5 [cytosol]RAE1 [nuclearenvelope]UBB(1-76) [cytosol]AP2M1 [cytosol]TCEB1 [cytosol]GDP [cytosol]CD4 [endoplasmicreticulum membrane]Nef:class I MHCcomplex:AP-1:PACS-1ComplexSLC25A4[mitochondrial innermembrane]AP1B1 [cytosol]VPU (P05919)[endoplasmicreticulum membrane]TPR [nucleoplasm]NUP133 [nuclearenvelope]POM121 [nuclearenvelope]PSMB9 [cytosol]UBC(153-228)[cytosol]AP2M1 [plasmamembrane]PSMD13 [cytosol]NUP85 [nuclearenvelope]Tat:P-TEFb(CyclinT1:Cdk9) complexLCKPSMF1(2-271)[cytosol]PSMD11 [cytosol]nucleoporin-associatedRev:Importin-beta:B23complexCD8B [early endosomemembrane]Rev:Importin-beta:NPM1GDP [nucleoplasm]DOCK2:ELMO1:RAC1:NefComplexSKP1 [cytosol]p6 (P04591) protein[cytosol]TPR [nucleoplasm]IN (Integrase)(P04585) protein[cytosol]NUP50 [nucleoplasm]PSMD9 [cytosol]MA (P04591) protein[cytosol]NUP107 [nuclearenvelope]AP2A1 [cytosol]PSMB8 [cytosol]AP1S2 [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]RAN [nucleoplasm]AP2S1 [cytosol]APOBEC3G-3 [cytosol]UBC(1-76) [cytosol]NUP160 [nuclearenvelope]AP2A2(1-939)[cytosol]PSMD14 [cytosol]NUP50 [nucleoplasm]HIV-1 mRNA[nucleoplasm]Lck:NefAP1M1 [cytosol]REV (P04618) protein[cytosol]p6 (P04585) protein[cytosol]AP-2 ComplexNUP205(2-2012)[nuclear envelope]PSMD5 [cytosol]CD4 [plasmamembrane]NUP37 [nuclearenvelope]TCEB1 [cytosol]Tat (P04608)p6 (P04585) protein[cytosol]GTP [nucleoplasm]NUPL1-2 [nuclearenvelope]GTP [nucleoplasm]Nup45 [nuclearenvelope]IN (Integrase)(P04585) protein[cytosol]PSMB3 [cytosol]RANBP1(2-201)MA (P04585) protein[cytosol]Rev multimer-boundHIV-1 mRNAVIF (P69723) protein[cytosol]NUP85 [nuclearenvelope]AP2S1 [cytosol]BTRCNUP88 [cytosol]PSMC6(2-389)[cytosol]RANBP2 [cytosol]PSMA4 [cytosol]NUP43 [nuclearenvelope]26S proteasomeAP2M1 [cytosol]NUP188(2-1749)[nuclear envelope]NUP54 [nuclearenvelope]myristoylated NefProtein(UniProt:P04601)[cytosol]APOBEC3G:RTC withminus sssDNA:tRNAprimer:RNA templateHLA class Ihistocompatibilityantigen, A-2 alphachain [Golgimembrane]CD28ATP6V1HDOCK2 [cytosol]HIV-1 mRNA [cytosol]AAAS [nuclearenvelope]AP1G1 [cytosol]REV (P04618) proteinAP2M1APOBEC3GUBC(229-304)[cytosol]PSMB7 [cytosol]MA (P04585) protein[cytosol]PSME2 [cytosol]CD4:Lck ComplexNUPL1-2 [nuclearenvelope]myristoylated NefProtein(UniProt:P04601)[cytosol]TCEB2 [cytosol]CD28 [plasmamembrane]AP2A1 [cytosol]VIF (P69723) protein[cytosol]HIV-1 unspliced RNAARF1(2-181)B2M(21-119) [Golgimembrane]VIF (P69723) protein[cytosol]ANT1:Vpr complexCD28:Nef:Clathrin-coatedPit Adapter ProteinComplexAP1S1 [cytosol]PACS1(2-963)[cytosol]CD4:Nef ComplexRev:Importin-beta:B23Nuclear Pore Complex(NPC)B2M(21-119) [Golgimembrane]PSMD8 [cytosol]PSMC3 [cytosol]ATP6V1HPSMB1 [cytosol]SEH1L-2 [nuclearenvelope]CD4 [endoplasmicreticulum membrane]NUP62 [nuclearenvelope]NUP35 [nuclearenvelope]AP2M1 [cytosol]AP2A2(1-939)[cytosol]Nup45 [nuclearenvelope]PSMD7(2-324)[cytosol]RAN [nucleoplasm]PSMC2 [cytosol]AP2S1 [cytosol]NUP93 [nuclearenvelope]BTRC [cytosol]KPNB1 [cytosol]Nef:T cell Receptorzeta:Lipid Raft: Pak2 ComplexRAN [cytosol]Rev multimer-boundHIV-1mRNA:Crm1:Ran:GTP:NPCGTP [cytosol]LCKVPR (P69726) protein[nucleoplasm]PSMA8 [cytosol]PSMB11 [cytosol]VPU (P05919)[endoplasmicreticulum membrane]PSMD2 [cytosol]p6 (P04591) protein[cytosol]PSMC3 [cytosol]PSMB11 [cytosol]BANF1 [cytosol]TCEB2 [cytosol]NUP107 [nuclearenvelope]PSMA2 [cytosol]HIV-1 RNA template[cytosol]p51 (RT) [cytosol]RAN [nucleoplasm]PSME3 [cytosol]GTP [nucleoplasm]NUP43 [nuclearenvelope]UBC(77-152)[cytosol]GTP [nucleoplasm]HIV-1 mRNA[nucleoplasm]MA (P04585) protein[cytosol]PSMD3 [cytosol]PSMB7 [cytosol]VPR (P69726) protein[mitochondrialintermembrane space]PSMD8 [cytosol]AP2B1 [cytosol]REV (P04618) protein[cytosol]MA (P04585) protein[cytosol]RAN [cytosol]Vpu:beta-TrCP1:Skp1complexPSMB9 [cytosol]VPU (P05919)[endoplasmicreticulum membrane]NUP214 [cytosol]CD247-1RBX1 [cytosol]RANBP2 [cytosol]PSMA1 [cytosol]CD8B [plasmamembrane]multiubiquitinatedCD4:Vpu:beta-TrCP_1:Skp1complexNUP160 [nuclearenvelope]SLC25A6[mitochondrial innermembrane]NUP98-5 [nuclearenvelope]SLC25A5[mitochondrial innermembrane]myristoylated NefProtein(UniProt:P04601)[cytosol]UBC(609-684)[cytosol]SEH1L-2 [nuclearenvelope]LCK [cytosol]PSIP1 [cytosol]PSMD6(2-389)[cytosol]NUP35 [nuclearenvelope]AP2M1 [cytosol]NUP210 [nuclearenvelope]p6 (P04591) protein[cytosol]HMGA1 [cytosol]Rev-multimerGTP [nucleoplasm]PIC anchored to theNPCXPO1myristoylated NefProtein(UniProt:P04601)[cytosol]PSMC4 [cytosol]APOBEC3G-3 [cytosol]PiRan:GTPGTP [cytosol]B2M(21-119) [Golgimembrane]NUP50 [nucleoplasm]POM121 [nuclearenvelope]AP1S3 [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]UBC(305-380)[cytosol]VPR (P69726) protein[nucleoplasm]TCEB2 [cytosol]AP2S1 [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]UBC(381-456)[cytosol]NPM1 [cytosol]REV (P04618) protein[nucleoplasm]CCNT1 [nucleoplasm]AP1S1 [cytosol]PSME4 [cytosol]NUP205(2-2012)[nuclear envelope]Ran-GTPNUP93 [nuclearenvelope]HIV-1 RNA template[cytosol]NUP35 [nuclearenvelope]CD4 [plasmamembrane]UBC(1-76) [cytosol]APOBEC3G:HIV-1PICNUP205(2-2012)[nuclear envelope]NUP62 [nuclearenvelope]AP2B1 [cytosol]GTP [cytosol]CD8:Nef ComplexNUP35 [nuclearenvelope]HIV-1 RNA template[cytosol]KPNB1 [cytosol]myristoylated NefProtein(UniProt:P04601)NUP98-5 [nuclearenvelope]VPU (P05919)IN bound to sticky3' ends of viral DNAin PICIN (Integrase)(P04585) protein[cytosol]PSMD12 [cytosol]HCK(2-526) [cytosol]MA (P04591) protein[cytosol]P-TEFb(CyclinT1:Cdk9) complexImportin beta-1:Revmultimer complexKPNB1 [cytosol]NUP214 [cytosol]AP1S2 [cytosol]KPNB1 [nucleoplasm]UBC(533-608)[cytosol]myristoylated NefProtein(UniProt:P04601)RAN [cytosol]XPO1 [cytosol]CD4 [plasmamembrane]NPM1 [nucleoplasm]NUP93 [nuclearenvelope]CD4:Vpu complexVIF (P69723) protein[cytosol]AP2B1 [cytosol]PSMB10 [cytosol]PSMD6(2-389)[cytosol]PSMD9 [cytosol]NUPL2 [cytosol]VIF (P69723) proteinPSMB10 [cytosol]Lipid RaftPSMC1(2-440)[cytosol]p6 (P04585) protein[cytosol]p6 (P04585) protein[cytosol]AP1M1 [cytosol]CUL5 [cytosol]HIV-1 mRNA[nucleoplasm]REV (P04618) protein[cytosol]APOBEC3G-3 [cytosol]LCK [cytosol]NUP205(2-2012)[nuclear envelope]CD28:Nef:Clathrin-coatedPit Adapter ProteinPSMD7(2-324)[cytosol]REV (P04618) protein[nucleoplasm]AP1M2(2-423)[cytosol]PSMC5 [cytosol]AP2B1 [cytosol]KPNB1myristoylated NefProtein(UniProt:P04601)[cytosol]APOBEC3G-3 [cytosol]PSMC4 [cytosol]APOBEC3G:Vif:Cul5:SCFcomplexCD28 [cytosol]PSMA2 [cytosol]PSME4 [cytosol]NUP85 [nuclearenvelope]AP2S1 [cytosol]BANF1 [cytosol]VPR (P69726) protein[cytosol]PSMD4(2-377)[cytosol]RAN [cytosol]VPU (P05919) protein[cytosol]BANF1 [cytosol]Rev multimer-boundHIV-1 mRNA:CRM1complexVPR (P69726) protein[nucleoplasm]CD8:Nef:AP-2Complex:v-ATPaseComplexVIF (P69723) protein[cytosol]NUP54 [nuclearenvelope]PSMA7(2-248)[cytosol]NUP43 [nuclearenvelope]AP2S1 [cytosol]RAN [nucleoplasm]PSMD13 [cytosol]myristoylated NefProtein(UniProt:P04601)[cytosol]NUP153 [nucleoplasm]PSMD10 [cytosol]NUP37 [nuclearenvelope]AP2M1 [cytosol]RPS27A(1-76)[cytosol]ATP6V1H [cytosol]Reversetranscriptase/ribonucleaseH [cytosol]VPR (P69726) protein395, 23, 3439353515, 35


Description

Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=162909

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Bibliography

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  27. Wei P, Garber ME, Fang SM, Fischer WH, Jones KA.; ''A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.''; PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
114683view16:15, 25 January 2021ReactomeTeamReactome version 75
113130view11:19, 2 November 2020ReactomeTeamReactome version 74
112362view15:29, 9 October 2020ReactomeTeamReactome version 73
101263view11:15, 1 November 2018ReactomeTeamreactome version 66
100801view20:43, 31 October 2018ReactomeTeamreactome version 65
100343view19:21, 31 October 2018ReactomeTeamreactome version 64
99888view16:03, 31 October 2018ReactomeTeamreactome version 63
99445view14:37, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
96358view20:11, 9 March 2018AndrewlmasonHIV down regulated
93974view13:49, 16 August 2017ReactomeTeamreactome version 61
93575view11:27, 9 August 2017ReactomeTeamreactome version 61
87139view18:51, 18 July 2016MkutmonOntology Term : 'infectious disease pathway' added !
86678view09:24, 11 July 2016ReactomeTeamreactome version 56
83092view09:57, 18 November 2015ReactomeTeamVersion54
81413view12:56, 21 August 2015ReactomeTeamVersion53
76883view08:15, 17 July 2014ReactomeTeamFixed remaining interactions
76588view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75920view09:57, 11 June 2014ReactomeTeamRe-fixing comment source
75621view10:48, 10 June 2014ReactomeTeamReactome 48 Update
74976view13:49, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74620view08:40, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Protein
26S proteasomeComplexREACT_2353 (Reactome)
AAAS [nuclear envelope]ProteinQ9NRG9 (Uniprot-TrEMBL)
ADP/ATP translocase monomer (generic)ProteinREACT_8605 (Reactome)
ANT1:Vpr complexComplexREACT_8897 (Reactome)
AP-1 ComplexComplexREACT_11249 (Reactome)
AP-2 ComplexComplexREACT_11732 (Reactome)
AP1B1 [cytosol]ProteinQ10567 (Uniprot-TrEMBL)
AP1G1 [cytosol]ProteinO43747 (Uniprot-TrEMBL)
AP1M1 [cytosol]ProteinQ9BXS5 (Uniprot-TrEMBL)
AP1M2(2-423) [cytosol]ProteinQ9Y6Q5 (Uniprot-TrEMBL)
AP1S1 [cytosol]ProteinP61966 (Uniprot-TrEMBL)
AP1S2 [cytosol]ProteinP56377 (Uniprot-TrEMBL)
AP1S3 [cytosol]ProteinQ96PC3 (Uniprot-TrEMBL)
AP2A1 [cytosol]ProteinO95782 (Uniprot-TrEMBL)
AP2A2(1-939) [cytosol]ProteinO94973 (Uniprot-TrEMBL)
AP2B1 [cytosol]ProteinP63010 (Uniprot-TrEMBL)
AP2M1 [cytosol]ProteinQ96CW1 (Uniprot-TrEMBL)
AP2M1 [plasma membrane]ProteinQ96CW1 (Uniprot-TrEMBL)
AP2M1ProteinQ96CW1 (Uniprot-TrEMBL)
AP2S1 [cytosol]ProteinP53680 (Uniprot-TrEMBL)
APOBEC3G-3 [cytosol]ProteinQ9HC16-3 (Uniprot-TrEMBL)
APOBEC3G:HIV-1PICComplexREACT_9691 (Reactome)
APOBEC3G:RTC with

deaminated minus sssDNA:tRNA

primer:RNA template		ComplexREACT_9785 (Reactome)
APOBEC3G:RTC with

minus sssDNA:tRNA

primer:RNA template		ComplexREACT_9745 (Reactome)
APOBEC3G:Vif:Cul5:SCF complexComplexREACT_9643 (Reactome)
APOBEC3GProteinREACT_9891 (Reactome)
ARF1(2-181) [cytosol]ProteinP84077 (Uniprot-TrEMBL)
ARF1(2-181)ProteinP84077 (Uniprot-TrEMBL)
ATP6V1H [cytosol]ProteinQ9UI12 (Uniprot-TrEMBL)
ATP6V1H [plasma membrane]ProteinQ9UI12 (Uniprot-TrEMBL)
ATP6V1HProteinQ9UI12 (Uniprot-TrEMBL)
Arf1:Nef:endosomal CD4ComplexREACT_11580 (Reactome)
B2M(21-119) [Golgi membrane]ProteinP61769 (Uniprot-TrEMBL)
B2M(21-119) [early endosome membrane]ProteinP61769 (Uniprot-TrEMBL)
BANF1 [cytosol]ProteinO75531 (Uniprot-TrEMBL)
BTRC [cytosol]ProteinQ9Y297 (Uniprot-TrEMBL)
BTRCProteinQ9Y297 (Uniprot-TrEMBL)
CCNT1 [nucleoplasm]ProteinO60563 (Uniprot-TrEMBL)
CD247-1 [plasma membrane]ProteinP20963-1 (Uniprot-TrEMBL)
CD247-1ProteinP20963-1 (Uniprot-TrEMBL)
CD28 [cytosol]ProteinP10747 (Uniprot-TrEMBL)
CD28 [plasma membrane]ProteinP10747 (Uniprot-TrEMBL)
CD28:Nef:Clathrin-coated

Pit Adapter Protein

Complex		ComplexREACT_11677 (Reactome)
CD28:Nef:Clathrin-coated Pit Adapter ProteinComplexREACT_11442 (Reactome)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD4 [early endosome]ProteinP01730 (Uniprot-TrEMBL)
CD4 [endoplasmic reticulum membrane]ProteinP01730 (Uniprot-TrEMBL)
CD4 [plasma membrane]ProteinP01730 (Uniprot-TrEMBL)
CD4:Lck ComplexComplexREACT_11737 (Reactome)
CD4:Nef ComplexComplexREACT_11987 (Reactome)
CD4:Nef:AP-2

Complex:v-ATPase

Complex		ComplexREACT_11339 (Reactome)
CD4:Vpu complexComplexREACT_9255 (Reactome)
CD4:Vpu:beta-TrCP_1:Skp1 complexComplexREACT_9120 (Reactome)
CD4:Vpu:beta-TrCP_1ComplexREACT_9238 (Reactome)
CD4ProteinP01730 (Uniprot-TrEMBL)
CD8:Nef ComplexComplexREACT_11411 (Reactome)
CD8:Nef:AP-2

Complex:v-ATPase

Complex		ComplexREACT_11369 (Reactome)
CD8B [early endosome membrane]ProteinP10966 (Uniprot-TrEMBL)
CD8B [plasma membrane]ProteinP10966 (Uniprot-TrEMBL)
CDK9 [nucleoplasm]ProteinP50750 (Uniprot-TrEMBL)
CUL5 [cytosol]ProteinQ93034 (Uniprot-TrEMBL)
Cul5-SCF complexComplexREACT_9690 (Reactome)
DOCK2 [cytosol]ProteinQ92608 (Uniprot-TrEMBL)
DOCK2:ELMO1:RAC1:Nef ComplexComplexREACT_11827 (Reactome)
DOCK2ProteinQ92608 (Uniprot-TrEMBL)
ELMO1 [cytosol]ProteinQ92556 (Uniprot-TrEMBL)
ELMO1ProteinQ92556 (Uniprot-TrEMBL)
FYN(2-537) [cytosol]ProteinP06241 (Uniprot-TrEMBL)
FYN(2-537)ProteinP06241 (Uniprot-TrEMBL)
Fyn:Nef ComplexComplexREACT_11637 (Reactome)
GDP [cytosol]MetaboliteCHEBI:17552 (ChEBI)
GDP [nucleoplasm]MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GTP [cytosol]MetaboliteCHEBI:15996 (ChEBI)
GTP [nucleoplasm]MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCK(2-526) [cytosol]ProteinP08631 (Uniprot-TrEMBL)
HCK(2-526)ProteinP08631 (Uniprot-TrEMBL)
HIV-1 RNA template [cytosol]ProteinAF033819 (EMBL)
HIV-1 mRNA [nucleoplasm]ProteinAF033819 (EMBL)
HIV-1 mRNA [cytosol]ProteinAF033819 (EMBL)
HIV-1 mRNARnaAF033819 (EMBL)
HIV-1 unspliced RNARnaAF033819 (EMBL)
HLA class I

histocompatibility antigen, A-2 alpha chain [Golgi

membrane]		ProteinP01892 (Uniprot-TrEMBL)
HLA class I

histocompatibility antigen, A-2 alpha chain [early

endosome membrane]		ProteinP01892 (Uniprot-TrEMBL)
HMGA1 [cytosol]ProteinP17096 (Uniprot-TrEMBL)
Hck-1:NefComplexREACT_11973 (Reactome)
IN (Integrase)

(P04585) protein

[cytosol]		ProteinP04585 (Uniprot-TrEMBL)
IN bound to sticky

3' ends of viral DNA

in PIC		ComplexREACT_8354 (Reactome)
Importin beta-1:Rev multimer complexComplexREACT_9841 (Reactome)
Importin-beta:Ran GTP complexComplexREACT_9883 (Reactome)
Internalized

CD4:Nef:Clathrin-Coated Pit Adapter

Protein:v-ATPase		ComplexREACT_11967 (Reactome)
Internalized

CD8:Nef:Clathrin-Coated Pit Adapter

Protein:v-ATPase		ComplexREACT_11305 (Reactome)
KPNA1 [cytosol]ProteinP52294 (Uniprot-TrEMBL)
KPNA1ProteinP52294 (Uniprot-TrEMBL)
KPNB1 [cytosol]ProteinQ14974 (Uniprot-TrEMBL)
KPNB1 [nucleoplasm]ProteinQ14974 (Uniprot-TrEMBL)
KPNB1ProteinQ14974 (Uniprot-TrEMBL)
LCK [cytosol]ProteinP06239 (Uniprot-TrEMBL)
LCKProteinP06239 (Uniprot-TrEMBL)
Lck:NefComplexREACT_11930 (Reactome)
Lipid RaftREACT_11624 (Reactome)
MA (P04585) protein [cytosol]ProteinP04585 (Uniprot-TrEMBL)
MA (P04591) protein [cytosol]ProteinP04591 (Uniprot-TrEMBL)
NH3MetaboliteCHEBI:16134 (ChEBI)
NPM1 [cytosol]ProteinP06748 (Uniprot-TrEMBL)
NPM1 [nucleoplasm]ProteinP06748 (Uniprot-TrEMBL)
NPM1ProteinP06748 (Uniprot-TrEMBL)
NUP107 [nuclear envelope]ProteinP57740 (Uniprot-TrEMBL)
NUP133 [nuclear envelope]ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 [nucleoplasm]ProteinP49790 (Uniprot-TrEMBL)
NUP155 [nuclear envelope]ProteinO75694 (Uniprot-TrEMBL)
NUP160 [nuclear envelope]ProteinQ12769 (Uniprot-TrEMBL)
NUP188(2-1749) [nuclear envelope]ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205(2-2012) [nuclear envelope]ProteinQ92621 (Uniprot-TrEMBL)
NUP210 [nuclear envelope]ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 [cytosol]ProteinP35658 (Uniprot-TrEMBL)
NUP35 [nuclear envelope]ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 [nuclear envelope]ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 [nuclear envelope]ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 [nucleoplasm]ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 [nuclear envelope]ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 [nuclear envelope]ProteinP37198 (Uniprot-TrEMBL)
NUP85 [nuclear envelope]ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 [cytosol]ProteinQ99567 (Uniprot-TrEMBL)
NUP93 [nuclear envelope]ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-5 [nuclear envelope]ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 [nuclear envelope]ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 [cytosol]ProteinO15504 (Uniprot-TrEMBL)
Nef:CD28 ComplexComplexREACT_11853 (Reactome)
Nef:T cell Receptor

zeta:Lipid Raft: Pak

2 Complex		ComplexREACT_11396 (Reactome)
Nef:class I MHC

complex:AP-1:PACS-1

Complex		ComplexREACT_11657 (Reactome)
Nef:class I MHC

complex:Ap-1:PACS-1

Complex		ComplexREACT_11308 (Reactome)
Nef:class I MHC complexComplexREACT_11813 (Reactome)
Nuclear Pore Complex (NPC)ComplexREACT_5542 (Reactome)
Nup45 [nuclear envelope]ProteinQ9BVL2-2 (Uniprot-TrEMBL)
P-TEFb(Cyclin T1:Cdk9) complexComplexREACT_6577 (Reactome)
PACS1(2-963) [cytosol]ProteinQ6VY07 (Uniprot-TrEMBL)
PACS1(2-963)ProteinQ6VY07 (Uniprot-TrEMBL)
PAK2(1-524) [plasma membrane]ProteinQ13177 (Uniprot-TrEMBL)
PAK2(1-524)ProteinQ13177 (Uniprot-TrEMBL)
PIC anchored to the NPCComplexREACT_8912 (Reactome)
POM121 [nuclear envelope]ProteinQ96HA1 (Uniprot-TrEMBL)
PPIA [cytosol]ProteinP62937 (Uniprot-TrEMBL)
PSIP1 [cytosol]ProteinO75475 (Uniprot-TrEMBL)
PSMA1 [cytosol]ProteinP25786 (Uniprot-TrEMBL)
PSMA2 [cytosol]ProteinP25787 (Uniprot-TrEMBL)
PSMA3 [cytosol]ProteinP25788 (Uniprot-TrEMBL)
PSMA4 [cytosol]ProteinP25789 (Uniprot-TrEMBL)
PSMA5 [cytosol]ProteinP28066 (Uniprot-TrEMBL)
PSMA6 [cytosol]ProteinP60900 (Uniprot-TrEMBL)
PSMA7(2-248) [cytosol]ProteinO14818 (Uniprot-TrEMBL)
PSMA8 [cytosol]ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 [cytosol]ProteinP20618 (Uniprot-TrEMBL)
PSMB10 [cytosol]ProteinP40306 (Uniprot-TrEMBL)
PSMB11 [cytosol]ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 [cytosol]ProteinP49721 (Uniprot-TrEMBL)
PSMB3 [cytosol]ProteinP49720 (Uniprot-TrEMBL)
PSMB4 [cytosol]ProteinP28070 (Uniprot-TrEMBL)
PSMB5 [cytosol]ProteinP28074 (Uniprot-TrEMBL)
PSMB6 [cytosol]ProteinP28072 (Uniprot-TrEMBL)
PSMB7 [cytosol]ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 [cytosol]ProteinP28062 (Uniprot-TrEMBL)
PSMB9 [cytosol]ProteinP28065 (Uniprot-TrEMBL)
PSMC1(2-440) [cytosol]ProteinP62191 (Uniprot-TrEMBL)
PSMC2 [cytosol]ProteinP35998 (Uniprot-TrEMBL)
PSMC3 [cytosol]ProteinP17980 (Uniprot-TrEMBL)
PSMC4 [cytosol]ProteinP43686 (Uniprot-TrEMBL)
PSMC5 [cytosol]ProteinP62195 (Uniprot-TrEMBL)
PSMC6(2-389) [cytosol]ProteinP62333 (Uniprot-TrEMBL)
PSMD1 [cytosol]ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 [cytosol]ProteinO75832 (Uniprot-TrEMBL)
PSMD11 [cytosol]ProteinO00231 (Uniprot-TrEMBL)
PSMD12 [cytosol]ProteinO00232 (Uniprot-TrEMBL)
PSMD13 [cytosol]ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 [cytosol]ProteinO00487 (Uniprot-TrEMBL)
PSMD2 [cytosol]ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 [cytosol]ProteinO43242 (Uniprot-TrEMBL)
PSMD4(2-377) [cytosol]ProteinP55036 (Uniprot-TrEMBL)
PSMD5 [cytosol]ProteinQ16401 (Uniprot-TrEMBL)
PSMD6(2-389) [cytosol]ProteinQ15008 (Uniprot-TrEMBL)
PSMD7(2-324) [cytosol]ProteinP51665 (Uniprot-TrEMBL)
PSMD8 [cytosol]ProteinP48556 (Uniprot-TrEMBL)
PSMD9 [cytosol]ProteinO00233 (Uniprot-TrEMBL)
PSME1 [cytosol]ProteinQ06323 (Uniprot-TrEMBL)
PSME2 [cytosol]ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 [cytosol]ProteinP61289 (Uniprot-TrEMBL)
PSME4 [cytosol]ProteinQ14997 (Uniprot-TrEMBL)
PSMF1(2-271) [cytosol]ProteinQ92530 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RAC1-1 [cytosol]ProteinP63000-1 (Uniprot-TrEMBL)
RAC1-1ProteinP63000-1 (Uniprot-TrEMBL)
RAE1 [nuclear envelope]ProteinP78406 (Uniprot-TrEMBL)
RAN [cytosol]ProteinP62826 (Uniprot-TrEMBL)
RAN [nucleoplasm]ProteinP62826 (Uniprot-TrEMBL)
RANBP1(2-201) [nuclear envelope]ProteinP43487 (Uniprot-TrEMBL)
RANBP1(2-201)ProteinP43487 (Uniprot-TrEMBL)
RANBP2 [cytosol]ProteinP49792 (Uniprot-TrEMBL)
RANGAP1ProteinP46060 (Uniprot-TrEMBL)
RBX1 [cytosol]ProteinP62877 (Uniprot-TrEMBL)
RCC1ProteinP18754 (Uniprot-TrEMBL)
REV (P04618) protein [cytosol]ProteinP04618 (Uniprot-TrEMBL)
REV (P04618) protein [nucleoplasm]ProteinP04618 (Uniprot-TrEMBL)
REV (P04618) proteinProteinP04618 (Uniprot-TrEMBL)
RPS27A(1-76) [cytosol]ProteinP62979 (Uniprot-TrEMBL)
RTC with minus

sssDNA:tRNA

primer:RNA template		ComplexREACT_9297 (Reactome)
Ran GTPase:GDPComplexREACT_6416 (Reactome)
Ran-GDPComplexREACT_9732 (Reactome)
Ran-GTPComplexREACT_8980 (Reactome)
Ran:GTPComplexREACT_8632 (Reactome)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complexComplexREACT_8366 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP:NPC		ComplexREACT_6537 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		ComplexREACT_6428 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		ComplexREACT_6601 (Reactome)
Rev multimer-bound

HIV-1 mRNA:CRM1

complex		ComplexREACT_8117 (Reactome)
Rev multimer-bound HIV-1 mRNAComplexREACT_6517 (Reactome)
Rev-bound HIV-1 mRNAComplexREACT_6419 (Reactome)
Rev-multimerREACT_6379 (Reactome)
Rev-multimerREACT_6511 (Reactome)
Rev:Importin-beta:B23ComplexREACT_9742 (Reactome)
Rev:Importin-beta:NPM1ComplexREACT_9868 (Reactome)
Rev:importin-beta:B23:Ran-GTP complexComplexREACT_9842 (Reactome)
Reverse

transcriptase/ribonuclease

H [cytosol]		ProteinP04585 (Uniprot-TrEMBL)
SEH1L-2 [nuclear envelope]ProteinQ96EE3-2 (Uniprot-TrEMBL)
SKP1 [cytosol]ProteinP63208 (Uniprot-TrEMBL)
SKP1ProteinP63208 (Uniprot-TrEMBL)
SLC25A4

[mitochondrial inner

membrane]		ProteinP12235 (Uniprot-TrEMBL)
SLC25A5

[mitochondrial inner

membrane]		ProteinP05141 (Uniprot-TrEMBL)
SLC25A6

[mitochondrial inner

membrane]		ProteinP12236 (Uniprot-TrEMBL)
TCEB1 [cytosol]ProteinQ15369 (Uniprot-TrEMBL)
TCEB2 [cytosol]ProteinQ15370 (Uniprot-TrEMBL)
TPR [nucleoplasm]ProteinP12270 (Uniprot-TrEMBL)
Tat (P04608) [nucleoplasm]ProteinP04608 (Uniprot-TrEMBL)
Tat (P04608)ProteinP04608 (Uniprot-TrEMBL)
Tat:P-TEFb(Cyclin T1:Cdk9) complexComplexREACT_6496 (Reactome)
UBA52(1-76) [cytosol]ProteinP62987 (Uniprot-TrEMBL)
UBB(1-76) [cytosol]ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) [cytosol]ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) [cytosol]ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) [cytosol]ProteinP0CG48 (Uniprot-TrEMBL)
UbProteinREACT_3316 (Reactome)
VIF (P69723) protein [cytosol]ProteinP69723 (Uniprot-TrEMBL)
VIF (P69723) proteinProteinP69723 (Uniprot-TrEMBL)
VPR (P69726) protein [cytosol]ProteinP69726 (Uniprot-TrEMBL)
VPR (P69726) protein

[mitochondrial

intermembrane space]		ProteinP69726 (Uniprot-TrEMBL)
VPR (P69726) protein [nucleoplasm]ProteinP69726 (Uniprot-TrEMBL)
VPR (P69726) proteinProteinP69726 (Uniprot-TrEMBL)
VPU (P05919)

[endoplasmic

reticulum membrane]		ProteinP05919 (Uniprot-TrEMBL)
VPU (P05919) protein [cytosol]ProteinP05919 (Uniprot-TrEMBL)
VPU (P05919)ProteinP05919 (Uniprot-TrEMBL)
Vif:APOBEC3G complexComplexREACT_9662 (Reactome)
Vif:Cul5:SCF complexComplexREACT_9902 (Reactome)
Vpr:importin-alpha complexComplexREACT_8944 (Reactome)
Vpu:beta-TrCP1:Skp1 complexComplexREACT_9101 (Reactome)
XPO1 [cytosol]ProteinO14980 (Uniprot-TrEMBL)
XPO1 [nucleoplasm]ProteinO14980 (Uniprot-TrEMBL)
XPO1ProteinO14980 (Uniprot-TrEMBL)
class I MHC complexComplexREACT_11465 (Reactome)
multi-ubiquitinated

APOBEC3G:Vif:Cul5:SCF

complex		ComplexREACT_9570 (Reactome)
multiubiquitinated

CD4:Vpu:beta-TrCP_1:Skp1

complex		ComplexREACT_9344 (Reactome)
myristoylated Nef

Protein (UniProt:P04601)

[cytosol]		ProteinP04601 (Uniprot-TrEMBL)
myristoylated Nef

Protein

(UniProt:P04601)		ProteinP04601 (Uniprot-TrEMBL)
nucleoporin-associated

Rev:Importin-beta:B23

complex		ComplexREACT_9793 (Reactome)
p51 (RT) [cytosol]ProteinP04585 (Uniprot-TrEMBL)
p6 (P04585) protein [cytosol]ProteinP04585 (Uniprot-TrEMBL)
p6 (P04591) protein [cytosol]ProteinP04591 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisREACT_9018 (Reactome)
26S proteasomemim-catalysisREACT_9466 (Reactome)
ADP/ATP translocase monomer (generic)REACT_7958 (Reactome)
ANT1:Vpr complexArrowREACT_7958 (Reactome)
AP-1 ComplexArrowREACT_11147 (Reactome)
AP-1 ComplexREACT_11186 (Reactome)
AP-2 ComplexArrowREACT_11144 (Reactome)
AP-2 ComplexArrowREACT_11177 (Reactome)
AP-2 ComplexREACT_11091 (Reactome)
AP-2 ComplexREACT_11125 (Reactome)
AP2M1REACT_11122 (Reactome)
APOBEC3G:HIV-1PICArrowREACT_9450 (Reactome)
APOBEC3G:RTC with

deaminated minus sssDNA:tRNA

primer:RNA template		ArrowREACT_9435 (Reactome)
APOBEC3G:RTC with

minus sssDNA:tRNA

primer:RNA template		ArrowREACT_9444 (Reactome)
APOBEC3G:RTC with

minus sssDNA:tRNA

primer:RNA template		REACT_9435 (Reactome)
APOBEC3G:Vif:Cul5:SCF complexArrowREACT_9469 (Reactome)
APOBEC3G:Vif:Cul5:SCF complexREACT_9471 (Reactome)
APOBEC3G:Vif:Cul5:SCF complexmim-catalysisREACT_9471 (Reactome)
APOBEC3GREACT_9444 (Reactome)
APOBEC3GREACT_9445 (Reactome)
APOBEC3GREACT_9450 (Reactome)
APOBEC3Gmim-catalysisREACT_9435 (Reactome)
ARF1(2-181)REACT_11227 (Reactome)
ATP6V1HArrowREACT_11144 (Reactome)
ATP6V1HArrowREACT_11177 (Reactome)
ATP6V1HREACT_11091 (Reactome)
ATP6V1HREACT_11125 (Reactome)
Arf1:Nef:endosomal CD4ArrowREACT_11227 (Reactome)
BTRCREACT_9009 (Reactome)
CD247-1REACT_11221 (Reactome)
CD28:Nef:Clathrin-coated

Pit Adapter Protein

Complex		ArrowREACT_11122 (Reactome)
CD28:Nef:Clathrin-coated

Pit Adapter Protein

Complex		REACT_11164 (Reactome)
CD28:Nef:Clathrin-coated Pit Adapter ProteinArrowREACT_11164 (Reactome)
CD28REACT_11194 (Reactome)
CD4:Lck ComplexREACT_11148 (Reactome)
CD4:Nef ComplexArrowREACT_11148 (Reactome)
CD4:Nef ComplexREACT_11091 (Reactome)
CD4:Nef:AP-2

Complex:v-ATPase

Complex		ArrowREACT_11091 (Reactome)
CD4:Nef:AP-2

Complex:v-ATPase

Complex		REACT_11160 (Reactome)
CD4:Vpu complexArrowREACT_9024 (Reactome)
CD4:Vpu complexREACT_9009 (Reactome)
CD4:Vpu:beta-TrCP_1:Skp1 complexArrowREACT_9071 (Reactome)
CD4:Vpu:beta-TrCP_1:Skp1 complexREACT_9063 (Reactome)
CD4:Vpu:beta-TrCP_1:Skp1 complexmim-catalysisREACT_9063 (Reactome)
CD4:Vpu:beta-TrCP_1ArrowREACT_9009 (Reactome)
CD4:Vpu:beta-TrCP_1REACT_9071 (Reactome)
CD4REACT_11227 (Reactome)
CD4REACT_9024 (Reactome)
CD8:Nef ComplexREACT_11125 (Reactome)
CD8:Nef:AP-2

Complex:v-ATPase

Complex		ArrowREACT_11125 (Reactome)
CD8:Nef:AP-2

Complex:v-ATPase

Complex		REACT_11069 (Reactome)
Cul5-SCF complexREACT_9469 (Reactome)
DOCK2:ELMO1:RAC1:Nef ComplexArrowREACT_11090 (Reactome)
DOCK2REACT_11090 (Reactome)
ELMO1REACT_11090 (Reactome)
FYN(2-537)REACT_11075 (Reactome)
Fyn:Nef ComplexArrowREACT_11075 (Reactome)
GDPArrowREACT_9507 (Reactome)
GTPREACT_9507 (Reactome)
H2OREACT_9435 (Reactome)
HCK(2-526)REACT_11224 (Reactome)
HIV-1 mRNAREACT_6161 (Reactome)
HIV-1 unspliced RNAArrowREACT_6318 (Reactome)
Hck-1:NefArrowREACT_11224 (Reactome)
IN bound to sticky

3' ends of viral DNA

in PIC		REACT_7952 (Reactome)
IN bound to sticky

3' ends of viral DNA

in PIC		REACT_8011 (Reactome)
IN bound to sticky

3' ends of viral DNA

in PIC		REACT_9450 (Reactome)
Importin beta-1:Rev multimer complexArrowREACT_9394 (Reactome)
Importin beta-1:Rev multimer complexREACT_9511 (Reactome)
Importin-beta:Ran GTP complexArrowREACT_9456 (Reactome)
Internalized

CD4:Nef:Clathrin-Coated Pit Adapter

Protein:v-ATPase		ArrowREACT_11160 (Reactome)
Internalized

CD4:Nef:Clathrin-Coated Pit Adapter

Protein:v-ATPase		REACT_11177 (Reactome)
Internalized

CD8:Nef:Clathrin-Coated Pit Adapter

Protein:v-ATPase		ArrowREACT_11069 (Reactome)
Internalized

CD8:Nef:Clathrin-Coated Pit Adapter

Protein:v-ATPase		REACT_11144 (Reactome)
KPNA1REACT_8011 (Reactome)
KPNB1REACT_9394 (Reactome)
LCKArrowREACT_11148 (Reactome)
LCKREACT_11220 (Reactome)
Lck:NefArrowREACT_11220 (Reactome)
Lipid RaftREACT_11221 (Reactome)
NH3ArrowREACT_9435 (Reactome)
NPM1ArrowREACT_9456 (Reactome)
NPM1REACT_9511 (Reactome)
Nef:CD28 ComplexArrowREACT_11194 (Reactome)
Nef:CD28 ComplexREACT_11122 (Reactome)
Nef:T cell Receptor

zeta:Lipid Raft: Pak

2 Complex		ArrowREACT_11221 (Reactome)
Nef:class I MHC

complex:AP-1:PACS-1

Complex		ArrowREACT_11229 (Reactome)
Nef:class I MHC

complex:AP-1:PACS-1

Complex		REACT_11147 (Reactome)
Nef:class I MHC

complex:Ap-1:PACS-1

Complex		ArrowREACT_11186 (Reactome)
Nef:class I MHC

complex:Ap-1:PACS-1

Complex		REACT_11229 (Reactome)
Nef:class I MHC complexArrowREACT_11071 (Reactome)
Nef:class I MHC complexREACT_11186 (Reactome)
Nuclear Pore Complex (NPC)ArrowREACT_6340 (Reactome)
Nuclear Pore Complex (NPC)ArrowREACT_9521 (Reactome)
Nuclear Pore Complex (NPC)REACT_6337 (Reactome)
Nuclear Pore Complex (NPC)REACT_7952 (Reactome)
Nuclear Pore Complex (NPC)REACT_9516 (Reactome)
P-TEFb(Cyclin T1:Cdk9) complexREACT_6356 (Reactome)
PACS1(2-963)ArrowREACT_11147 (Reactome)
PACS1(2-963)REACT_11186 (Reactome)
PAK2(1-524)REACT_11221 (Reactome)
PIC anchored to the NPCArrowREACT_7952 (Reactome)
PiArrowREACT_6171 (Reactome)
RAC1-1REACT_11090 (Reactome)
RANBP1(2-201)ArrowREACT_6171 (Reactome)
RANBP1(2-201)ArrowREACT_6318 (Reactome)
RANBP1(2-201)REACT_9478 (Reactome)
RANGAP1ArrowREACT_6171 (Reactome)
RCC1mim-catalysisREACT_9507 (Reactome)
REACT_11069 (Reactome) The CD8alphabeta receptor is internalized via endocytosis.
REACT_11071 (Reactome) Nef disrupts the transport of major histocompatibility complex class I molecules by first binding to the the cytoplasmic side of the transmembrane complex.
REACT_11075 (Reactome) Nef has been shown to bind specifically to a subset of the Src family of kinases. Nef/Fyn interaction centers on a proline-rich motif (Pro-x-x-Pro), which is implicated in SH3 binding. This domain is partially disordered in the absence of the binding partner; when bound this motif fully adopts a left-handed polyproline type II helix conformation upon complex formation with the Fyn SH3 domain. Within this structure the arginine residue (Arg77) of Nef interacts with Asp 100 of the RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface. The Arg96 residue of the Fyn SH3 domain is specifically accommodated in the same hydrophobic pocket of Nef. The Nef-Fyn complex forms in vivo and may have a crucial role in the T cell perturbating action of Nef by altering T cell receptor signaling.
REACT_11090 (Reactome) The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase lentiviral replication in the host, functioning as an adaptor protein. Nef activates Rac in T cell lines and in primary T cells following infection with HIV-1 in the absence of antigenic stimuli. Nef activates Rac by binding the DOCK2-ELMO1 complex, and this interaction is linked to the abilities of Nef to inhibit chemotaxis and promote T cell activation. Nef targets a critical switch that regulates Rac GTPases downstream of chemokine- and antigen-initiated signaling pathways. This interaction enables Nef to influence multiple aspects of T cell function and thus provides an important mechanism by which Nef impacts pathogenesis by primate lentiviruses.
REACT_11091 (Reactome) AP-2 is recruited to the newly formed Nef:CD4 complex
REACT_11122 (Reactome) Nef induces accelerated endocytosis of CD28 via clathrin-coated pits.
REACT_11125 (Reactome) The presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD8. Nef facilitates a cascade of protein interactions that ultimately result in the degradation of internalized CD8 protein. The final set of protein interactions that direct Nef to the beta-subunit of the COPI coatomers are at this time unclear.
A number of sites within Nef are proposed to be required for CD8 down-regulation, the myristoylation signal and N-terminal anchor regions, the C-terminal flexible loop, and amino acid positions 57 to 58. Consistent with all reported Nef functions, the myristoylation signal was found to be essential for CD8 down-modulation. The flexible loop contains a dileucine-based internalization motif, which is flanked by acidic clusters and is involved in enhanced internalization of the Nef-CD4 complex.
REACT_11144 (Reactome) Once the CD8alphabeta receptor has been internalized via endocytosis, the vesicles are targeted for lysosomal degradation.
REACT_11147 (Reactome) Once the complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 arrives at the endosome, the MHC I complex is targeted for degradation.
REACT_11148 (Reactome) Nef disrupts the CD4 Lck complex
REACT_11160 (Reactome) The Nef:CD4:AP-2 complex is internalized
REACT_11164 (Reactome) Once Nef has induced endocytosis of CD28, CD28 containing vesicles are targeted for lysosomal degradation.
REACT_11177 (Reactome) CD4 is degraded
REACT_11186 (Reactome) The complex formed by Nef and the major histocompatibility complex class I molecules creates binding sites for PACS-1 and the AP-1 complex.
REACT_11194 (Reactome) Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery.
REACT_11220 (Reactome) The Nef protein of the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV), is a myristylated protein associated with increased viral replication and enhanced pathogenicity. Both the potentiation of T-lymphocyte activation and the enhanced serine-phosphorylation of HIV-1 capsid by Nef correlate with increased viral replication. The Nef proteins from HIV-1 and SIV bind to Lck. The SH3 and SH2 domains of Lck are sufficient for coprecipitation with non-tyrosine-phosphorylated Nef proteins. The conserved core region of HIV-1 Nef is essential for the interaction with Lck and is also important for enhanced HIV-1 replication in T-lymphocytes. The SIV and HIV-1 Nef proteins are differentially tyrosine-phosphorylated. The kinase-active Lck tyrosine-phosphorylates SIVmac239 Nef but does not phosphorylate HIV-1 Nef.
REACT_11221 (Reactome) Nef drives the formation of lipid raft complexes.
REACT_11224 (Reactome) The protein Hck is a member of the Src family of non-receptor tyrosine kinases which is preferentially expressed in haematopoietic cells of the myeloid and B-lymphoid lineages. Src kinases are inhibited by tyrosine-phosphorylation at a carboxy-terminal site. The SH2 domains of these enzymes play an essential role in this regulation by binding to the tyrosine-phosphorylated tail. The SH2 domain of Hck regulates enzymatic activity indirectly; intramolecular interactions between the SH3 and catalytic domains appear to stabilize an inactive form of the kinase. The HIV-1 Nef protein, which is a high-affinity ligand for the Hck SH3 domain, binds to either the downregulated or activated form of Hck causing a large increase in Hck catalytic activity. The intact SH3-binding motif in Nef is crucial for Hck activation.
REACT_11227 (Reactome) The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. The small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4. Nef binds ARF1 directly and can recruit the GTPase onto endosomal membranes, leading to the eventual degradation of CD4 (Faure et al. 2004).
REACT_11229 (Reactome) The complex of Nef, major histocompatibility complex class I molecules, PACS-1 and AP-1 is transported from the trans-Golgi network to an endosome, where the MHC I complex will be degraded.
REACT_6140 (Reactome) RanGTP binds to a preformed Rev-CRM1 complex.
REACT_6161 (Reactome) Nuclear export of the unspliced and partially spliced HIV-1 transcripts requires the association of the HIV-1 Rev protein with a cis-acting RNA sequence known as the Rev Response Element (RRE) located within the env gene. The RRE forms a stem loop structure that associates with an arginine-rich RNA binding motif (ARM) within Rev.
REACT_6171 (Reactome) Ran-GAP, a Ran-specific GTPase-activating protein converts Ran-GTP to Ran-GDP, producing a Ran-GTP gradient across the nuclear membrane.
REACT_6228 (Reactome) In order for Rev to function, multiple molecules must bind sequentiallly to the RRE (Malim and Cullen 1991).
REACT_6318 (Reactome) The association of RanBp1 with RanGTP:CRM1:Rev promotes disassembly of the complex and release of the Rev:RNA cargo.
REACT_6337 (Reactome) The Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP complex associates with the NPC.
REACT_6340 (Reactome) Crm1 is a nucleocytoplasmic transport factor that is believed to interact with nucleoporins facilitating docking of the RRE-Rev-CRM1-RanGTP complex to the nuclear pore and the translocation of the complex across the nuclear pore complex (see Cullen 1998) Crm1 has been found in complex with two such nucleoporins, CAN/Nup214 and Nup88 which have been shown to be components of the human nuclear pore complex (Fornerod et al., 1997).
REACT_6356 (Reactome) Tat associates with the Cyclin T1 subunit of P-TEFb (Cyclin T1:Cdk9) through a region of cysteine-rich and core sequences referred to as the ARM domain within Tat (Wei et al., 1998; see also Herrmann 1995). This interaction is believed to involve metal ions stabilized by cysteine residues in both proteins (Bieniasz et al., 1998; Garber et al., 1998).
REACT_7952 (Reactome)
REACT_7958 (Reactome) Vpr interacts with the PTPC component ANT1. This interaction induces mitochondrial membrane permeabilization and release of cytochrome c and apoptotic factors.
REACT_7969 (Reactome) Vpr translocates to the mitochondria.
REACT_8011 (Reactome) Vpr interacts with importin-alpha through alphaH1 and alphaH2. The interaction via alphaH1 is indispensable for the nuclear entry of Vpr (Kamata et al., 2005) .
REACT_9009 (Reactome) Vpu links beta-TrCP to CD4 at the ER membrane through interactions with beta-TrCP and the cytoplasmic tail of CD4.
REACT_9018 (Reactome) Ubiquitinated CD4 is then subject to proteasome-mediated degradation.
REACT_9024 (Reactome) Vpu is expressed in the ER and associates with a membrane-proximal region in the cytoplasmic tail of CD4.
REACT_9063 (Reactome) CD4 is ubiquitinated in the CD4:Vpu–h-βTrCP:Skp1 complex.
REACT_9071 (Reactome) The SKP1 component of the SCF complex is recruited to the Vpu:beta-TrCP:CD4 complex.
REACT_9394 (Reactome) The association of Rev with importin-beta is mediated by the Rev nuclear localisation signal.
REACT_9399 (Reactome) Inside the nucleus, Ran-GTP associates with importin-beta.
REACT_9435 (Reactome) During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004).
The polypurine tract is essential for plus strand synthesis and is located at the 3’ end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5’ to 3’ regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)
REACT_9444 (Reactome) In the target cell, HIV-1-associated APOBEC3G binds to the HIV-1 reverse transcript minus strand and catalyzes the deamination of cytidines in a specific dinucleotide context (e.g., dCC). In contrast, APOBEC3F and APOBEC3B display a preference for dTC.
REACT_9445 (Reactome) The HIV-1 Vif protein associates with the DNA editing enzyme APOBEC3G Marin et al) . The binding site has not yet been mapped but emerging evidence suggest that the N-terminal lregion of Vif is essential for APOBEC3G recognition (Tian et al) .
Substitution of a single amino acid in the human APOBEC3G (Asp128Lys) abolishes binding and renders it resistant to HIV-1 Vif (Schrofelbauer et al; Bogerd et al.).

REACT_9450 (Reactome) APOBEC3G is incorporated into virus particles through its association with components of the viral RNA packaging machinery. It binds to the nucleocapsid portion of Gag (NC), a region of the polyprotein that associates with genomic RNA and functions in RNA encapsidation.
REACT_9456 (Reactome) The association of importin-beta with Ran-GTP causes the disassembly of the Rev-importin β-B23 complex releasing the Rev in the nucleus.
REACT_9466 (Reactome) Following multi-ubiquitination by the Vif-Cul5-SCF complex, APOBEC3G is degraded by the 26S proteasome.
REACT_9469 (Reactome) The interaction between Vif and the E3 ubiquitin ligase complex (Cullin5, Elongin B and Elongin C, and Rbx1) takes place through direct binding of the SOCS box motif in the viral protein Vif to the host protein Elongin C. Moreover, a conserved HCCH motif in Vif allows binding to Cullin 5.
REACT_9471 (Reactome) APOBEC3G is multi-ubiquitinated by the Vif-Cul5-SCF complex.
REACT_9478 (Reactome) Upon translocation to the cytoplasm, RanBP1 associates with Ran-GTP in the Rev-CRM1-Ran-GTP complex.
REACT_9507 (Reactome) Free, nuclear RanGTP is required for export processes out of the nucleus. RCC1 catalyses the conversion of Ran-GDP to Ran-GTP in the nucleus.
REACT_9511 (Reactome) B23 may function as a shuttle for the import of HIV Rev from the cytoplasm into the nucleus or nucleolus permitting additional rounds of export of viral RNAs.
REACT_9516 (Reactome) The Rev-importin β-B23 complex is recruited to the nuclear pore by an interaction between importin β and nucleoporin.
REACT_9521 (Reactome) Following the association of Rev with importin-beta, the Rev:B23:importin-beta complex is imported into the nucleus.
REACT_9530 (Reactome) CRM1 associates directly with Rev through the Rev nuclear export signal (NES) domain and acts as the nuclear export receptor for the Rev-RRE ribonucleoprotein complex.
REV (P04618) proteinArrowREACT_6318 (Reactome)
REV (P04618) proteinREACT_6161 (Reactome)
RTC with minus

sssDNA:tRNA

primer:RNA template		REACT_9444 (Reactome)
Ran GTPase:GDPArrowREACT_6171 (Reactome)
Ran-GDPREACT_9507 (Reactome)
Ran-GTPArrowREACT_9507 (Reactome)
Ran-GTPREACT_6140 (Reactome)
Ran-GTPREACT_9399 (Reactome)
Ran:GTPArrowREACT_6318 (Reactome)
Ran:GTPREACT_6171 (Reactome)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complexArrowREACT_9478 (Reactome)
RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complexREACT_6318 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP:NPC		ArrowREACT_6337 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP:NPC		REACT_6340 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		ArrowREACT_6140 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		ArrowREACT_6340 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		REACT_6337 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		REACT_9478 (Reactome)
Rev multimer-bound

HIV-1

mRNA:Crm1:Ran:GTP		mim-catalysisREACT_6171 (Reactome)
Rev multimer-bound

HIV-1 mRNA:CRM1

complex		ArrowREACT_9530 (Reactome)
Rev multimer-bound

HIV-1 mRNA:CRM1

complex		REACT_6140 (Reactome)
Rev multimer-bound HIV-1 mRNAArrowREACT_6228 (Reactome)
Rev multimer-bound HIV-1 mRNAREACT_9530 (Reactome)
Rev-bound HIV-1 mRNAArrowREACT_6161 (Reactome)
Rev-bound HIV-1 mRNAREACT_6228 (Reactome)
Rev-multimerArrowREACT_6318 (Reactome)
Rev-multimerArrowREACT_9456 (Reactome)
Rev-multimerREACT_6228 (Reactome)
Rev-multimerREACT_9394 (Reactome)
Rev:Importin-beta:B23ArrowREACT_9521 (Reactome)
Rev:Importin-beta:B23REACT_9399 (Reactome)
Rev:Importin-beta:NPM1ArrowREACT_9511 (Reactome)
Rev:Importin-beta:NPM1REACT_9516 (Reactome)
Rev:importin-beta:B23:Ran-GTP complexArrowREACT_9399 (Reactome)
Rev:importin-beta:B23:Ran-GTP complexREACT_9456 (Reactome)
SKP1REACT_9071 (Reactome)
Tat (P04608)REACT_6356 (Reactome)
Tat:P-TEFb(Cyclin T1:Cdk9) complexArrowREACT_6356 (Reactome)
UbArrowREACT_9018 (Reactome)
UbArrowREACT_9466 (Reactome)
UbREACT_9063 (Reactome)
UbREACT_9471 (Reactome)
VIF (P69723) proteinREACT_9445 (Reactome)
VPR (P69726) proteinArrowREACT_7969 (Reactome)
VPR (P69726) proteinREACT_7958 (Reactome)
VPR (P69726) proteinREACT_7969 (Reactome)
VPU (P05919)REACT_9024 (Reactome)
Vif:APOBEC3G complexArrowREACT_9445 (Reactome)
Vif:APOBEC3G complexREACT_9469 (Reactome)
Vif:Cul5:SCF complexArrowREACT_9466 (Reactome)
Vpr:importin-alpha complexArrowREACT_8011 (Reactome)
Vpu:beta-TrCP1:Skp1 complexArrowREACT_9018 (Reactome)
XPO1ArrowREACT_6318 (Reactome)
XPO1REACT_9530 (Reactome)
class I MHC complexREACT_11071 (Reactome)
multi-ubiquitinated

APOBEC3G:Vif:Cul5:SCF

complex		ArrowREACT_9471 (Reactome)
multi-ubiquitinated

APOBEC3G:Vif:Cul5:SCF

complex		REACT_9466 (Reactome)
multiubiquitinated

CD4:Vpu:beta-TrCP_1:Skp1

complex		ArrowREACT_9063 (Reactome)
multiubiquitinated

CD4:Vpu:beta-TrCP_1:Skp1

complex		REACT_9018 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		ArrowREACT_11144 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		ArrowREACT_11147 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		ArrowREACT_11177 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11071 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11075 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11090 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11148 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11194 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11220 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11221 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11224 (Reactome)
myristoylated Nef

Protein

(UniProt:P04601)		REACT_11227 (Reactome)
nucleoporin-associated

Rev:Importin-beta:B23

complex		ArrowREACT_9516 (Reactome)
nucleoporin-associated

Rev:Importin-beta:B23

complex		REACT_9521 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2684"
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