Vasopressin regulates renal water homeostasis via aquaporins (Homo sapiens)

From WikiPathways

Revision as of 08:06, 17 July 2014 by ReactomeTeam (Talk | contribs)
Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none cytosolcytosolcytoplasmic membrane-bounded vesicle lumenAQP1 tetramer[plasma membrane]Vasopressin receptortype 2:AVP [plasmamembrane]G-alpha(s):GDP:G-beta:G-gamma[plasma membrane]G-beta:G-gamma(candidates) [plasmamembrane]G-protein alpha(s):GDP [plasmamembrane]AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma[plasma membrane]G-alpha(s):GDP:G-beta:G-gamma[plasma membrane]G-beta:G-gamma(candidates) [plasmamembrane]G-protein alpha(s):GDP [plasmamembrane]Vasopressin receptortype 2:AVP [plasmamembrane]AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma[plasma membrane]Vasopressin receptortype 2:AVP [plasmamembrane]G-alpha(s):GTP:G-beta:G-gamma[plasma membrane]G-protein alpha(s):GTP [plasmamembrane]G-beta:G-gamma(candidates) [plasmamembrane]G-protein alpha(s):GTP [plasmamembrane]Gs-activatedadenylate cyclase[plasma membrane]G-protein alpha(s):GTP [plasmamembrane]Adenylate cyclase(Mg2+ cofactor)[plasma membrane]Adenylate cyclase[plasma membrane]PKA tetramer[cytosol]PKA regulatorysubunit [cytosol]PKA catalyticsubunit [cytosol]cAMP:PKA regulatorysubunit [cytosol]PKA regulatorysubunit [cytosol]AQP2 tetramer[transport vesiclemembrane]p-S256-AQP2[transport vesiclemembrane]p-S256-AQP2 [plasmamembrane]AQP3 tetramer[plasma membrane]AQP4 tetramer[plasma membrane]Adenylate cyclase(Mg2+ cofactor)[plasma membrane]Adenylate cyclase[plasma membrane]G-alpha(s):GTP:G-beta:G-gamma[plasma membrane]G-protein alpha(s):GTP [plasmamembrane]G-beta:G-gamma(candidates) [plasmamembrane]G-beta:G-gamma(candidates) [plasmamembrane]MYO5B:RABFIP2:RAB11A[cytoplasmic vesiclemembrane]RAB11A:GTP[cytoplasmic vesiclemembrane]FiltrateBloodstreamProximal tubule, descending thin limb of HenleCollecting ductH2OH2OAQP1 tetramerH2OAVP(20-28)AVPR2Vasopressin receptortype 2:AVPG-alpha(s):GDP:G-beta:G-gammaAVPR2:AVP:G-alpha(s):GDP:G-beta:G-gammaGTPGDPAVPR2:AVP:G-alpha(s):GTP:G-beta:G-gammaG-protein alpha(s):GTPGs-activatedadenylate cyclaseATPPPi3',5'-Cyclic AMPPKA tetramercAMP:PKA regulatorysubunitPKA catalyticsubunitAQP2 tetramerp-S256-AQP2p-S256-AQP2H2OAQP3 tetramerH2OAQP4 tetramerH2OH2OAdenylate cyclase(Mg2+ cofactor)G-alpha(s):GTP:G-beta:G-gammaG-beta:G-gamma(candidates)MYO5B:RABFIP2:RAB11AAQP1 [plasmamembrane]AVP(20-28)[extracellularregion]AVPR2 [plasmamembrane]GNAS(2-394) [plasmamembrane]GDP [plasmamembrane]GNAS(2-394) [plasmamembrane]GDP [plasmamembrane]AVP(20-28)[extracellularregion]AVPR2 [plasmamembrane]AVP(20-28)[extracellularregion]AVPR2 [plasmamembrane]GNAS(2-394) [plasmamembrane]GTP [plasmamembrane]GNAS(2-394) [plasmamembrane]GTP [plasmamembrane]GNAS(2-394) [plasmamembrane]GTP [plasmamembrane]Mg2+ [plasmamembrane]ADCY2 [plasmamembrane]ADCY3 [plasmamembrane]ADCY4 [plasmamembrane]ADCY6 [plasmamembrane]ADCY7 [plasmamembrane]ADCY9 [plasmamembrane]ADCY1 [plasmamembrane]ADCY5 [plasmamembrane]ADCY8 [plasmamembrane]PRKAR1A(1-381)[cytosol]PRKAR1B [cytosol]PRKAR2A [cytosol]PRKAR2B [cytosol]PRKACA [cytosol]PRKACB [cytosol]PRKACG [cytosol]PRKAR1A(1-381)[cytosol]PRKAR1B [cytosol]PRKAR2A [cytosol]PRKAR2B [cytosol]3',5'-Cyclic AMP[cytosol]AQP2 [transportvesicle membrane]p-S256-AQP2[transport vesiclemembrane]p-S256-AQP2 [plasmamembrane]AQP3 [plasmamembrane]AQP4 [plasmamembrane]Mg2+ [plasmamembrane]ADCY2 [plasmamembrane]ADCY3 [plasmamembrane]ADCY4 [plasmamembrane]ADCY6 [plasmamembrane]ADCY7 [plasmamembrane]ADCY9 [plasmamembrane]ADCY1 [plasmamembrane]ADCY5 [plasmamembrane]ADCY8 [plasmamembrane]GNAS(2-394) [plasmamembrane]GTP [plasmamembrane]MYO5B [cytoplasmicvesicle membrane]RAB11FIP2[cytoplasmic vesiclemembrane]RAB11A [cytoplasmicvesicle membrane]GTP [cytoplasmicvesicle membrane]Name: Regulation of Water Balance by Renal AquaporinsOrganism: Homo sapiens


Description

In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=432040

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:Reactome.pngCommunity: Reactome
Image:Unconnected.pngFix interactions

Ontology Terms

 

Bibliography

View all...
  1. Nielsen S, Kwon TH, Frøkiaer J, Agre P.; ''Regulation and dysregulation of aquaporins in water balance disorders.''; PubMed Europe PMC Scholia
  2. Nedvetsky PI, Tamma G, Beulshausen S, Valenti G, Rosenthal W, Klussmann E.; ''Regulation of aquaporin-2 trafficking.''; PubMed Europe PMC Scholia
  3. Walz T, Hirai T, Murata K, Heymann JB, Mitsuoka K, Fujiyoshi Y, Smith BL, Agre P, Engel A.; ''The three-dimensional structure of aquaporin-1.''; PubMed Europe PMC Scholia
  4. Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR.; ''Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.''; PubMed Europe PMC Scholia
  5. de Mattia F, Savelkoul PJ, Kamsteeg EJ, Konings IB, van der Sluijs P, Mallmann R, Oksche A, Deen PM.; ''Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus.''; PubMed Europe PMC Scholia
  6. Preston GM, Carroll TP, Guggino WB, Agre P.; ''Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein.''; PubMed Europe PMC Scholia
  7. Hendriks G, Koudijs M, van Balkom BW, Oorschot V, Klumperman J, Deen PM, van der Sluijs P.; ''Glycosylation is important for cell surface expression of the water channel aquaporin-2 but is not essential for tetramerization in the endoplasmic reticulum.''; PubMed Europe PMC Scholia
  8. Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM.; ''Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance.''; PubMed Europe PMC Scholia
  9. Tsunoda SP, Wiesner B, Lorenz D, Rosenthal W, Pohl P.; ''Aquaporin-1, nothing but a water channel.''; PubMed Europe PMC Scholia
  10. Birnbaumer M, Seibold A, Gilbert S, Ishido M, Barberis C, Antaramian A, Brabet P, Rosenthal W.; ''Molecular cloning of the receptor for human antidiuretic hormone.''; PubMed Europe PMC Scholia
  11. Echeverría V, Hinrichs MV, Torrejón M, Ropero S, Martinez J, Toro MJ, Olate J.; ''Mutagenesis in the switch IV of the helical domain of the human Gsalpha reduces its GDP/GTP exchange rate.''; PubMed Europe PMC Scholia
  12. Brito M, Guzmán L, Romo X, Soto X, Hinrichs MV, Olate J.; ''S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate.''; PubMed Europe PMC Scholia
  13. Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T.; ''Localization and trafficking of aquaporin 2 in the kidney.''; PubMed Europe PMC Scholia
  14. Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA.; ''Aquaporins in the kidney: from molecules to medicine.''; PubMed Europe PMC Scholia
  15. Nielsen S, Smith BL, Christensen EI, Knepper MA, Agre P.; ''CHIP28 water channels are localized in constitutively water-permeable segments of the nephron.''; PubMed Europe PMC Scholia
  16. Denker BM, Smith BL, Kuhajda FP, Agre P.; ''Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.''; PubMed Europe PMC Scholia
  17. Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y.; ''Structural determinants of water permeation through aquaporin-1.''; PubMed Europe PMC Scholia
  18. Gullingsrud J, Kim C, Taylor SS, McCammon JA.; ''Dynamic binding of PKA regulatory subunit RI alpha.''; PubMed Europe PMC Scholia
  19. Katsura T, Gustafson CE, Ausiello DA, Brown D.; ''Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells.''; PubMed Europe PMC Scholia
  20. de Groot BL, Engel A, Grubmüller H.; ''A refined structure of human aquaporin-1.''; PubMed Europe PMC Scholia
  21. Bedford JJ, Leader JP, Walker RJ.; ''Aquaporin expression in normal human kidney and in renal disease.''; PubMed Europe PMC Scholia
  22. Erlenbach I, Wess J.; ''Molecular basis of V2 vasopressin receptor/Gs coupling selectivity.''; PubMed Europe PMC Scholia
  23. Burghardt B, Elkaer ML, Kwon TH, Rácz GZ, Varga G, Steward MC, Nielsen S.; ''Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.''; PubMed Europe PMC Scholia
  24. Hub JS, de Groot BL.; ''Mechanism of selectivity in aquaporins and aquaglyceroporins.''; PubMed Europe PMC Scholia
  25. Mohr E, Hillers M, Ivell R, Haulica ID, Richter D.; ''Expression of the vasopressin and oxytocin genes in human hypothalami.''; PubMed Europe PMC Scholia
  26. Zeidel ML, Ambudkar SV, Smith BL, Agre P.; ''Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.''; PubMed Europe PMC Scholia
  27. Kamsteeg EJ, Heijnen I, van Os CH, Deen PM.; ''The subcellular localization of an aquaporin-2 tetramer depends on the stoichiometry of phosphorylated and nonphosphorylated monomers.''; PubMed Europe PMC Scholia
  28. Wu B, Steinbronn C, Alsterfjord M, Zeuthen T, Beitz E.; ''Concerted action of two cation filters in the aquaporin water channel.''; PubMed Europe PMC Scholia
  29. Beitz E, Wu B, Holm LM, Schultz JE, Zeuthen T.; ''Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia, and protons.''; PubMed Europe PMC Scholia
  30. Mobasheri A, Marples D.; ''Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology.''; PubMed Europe PMC Scholia
  31. Martin BR, Farndale RW, Wong SK.; ''The role of Gs in activation of adenylate cyclase.''; PubMed Europe PMC Scholia
  32. Sausville E, Carney D, Battey J.; ''The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.''; PubMed Europe PMC Scholia
  33. Liu J, Wess J.; ''Different single receptor domains determine the distinct G protein coupling profiles of members of the vasopressin receptor family.''; PubMed Europe PMC Scholia
  34. Meinild AK, Klaerke DA, Zeuthen T.; ''Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5.''; PubMed Europe PMC Scholia
  35. Nejsum LN.; ''The renal plumbing system: aquaporin water channels.''; PubMed Europe PMC Scholia
  36. van Balkom BW, Savelkoul PJ, Markovich D, Hofman E, Nielsen S, van der Sluijs P, Deen PM.; ''The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel.''; PubMed Europe PMC Scholia
  37. Roudier N, Bailly P, Gane P, Lucien N, Gobin R, Cartron JP, Ripoche P.; ''Erythroid expression and oligomeric state of the AQP3 protein.''; PubMed Europe PMC Scholia
  38. Dessauer CW, Chen-Goodspeed M, Chen J.; ''Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.''; PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116671view12:55, 9 May 2021EweitzModified title
115057
Reactome
view17:00, 25 January 2021ReactomeTeamReactome version 75
113501view11:57, 2 November 2020ReactomeTeamReactome version 74
112701view16:09, 9 October 2020ReactomeTeamReactome version 73
101617view11:48, 1 November 2018ReactomeTeamreactome version 66
101153view21:34, 31 October 2018ReactomeTeamreactome version 65
100680view20:07, 31 October 2018ReactomeTeamreactome version 64
100230view16:52, 31 October 2018ReactomeTeamreactome version 63
99781view15:18, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99336view12:47, 31 October 2018ReactomeTeamreactome version 62
93786view13:36, 16 August 2017ReactomeTeamreactome version 61
93319view11:20, 9 August 2017ReactomeTeamreactome version 61
88349view16:17, 1 August 2016FehrhartOntology Term : 'water transport pathway' added !
88348view16:16, 1 August 2016FehrhartOntology Term : 'vasopressin signaling pathway' added !
86404view09:17, 11 July 2016ReactomeTeamreactome version 56
83089view09:57, 18 November 2015ReactomeTeamVersion54
81747view08:20, 26 August 2015ReactomeTeamVersion53
76842view08:06, 17 July 2014ReactomeTeamFixed remaining interactions
76546view11:53, 16 July 2014ReactomeTeamFixed remaining interactions
75879view09:53, 11 June 2014ReactomeTeamRe-fixing comment source
75579view10:41, 10 June 2014ReactomeTeamReactome 48 Update
74934view13:46, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74578view08:37, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
3',5'-Cyclic AMP [cytosol]MetaboliteCHEBI:17489 (ChEBI)
3',5'-Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
ADCY1 [plasma membrane]ProteinQ08828 (Uniprot-TrEMBL)
ADCY2 [plasma membrane]ProteinQ08462 (Uniprot-TrEMBL)
ADCY3 [plasma membrane]ProteinO60266 (Uniprot-TrEMBL)
ADCY4 [plasma membrane]ProteinQ8NFM4 (Uniprot-TrEMBL)
ADCY5 [plasma membrane]ProteinO95622 (Uniprot-TrEMBL)
ADCY6 [plasma membrane]ProteinO43306 (Uniprot-TrEMBL)
ADCY7 [plasma membrane]ProteinP51828 (Uniprot-TrEMBL)
ADCY8 [plasma membrane]ProteinP40145 (Uniprot-TrEMBL)
ADCY9 [plasma membrane]ProteinO60503 (Uniprot-TrEMBL)
AQP1 [plasma membrane]ProteinP29972 (Uniprot-TrEMBL)
AQP1 tetramerComplexREACT_24230 (Reactome)
AQP2 [transport vesicle membrane]ProteinP41181 (Uniprot-TrEMBL)
AQP2 tetramerComplexREACT_24078 (Reactome)
AQP3 [plasma membrane]ProteinQ92482 (Uniprot-TrEMBL)
AQP3 tetramerComplexREACT_24542 (Reactome)
AQP4 [plasma membrane]ProteinP55087 (Uniprot-TrEMBL)
AQP4 tetramerComplexREACT_24757 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
AVP(20-28)

[extracellular

region]		ProteinP01185 (Uniprot-TrEMBL)
AVP(20-28)ProteinP01185 (Uniprot-TrEMBL)
AVPR2 [plasma membrane]ProteinP30518 (Uniprot-TrEMBL)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gammaComplexREACT_24450 (Reactome)
AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gammaComplexREACT_24244 (Reactome)
AVPR2ProteinP30518 (Uniprot-TrEMBL)
Adenylate cyclase (Mg2+ cofactor)ComplexREACT_17689 (Reactome)
G-alpha(s):GDP:G-beta:G-gammaComplexREACT_24149 (Reactome)
G-alpha(s):GTP:G-beta:G-gammaComplexREACT_18711 (Reactome)
G-beta:G-gamma (candidates)ComplexREACT_18827 (Reactome)
G-protein alpha (s):GTPComplexREACT_5470 (Reactome)
GDP [plasma membrane]MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GNAS(2-394) [plasma membrane]ProteinP63092 (Uniprot-TrEMBL)
GTP [cytoplasmic vesicle membrane]MetaboliteCHEBI:15996 (ChEBI)
GTP [plasma membrane]MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Gs-activated adenylate cyclaseComplexREACT_2537 (Reactome)
H2OMetaboliteCHEBI:15377 (ChEBI)
MYO5B [cytoplasmic vesicle membrane]ProteinQ9ULV0 (Uniprot-TrEMBL)
MYO5B:RABFIP2:RAB11AComplexREACT_119400 (Reactome)
Mg2+ [plasma membrane]MetaboliteCHEBI:18420 (ChEBI)
PKA catalytic subunitProteinREACT_3031 (Reactome)
PKA tetramerComplexREACT_5749 (Reactome)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRKACA [cytosol]ProteinP17612 (Uniprot-TrEMBL)
PRKACB [cytosol]ProteinP22694 (Uniprot-TrEMBL)
PRKACG [cytosol]ProteinP22612 (Uniprot-TrEMBL)
PRKAR1A(1-381) [cytosol]ProteinP10644 (Uniprot-TrEMBL)
PRKAR1B [cytosol]ProteinP31321 (Uniprot-TrEMBL)
PRKAR2A [cytosol]ProteinP13861 (Uniprot-TrEMBL)
PRKAR2B [cytosol]ProteinP31323 (Uniprot-TrEMBL)
RAB11A [cytoplasmic vesicle membrane]ProteinP62491 (Uniprot-TrEMBL)
RAB11FIP2

[cytoplasmic vesicle

membrane]		ProteinQ7L804 (Uniprot-TrEMBL)
Vasopressin receptor type 2:AVPComplexREACT_17670 (Reactome)
cAMP:PKA regulatory subunitComplexREACT_4571 (Reactome)
p-S256-AQP2

[transport vesicle

membrane]		ProteinP41181 (Uniprot-TrEMBL)
p-S256-AQP2 [plasma membrane]ProteinP41181 (Uniprot-TrEMBL)
p-S256-AQP2ComplexREACT_24265 (Reactome)
p-S256-AQP2ComplexREACT_24418 (Reactome)

Annotated Interactions

View all...
Source  ↓Target  ↓Type  ↓Database reference  ↓Comment  ↓
3',5'-Cyclic AMPArrowREACT_1292 (Reactome)
3',5'-Cyclic AMPREACT_1532 (Reactome)
AQP1 tetramermim-catalysisREACT_23786 (Reactome)
AQP1 tetramermim-catalysisREACT_23841 (Reactome)
AQP2 tetramerREACT_23840 (Reactome)
AQP3 tetramermim-catalysisREACT_23789 (Reactome)
AQP4 tetramermim-catalysisREACT_24005 (Reactome)
ATPREACT_1292 (Reactome)
AVP(20-28)REACT_16964 (Reactome)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gammaArrowREACT_23894 (Reactome)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gammaREACT_23926 (Reactome)
AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gammaArrowREACT_23926 (Reactome)
AVPR2REACT_16964 (Reactome)
Adenylate cyclase (Mg2+ cofactor)REACT_2219 (Reactome)
G-alpha(s):GDP:G-beta:G-gammaREACT_23894 (Reactome)
G-alpha(s):GTP:G-beta:G-gammaREACT_18433 (Reactome)
G-beta:G-gamma (candidates)ArrowREACT_18433 (Reactome)
G-protein alpha (s):GTPArrowREACT_18433 (Reactome)
G-protein alpha (s):GTPREACT_2219 (Reactome)
GDPArrowREACT_23926 (Reactome)
GTPREACT_23926 (Reactome)
Gs-activated adenylate cyclaseArrowREACT_2219 (Reactome)
Gs-activated adenylate cyclasemim-catalysisREACT_1292 (Reactome)
H2OArrowREACT_23786 (Reactome)
H2OArrowREACT_23788 (Reactome)
H2OArrowREACT_23789 (Reactome)
H2OArrowREACT_23841 (Reactome)
H2OArrowREACT_24005 (Reactome)
H2OREACT_23786 (Reactome)
H2OREACT_23788 (Reactome)
H2OREACT_23789 (Reactome)
H2OREACT_23841 (Reactome)
H2OREACT_24005 (Reactome)
MYO5B:RABFIP2:RAB11Amim-catalysisREACT_23863 (Reactome)
PKA catalytic subunitArrowREACT_1532 (Reactome)
PKA catalytic subunitmim-catalysisREACT_23840 (Reactome)
PKA tetramerREACT_1532 (Reactome)
PPiArrowREACT_1292 (Reactome)
REACT_1292 (Reactome) Activated adenylate cyclase associated with the plasma membrane catalyzes the reaction of cytosolic ATP to form 3',5'-cyclicAMP and pyrophosphate.
REACT_1532 (Reactome) The four protein kinase A (PKA) regulatory subunit isoforms differ in their tissue specificity and functional characteristics. The specific isoform activated in response to glucagon signalling is not known. The PKA kinase is a tetramer of two regulatory and two catalytic. The regulatory subunits block the catalytic subunits. Binding of cAMP to the regulatory subunit leads to the dissociation of the tetramer into two active dimers made up of a regulatory and a catalytic subunit.
REACT_16964 (Reactome) The arginine vasopressin (AVP) receptor AVPR2 (Birnbaumer M et al, 1992) is expressed in the kidneys and can bind vasopressin (AVP) (Mohr E et al, 1985; Sausville E et al, 1985). This receptor uses the G protein alpha s subunit as its second messenger system.
REACT_18433 (Reactome) The binding of GTP by G(s) alpha causes the heterotrimeric G-protein complex to reorientate, exposing previously bound faces of the G(s) alpha:GTP complex and the G-beta: G-gamma complex. Unlike the case with Gi/o heterotrimers, Gs heterotrimers are not observed to significantly dissociate in living cells.
REACT_2219 (Reactome) G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it.
REACT_23786 (Reactome) Aquaporin-1 (AQP1) passively transports water across the plasma membrane according to the osmotic gradient. In the kidney AQP1 is expressed in endothelial cells of the vasa recta, the proximal tubule, and thin descending limb of Henle, where it functions to recover water from filtrate during urine formation. AQP1 is expressed in many other tissues, such as red blood cells, pancreas, and choroid plexus. AQP1 plays a role in forming cerebrospinal fluid.
REACT_23788 (Reactome) Aquaporin-2 (AQP2) passively transports water across membranes according to the osmotic gradient. AQP2 is mainly expressed in principal cells of the collecting duct and connecting tubule in the kidney. AQP2 function is acutely regulated by the antidiuretc hormone vasopressin. In the presence of vasopressin AQP is phosphorylated at Ser256, As inferred from rat and mouse Ser261, Ser264, and Thr269 may also be phosphorylated. These phosphorylations are thought to influence AQP2 trafficking and compartmentalization.
REACT_23789 (Reactome) Aquaporin-3 (AQP3) passively transports water and glycerol across the plasma membrane according to the osmotic gradient. AQP3 is expressed in airway epithelia, secretory glands, skin, the collecting ducts of the kidney, and the basolateral surface of intestinal epithelium..
REACT_23840 (Reactome) Activated Protein Kinase A phosphorylates Aquaporin-2 at Serine 256. The phosphorylated form of AQP2 then traffics from intracellular vesicles to the apical plasma membrane.
REACT_23841 (Reactome) Aquaporin-1 (AQP1) passively transports water across the plasma membrane according to the osmotic gradient. In the kidney AQP1 is expressed in endothelial cells of the vasa recta, the proximal tubule, and thin descending limb of Henle, where it functions to recover water from filtrate during urine formation. AQP1 is expressed in many other tissues, such as red blood cells, pancreas, and choroid plexus. AQP1 plays a role in forming cerebrospinal fluid.
REACT_23863 (Reactome) Intracellular vesicles bearing phosphorylated Aquaporin-2 tetramers are transported to the plasma membrane by a mechanism that may involve motor activity of myosin VB (inferred from rat, Nedvetsky et al. 2007) and dynein (inferred from toad bladder, Marples et al. 1996).
REACT_23894 (Reactome) The vasopressin receptor type 2 (AVPR2) interacts with G-protein alpha s via the third intracellular loop of AVPR2.
REACT_23926 (Reactome) The AVP:AVPR2 complex activates G-protein alpha s by causing a conformational change in G-protein alpha s that causes it to release GDP and bind GTP.
REACT_24005 (Reactome) Aquaporin-4 (AQP4) passively transports water across the plasma membrane according to the osmotic gradient. AQP4 is expressed in the collecting duct of the kidney and in astroglial cells at the blood-brain barrier and ependymal cells lining the ventricles of the brain.
Vasopressin receptor type 2:AVPArrowREACT_16964 (Reactome)
Vasopressin receptor type 2:AVPREACT_23894 (Reactome)
cAMP:PKA regulatory subunitArrowREACT_1532 (Reactome)
p-S256-AQP2ArrowREACT_23840 (Reactome)
p-S256-AQP2ArrowREACT_23863 (Reactome)
p-S256-AQP2REACT_23863 (Reactome)
p-S256-AQP2mim-catalysisREACT_23788 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2662"
Personal tools