Collagen degradation (Homo sapiens)
From WikiPathways
Description
Collagen fibril diameter and spatial organisation are dependent on the species, tissue type and stage of development (Parry 1988). The lengths of collagen fibrils in mature tissues are largely unknown but in tendon can be measured in millimetres (Craig et al. 1989). Collagen fibrils isolated from adult bovine corneal stroma had ~350 collagen molecules in transverse section, tapering down to three molecules at the growing tip (Holmes & Kadler 2005).
The classical view of collagenases is that they actively unwind the triple helical chain, a process termed molecular tectonics (Overall 2002, Bode & Maskos 2003), before preferentially cleaving the alpha2 chain followed by the remaining chains (Chung et al. 2004). More recently it has been suggested that collagen fibrils exist in an equilibrium between protected and vulnerable states (Stultz 2002, Nerenberg & Stultz 2008). The prototypical triple-helical structure of collagen does not fit into the active site of collagenase MMPs. In addition the scissile bonds are not solvent-exposed and are therefore inaccessible to the collagenase active site (Chung et al. 2004, Stultz 2002). It was realized that collagen must locally unfold into non-triple helical regions to allow collagenolysis. Observations using circular dichroism and differential scanning calorimetry confirm that there is considerable heterogeneity along collagen fibres (Makareeva et al. 2008) allowing access for MMPs at physiological temperatures (Salsas-Escat et al. 2010).
Collagen fibrils with cut chains are unstable and accessible to proteinases that cannot cleave intact collagen strands (Woessner & Nagase 2000, Somerville et al. 2003). Continued degradation leads to the formation of gelatin (Lovejoy et al. 1999). Degradation of collagen types other than I-III is less well characterized but believed to occur in a similar manner.
Metalloproteinases (MMPs) play a major part in the degradation of several extracellular macromolecules including collagens. MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996), sometimes referred to as collagenases I, II and III respectively, are able to initiate the intrahelical cleavage of the major fibril forming collagens I, II and III at neutral pH, and thus thought to define the rate-limiting step in normal tissue remodeling events. All can cleave additional substrates including other collagen subtypes. Collagenases cut collagen alpha chains at a single conserved Gly-Ile/Leu site approximately 3/4 of the molecule's length from the N-terminus (Fields 1991, Chung et al. 2004). The cleavage site is characterised by the motif G(I/L)(A/L); the G-I/L bond is cleaved. In collagen type I this corresponds to G953-I954 in the Uniprot canonical alpha chain sequences (often given as G775-I776 in literature). It is not clear why only this bond is cleaved, as the motif occurs at several other places in the chain. MMP14, a membrane-associated MMP also known as Membrane-type matrix metalloproteinase 1 (MT-MMP1), is able to cleave collagen types I, II and III (Ohuchi et al. 1997).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=1442490
The classical view of collagenases is that they actively unwind the triple helical chain, a process termed molecular tectonics (Overall 2002, Bode & Maskos 2003), before preferentially cleaving the alpha2 chain followed by the remaining chains (Chung et al. 2004). More recently it has been suggested that collagen fibrils exist in an equilibrium between protected and vulnerable states (Stultz 2002, Nerenberg & Stultz 2008). The prototypical triple-helical structure of collagen does not fit into the active site of collagenase MMPs. In addition the scissile bonds are not solvent-exposed and are therefore inaccessible to the collagenase active site (Chung et al. 2004, Stultz 2002). It was realized that collagen must locally unfold into non-triple helical regions to allow collagenolysis. Observations using circular dichroism and differential scanning calorimetry confirm that there is considerable heterogeneity along collagen fibres (Makareeva et al. 2008) allowing access for MMPs at physiological temperatures (Salsas-Escat et al. 2010).
Collagen fibrils with cut chains are unstable and accessible to proteinases that cannot cleave intact collagen strands (Woessner & Nagase 2000, Somerville et al. 2003). Continued degradation leads to the formation of gelatin (Lovejoy et al. 1999). Degradation of collagen types other than I-III is less well characterized but believed to occur in a similar manner.
Metalloproteinases (MMPs) play a major part in the degradation of several extracellular macromolecules including collagens. MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996), sometimes referred to as collagenases I, II and III respectively, are able to initiate the intrahelical cleavage of the major fibril forming collagens I, II and III at neutral pH, and thus thought to define the rate-limiting step in normal tissue remodeling events. All can cleave additional substrates including other collagen subtypes. Collagenases cut collagen alpha chains at a single conserved Gly-Ile/Leu site approximately 3/4 of the molecule's length from the N-terminus (Fields 1991, Chung et al. 2004). The cleavage site is characterised by the motif G(I/L)(A/L); the G-I/L bond is cleaved. In collagen type I this corresponds to G953-I954 in the Uniprot canonical alpha chain sequences (often given as G775-I776 in literature). It is not clear why only this bond is cleaved, as the motif occurs at several other places in the chain. MMP14, a membrane-associated MMP also known as Membrane-type matrix metalloproteinase 1 (MT-MMP1), is able to cleave collagen types I, II and III (Ohuchi et al. 1997).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=1442490
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- Wu JJ, Lark MW, Chun LE, Eyre DR.; ''Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.''; PubMed Europe PMC Scholia
- Chandler S, Cossins J, Lury J, Wells G.; ''Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein.''; PubMed Europe PMC Scholia
- Seltzer JL, Eisen AZ, Bauer EA, Morris NP, Glanville RW, Burgeson RE.; ''Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin.''; PubMed Europe PMC Scholia
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- Stracke JO, Hutton M, Stewart M, Pendás AM, Smith B, López-Otin C, Murphy G, Knäuper V.; ''Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme.''; PubMed Europe PMC Scholia
- Leduc R, Molloy SS, Thorne BA, Thomas G.; ''Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.''; PubMed Europe PMC Scholia
- Aimes RT, Quigley JP.; ''Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments.''; PubMed Europe PMC Scholia
- Miyazaki K, Hattori Y, Umenishi F, Yasumitsu H, Umeda M.; ''Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.''; PubMed Europe PMC Scholia
- Chung L, Dinakarpandian D, Yoshida N, Lauer-Fields JL, Fields GB, Visse R, Nagase H.; ''Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis.''; PubMed Europe PMC Scholia
- Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI.; ''SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.''; PubMed Europe PMC Scholia
- Moll UM, Youngleib GL, Rosinski KB, Quigley JP.; ''Tumor promoter-stimulated Mr 92,000 gelatinase secreted by normal and malignant human cells: isolation and characterization of the enzyme from HT1080 tumor cells.''; PubMed Europe PMC Scholia
- Heljasvaara R, Nyberg P, Luostarinen J, Parikka M, Heikkilä P, Rehn M, Sorsa T, Salo T, Pihlajaniemi T.; ''Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases.''; PubMed Europe PMC Scholia
- Knäuper V, López-Otin C, Smith B, Knight G, Murphy G.; ''Biochemical characterization of human collagenase-3.''; PubMed Europe PMC Scholia
- Didangelos A, Yin X, Mandal K, Saje A, Smith A, Xu Q, Jahangiri M, Mayr M.; ''Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach.''; PubMed Europe PMC Scholia
- Wang Y, Johnson AR, Ye QZ, Dyer RD.; ''Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain.''; PubMed Europe PMC Scholia
- Väisänen MR, Väisänen T, Pihlajaniemi T.; ''The shed ectodomain of type XIII collagen affects cell behaviour in a matrix-dependent manner.''; PubMed Europe PMC Scholia
- Yang M, Kurkinen M.; ''Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP, and human MMP19 have a conserved unique cysteine in the catalytic domain.''; PubMed Europe PMC Scholia
- Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E.; ''Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.''; PubMed Europe PMC Scholia
- Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP.; ''Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin.''; PubMed Europe PMC Scholia
- Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG.; ''The collagen substrate specificity of human neutrophil collagenase.''; PubMed Europe PMC Scholia
- Nicholson R, Murphy G, Breathnach R.; ''Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases.''; PubMed Europe PMC Scholia
- Motrescu ER, Blaise S, Etique N, Messaddeq N, Chenard MP, Stoll I, Tomasetto C, Rio MC.; ''Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions.''; PubMed Europe PMC Scholia
- Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L, Winberg JO.; ''Regulation of matrix metalloproteinase activity in health and disease.''; PubMed Europe PMC Scholia
- Spinucci C, Zucker S, Wieman JM, Lysik RM, Imhof B, Ramamurthy N, Liotta LA, Nagase H.; ''Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts.''; PubMed Europe PMC Scholia
- Ohuchi E, Imai K, Fujii Y, Sato H, Seiki M, Okada Y.; ''Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules.''; PubMed Europe PMC Scholia
- Amenta PS, Hadad S, Lee MT, Barnard N, Li D, Myers JC.; ''Loss of types XV and XIX collagen precedes basement membrane invasion in ductal carcinoma of the female breast.''; PubMed Europe PMC Scholia
- Monaco S, Sparano V, Gioia M, Sbardella D, Di Pierro D, Marini S, Coletta M.; ''Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains.''; PubMed Europe PMC Scholia
- Shofuda K, Yasumitsu H, Nishihashi A, Miki K, Miyazaki K.; ''Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain.''; PubMed Europe PMC Scholia
- Veidal SS, Larsen DV, Chen X, Sun S, Zheng Q, Bay-Jensen AC, Leeming DJ, Nawrocki A, Larsen MR, Schett G, Karsdal MA.; ''MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis.''; PubMed Europe PMC Scholia
- Sanchez-Lopez R, Alexander CM, Behrendtsen O, Breathnach R, Werb Z.; ''Role of zinc-binding- and hemopexin domain-encoded sequences in the substrate specificity of collagenase and stromelysin-2 as revealed by chimeric proteins.''; PubMed Europe PMC Scholia
- Steinhusen U, Weiske J, Badock V, Tauber R, Bommert K, Huber O.; ''Cleavage and shedding of E-cadherin after induction of apoptosis.''; PubMed Europe PMC Scholia
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- Shapiro SD.; ''Matrix metalloproteinase degradation of extracellular matrix: biological consequences.''; PubMed Europe PMC Scholia
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History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| 3Hyp-4Hyp-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL)  | |
| 3Hyp-4Hyp-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3Hyp-4Hyp-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-5Hyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GalHyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-3Hyp-GlcGalHyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-5Hyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-GalHyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 3x4Hyp-GlcGalHyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| 5Hyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 5Hyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 5Hyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| 5Hyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 5Hyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| 5Hyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 5Hyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 5Hyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| 5Hyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 5Hyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 5Hyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| 5Hyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 5Hyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| 5Hyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| 5Hyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 5Hyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| 5Hyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 5Hyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| 5Hyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| COL26A1 [plasma membrane] | Protein | Q96A83 (Uniprot-TrEMBL) | |
| COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| Cleaved
tropocollagen type XVI | Complex | REACT_151587 (Reactome) | Collagen XVI is a homotrimeric member of the fibril-associated collagens with interrupted triple helices (FACIT)-family of collagens. Alpha-1(XVI) chains contain ten collagenous domains interspersed with 11 non-collagenous (NC) regions. In skin, collagen XVI is exclusively integrated into specialized fibrillin-1 rich microfibrils which do not overtly contain amorphous elastin cores. In contrast, collagen XVI is absent from the elastic microfibrils in the deeper reticular dermis, but can associate to not yet identified structural aggregates. This localization may indicate that collagen XVI plays an active role in anchoring microfibrils to basement membranes, a connection which principally occurs in many tissues. In cartilage, however, collagen XVI is a component of small heterotypic D-banded fibrils, preferentially occurring in the territorial matrix (Kassner et al. 2003). These fibrils are molecular alloys with collagen II as the major collagenous component and collagen XI as a minor constituent. |
| Cleaved collagen fibrils | REACT_151068 (Reactome) | ||
| Cleaved collagen type I fibril | REACT_152264 (Reactome) | ||
| Cleaved collagen type II fibril | REACT_151955 (Reactome) | ||
| Cleaved collagen type III fibril | REACT_151381 (Reactome) | ||
| Cleaved collagen type IV networks | REACT_150603 (Reactome) | ||
| Cleaved collagen type IX | Complex | REACT_151104 (Reactome) | |
| Cleaved collagen type V fibril | REACT_150493 (Reactome) | ||
| Cleaved collagen type VI fibril | REACT_151369 (Reactome) | ||
| Cleaved collagen type VII fibril | REACT_151813 (Reactome) | ||
| Cleaved collagen type VIII fibril | REACT_151193 (Reactome) | ||
| Cleaved collagen type X fibril | REACT_151538 (Reactome) | ||
| Cleaved collagen type XI fibril | REACT_150565 (Reactome) | ||
| Cleaved collagen type XIII | Complex | REACT_151119 (Reactome) | |
| Cleaved collagen type XII | Complex | REACT_151439 (Reactome) | Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. |
| Cleaved collagen type XIV | Complex | REACT_151586 (Reactome) | Type XIV collagen, also known as undulin, is a member of the fibril-associated collagen with interrupted triple helix (FACIT) class. It interacts with the fibril surface and has been implicated as a regulator of fibrillogenesis. Type XIV collagen is prevalent in skin, tendon, cornea, and articular cartilage, specifically in areas of high mechanical stress (Berthod et al. 1997). It is possible that collagen XIV modifies the interaction of fibrillar collagen (e.g. collagens I or II) with the surrounding matrix (Gerecke et al. 2003). |
| Cleaved collagen type XV multimer | REACT_151893 (Reactome) | ||
| Cleaved collagen type XVIII multimer | REACT_151434 (Reactome) | ||
| Cleaved collagen type XVII | Complex | REACT_152161 (Reactome) | |
| Cleaved collagen type XXIII | Complex | REACT_150891 (Reactome) | |
| Cleaved collagen type XXV | Complex | REACT_151359 (Reactome) | COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC (collagenous Alzheimer amyloid plaque component), a soluble form of COL25A1 containing the extracellular collagen domains. CLAC associates with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease, inhibiting amyloid fibril formation (Osada et al. 2005). |
| Collagen
alpha-1(XIII) ectodomains | Protein | REACT_152330 (Reactome) | |
| Collagen
alpha-1(XVII) ectodomains | Protein | REACT_152058 (Reactome) | |
| Collagen
alpha-1(XVIII) chain endostatin-like fragments | Protein | REACT_151787 (Reactome) | |
| Collagen
alpha-1(XXIII) ectodomains | Protein | REACT_151913 (Reactome) | |
| Collagen
alpha-1(XXV) ectodomains | Protein | REACT_151692 (Reactome) | |
| Collagen type I fibril | REACT_150867 (Reactome) | ||
| Collagen type II fibril | REACT_152451 (Reactome) | ||
| Collagen type III fibril | REACT_151594 (Reactome) | ||
| Collagen type IV networks | REACT_151427 (Reactome) | ||
| Collagen type IX | Complex | REACT_121565 (Reactome) | |
| Collagen type V fibril | REACT_150691 (Reactome) | ||
| Collagen type VI fibril | REACT_152217 (Reactome) | ||
| Collagen type VII fibril | REACT_151190 (Reactome) | ||
| Collagen type VIII fibril | REACT_151360 (Reactome) | ||
| Collagen type X fibril | REACT_150698 (Reactome) | ||
| Collagen type XI fibril | REACT_152212 (Reactome) | ||
| Collagen type XIII | Complex | REACT_123901 (Reactome) | |
| Collagen type XII | Complex | REACT_122636 (Reactome) | Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. |
| Collagen type XIV | Complex | REACT_123707 (Reactome) | Type XIV collagen, also known as undulin, is a member of the fibril-associated collagen with interrupted triple helix (FACIT) class. It interacts with the fibril surface and has been implicated as a regulator of fibrillogenesis. Type XIV collagen is prevalent in skin, tendon, cornea, and articular cartilage, specifically in areas of high mechanical stress (Berthod et al. 1997). It is possible that collagen XIV modifies the interaction of fibrillar collagen (e.g. collagens I or II) with the surrounding matrix (Gerecke et al. 2003). |
| Collagen type XIX | Complex | REACT_122742 (Reactome) | Collagen type IXI is a member of the fibril-associated collagens with interrupted triple helices (FACIT) group of collagens. It is homotrimeric and has low abundance (Boudko et al. 2008). |
| Collagen type XV multimer | REACT_151788 (Reactome) | ||
| Collagen type XVII sheddases | Protein | REACT_150624 (Reactome) | |
| Collagen type XVIII multimer | REACT_150706 (Reactome) | ||
| Collagen type XVII | Complex | REACT_152062 (Reactome) | |
| Collagen type XVI | Complex | REACT_121586 (Reactome) | Collagen XVI is a homotrimeric member of the fibril-associated collagens with interrupted triple helices (FACIT)-family of collagens. Alpha-1(XVI) chains contain ten collagenous domains interspersed with 11 non-collagenous (NC) regions. In skin, collagen XVI is exclusively integrated into specialized fibrillin-1 rich microfibrils which do not overtly contain amorphous elastin cores. In contrast, collagen XVI is absent from the elastic microfibrils in the deeper reticular dermis, but can associate to not yet identified structural aggregates. This localization may indicate that collagen XVI plays an active role in anchoring microfibrils to basement membranes, a connection which principally occurs in many tissues. In cartilage, however, collagen XVI is a component of small heterotypic D-banded fibrils, preferentially occurring in the territorial matrix (Kassner et al. 2003). These fibrils are molecular alloys with collagen II as the major collagenous component and collagen XI as a minor constituent. |
| Collagen type XXIII | Complex | REACT_152282 (Reactome) | |
| Collagen type XXV | Complex | REACT_124506 (Reactome) | COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC (collagenous Alzheimer amyloid plaque component), a soluble form of COL25A1 containing the extracellular collagen domains. CLAC associates with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease, inhibiting amyloid fibril formation (Osada et al. 2005). |
| ELANE | Protein | P08246 (Uniprot-TrEMBL) | |
| Endostatin-XV | Protein | REACT_152254 (Reactome) | |
| Endostatin-degrading cathepsins | Protein | REACT_150853 (Reactome) | |
| Endostatin-releasing proteases | Protein | REACT_151175 (Reactome) | |
| FURIN | Protein | P09958 (Uniprot-TrEMBL) | |
| GalHyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| GalHyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| GalHyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| GalHyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| GalHyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| GalHyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| GalHyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| GalHyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| GalHyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| GalHyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| GalHyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| GalHyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| GalHyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| GalHyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| GalHyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| GalHyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| GalHyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| GalHyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| GalHyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| GalHyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| GalHyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| GalHyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| GalHyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| GalHyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| GalHyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| GalHyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL12A1
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL12A1(24-?)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL12A1(?-3063)
[extracellular region] | Protein | Q99715 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL13A1 [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL13A1(1-?) [plasma membrane] | Protein | Q5TAT6 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL14A1
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL14A1(29-?)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL14A1(?-1796)
[extracellular region] | Protein | Q05707 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL16A1
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL16A1(22-?)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL16A1(?-1604)
[extracellular region] | Protein | Q07092 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL17A1(1-1497) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL17A1(1-?) [plasma membrane] | Protein | Q9UMD9 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL19A1
[extracellular region] | Protein | Q14993 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL23A1 [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL23A1(1-?) [plasma membrane] | Protein | Q86Y22 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL25A1(1-654) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL25A1(1-?) [plasma membrane] | Protein | Q9BXS0 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A1
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A1(24-?)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A1(?-921)
[extracellular region] | Protein | P20849 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A2
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A2(24-?)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A2(?-689)
[extracellular region] | Protein | Q14055 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A3
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A3(26-?)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| GlcGalHyl-COL9A3(?-684)
[extracellular region] | Protein | Q14050 (Uniprot-TrEMBL) | |
| MMP-1 and MMP-2 | Protein | REACT_15989 (Reactome) | |
| MMP1(100-469) | Protein | P03956 (Uniprot-TrEMBL) | |
| MMP1,2,3,9 | Protein | REACT_152171 (Reactome) | |
| MMP1,2,3 | Protein | REACT_151170 (Reactome) | |
| MMP1,2,8,13, PRSS2 | Protein | REACT_151771 (Reactome) | |
| MMP1,3,8,13, PRSS2 | Protein | REACT_150610 (Reactome) | |
| MMP1,8,9,13 | Protein | REACT_151454 (Reactome) | |
| MMP1-3, 7-9, 12, 13 | Protein | REACT_151110 (Reactome) | |
| MMP10 | Protein | P09238 (Uniprot-TrEMBL) | |
| MMP12 | Protein | P39900 (Uniprot-TrEMBL) | |
| MMP14 | Protein | P50281 (Uniprot-TrEMBL) | |
| MMP15 | Protein | P51511 (Uniprot-TrEMBL) | |
| MMP19 | Protein | Q99542 (Uniprot-TrEMBL) | |
| MMP2,3,4,9,10,12 | Protein | REACT_151325 (Reactome) | |
| MMP2,9,10 | Protein | REACT_151890 (Reactome) | |
| MMP2,9,11 | Protein | REACT_151459 (Reactome) | |
| MMP3,13 | Protein | REACT_152152 (Reactome) | |
| MMP3,13 | Protein | REACT_152236 (Reactome) | |
| MMP9,13 | Protein | REACT_151640 (Reactome) | |
| MMP9 | Protein | P14780 (Uniprot-TrEMBL) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| Cleaved
tropocollagen type XVI | Arrow | REACT_150173 (Reactome) | ||
| Cleaved collagen fibrils | REACT_150252 (Reactome) | |||
| Cleaved collagen fibrils | REACT_150344 (Reactome) | |||
| Cleaved collagen type I fibril | Arrow | REACT_150199 (Reactome) | ||
| Cleaved collagen type I fibril | Arrow | REACT_150364 (Reactome) | ||
| Cleaved collagen type I fibril | Arrow | REACT_150397 (Reactome) | ||
| Cleaved collagen type II fibril | Arrow | REACT_150211 (Reactome) | ||
| Cleaved collagen type II fibril | Arrow | REACT_150221 (Reactome) | ||
| Cleaved collagen type II fibril | Arrow | REACT_150223 (Reactome) | ||
| Cleaved collagen type III fibril | Arrow | REACT_150170 (Reactome) | ||
| Cleaved collagen type III fibril | Arrow | REACT_150213 (Reactome) | ||
| Cleaved collagen type III fibril | Arrow | REACT_150222 (Reactome) | ||
| Cleaved collagen type III fibril | Arrow | REACT_150439 (Reactome) | ||
| Cleaved collagen type IV networks | Arrow | REACT_150293 (Reactome) | ||
| Cleaved collagen type IX | Arrow | REACT_150281 (Reactome) | ||
| Cleaved collagen type V fibril | Arrow | REACT_150374 (Reactome) | ||
| Cleaved collagen type VI fibril | Arrow | REACT_150235 (Reactome) | ||
| Cleaved collagen type VII fibril | Arrow | REACT_150453 (Reactome) | ||
| Cleaved collagen type VIII fibril | Arrow | REACT_150162 (Reactome) | ||
| Cleaved collagen type VIII fibril | Arrow | REACT_150332 (Reactome) | ||
| Cleaved collagen type X fibril | Arrow | REACT_150197 (Reactome) | ||
| Cleaved collagen type X fibril | Arrow | REACT_150432 (Reactome) | ||
| Cleaved collagen type XI fibril | Arrow | REACT_150259 (Reactome) | ||
| Cleaved collagen type XII | Arrow | REACT_150466 (Reactome) | ||
| Cleaved collagen type XIII | Arrow | REACT_150341 (Reactome) | ||
| Cleaved collagen type XIV | Arrow | REACT_150248 (Reactome) | ||
| Cleaved collagen type XV multimer | Arrow | REACT_150289 (Reactome) | ||
| Cleaved collagen type XVII | Arrow | REACT_150324 (Reactome) | ||
| Cleaved collagen type XVIII multimer | Arrow | REACT_150437 (Reactome) | ||
| Cleaved collagen type XXIII | Arrow | REACT_150339 (Reactome) | ||
| Cleaved collagen type XXV | Arrow | REACT_150355 (Reactome) | ||
| Collagen
alpha-1(XIII) ectodomains | Arrow | REACT_150341 (Reactome) | ||
| Collagen
alpha-1(XVII) ectodomains | Arrow | REACT_150324 (Reactome) | ||
| Collagen
alpha-1(XVIII) chain endostatin-like fragments | Arrow | REACT_150437 (Reactome) | ||
| Collagen
alpha-1(XVIII) chain endostatin-like fragments | REACT_150386 (Reactome) | |||
| Collagen
alpha-1(XXIII) ectodomains | Arrow | REACT_150339 (Reactome) | ||
| Collagen
alpha-1(XXV) ectodomains | Arrow | REACT_150355 (Reactome) | ||
| Collagen type I fibril | REACT_150199 (Reactome) | |||
| Collagen type I fibril | REACT_150364 (Reactome) | |||
| Collagen type I fibril | REACT_150397 (Reactome) | |||
| Collagen type II fibril | REACT_150211 (Reactome) | |||
| Collagen type II fibril | REACT_150221 (Reactome) | |||
| Collagen type II fibril | REACT_150223 (Reactome) | |||
| Collagen type III fibril | REACT_150170 (Reactome) | |||
| Collagen type III fibril | REACT_150213 (Reactome) | |||
| Collagen type III fibril | REACT_150222 (Reactome) | |||
| Collagen type III fibril | REACT_150439 (Reactome) | |||
| Collagen type IV networks | REACT_150293 (Reactome) | |||
| Collagen type IX | REACT_150281 (Reactome) | |||
| Collagen type V fibril | REACT_150374 (Reactome) | |||
| Collagen type VI fibril | REACT_150235 (Reactome) | |||
| Collagen type VII fibril | REACT_150453 (Reactome) | |||
| Collagen type VIII fibril | REACT_150162 (Reactome) | |||
| Collagen type VIII fibril | REACT_150332 (Reactome) | |||
| Collagen type X fibril | REACT_150197 (Reactome) | |||
| Collagen type X fibril | REACT_150432 (Reactome) | |||
| Collagen type XI fibril | REACT_150259 (Reactome) | |||
| Collagen type XIII | REACT_150341 (Reactome) | |||
| Collagen type XII | REACT_150466 (Reactome) | |||
| Collagen type XIV | REACT_150248 (Reactome) | |||
| Collagen type XIX | REACT_150411 (Reactome) | |||
| Collagen type XV multimer | REACT_150289 (Reactome) | |||
| Collagen type XVII sheddases | mim-catalysis | REACT_150324 (Reactome) | ||
| Collagen type XVIII multimer | REACT_150437 (Reactome) | |||
| Collagen type XVII | REACT_150324 (Reactome) | |||
| Collagen type XVI | REACT_150173 (Reactome) | |||
| Collagen type XXIII | REACT_150339 (Reactome) | |||
| Collagen type XXV | REACT_150355 (Reactome) | |||
| ELANE | mim-catalysis | REACT_150332 (Reactome) | ||
| Endostatin-XV | Arrow | REACT_150289 (Reactome) | ||
| Endostatin-degrading cathepsins | mim-catalysis | REACT_150386 (Reactome) | ||
| Endostatin-releasing proteases | mim-catalysis | REACT_150437 (Reactome) | ||
| FURIN | mim-catalysis | REACT_150339 (Reactome) | ||
| FURIN | mim-catalysis | REACT_150355 (Reactome) | ||
| MMP-1 and MMP-2 | mim-catalysis | REACT_150197 (Reactome) | ||
| MMP1(100-469) | mim-catalysis | REACT_150162 (Reactome) | ||
| MMP1,2,3,9 | mim-catalysis | REACT_150259 (Reactome) | ||
| MMP1,2,3 | mim-catalysis | REACT_150453 (Reactome) | ||
| MMP1,2,8,13, PRSS2 | mim-catalysis | REACT_150397 (Reactome) | ||
| MMP1,3,8,13, PRSS2 | mim-catalysis | REACT_150223 (Reactome) | ||
| MMP1,8,9,13 | mim-catalysis | REACT_150222 (Reactome) | ||
| MMP1-3, 7-9, 12, 13 | mim-catalysis | REACT_150344 (Reactome) | ||
| MMP10 | mim-catalysis | REACT_150170 (Reactome) | ||
| MMP12 | mim-catalysis | REACT_150466 (Reactome) | ||
| MMP14 | mim-catalysis | REACT_150213 (Reactome) | ||
| MMP14 | mim-catalysis | REACT_150221 (Reactome) | ||
| MMP14 | mim-catalysis | REACT_150364 (Reactome) | ||
| MMP15 | mim-catalysis | REACT_150199 (Reactome) | ||
| MMP15 | mim-catalysis | REACT_150211 (Reactome) | ||
| MMP15 | mim-catalysis | REACT_150439 (Reactome) | ||
| MMP19 | mim-catalysis | REACT_150252 (Reactome) | ||
| MMP2,3,4,9,10,12 | mim-catalysis | REACT_150293 (Reactome) | ||
| MMP2,9,10 | mim-catalysis | REACT_150374 (Reactome) | ||
| MMP2,9,11 | mim-catalysis | REACT_150235 (Reactome) | ||
| MMP3,13 | mim-catalysis | REACT_150281 (Reactome) | ||
| MMP3,13 | mim-catalysis | REACT_150432 (Reactome) | ||
| MMP9,13 | mim-catalysis | REACT_150248 (Reactome) | ||
| MMP9 | mim-catalysis | REACT_150173 (Reactome) | ||
| REACT_150162 (Reactome) | Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet's membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012). Collagen type VIII can be degraded by MMP1 (Sage et al. 1983, 1984). | |||
| REACT_150170 (Reactome) | MMP10 (Stromelysin-2) is able to degrade collagen type III (Nicholson et al. 1989). | |||
| REACT_150173 (Reactome) | Type XVI collagen is a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). During early mouse development, it occurs in many tissues and is co-distributed with the major fibrillar collagens (Lai & Chu 1996). In skin, collagen XVI preferentially occurs in narrow zones near basement membranes at the dermo-epidermal junction (DEJ) of blood vessels (Grässel et al., 1999). In papillary dermis, the protein unexpectedly does not occur in banded collagen fibrils, but is a component of specialized fibrillin-1-containing microfibrils. However, in cartilage matrix it does not aggregate with fibrillin-1, rather it exists as a discrete population of thin, weakly banded collagen fibrils in association with collagens II and XI (Kassner et al. 2003, 2004). Collagen XVI induces the recruitment of integrins alpha1 beta1 and alpha1 beta 2 into focal adhesion plaques, a principal step in integrin signaling (Eble et al. 2006), allowing cells to affect the architecture of the ECM networks by binding and moving ECM proteins. Collagen type XVI is cleaved by MMP9 (Sires et al. 1995). | |||
| REACT_150197 (Reactome) | Collagen X is thought to form extended hexagonal networks (Kwan et al. 1991, Jacenko et al. 2001). It's distribution is limited to regions of hypertrophic cartilage destined for degradation during endochondral ossification (Schmid & Conrad 1982). It is also found in areas of surface fibrillation and osteophyte formation during the development of osteoarthritic lesions in articular cartilage (von der Mark et al. 1992). In Timp3 knockout mice type X collagen was observed mostly in areas of articular cartilage that stained strongly for collagen cleavage products, suggesting that deposition of type X collagen might be a damage repair mechanism (Sahebjam et al. 2007). Mutations in the gene COL10A1 are associated with Schmid/Japanese type metaphyseal chondrodysplasia (SMCD) (Warman et al. 1993, Ho et al. 2007, Woelfle et al. 2011). Type X collagen is degraded by MMP1 (Schmid et al. 1986, Welgus et al. 1990, Cole et al. 1993), MMP2 (Cole et al. 1993, Welgus et al. 1990), MMP3 (Wu et al. 1991), MMP13 (Knauper et al. 1997) and neutrophil elastase (Kittelberger et al. 1992). | |||
| REACT_150199 (Reactome) | The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase able to degrade collagen type I (Morrison and Overall 2006) and believed able to degrade types II and III (Somerville et al. 2003). | |||
| REACT_150211 (Reactome) | The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase. MMP15 is able to degrade collagen type I (Morrison & Overall 2006) and believed able to degrade types II and III (Somerville et al. 2003). | |||
| REACT_150213 (Reactome) | The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collagenase able to degrade collagen types I, II and III (Ohuchi et al. 1997). | |||
| REACT_150221 (Reactome) | The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collagenase. MMP14 is able to degrade collagen types I, II and III (Ohuchi et al. 1997). | |||
| REACT_150222 (Reactome) | MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996), called collagenases I, II and III respectively, are all able to cleave the intrahelical bonds of collagen type III, cleaving between amino acids Gly948 and Ile949 of the Uniprot canonical sequence. MMP9 (Bigg et al. Veidal et al. 2010) and MMP10 (Stromelysin-2) are able to degrade collagen type III (Nicholson et al. 1989). | |||
| REACT_150223 (Reactome) | MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996, Billinghurst et al. 1997) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type II, cleaving between amino acids Gly975 and Leu976 of the Uniprot canonical sequence. Human trypsin-2 is also capable of cleaving the triple helix of human cartilage collagen type II (Stenman et al. 2005). | |||
| REACT_150235 (Reactome) | Type VI collagen aggregates into distinctive microfibrils known as beaded filaments that form an independent microfibrillar network in virtually all connective tissues except for bone (von der Mark et al. 1984). It plays a role in the maintenance of tissue integrity since it participates in both cell-matrix and matrix-matrix interactions, interacting with many other ECM proteins including fibronectin (Chang et al. 1997), type IV collagen (Kuo et al. 1997), type II collagen, decorin and biglycan (Bidanset et al. 1992). Collagen type VI has been described as a connecting protein (Gelse et al. 2003). Collagen type VI is resistant to digestion by many MMPs but is cleaved by MMP2 (Myint et al. 1996, Veidal et al. 2011), MMP9 (Veidal et al. 2011) and MMP11 (Motrescu et al. 2008). | |||
| REACT_150248 (Reactome) | Collagen type XIV is a member of the fibril-associated collagens with interrupted triple helices (FACIT) family, expressed in most mesenchymal tissues. The non-collagenous domain at the N-terminus of collagen XIV is extremely large, nearly 80% of the entire polypeptide. This domain is composed of eight fibronectin type III repeats, two von Willebrand factor A-like (vWFA) domains and one non-collagenous domain 4 (NC4 domain) related to collagen type IX. Collagen XIV is expressed in most mesenchymal tissues where it appears to interact with collagen type VI, glycosaminoglycans, proteoglycans and matrix receptors (Brown et al. 1993, Imhof & Trueb 1998). It has been implicated as a regulator of fibrillogenesis. Collagen type XIV deficient mice have a grossly normal phenotype but their skin has altered mechanical properties. Tendons were seen to be enlarged at postnatal day 4 though mature tendons appeared normal. Tendons from postnatal day 7 KO mice had reduced strength but by 60 days were comparable with wild-type (Ansorge et al. 2009). Adult Col14a1 mice have defects in ventricular morphogenesis (Tao et al. 2012). Collagen type XIV is degraded by MMP9 (Sires et al. 1995) and MMP13 (Knauper et al. 1997). | |||
| REACT_150252 (Reactome) | Gelatin is formed when collagen becomes partly or completely uncoiled when compared with the regular triple helix structure of fibrillar collagen. In vivo, once collagens are initially cleaved into clasical 3/4 and 1/4 fragments (by collagenases) they rapidly denature at body temperature and are degraded by gelatinases and other nonspecific tissue proteinases (Chung et al. 2004) to a semi-solid colloid gel. MMP2 and MMP9 are the major gelatinases (Collier et al. 1988, Wilhelm et al. 1989) often referred to respectively as Gelatinase A and Gelatinase B (Murphy & Crabbe 1995). However many other MMPs have gelatinase activity, including MMP1 (Murphy et al. 1982, Isaksen & Fagerhol 2001, Chung et al. 2004), MMP3 (Chin et al. 1985, Isaksen & Fagerhol 2001), MMP7 (Isaksen & Fagerhol 2001), MMP8 (Isaksen & Fagerhol 2001) MMP10 (Sanches-Lopez et al. 1993), MMP12 (Chandler et al. 1996), MMP13 (Knäuper et al. 1993, Isaksen & Fagerhol 2001), MMP16 (Shofuda et al. 1997), MMP17 (Wang et al. 1999), MMP18 (Spinucci et al. 1988), MMP19 (Stracke et al. 2000) and MMP22 (Yang & Kurkinen 1998). | |||
| REACT_150259 (Reactome) | Collagen type XI has 3 types of alpha chain. The alpha1(XI) and alpha2(XI) chains are distinct gene products unique to collagen XI, while alpha3(XI) is a hyperglycosylated form of the alpha1 chain for collagen II (Burgeson & Hollister 1979, Morris & Bächinger 1987). Collagen type XI is a fibril-forming collagen found in conjunction with collagens type II and IX in cartilage fibrils (Miller & Gay 1987, Mendler et al. 1989). It is thought to be the structural equivalent of collagen V in connective tissue collagen fibrils. The formation of cartilage collagen fibrils requires collagen XI, suggesting a regulatory function (Li et al. 1995, Wu & Eyre 1995). Mutations in COL11A1 result in fibrochondrogenesis, a severe, autosomal-recessive, short-limbed skeletal dysplasia (Tompson et al. 2010). Variations in COL11A1, COL11A2 and COL2A1 are associated with the inherited chondrodysplasias Marshall and Stickler syndromes (Annunen et al. 1999). Collagen type XI is degraded by MMP1 (Eyre et al. 1984), MMP2 (Yu et al. 1990, Smith et al. 1991, Brown et al. 1996), MMP3 (Wu et al. 1991) and MMP9 (Hirose et al. 1992, Pormotabbed et al. 1994). | |||
| REACT_150281 (Reactome) | Type IX collagen interacts covalently with type II collagen fibril surfaces, suggesting that it represents a macromolecular bridge between fibrils and other cartilage matrix components (Eyre et al. 1987, Olsen 1997). Degradation of type IX (and type II) collagen is seen at the onset of inflammatory arthritis (Kojima et al. 2001). Collagen type IX is cleaved by MMP3 (Okada et al. 1989, Eyre et al. 1991, Wu et al. 1991) and MMP13 (Knauper et al. 1997). | |||
| REACT_150289 (Reactome) | Collagens type XV and XVIII are closely related non-fibrillar collagens that define the multiplexin (multiple triple helix domains with interruptions) subfamily of collagens. Both are homotrimers characterized by highly interrupted collagenous domains flanked by large globular domains with attached glycosaminoglycan chains. Collagen XV is localized in the outermost layer of the basement membrane (BM) and in the fibrillar matrix. Collagen type XV is the only collagen able to self-assemble into higher-order cruciform structures with intermolecular binding sites (Myers et al. 2007). The interaction is mediated by interactions between triple helical regions (Hurskainen et al. 2010). It is predominantly located in the basement membranes of microvessels, and cardiac and skeletal myocytes (Hägg et al. 1997), where it binds basement membrane and microfibrillar components such as fibulin-2, nidogen-2, vitronectin, laminin, and fibronectin (Sasaki et al. 2000, Hurskainen et al. 2010). It may form a bridge between fibrillar collagens and the basement membrane (Amenta et al. 2005), acting as a molecular shock absorber to stabilize and enhance resilience to compressive and expansive forces (Myers et al. 2007). Lack of Collagen type XV in Col15a1-null mice resulted in increased permeability and impaired microvascular hemodynamics, distinct early-onset and age-dependent defects in heart structure and function, a poorly organized fibrillar collagen matrix with marked interstitial deposition of nonfibrillar protein aggregates, increased tissue stiffness, and irregularly organized cardiomyocytes (Rasi et al. 2010a). Col15a1 knockout also leads to loosely packed axons in C-fibers and polyaxonal myelination. Simultaneous knockout with laminin alpha-4 leads to severely impaired radial sorting and myelination (Rasi et al. 2010b). The C-terminal non-collagenous region of collagen type XV is known as restin because it resembles endostatin, having antiangiogenic effects (Ramchandran et al. 1999, Sasaki et al. 2000). | |||
| REACT_150293 (Reactome) | Type IV collagen is the most abundant structural basement membrane (BM) component, providing a scaffold for other major BM proteins such as laminin (Charonis et al. 1985, 1986). There are six different genes encoding type IV collagen chains, alpha-1 to alpha-6(IV) with distinct tissue distributions. Three alpha chains fold to form the triple helical unit of collagen IV. Three chain combinations have been identified, alpha-1X2 alpha-2(IV), alpha-3,alpha-4, alpha-5(IV) and alpha-5X2, alpha-6(IV) (Borza et al. 2001). The first is the major form, found in all basement membranes, the other types have more restricted distributions. Collagen IV forms a lattice network rather than extended fibrils. It can be digested by MMP2 (Liotta et al. 1981, Salo et al. 1983, Bergers et al. 2000, Monaco et al. 2006), MMP3 (Okada et al. 1986, Wilhelm et al. 1987, Bejarano et al. 1988, Nicholson et al. 1989), MMP7 (Miyazaki et al. 1990, Murphy et al. 1991), MMP9 (Moll et al. 1990, Morodomi et al. 1992, Murphy et al. 1991, Watanabe et al. 1993, Bergers et al. 2000), MMP10 (Nicholson et al. 1989) and MMP12 (Chandler et al. 1996). | |||
| REACT_150324 (Reactome) | Collagen type XVII, identified as the 180-kDa bullous pemphigoid antigen or BP180, is a transmembrane protein forming a family with collagen type XIII. It is an important structural component of hemidesmosomes, complexes found in the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane (Franzke et al. 2005). The intracellular ligands of collagen XVII include Beta 4-integrins, plectin and BP230 in the hemidesmosomal plaque (Koster et al. 2003). Extracellular ligands include alpha 6-integrin and laminin-5 in anchoring filaments (Hopkinson et al. 1995, Tasanen et al. 2004). Mutations in the human collagen XVII gene COL17A1 lead to diminished epidermal adhesion and skin blistering in response to minimal shearing forces, a disorder called junctional epidermolysis bullosa (JEB). A soluble ectodomain form of collagen type XVII referred to as LAD-1 is generated by proteolytic processing of the full length form (Hirako et al. 1988, Schäcke et al. 1998). Collagen XVII has a furin consensus sequence but is cleaved by proteinases of the ADAM family rather than furin convertases. ADAM-17 (TACE) appears to be the major physiologically-relevant sheddase for collagen XVII, though ADAM-9 and -10 may substitute (Franzke et al. 2002). These proteinases are activated by furin (Franzke et al. 2005). | |||
| REACT_150332 (Reactome) | Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet’s membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012). Collagen type VIII can be degraded by neutrophil elastase (ELANE, ELA2; Kittelberger et al. 1992). | |||
| REACT_150339 (Reactome) | Collagen type XXIII is a type II transmembrane collagen with a relatively small ectodomain. It exists in a membrane-bound form and a shed form, cleaved by furin (Veit et al. 2007). Both forms can bind alpha2beta1 integrin via the ectodomain, stimulating the formation of focal adhesion plaques (Veit et al. 2011). | |||
| REACT_150341 (Reactome) | Type XIII is a non-fibril-forming type II transmembrane protein with a large amino terminal NC1 domain. This domain has a hydrophobic membrane-spanning segment that anchors the molecule to the plasma membrane and a large extracellular, mostly collagenous carboxyterminal domain (Hägg et al. 1998). Recombinant type XIII collagen can form homotrimers with triple-helical collagenous domains (Snellman et al. 2000a). It is detected at low levels in all connective tissue-producing cells; in cultured cells it is localized in focal adhesions (Hägg et al. 2001). The extracellular region has an adhesion-related function (Hägg et al. 2001) that is involved in formation of the neuromuscular junction (Latvanlehto et al. 2010). The purified protein has been shown to interact with Integrin alpha1beta1 (Nykvist et al. 2000). An N-terminal ectodomain portion of type XIII collagen is cleaved in culture medium by a furin-like protease (Snellman et al. 2000b, Väisänen et al. 2004). This ectodomain interacts with fibronectin, nidogen-2 and perlecan (Tu et al. 2002, Väisänen et al. 2006). | |||
| REACT_150344 (Reactome) | Gelatin is formed when collagen becomes partly or completely uncoiled when compared with the regular triple helix structure of fibrillar collagen. In vivo, once collagens are initially cleaved into clasical 3/4 and 1/4 fragments (by collagenases) they rapidly denature at body temperature and are degraded by gelatinases and other nonspecific tissue proteinases (Chung et al. 2004) to a semi-solid colloid gel. MMP2 and MMP9 are the major gelatinases (Collier et al. 1988, Wilhelm et al. 1989) often referred to respectively as Gelatinase A and Gelatinase B (Murphy & Crabbe 1995). However many other MMPs have gelatinase activity, including MMP1 (Murphy et al. 1982, Isaksen & Fagerhol 2001, Chung et al. 2004), MMP3 (Chin et al. 1985, Isaksen & Fagerhol 2001), MMP7 (Isaksen & Fagerhol 2001), MMP8 (Isaksen & Fagerhol 2001) MMP10 (Sanches-Lopez et al. 1993), MMP12 (Chandler et al. 1996), MMP13 (Knäuper et al. 1993, Isaksen & Fagerhol 2001), MMP16 (Shofuda et al. 1997), MMP17 (Wang et al. 1999), MMP18 (Spinucci et al. 1988), MMP19 (Stracke et al. 2000) and MMP22 (Yang & Kurkinen 1998). | |||
| REACT_150355 (Reactome) | Identified as a component of amyloid plaques in Alzheimer's brain, the ectodomain of type XXV collagen (known as CLAC) is released by furin convertase activity (Hashimoto et al. 2002). The presence of CLAC leads to Abeta fibril bundles that have an increased resistance to proteases (Söderberg et al. 2005). | |||
| REACT_150364 (Reactome) | The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collagenase able to degrade collagen types I, II and III (Ohuchi et al. 1997). | |||
| REACT_150374 (Reactome) | Type V collagen is a fibril-forming collagen forming a group with collagen types I, II, III and XI (Gelse et al. 2003). Three different alpha chains exist that can combine in three distinct trimers. Collagen V forms fibrils that are associated with type I and to a lesser extent III collagen, as a minor but critical component of bone matrix, corneal stroma and the interstitial matrix of muscle, liver, lung and placenta (Birk et al. 1988). COL5A1-/- mice have an almost complete lack of collagen fibrils reflecting a central role in fibrillogenesis (Wenstrup et al. 2004). Type V collagen mutation results in a range of connective tissue diseases including Ehlers-Danlos syndrome (EDS), which is a heterogeneous group of disorders characterized by joint hypermobility and skin hyperextensibility, thinness and fragility. These result from mutations in the COL5A1 and COL5A2 genes (Michalickova et al. 1998, Schwarze et al. 2000).
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| REACT_150386 (Reactome) | As well as generating endostatin from collagen XVIII, cathepsins L and B quickly degrade it, as do cathepsins D and K. In contrast MMPs that produce endostatin do not cleave it further (Ferreras et al. 2000). | |||
| REACT_150397 (Reactome) | MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996) known in the literature as collagenases I, II and III respectively are able to digest the intrahelical bonds of collagen type I. MMP2, also known as Gelatinase-A, was found to cleave collagen type I fibrils (Aimes & Quigley 1995). Though this was disputed (Seltzre & Eisen 1999) there is a structural explanation for the apparent discrepancies in experimental data (Patterson et al. 2001). In addition trypsin-2 is able to degrade native soluble type I collagen (Moilanen et al. 2003). Degradation is represented here at a theoretical end point where every alpha strand has been cleaved. | |||
| REACT_150411 (Reactome) | Collagen type XIX is a FACIT (fibril-associated collagens with interrupted triple helix) collagen family member (Inoguchi et al. 1995) with a large non-collagenous N terminal domain that can self-assemble into higher order structures that are stabilized by intermolecular disulfide cross-links. Collagen type XIX is the least abundant collagen so far purified, comprising ?10-6% of dry weight in human umbilical cord (Myers et al. 2003). It is found in the basement membrane (BM) of normal human tissues. In developing embryos it is transiently expressed in certain muscular tissues and brain areas. Due to this localized expression, it is thought to be involved in the formation of specialized BM zones (Sumiyoshi et al. 2001). Collagen XIX is lost early in the development of invasive tumours, prior to penetration and eventual dissolution of the epithelial BM (Amenta et al. 2003). The NC1 domain of type XIX collagen exerts antitumor activity (Ramont et al. 2007). | |||
| REACT_150432 (Reactome) | Collagen X forms extended hexagonal networks (Kwan et al. 1991, Jacenko et al. 2001). It's distribution is limited to regions of hypertrophic cartilage destined for degradation during endochondral ossification (Schmid & Conrad 1982). It is also found in areas of surface fibrillation and osteophyte formation during the development of osteoarthritic lesions in articular cartilage (von der Mark et al. 1992). In Timp3 knockout mice type X collagen was observed mostly in areas of articular cartilage that stained strongly for collagen cleavage products, suggesting that deposition of type X collagen might be a damage repair mechanism (Sahebjam et al. 2007). Mutations in the gene COL10A1 are associated with Schmid/Japanese type metaphyseal chondrodysplasia (SMCD) (Warman et al. 1993, Ho et al. 2007, Woelfle et al. 2011). Type X collagen is degraded by MMP1 (Schmid et al. 1986, Welgus et al. 1990, Cole et al. 1993), MMP2 (Cole et al. 1993, Welgus et al. 1990), MMP3 (Wu et al. 1991), MMP13 (Knauper et al. 1997) and ELANE (neutrophil elastase - Kittelberger et al. 1992). | |||
| REACT_150437 (Reactome) | Collagen type XVIII is a heparan sulfate proteoglycan associated with the basement membranes of almost all epithelia and endothelia. It has a large C-terminal noncollagenous domain. Mouse knockouts suggest that it may have a role in maintaining the structural integrity of the extracellular matrix (Utriainen et al. 2004). Proteolytic cleavage of the C-terminal noncollagenous domain by matrix metalloproteinases (Heljasvaara et al. 2005) releases 18 to 38 kDa C-terminal proteolytic fragments, collectively named endostatin. They have anti-angiogenic activity (O'Reilly et al. 1997, Ständker et al. 1997) and suppress primary tumor and metastasis growth in experimental animal models (Ortega & Werb 2002). It is not clear whether this collagen subtype forms supramolecular assemblies (Myllyharju & Kivirikko, 2004) but thought likely, via a similar mechanism to the related collagen XV (Hurskainen et al. 2010). Endostatin-like fragments are released from collagen type XVIII by MMP 7 (Lin et al. 2001), 3, 9, 12, 13 (Ferreras et al. 2000) and 20 (Heljasvaara et al. 2005). Several cathepsins and elastase can bring about endostatin release (Ferreras et al. 2000, Felbor et al. 2000). | |||
| REACT_150439 (Reactome) | The membrane-type MMP MMP15 (MT2-MMP) is a fibrillar collagenase able to degrade collagen type I (Morrison & Overall 2006) and believed able to degrade collagen types II and III (Somerville et al. 2002). | |||
| REACT_150453 (Reactome) | Type VII collagen is the major collagen component of anchoring fibrils, which are essential for the attachment of the epidermis to the dermis. It is degraded by MMP1 (Seltzer et al. 1989), MMP2 (Seltzer et al. 1989, Sawamura et al. 1991, Karelina et al. 2000) and MMP3 (Sawamura et al. 1991). MMP2 is 3000-fold more active than MMP1 (Seltzer et al. 1989). | |||
| REACT_150466 (Reactome) | Collagen type XII is a member of the fibril-associated collagens with interrupted triple helices (FACIT) group, thought to be bound to the surface of interstitial collagen fibrils (Keene et al.1991). It has only one alpha chain type, with two collagenous (Col1 and Col2) and three noncollagenous domains (NC1-NC3). Whereas the collagenous and the NC1 and NC2 regions are short, the NHE-terminal NC3 is a huge trimeric domain (Yamagata et al. 1991, Wälchli et al. 1993). Collagen XII may enhance the stability of connective tissues by bridging collagen fibrils (Nishiyama et al. 1994, Bader et al. 2009). It may be a stress response molecule, directly influenced by stretch and shear stress. Expression of COL12A1 is directly stimulated by mechanical forces (Flück et al. 2003, Jin et al. 2003, Arai et al. 2008). Expression is predominantly in bone, suggesting involvement of type XII collagen in the regulation of osteoblasts and cell interactions. Transgenic type XII collagen-null mice have skeletal abnormalities. They have decreased bone matrix deposition and delayed maturation. Compared with controls, Col12a knockout osteoblasts are disorganized, being less polarized with disrupted cell-cell interactions, decreased connexin43 expression and impaired gap junction function (Izu et al. 2011). MMP12 can cleave collagen XII (Didangelos et al. 2011). |
