YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)

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2, 4223, 51, 3, 565TBX5:WWTR1:PCAF[nucleoplasm]cytosolCoactivators ofPPARalpha[nucleoplasm]TEAD [nucleoplasm]RUNX2:WWTR1(TAZ)[nucleoplasm]TEAD:YAP1[nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]nucleoplasmActivated PPARA:RXRAHeterodimer[nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]TEAD [nucleoplasm]Ligands of PPARA[nucleoplasm]TEAD:WWTR1(TAZ)[nucleoplasm]TEAD4 [nucleoplasm]RXRA [nucleoplasm]TBX5TEAD1 [nucleoplasm]HELZ2 [nucleoplasm]YAP1KAT2BTEAD:WWTR1(TAZ)TEAD3(1-435)[nucleoplasm]PPARA [nucleoplasm]EPA [nucleoplasm]AA [nucleoplasm]NCOA2 [nucleoplasm]TEAD4 [nucleoplasm]TEAD2 [nucleoplasm]WWTR1 [nucleoplasm]NCOA6 [nucleoplasm]TEADWWTR1 [nucleoplasm]TEAD2 [nucleoplasm]TBL1XR1[nucleoplasm]LINA [nucleoplasm]RUNX2 [nucleoplasm]Palm [nucleoplasm]TEAD1 [nucleoplasm]NCOA1 [nucleoplasm]CHD9 [nucleoplasm]TBX5:WWTR1:PCAFCREBBP(2-2442)[nucleoplasm]RUNX2YAP1 [nucleoplasm]SMARCD3[nucleoplasm]CTGFTBL1X [nucleoplasm]MED1 [nucleoplasm]CARM1(2-608)[nucleoplasm]TEAD3(1-435)[nucleoplasm]WWTR1KAT2B [nucleoplasm]TGS1 [nucleoplasm]TEAD:YAP1PPARA:RXRACoactivator ComplexWWTR1 [nucleoplasm]RUNX2:WWTR1(TAZ)NPPA(1-670)ALA [nucleoplasm]TBX5 [nucleoplasm]523, 5


Description

YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2032785

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114969view16:49, 25 January 2021ReactomeTeamReactome version 75
113413view11:48, 2 November 2020ReactomeTeamReactome version 74
112615view15:59, 9 October 2020ReactomeTeamReactome version 73
101531view11:40, 1 November 2018ReactomeTeamreactome version 66
101066view21:22, 31 October 2018ReactomeTeamreactome version 65
100596view19:56, 31 October 2018ReactomeTeamreactome version 64
100145view16:41, 31 October 2018ReactomeTeamreactome version 63
99695view15:10, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99283view12:46, 31 October 2018ReactomeTeamreactome version 62
93910view13:44, 16 August 2017ReactomeTeamreactome version 61
93486view11:24, 9 August 2017ReactomeTeamreactome version 61
87190view08:26, 19 July 2016EgonwOntology Term : 'regulatory pathway' added !
86582view09:21, 11 July 2016ReactomeTeamreactome version 56
83145view10:09, 18 November 2015ReactomeTeamVersion54
81495view13:02, 21 August 2015ReactomeTeamVersion53
76971view08:26, 17 July 2014ReactomeTeamFixed remaining interactions
76676view12:04, 16 July 2014ReactomeTeamFixed remaining interactions
76004view10:06, 11 June 2014ReactomeTeamRe-fixing comment source
75710view11:05, 10 June 2014ReactomeTeamReactome 48 Update
75064view13:57, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74708view08:47, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AA [nucleoplasm]MetaboliteCHEBI:15843 (ChEBI)
ALA [nucleoplasm]MetaboliteCHEBI:27432 (ChEBI)
CARM1(2-608) [nucleoplasm]ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 [nucleoplasm]ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP(2-2442) [nucleoplasm]ProteinQ92793 (Uniprot-TrEMBL)
CTGFProteinP29279 (Uniprot-TrEMBL)
EPA [nucleoplasm]MetaboliteCHEBI:28364 (ChEBI)
HELZ2 [nucleoplasm]ProteinQ9BYK8 (Uniprot-TrEMBL)
KAT2B [nucleoplasm]ProteinQ92831 (Uniprot-TrEMBL)
KAT2BProteinQ92831 (Uniprot-TrEMBL)
LINA [nucleoplasm]MetaboliteCHEBI:17351 (ChEBI)
MED1 [nucleoplasm]ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
NCOA1 [nucleoplasm]ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 [nucleoplasm]ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 [nucleoplasm]ProteinQ14686 (Uniprot-TrEMBL)
NPPA(1-670)ProteinP01160 (Uniprot-TrEMBL)
PPARA [nucleoplasm]ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
Palm [nucleoplasm]MetaboliteCHEBI:15756 (ChEBI)
RUNX2 [nucleoplasm]ProteinQ13950 (Uniprot-TrEMBL)
RUNX2:WWTR1(TAZ)ComplexREACT_119164 (Reactome)
RUNX2ProteinQ13950 (Uniprot-TrEMBL)
RXRA [nucleoplasm]ProteinP19793 (Uniprot-TrEMBL)
SMARCD3 [nucleoplasm]ProteinQ6STE5 (Uniprot-TrEMBL)
TBL1X [nucleoplasm]ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 [nucleoplasm]ProteinQ9BZK7 (Uniprot-TrEMBL)
TBX5 [nucleoplasm]ProteinQ99593 (Uniprot-TrEMBL)
TBX5:WWTR1:PCAFComplexREACT_119245 (Reactome)
TBX5ProteinQ99593 (Uniprot-TrEMBL)
TEAD1 [nucleoplasm]ProteinP28347 (Uniprot-TrEMBL)
TEAD2 [nucleoplasm]ProteinQ15562 (Uniprot-TrEMBL)
TEAD3(1-435) [nucleoplasm]ProteinQ99594 (Uniprot-TrEMBL)
TEAD4 [nucleoplasm]ProteinQ15561 (Uniprot-TrEMBL)
TEAD:WWTR1(TAZ)ComplexREACT_120065 (Reactome)
TEAD:YAP1ComplexREACT_119773 (Reactome)
TEADProteinREACT_119570 (Reactome)
TGS1 [nucleoplasm]ProteinQ96RS0 (Uniprot-TrEMBL)
WWTR1 [nucleoplasm]ProteinQ9GZV5 (Uniprot-TrEMBL)
WWTR1ProteinQ9GZV5 (Uniprot-TrEMBL)
YAP1 [nucleoplasm]ProteinP46937 (Uniprot-TrEMBL)
YAP1ProteinP46937 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
CTGFArrowREACT_116163 (Reactome)
KAT2BREACT_118620 (Reactome)
NPPA(1-670)ArrowREACT_118863 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116163 (Reactome)
REACT_116163 (Reactome) The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTFG is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).
REACT_118620 (Reactome) In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind the TBX5 transcription factor and PCAF (KAT2B) histone acetyltransferase to form a complex. The stoichiometry of this complex is unknown (Murakami et al. 2005).
REACT_118717 (Reactome) In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind the RUNX2 transcription factor to form a complex. This interaction has not been experimentally characterized in human cells but is inferred from properties of the homologous mouse proteins. The stoichiometry of this complex is unknown (Cui et al. 2003).
REACT_118805 (Reactome) In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009; Zhang et al. 2009).
REACT_118835 (Reactome) In the nucleus the YAP1 transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009).
REACT_118863 (Reactome) Transcription of the NPPA (ANF) gene is stimulated by the action of a transcription factor complex that includes WWTR1 (TAZ), TBX5, and the PCAF (KAT2B) histone acetyltransferase (Murakami et al. 2005).
RUNX2:WWTR1(TAZ)ArrowREACT_118717 (Reactome)
RUNX2REACT_118717 (Reactome)
TBX5:WWTR1:PCAFArrowREACT_118620 (Reactome)
TBX5:WWTR1:PCAFArrowREACT_118863 (Reactome)
TBX5REACT_118620 (Reactome)
TEAD:WWTR1(TAZ)ArrowREACT_116163 (Reactome)
TEAD:WWTR1(TAZ)ArrowREACT_118805 (Reactome)
TEAD:YAP1ArrowREACT_116163 (Reactome)
TEAD:YAP1ArrowREACT_118835 (Reactome)
TEADREACT_118805 (Reactome)
TEADREACT_118835 (Reactome)
WWTR1REACT_118620 (Reactome)
WWTR1REACT_118717 (Reactome)
WWTR1REACT_118805 (Reactome)
YAP1REACT_118835 (Reactome)
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