Degradation of beta-catenin by the destruction complex (Homo sapiens)

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9671518, 1052, 4, 127151415p-S37,T41,S45-beta-catenin[cytosol]p-S33,S37,T41,S45-beta-catenin[cytosol]p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC(20 aa repeatregion):PP2A:FAM123Bcomplex [cytosol]p-S33,S37,T41,S45-beta-catenin[cytosol]PP2A [cytosol]PP2A [cytosol]pS45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123Bcomplex [cytosol]Axin:GSK3:CK1alpha:APC:PP2A:FAM123Bcomplex [cytosol]p-S33,S37,T41,S45-beta-catenin[cytosol]PP2A [cytosol]PP2A [cytosol]FRAT1 or FRAT2[cytosol]SCF-beta-TrCP1complex [cytosol]PP2A [cytosol]p-S37,T41,S45-beta-catenin:Axin,GSK3:CK1alpha:APC:PP2A:FAM123Bcomplex [cytosol]pS45- beta-catenin[cytosol]PP2A [cytosol]p-S33,S37,T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123Bcomplex [cytosol]FRAT1/FRAT2:GSK3betaComplex [cytosol]cytosolp-T41,S45-betacatenin [cytosol]PP2A [cytosol]PP2A [cytosol]beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123Bcomplex [cytosol]p-T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123Bcomplex [cytosol]26S proteasome[cytosol]p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC(20 aa repeatregion):PP2A:FAM123Bcomplex [cytosol]PP2A [cytosol]GSK3B [cytosol]CUL1 [cytosol]PSMA8 [cytosol]PSMC2 [cytosol]p-S37,T41,S45-beta-catenin:Axin,GSK3:CK1alpha:APC:PP2A:FAM123BcomplexCSNK1A1(1-337)[cytosol]GSK3B [cytosol]UbPSMA3 [cytosol]GSK3B [cytosol]SKP1 [cytosol]AXIN1 [cytosol]PSME1 [cytosol]p-S33,S37,T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123Bcomplexp-S37,S45,T41-CTNNB1-1[cytosol]PSMD14 [cytosol]GSK3B [cytosol]PSMB3 [cytosol]PSMB4 [cytosol]APCPSMA1 [cytosol]26S proteasomepS45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123BcomplexAXIN1ATPGSK3BADPPSMD12 [cytosol]PP2AAPC [cytosol]ATPGSK3B [cytosol]ATPubiquitinatedphospho-beta-catenin:SCF:beta-TrCP1complexPSMD2 [cytosol]AMER1 [cytosol]p-T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123BcomplexAPC [cytosol]AMER1 [cytosol]CSNK1A1(1-337)[cytosol]PSMF1(2-271)[cytosol]PSMB10 [cytosol]APC [cytosol]BTRC [cytosol]PSME3 [cytosol]PSMA2 [cytosol]p-APC [cytosol]PSMA6 [cytosol]PSMA7(2-248)[cytosol]AMER1 [cytosol]CSNK1A1(1-337)[cytosol]SCF-beta-TrCP1complex associatedwith phosphorylatedbeta-cateninFRAT1/FRAT2:GSK3betaComplexPSMD3 [cytosol]p-APC [cytosol]PSMD13 [cytosol]Axin:GSK3:CK1alpha:APC:PP2A:FAM123BcomplexCSNK1A1(1-337)beta-cateninAMER1 [cytosol]p-S33,S37,S45,T41-CTNNB1-1[cytosol]AMER1CSNK1A1(1-337)[cytosol]PSMC4 [cytosol]GSK3B [cytosol]p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC(20 aa repeatregion):PP2A:FAM123BcomplexADPPSMA4 [cytosol]APC [cytosol]PSME4 [cytosol]PSMA5 [cytosol]PSMB9 [cytosol]CSNK1A1(1-337)[cytosol]beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123BcomplexGSK3B [cytosol]p-S45,T41-CTNNB1-1[cytosol]PSMD7(2-324)[cytosol]GSK3B [cytosol]PSMC6(2-389)[cytosol]PSMD11 [cytosol]PSMC3 [cytosol]APC [cytosol]SCF-beta-TrCP1complexPSMB6 [cytosol]FRAT2 [cytosol]Axin:CK1alpha:GSK3B:phospho-APC(20 aa repeatregion):PP2A:FAM123BcomplexATPPSMC1(2-440)[cytosol]PSMD1 [cytosol]ATPp-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC(20 aa repeatregion):PP2A:FAM123BcomplexPSMD8 [cytosol]PSMD6(2-389)[cytosol]PSMC5 [cytosol]ADPp-S45-CTNNB1-1[cytosol]PSMD5 [cytosol]CSNK1A1(1-337)[cytosol]PSMB11 [cytosol]GSK3B [cytosol]FRAT1 [cytosol]PSMD9 [cytosol]CSNK1A1(1-337)[cytosol]PSMB2 [cytosol]PSMD4(2-377)[cytosol]AMER1 [cytosol]PSMB7 [cytosol]PSMB8 [cytosol]APC [cytosol]AMER1 [cytosol]PSME2 [cytosol]p-S33,S37,S45,T41-CTNNB1-1[cytosol]AMER1 [cytosol]CSNK1A1(1-337)[cytosol]p-S33,S37,S45,T41-CTNNB1-1[cytosol]AMER1 [cytosol]PSMB1 [cytosol]ADPADPPSMB5 [cytosol]PSMD10 [cytosol]10133, 11


Description

The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=195253

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Bibliography

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History

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CompareRevisionActionTimeUserComment
114976view16:50, 25 January 2021ReactomeTeamReactome version 75
113420view11:49, 2 November 2020ReactomeTeamReactome version 74
112622view16:00, 9 October 2020ReactomeTeamReactome version 73
101538view11:40, 1 November 2018ReactomeTeamreactome version 66
101073view21:22, 31 October 2018ReactomeTeamreactome version 65
100603view19:57, 31 October 2018ReactomeTeamreactome version 64
100154view16:42, 31 October 2018ReactomeTeamreactome version 63
99704view15:10, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93998view13:50, 16 August 2017ReactomeTeamreactome version 61
93607view11:28, 9 August 2017ReactomeTeamreactome version 61
87171view19:24, 18 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
86716view09:24, 11 July 2016ReactomeTeamreactome version 56
83396view11:07, 18 November 2015ReactomeTeamVersion54
81590view13:07, 21 August 2015ReactomeTeamVersion53
77050view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76755view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76080view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75790view11:32, 10 June 2014ReactomeTeamReactome 48 Update
75140view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74831view10:05, 30 April 2014ReactomeTeamReactome46
74787view08:52, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Protein
26S proteasomeComplexREACT_2353 (Reactome)
ADPMetaboliteCHEBI:16761 (ChEBI)
AMER1 [cytosol]ProteinQ5JTC6 (Uniprot-TrEMBL)
AMER1ProteinQ5JTC6 (Uniprot-TrEMBL)
APC [cytosol]ProteinP25054 (Uniprot-TrEMBL)
APCProteinP25054 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AXIN1 [cytosol]ProteinO15169 (Uniprot-TrEMBL)
AXIN1ProteinO15169 (Uniprot-TrEMBL)
Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		ComplexREACT_10381 (Reactome) In this complex Axin is bound to beta-catenin.
Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexComplexREACT_10218 (Reactome)
BTRC [cytosol]ProteinQ9Y297 (Uniprot-TrEMBL)
CSNK1A1(1-337) [cytosol]ProteinP48729 (Uniprot-TrEMBL)
CSNK1A1(1-337)ProteinP48729 (Uniprot-TrEMBL)
CUL1 [cytosol]ProteinQ13616 (Uniprot-TrEMBL)
FRAT1 [cytosol]ProteinQ92837 (Uniprot-TrEMBL)
FRAT1/FRAT2:GSK3beta ComplexComplexREACT_76688 (Reactome)
FRAT2 [cytosol]ProteinO75474 (Uniprot-TrEMBL)
GSK3B [cytosol]ProteinP49841 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
PP2AComplexREACT_10628 (Reactome)
PSMA1 [cytosol]ProteinP25786 (Uniprot-TrEMBL)
PSMA2 [cytosol]ProteinP25787 (Uniprot-TrEMBL)
PSMA3 [cytosol]ProteinP25788 (Uniprot-TrEMBL)
PSMA4 [cytosol]ProteinP25789 (Uniprot-TrEMBL)
PSMA5 [cytosol]ProteinP28066 (Uniprot-TrEMBL)
PSMA6 [cytosol]ProteinP60900 (Uniprot-TrEMBL)
PSMA7(2-248) [cytosol]ProteinO14818 (Uniprot-TrEMBL)
PSMA8 [cytosol]ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 [cytosol]ProteinP20618 (Uniprot-TrEMBL)
PSMB10 [cytosol]ProteinP40306 (Uniprot-TrEMBL)
PSMB11 [cytosol]ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 [cytosol]ProteinP49721 (Uniprot-TrEMBL)
PSMB3 [cytosol]ProteinP49720 (Uniprot-TrEMBL)
PSMB4 [cytosol]ProteinP28070 (Uniprot-TrEMBL)
PSMB5 [cytosol]ProteinP28074 (Uniprot-TrEMBL)
PSMB6 [cytosol]ProteinP28072 (Uniprot-TrEMBL)
PSMB7 [cytosol]ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 [cytosol]ProteinP28062 (Uniprot-TrEMBL)
PSMB9 [cytosol]ProteinP28065 (Uniprot-TrEMBL)
PSMC1(2-440) [cytosol]ProteinP62191 (Uniprot-TrEMBL)
PSMC2 [cytosol]ProteinP35998 (Uniprot-TrEMBL)
PSMC3 [cytosol]ProteinP17980 (Uniprot-TrEMBL)
PSMC4 [cytosol]ProteinP43686 (Uniprot-TrEMBL)
PSMC5 [cytosol]ProteinP62195 (Uniprot-TrEMBL)
PSMC6(2-389) [cytosol]ProteinP62333 (Uniprot-TrEMBL)
PSMD1 [cytosol]ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 [cytosol]ProteinO75832 (Uniprot-TrEMBL)
PSMD11 [cytosol]ProteinO00231 (Uniprot-TrEMBL)
PSMD12 [cytosol]ProteinO00232 (Uniprot-TrEMBL)
PSMD13 [cytosol]ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 [cytosol]ProteinO00487 (Uniprot-TrEMBL)
PSMD2 [cytosol]ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 [cytosol]ProteinO43242 (Uniprot-TrEMBL)
PSMD4(2-377) [cytosol]ProteinP55036 (Uniprot-TrEMBL)
PSMD5 [cytosol]ProteinQ16401 (Uniprot-TrEMBL)
PSMD6(2-389) [cytosol]ProteinQ15008 (Uniprot-TrEMBL)
PSMD7(2-324) [cytosol]ProteinP51665 (Uniprot-TrEMBL)
PSMD8 [cytosol]ProteinP48556 (Uniprot-TrEMBL)
PSMD9 [cytosol]ProteinO00233 (Uniprot-TrEMBL)
PSME1 [cytosol]ProteinQ06323 (Uniprot-TrEMBL)
PSME2 [cytosol]ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 [cytosol]ProteinP61289 (Uniprot-TrEMBL)
PSME4 [cytosol]ProteinQ14997 (Uniprot-TrEMBL)
PSMF1(2-271) [cytosol]ProteinQ92530 (Uniprot-TrEMBL)
SCF-beta-TrCP1

complex associated with phosphorylated

beta-catenin		ComplexREACT_10593 (Reactome) B-TrCP associates with phosphorylated beta-catenin through the B-TrCP WD40 repeat region. Currently, it is unclear whether the ubiquitin ligase binds beta-catenin after it leaves the complex. It is equally possible that it binds beta-catenin while beta-catenin is still bound to Axin.
SCF-beta-TrCP1 complexComplexREACT_6992 (Reactome)
SKP1 [cytosol]ProteinP63208 (Uniprot-TrEMBL)
UbProteinREACT_3316 (Reactome)
beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexComplexREACT_10837 (Reactome)
beta-cateninProteinREACT_10304 (Reactome)
p-APC [cytosol]ProteinP25054 (Uniprot-TrEMBL)
p-S33,S37,S45,T41-CTNNB1-1 [cytosol]ProteinP35222-1 (Uniprot-TrEMBL)
p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		ComplexREACT_10660 (Reactome) In this complex Axin is bound to beta-catenin.
p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		ComplexREACT_10886 (Reactome) In this form of the destruction complex, beta-catenin is no longer associated with Axin, but instead with phospho-(20aa) APC.
p-S33,S37,T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexComplexREACT_10610 (Reactome)
p-S37,S45,T41-CTNNB1-1 [cytosol]ProteinP35222-1 (Uniprot-TrEMBL)
p-S37,T41,S45-beta-catenin:Axin,GSK3:CK1alpha:APC:PP2A:FAM123B complexComplexREACT_10861 (Reactome)
p-S45,T41-CTNNB1-1 [cytosol]ProteinP35222-1 (Uniprot-TrEMBL)
p-S45-CTNNB1-1 [cytosol]ProteinP35222-1 (Uniprot-TrEMBL)
p-T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexComplexREACT_10844 (Reactome)
pS45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexComplexREACT_10809 (Reactome)
ubiquitinated

phospho-beta-catenin:SCF:beta-TrCP1

complex		ComplexREACT_10202 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
26S proteasomemim-catalysisREACT_10017 (Reactome)
ADPArrowREACT_9955 (Reactome)
ADPArrowREACT_9959 (Reactome)
ADPArrowREACT_9978 (Reactome)
ADPArrowREACT_9983 (Reactome)
ADPArrowREACT_9987 (Reactome)
AMER1REACT_10134 (Reactome)
APCREACT_10134 (Reactome)
ATPREACT_9955 (Reactome)
ATPREACT_9959 (Reactome)
ATPREACT_9978 (Reactome)
ATPREACT_9983 (Reactome)
ATPREACT_9987 (Reactome)
AXIN1REACT_10134 (Reactome)
Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		ArrowREACT_10017 (Reactome)
Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexArrowREACT_10134 (Reactome)
Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexREACT_10111 (Reactome)
CSNK1A1(1-337)REACT_10134 (Reactome)
FRAT1/FRAT2:GSK3beta ComplexTBarREACT_9955 (Reactome)
FRAT1/FRAT2:GSK3beta ComplexTBarREACT_9959 (Reactome)
FRAT1/FRAT2:GSK3beta ComplexTBarREACT_9987 (Reactome)
GSK3BREACT_10134 (Reactome)
PP2AREACT_10134 (Reactome)
REACT_10017 (Reactome) Ubiquitinated beta-catenin is degraded by the proteasome.
REACT_10082 (Reactome) Beta-catenin is ubiquitinated by the SCF-B-TrCP1 complex.
REACT_10111 (Reactome) Beta-catenin associates with the destruction complex through an interaction with Axin and or APC. This association may also involve interactions with the 15 aa repeats in APC (Spink et al., 2001) or the third APC 20aa repeat and its N-terminal flanking residues (Ha et al., 2004, Xing et al., 2004; Liu et al., 2006).
REACT_10127 (Reactome) The phosphorylation of the 20 aa repeats in APC results in an increase in affinity for beta-catenin (Ha et al., 2004, Xing et al., 2004; Liu et al., 2006). The binding site of phospho -(20 aa) APC on beta-catenin overlaps the binding site of Axin on beta catenin. In addition, phosphorylated APC prevents the association of Axin with beta-catenin (Ha et al., 2004, Xing et al., 2004). In this model, phosphorylated APC may compete with Axin for beta-catenin binding, resulting in dissociation of the Axin:beta-catenin interaction in the destruction complex (see Kimelman and Xu 2006).
REACT_10134 (Reactome) The exact composition of the destruction complex is not known. A number of components appear to form a core complex, while others may associate with the complex transiently when a Wnt signal is present (reviewed in Kimelman and Xu, 2006). The core components include Axin, glycogen synthase kinase 3 (GSK-3), Casein kinase 1 (CKI) alpha, beta-catenin, Protein phosphatase 2A (PP2A) and Adenomatous Polyposis Coli (APC). CK1 epsilon, Diversin and PP1 may also be components of the complex.
REACT_9955 (Reactome) Following CKI-mediated phosphorylation at Ser45, beta-catenin is phosphorylated by GSK3 at Thr41.
REACT_9959 (Reactome) Phospho-(Ser45, Thr41) beta-catenin is phosphorylated by GSK3 at Ser37.
REACT_9977 (Reactome) B-TrCP associates with phosphorylated beta-catenin through the B-TrCP WD40 repeat region. Currently, it is unclear whether the ubiquitin ligase binds beta-catenin after it leaves the complex. It is equally possible that it binds beta-catenin while beta-catenin is still bound to Axin.
REACT_9978 (Reactome) CK1a binds to Axin and phosphorylates beta-catenin at Ser45 priming GSK3 mediated phosphorylation at the more N-terminal residues (Amit et al., 2002; Liu et al., 2002; Yanagawa et al., 2002).
REACT_9983 (Reactome) APC is phosphorylated on the 20 aa repeats by CK1 and potentially GSK-3. This significantly increases the binding affinity of the APC 20 aa repeats for beta-catenin, causing one of them to bind b-catenin in the same region as beta-catenin binds Axin, thus displacing beta-catenin from Axin ( Step 5 above) (Reviewed in Kimelman, 2006).
REACT_9987 (Reactome) Beta-catenin is then phosphorylated at Ser33. Phosphorylated S37 and S33 together with neighboring residues constitute the recognition motif for beta-TrCP.
SCF-beta-TrCP1

complex associated with phosphorylated

beta-catenin		ArrowREACT_9977 (Reactome)
SCF-beta-TrCP1

complex associated with phosphorylated

beta-catenin		REACT_10082 (Reactome)
SCF-beta-TrCP1 complexArrowREACT_10017 (Reactome)
SCF-beta-TrCP1 complexREACT_9977 (Reactome)
UbArrowREACT_10017 (Reactome)
UbREACT_10082 (Reactome)
beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexArrowREACT_10111 (Reactome)
beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexREACT_9978 (Reactome)
beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexmim-catalysisREACT_9978 (Reactome)
beta-cateninREACT_10111 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		ArrowREACT_10127 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		ArrowREACT_9983 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		REACT_10127 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:CK1alpha:GSK3B:phospho-APC

(20 aa repeat region):PP2A:FAM123B

complex		REACT_9977 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexArrowREACT_9987 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexREACT_9983 (Reactome)
p-S33,S37,T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexmim-catalysisREACT_9983 (Reactome)
p-S37,T41,S45-beta-catenin:Axin,GSK3:CK1alpha:APC:PP2A:FAM123B complexArrowREACT_9959 (Reactome)
p-S37,T41,S45-beta-catenin:Axin,GSK3:CK1alpha:APC:PP2A:FAM123B complexREACT_9987 (Reactome)
p-S37,T41,S45-beta-catenin:Axin,GSK3:CK1alpha:APC:PP2A:FAM123B complexmim-catalysisREACT_9987 (Reactome)
p-T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexArrowREACT_9955 (Reactome)
p-T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexREACT_9959 (Reactome)
p-T41,S45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexmim-catalysisREACT_9959 (Reactome)
pS45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexArrowREACT_9978 (Reactome)
pS45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexREACT_9955 (Reactome)
pS45-beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A:FAM123B complexmim-catalysisREACT_9955 (Reactome)
ubiquitinated

phospho-beta-catenin:SCF:beta-TrCP1

complex		ArrowREACT_10082 (Reactome)
ubiquitinated

phospho-beta-catenin:SCF:beta-TrCP1

complex		REACT_10017 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2773"
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