Regulation of lipid metabolism by PPARalpha (Homo sapiens)

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3, 38, 43, 4639393919, 39283934491919, 29, 4239, 4112, 393916, 39, 413, 7, 38, 43, 46...21, 3939191923-8, 14, 20...19117, 3939471939391139193, 7, 9, 38, 43...3919, 3919, 3919, 3923393213, 303919, 4018, 2619, 39lipid particleCoactivators ofPPARalpha[nucleoplasm]mitochondrial outer membraneLigands of PPARA[nucleoplasm]nucleoplasmActivated PPARG:RXRA[nucleoplasm]PPARA:RXRAHeterodimer[nucleoplasm]endoplasmic reticulum membraneFABP1:Ligands ofPPARA [nucleoplasm]PPARG:Fatty AcidLigand [nucleoplasm]SREBP1A/1C/2:NF-Y:HMGCS1gene [nucleoplasm]SREBP1A/2:NF-Y:HMGCRgene [nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]NR1D1(REV-ERBA):heme:Corepressor[nucleoplasm]mitochondrial matrixNF-Y [nucleoplasm]TEAD:YAP1[nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]ROR-alpha:Coactivator[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]TEAD [nucleoplasm]Mediator Complex(consensus)[nucleoplasm]ALAS1gene:NRF1:PPARGC1B[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]cytosolPPARA:RXRAHeterodimer[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]TEAD:WWTR1(TAZ)[nucleoplasm]PPARA:RXRA RepressorComplex[nucleoplasm]Ligands of PPARA[nucleoplasm]p-BMAL1:p-CLOCK/NPAS2:DNA[nucleoplasm]TEAD [nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]p-CLOCK/p-NPAS2[nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]peroxisomal matrixNF-Y [nucleoplasm]Ligands of PPARG[nucleoplasm]SREBP1A/1C/2:NF-Y:SP1:FDFT1gene [nucleoplasm]SREBF1A,2[nucleoplasm]Corepressors ofPPARalpha[nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]PPARG:FattyAcid:RXRA:Mediator:CoactivatorComplex[nucleoplasm]NR1D1(REV-ERBA):heme[nucleoplasm]p-S-ARNTL[nucleoplasm]ROR-alpha:CoactivatorCDK8 [nucleoplasm]HMGCR-1MED20 [nucleoplasm]SIN3B-1[nucleoplasm]NCOA1 [nucleoplasm]TEAD1 [nucleoplasm]PEX11ARORA [nucleoplasm]SREBF2(1-484)[nucleoplasm]HMGCR gene[nucleoplasm]ALA [nucleoplasm]HMGCS1 gene[nucleoplasm]CPT2TEAD4 [nucleoplasm]CYP1A1YAP1 [nucleoplasm]CYP4A11SREBF2(1-484)[nucleoplasm]Palm [nucleoplasm]CYP7A1RGZ [nucleoplasm]CARM1(2-608)[nucleoplasm]MED27 [nucleoplasm]TEAD1 [nucleoplasm]EP300(1-2414)[nucleoplasm]MED11 [nucleoplasm]APOA2(24-100)FDFT1 gene[nucleoplasm]MED9 [nucleoplasm]LINA [nucleoplasm]Palm [nucleoplasm]PPARATBL1X [nucleoplasm]MED13 [nucleoplasm]NR1D1 [nucleoplasm]TXNRD1Actos [nucleoplasm]ACADMGLIPR1NR1D1(REV-ERBA):heme:CorepressorABCB4APOA5PPARA [nucleoplasm]FADS1(1-444)LINA [nucleoplasm]TEAD2 [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]MED24 [nucleoplasm]EPA [nucleoplasm]ANGPTL4PPARG:FattyAcid:RXRA:Mediator:CoactivatorComplexferriheme b[nucleoplasm]FABP1:Ligands ofPPARAPPARA:RXRA RepressorComplexNCOR2 [nucleoplasm]TEAD:YAP1TBL1X [nucleoplasm]EPA [nucleoplasm]ABCA1MED22 [nucleoplasm]CHD9 [nucleoplasm]HELZ2 [nucleoplasm]NFYB [nucleoplasm]HELZ2 [nucleoplasm]MED30(1-178)[nucleoplasm]FDFT1MED31 [nucleoplasm]TEAD3(1-435)[nucleoplasm]13(S')-HODE[nucleoplasm]SREBF1-3[nucleoplasm]SREBP1A/1C/2:NF-Y:HMGCS1geneAGTNCOA2 [nucleoplasm]WWTR1 [nucleoplasm]MED25 [nucleoplasm]CCNC [nucleoplasm]4xPalmC-CD36SIN3A [nucleoplasm]MED12 [nucleoplasm]SULT2A1(2-285)NFYB [nucleoplasm]9S-HODE[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]MED10(2-135)[nucleoplasm]RXRA [nucleoplasm]MED1 [nucleoplasm]MED19 [nucleoplasm]ACOX1-1MED15 [nucleoplasm]G0S2SREBP1A/1C/2:NF-Y:SP1:FDFT1geneNCOR1 [nucleoplasm]MED23 [nucleoplasm]CREBBP(2-2442)[nucleoplasm]HMGCS2p-BMAL1:p-CLOCK/NPAS2:DNAPPARA [nucleoplasm]GRHL1Corepressors ofPPARalphaSMARCD3[nucleoplasm]TBL1XR1FHL2MED18 [nucleoplasm]MED4 [nucleoplasm]SREBP1A/2:NF-Y:HMGCRgeneCoactivators ofPPARalphaMED29(2-200)[nucleoplasm]ALAS1gene:NRF1:PPARGC1BMED17 [nucleoplasm]AA [nucleoplasm]ACSL1FABP1TBL1XR1[nucleoplasm]SREBF1-3[nucleoplasm]ALA [nucleoplasm]p-S-CLOCK[nucleoplasm]TEAD4 [nucleoplasm]SLC27A1NCOA1 [nucleoplasm]RGL1NFYC [nucleoplasm]TNFRSF21UGT1A9FABP1 [nucleoplasm]NPAS2TBL1XR1[nucleoplasm]p-S-NPAS2[nucleoplasm]CDK19 [nucleoplasm]CTGFPPARGC1A[nucleoplasm]HDAC3 [nucleoplasm]CREBBP(2-2442)[nucleoplasm]NRF1 [nucleoplasm]SREBF2(1-484)[nucleoplasm]MED16 [nucleoplasm]ALAS1 gene[nucleoplasm]NFYC [nucleoplasm]RXRAAA [nucleoplasm]NFYC [nucleoplasm]TBL1XSP1(1-785)[nucleoplasm]PPARA:RXRACoactivator ComplexPPARA [nucleoplasm]MED6 [nucleoplasm]RXRA [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NFYB [nucleoplasm]ANKRD1NCOA3 [nucleoplasm]MED7 [nucleoplasm]ALAS1PPARG [nucleoplasm]NCOR1 [nucleoplasm]PPARGC1A[nucleoplasm]MED8 [nucleoplasm]MED14 [nucleoplasm]NFYA [nucleoplasm]PeroxisomeProliferatorReceptor Element(PPRE)TGS1 [nucleoplasm]PPARGC1B[nucleoplasm]MED26 [nucleoplasm]HMGCS1TEAD:WWTR1(TAZ)NCOA6 [nucleoplasm]TEAD2 [nucleoplasm]ME1HDAC3 [nucleoplasm]EP300(1-2414)[nucleoplasm]TIAM2(2-1701)MED1 [nucleoplasm]CPT1APPARA:RXRAHeterodimerPLIN2MED13L [nucleoplasm]TEAD3(1-435)[nucleoplasm]APOA1(25-266)NFYA [nucleoplasm]TRIB3ESRRANCOA2 [nucleoplasm]NFYA [nucleoplasm]MED21 [nucleoplasm]RXRA [nucleoplasm]RXRA [nucleoplasm]2722, 254215, 36, 3710, 443522, 2529, 42312724, 455, 145, 142733


Description

Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels.
PPAR-alpha is a type II nuclear receptor (its subcellular location does not depend on ligand binding). PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha), another type II nuclear receptor. PPAR-alpha is activated by binding fatty acid ligands, especially polyunsaturated fatty acids having 18-22 carbon groups and 2-6 double bonds.
The PPAR-alpha:RXR-alpha heterodimer binds peroxisome proliferator receptor elements (PPREs) in and around target genes. Binding of fatty acids and synthetic ligands causes a conformational change in PPAR-alpha such that it releases the corepressors and binds coactivators (CBP-SRC-HAT complex, ASC complex, and TRAP-Mediator complex) which initiate transcription of the target genes.
Target genes of PPAR-alpha participate in fatty acid transport, fatty acid oxidation, triglyceride clearance, lipoprotein production, and cholesterol homeostasis.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=400206

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Bibliography

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  1. Hua F, Mu R, Liu J, Xue J, Wang Z, Lin H, Yang H, Chen X, Hu Z.; ''TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.''; PubMed Europe PMC Scholia
  2. Vock C, Döring F, Nitz I.; ''Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.''; PubMed Europe PMC Scholia
  3. Guo L, Guo ZX, Gong HP, Shang YY, Zhong M, Zhang Y, Zhang W.; ''Tribbles homolog 3 is induced by high glucose and associated with apoptosis in human endothelial cells.''; PubMed Europe PMC Scholia
  4. Haarmann-Stemmann T, Abel J.; ''The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function.''; PubMed Europe PMC Scholia
  5. Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W.; ''Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay.''; PubMed Europe PMC Scholia
  6. Mukherjee R, Jow L, Noonan D, McDonnell DP.; ''Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators.''; PubMed Europe PMC Scholia
  7. Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C.; ''Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes.''; PubMed Europe PMC Scholia
  8. Krammer J, Digel M, Ehehalt F, Stremmel W, Füllekrug J, Ehehalt R.; ''Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells.''; PubMed Europe PMC Scholia
  9. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.; ''Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.''; PubMed Europe PMC Scholia
  10. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; PubMed Europe PMC Scholia
  11. Bardot O, Aldridge TC, Latruffe N, Green S.; ''PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.''; PubMed Europe PMC Scholia
  12. Xu J, Lv S, Qin Y, Shu F, Xu Y, Chen J, Xu BE, Sun X, Wu J.; ''TRB3 interacts with CtIP and is overexpressed in certain cancers.''; PubMed Europe PMC Scholia
  13. van der Meer DL, Degenhardt T, Väisänen S, de Groot PJ, Heinäniemi M, de Vries SC, Müller M, Carlberg C, Kersten S.; ''Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis.''; PubMed Europe PMC Scholia
  14. Hahn ME, Allan LL, Sherr DH.; ''Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor.''; PubMed Europe PMC Scholia
  15. Wolfrum C, Borrmann CM, Borchers T, Spener F.; ''Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.''; PubMed Europe PMC Scholia
  16. Rakhshandehroo M, Hooiveld G, Müller M, Kersten S.; ''Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.''; PubMed Europe PMC Scholia
  17. Zheng J, Shan Y, Lambrecht RW, Donohue SE, Bonkovsky HL.; ''Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin.''; PubMed Europe PMC Scholia
  18. Roberts AG, Elder GH.; ''Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes.''; PubMed Europe PMC Scholia
  19. Beischlag TV, Luis Morales J, Hollingshead BD, Perdew GH.; ''The aryl hydrocarbon receptor complex and the control of gene expression.''; PubMed Europe PMC Scholia
  20. Jiang G, McKenzie TL, Conrad DG, Shechter I.; ''Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.''; PubMed Europe PMC Scholia
  21. Johnson EF, Hsu MH, Savas U, Griffin KJ.; ''Regulation of P450 4A expression by peroxisome proliferator activated receptors.''; PubMed Europe PMC Scholia
  22. Qi C, Zhu Y, Reddy JK.; ''Peroxisome proliferator-activated receptors, coactivators, and downstream targets.''; PubMed Europe PMC Scholia
  23. Shimamoto Y, Hirota K, Fukamizu A.; ''Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter.''; PubMed Europe PMC Scholia
  24. Barbier O, Villeneuve L, Bocher V, Fontaine C, Torra IP, Duhem C, Kosykh V, Fruchart JC, Guillemette C, Staels B.; ''The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.''; PubMed Europe PMC Scholia
  25. Tian L, Zhou J, Casimiro MC, Liang B, Ojeifo JO, Wang M, Hyslop T, Wang C, Pestell RG.; ''Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis.''; PubMed Europe PMC Scholia
  26. Yang X, Lu X, Lombès M, Rha GB, Chi YI, Guerin TM, Smart EJ, Liu J.; ''The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase.''; PubMed Europe PMC Scholia
  27. Kersten S.; ''Peroxisome proliferator activated receptors and lipoprotein metabolism.''; PubMed Europe PMC Scholia
  28. Knutti D, Kaul A, Kralli A.; ''A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.''; PubMed Europe PMC Scholia
  29. Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL.; ''Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.''; PubMed Europe PMC Scholia
  30. Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF.; ''A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.''; PubMed Europe PMC Scholia
  31. Gouni-Berthold I, Krone W.; ''Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis.''; PubMed Europe PMC Scholia
  32. Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG.; ''A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.''; PubMed Europe PMC Scholia
  33. Mochizuki K, Suruga K, Fukami H, Kiso Y, Takase S, Goda T.; ''Selectivity of fatty acid ligands for PPARalpha which correlates both with binding to cis-element and DNA binding-independent transactivity in Caco-2 cells.''; PubMed Europe PMC Scholia
  34. Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, McGarry JD.; ''Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene.''; PubMed Europe PMC Scholia
  35. Fang HL, Strom SC, Cai H, Falany CN, Kocarek TA, Runge-Morris M.; ''Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.''; PubMed Europe PMC Scholia
  36. Yu S, Reddy JK.; ''Transcription coactivators for peroxisome proliferator-activated receptors.''; PubMed Europe PMC Scholia
  37. Matsumura R, Matsubara C, Node K, Takumi T, Akashi M.; ''Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2).''; PubMed Europe PMC Scholia
  38. Cheema SK, Agellon LB.; ''The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha.''; PubMed Europe PMC Scholia
  39. Crumbley C, Wang Y, Kojetin DJ, Burris TP.; ''Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.''; PubMed Europe PMC Scholia
  40. Lu X, Yang X, Liu J.; ''Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2.''; PubMed Europe PMC Scholia
  41. Vu-Dac N, Chopin-Delannoy S, Gervois P, Bonnelye E, Martin G, Fruchart JC, Laudet V, Staels B.; ''The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates.''; PubMed Europe PMC Scholia
  42. Wang M, Yang F, Zhang X, Zhao H, Wang Q, Pan Y.; ''Comparative analysis of MTF-1 binding sites between human and mouse.''; PubMed Europe PMC Scholia
  43. Desvergne B, Wahli W.; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; PubMed Europe PMC Scholia
  44. Hostetler HA, McIntosh AL, Atshaves BP, Storey SM, Payne HR, Kier AB, Schroeder F.; ''L-FABP directly interacts with PPARalpha in cultured primary hepatocytes.''; PubMed Europe PMC Scholia
  45. Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M.; ''Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.''; PubMed Europe PMC Scholia
  46. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B.; ''DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.''; PubMed Europe PMC Scholia
  47. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM.; ''A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.''; PubMed Europe PMC Scholia
  48. Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E.; ''GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.''; PubMed Europe PMC Scholia
  49. Perera RJ, Marcusson EG, Koo S, Kang X, Kim Y, White N, Dean NM.; ''Identification of novel PPARgamma target genes in primary human adipocytes.''; PubMed Europe PMC Scholia
  50. Schachtrup C, Emmler T, Bleck B, Sandqvist A, Spener F.; ''Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins.''; PubMed Europe PMC Scholia
  51. Tao N, Wagner SJ, Lublin DM.; ''CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails.''; PubMed Europe PMC Scholia
  52. Liu MH, Li J, Shen P, Husna B, Tai ES, Yong EL.; ''A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
115040view16:58, 25 January 2021ReactomeTeamReactome version 75
113484view11:56, 2 November 2020ReactomeTeamReactome version 74
112683view16:07, 9 October 2020ReactomeTeamReactome version 73
109289view21:21, 5 March 2020KhanspersReverted to version '11:47, 1 November 2018' by Khanspers
109272view15:00, 3 March 2020ClorisModified title
101600view11:47, 1 November 2018ReactomeTeamreactome version 66
101136view21:32, 31 October 2018ReactomeTeamreactome version 65
100664view20:05, 31 October 2018ReactomeTeamreactome version 64
100214view16:50, 31 October 2018ReactomeTeamreactome version 63
99765view15:16, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99324view12:47, 31 October 2018ReactomeTeamreactome version 62
93918view13:44, 16 August 2017ReactomeTeamreactome version 61
93495view11:25, 9 August 2017ReactomeTeamreactome version 61
88142view12:57, 26 July 2016RyanmillerOntology Term : 'fatty acid metabolic pathway' added !
88141view12:56, 26 July 2016RyanmillerOntology Term : 'classic metabolic pathway' added !
86591view09:21, 11 July 2016ReactomeTeamreactome version 56
83414view11:10, 18 November 2015ReactomeTeamVersion54
81776view10:35, 26 August 2015ReactomeTeamVersion53
77088view08:38, 17 July 2014ReactomeTeamFixed remaining interactions
76794view12:17, 16 July 2014ReactomeTeamFixed remaining interactions
76117view10:18, 11 June 2014ReactomeTeamRe-fixing comment source
75829view11:39, 10 June 2014ReactomeTeamReactome 48 Update
75190view09:39, 9 May 2014AnweshaFixing comment source for displaying WikiPathways description
74834view10:06, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
13(S')-HODE [nucleoplasm]MetaboliteCHEBI:34154 (ChEBI)
4xPalmC-CD36ProteinP16671 (Uniprot-TrEMBL)
9S-HODE [nucleoplasm]MetaboliteCHEBI:34496 (ChEBI)
AA [nucleoplasm]MetaboliteCHEBI:15843 (ChEBI)
ABCA1ProteinO95477 (Uniprot-TrEMBL)
ABCB4ProteinP21439 (Uniprot-TrEMBL)
ACADMProteinP11310 (Uniprot-TrEMBL)
ACOX1-1ProteinQ15067-1 (Uniprot-TrEMBL)
ACSL1ProteinP33121 (Uniprot-TrEMBL)
AGTProteinP01019 (Uniprot-TrEMBL)
ALA [nucleoplasm]MetaboliteCHEBI:27432 (ChEBI)
ALAS1 gene:NRF1:PPARGC1BComplexREACT_151863 (Reactome)
ALAS1 gene [nucleoplasm]ProteinENSG00000023330 (ENSEMBL)
ALAS1ProteinP13196 (Uniprot-TrEMBL)
ANGPTL4ProteinQ9BY76 (Uniprot-TrEMBL)
ANKRD1ProteinQ15327 (Uniprot-TrEMBL)
APOA1(25-266)ProteinP02647 (Uniprot-TrEMBL)
APOA2(24-100)ProteinP02652 (Uniprot-TrEMBL)
APOA5ProteinQ6Q788 (Uniprot-TrEMBL)
Actos [nucleoplasm]MetaboliteCHEBI:8228 (ChEBI)
CARM1(2-608) [nucleoplasm]ProteinQ86X55 (Uniprot-TrEMBL)
CCNC [nucleoplasm]ProteinP24863 (Uniprot-TrEMBL)
CDK19 [nucleoplasm]ProteinQ9BWU1 (Uniprot-TrEMBL)
CDK8 [nucleoplasm]ProteinP49336 (Uniprot-TrEMBL)
CHD9 [nucleoplasm]ProteinQ3L8U1 (Uniprot-TrEMBL)
CPT1AProteinP50416 (Uniprot-TrEMBL)
CPT2ProteinP23786 (Uniprot-TrEMBL)
CREBBP(2-2442) [nucleoplasm]ProteinQ92793 (Uniprot-TrEMBL)
CTGFProteinP29279 (Uniprot-TrEMBL)
CYP1A1ProteinP04798 (Uniprot-TrEMBL)
CYP4A11ProteinQ02928 (Uniprot-TrEMBL)
CYP7A1ProteinP22680 (Uniprot-TrEMBL)
Coactivators of PPARalphaProteinREACT_20313 (Reactome)
Corepressors of PPARalphaProteinREACT_19786 (Reactome)
EP300(1-2414) [nucleoplasm]ProteinQ09472 (Uniprot-TrEMBL)
EPA [nucleoplasm]MetaboliteCHEBI:28364 (ChEBI)
ESRRAProteinP11474 (Uniprot-TrEMBL)
FABP1 [nucleoplasm]ProteinP07148 (Uniprot-TrEMBL) As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.
FABP1:Ligands of PPARAComplexREACT_119390 (Reactome)
FABP1ProteinP07148 (Uniprot-TrEMBL) As inferred from mouse, FABP1 localizes to the nucleus where it may deliver lipids to PPARA.
FADS1(1-444)ProteinO60427 (Uniprot-TrEMBL)
FDFT1 gene [nucleoplasm]ProteinENSG00000079459 (ENSEMBL)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FHL2ProteinQ14192 (Uniprot-TrEMBL)
G0S2ProteinP27469 (Uniprot-TrEMBL)
GLIPR1ProteinP48060 (Uniprot-TrEMBL)
GRHL1ProteinQ9NZI5 (Uniprot-TrEMBL)
HDAC3 [nucleoplasm]ProteinO15379 (Uniprot-TrEMBL)
HELZ2 [nucleoplasm]ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene [nucleoplasm]ProteinENSG00000113161 (ENSEMBL)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene [nucleoplasm]ProteinENSG00000112972 (ENSEMBL)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
HMGCS2ProteinP54868 (Uniprot-TrEMBL)
LINA [nucleoplasm]MetaboliteCHEBI:17351 (ChEBI)
ME1ProteinP48163 (Uniprot-TrEMBL)
MED1 [nucleoplasm]ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MED10(2-135) [nucleoplasm]ProteinQ9BTT4 (Uniprot-TrEMBL)
MED11 [nucleoplasm]ProteinQ9P086 (Uniprot-TrEMBL)
MED12 [nucleoplasm]ProteinQ93074 (Uniprot-TrEMBL)
MED13 [nucleoplasm]ProteinQ9UHV7 (Uniprot-TrEMBL)
MED13L [nucleoplasm]ProteinQ71F56 (Uniprot-TrEMBL)
MED14 [nucleoplasm]ProteinO60244 (Uniprot-TrEMBL)
MED15 [nucleoplasm]ProteinQ96RN5 (Uniprot-TrEMBL)
MED16 [nucleoplasm]ProteinQ9Y2X0 (Uniprot-TrEMBL)
MED17 [nucleoplasm]ProteinQ9NVC6 (Uniprot-TrEMBL)
MED18 [nucleoplasm]ProteinQ9BUE0 (Uniprot-TrEMBL)
MED19 [nucleoplasm]ProteinA0JLT2 (Uniprot-TrEMBL)
MED20 [nucleoplasm]ProteinQ9H944 (Uniprot-TrEMBL)
MED21 [nucleoplasm]ProteinQ13503 (Uniprot-TrEMBL)
MED22 [nucleoplasm]ProteinQ15528 (Uniprot-TrEMBL)
MED23 [nucleoplasm]ProteinQ9ULK4 (Uniprot-TrEMBL)
MED24 [nucleoplasm]ProteinO75448 (Uniprot-TrEMBL)
MED25 [nucleoplasm]ProteinQ71SY5 (Uniprot-TrEMBL)
MED26 [nucleoplasm]ProteinO95402 (Uniprot-TrEMBL)
MED27 [nucleoplasm]ProteinQ6P2C8 (Uniprot-TrEMBL)
MED29(2-200) [nucleoplasm]ProteinQ9NX70 (Uniprot-TrEMBL)
MED30(1-178) [nucleoplasm]ProteinQ96HR3 (Uniprot-TrEMBL)
MED31 [nucleoplasm]ProteinQ9Y3C7 (Uniprot-TrEMBL)
MED4 [nucleoplasm]ProteinQ9NPJ6 (Uniprot-TrEMBL)
MED6 [nucleoplasm]ProteinO75586 (Uniprot-TrEMBL)
MED7 [nucleoplasm]ProteinO43513 (Uniprot-TrEMBL)
MED8 [nucleoplasm]ProteinQ96G25 (Uniprot-TrEMBL)
MED9 [nucleoplasm]ProteinQ9NWA0 (Uniprot-TrEMBL)
NCOA1 [nucleoplasm]ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 [nucleoplasm]ProteinQ15596 (Uniprot-TrEMBL)
NCOA3 [nucleoplasm]ProteinQ9Y6Q9 (Uniprot-TrEMBL)
NCOA6 [nucleoplasm]ProteinQ14686 (Uniprot-TrEMBL)
NCOR1 [nucleoplasm]ProteinO75376 (Uniprot-TrEMBL)
NCOR2 [nucleoplasm]ProteinQ9Y618 (Uniprot-TrEMBL)
NFYA [nucleoplasm]ProteinP23511 (Uniprot-TrEMBL)
NFYB [nucleoplasm]ProteinP25208 (Uniprot-TrEMBL)
NFYC [nucleoplasm]ProteinQ13952 (Uniprot-TrEMBL)
NPAS2ProteinQ99743 (Uniprot-TrEMBL)
NR1D1 (REV-ERBA):heme:CorepressorComplexREACT_111441 (Reactome)
NR1D1 [nucleoplasm]ProteinP20393 (Uniprot-TrEMBL)
NRF1 [nucleoplasm]ProteinQ16656 (Uniprot-TrEMBL)
PEX11AProteinO75192 (Uniprot-TrEMBL)
PLIN2ProteinQ99541 (Uniprot-TrEMBL)
PPARA [nucleoplasm]ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
PPARA:RXRA HeterodimerComplexREACT_20362 (Reactome)
PPARA:RXRA Repressor ComplexComplexREACT_19814 (Reactome)
PPARAProteinQ07869 (Uniprot-TrEMBL)
PPARG [nucleoplasm]ProteinP37231 (Uniprot-TrEMBL)
PPARG:Fatty

Acid:RXRA:Mediator:Coactivator

Complex		ComplexREACT_27768 (Reactome)
PPARGC1A [nucleoplasm]ProteinQ9UBK2 (Uniprot-TrEMBL)
PPARGC1B [nucleoplasm]ProteinQ86YN6 (Uniprot-TrEMBL)
Palm [nucleoplasm]MetaboliteCHEBI:15756 (ChEBI)
Peroxisome

Proliferator Receptor Element

(PPRE)		REACT_20340 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RGL1ProteinQ9NZL6 (Uniprot-TrEMBL)
RGZ [nucleoplasm]MetaboliteCHEBI:50122 (ChEBI)
ROR-alpha:CoactivatorComplexREACT_111748 (Reactome)
RORA [nucleoplasm]ProteinP35398 (Uniprot-TrEMBL)
RXRA [nucleoplasm]ProteinP19793 (Uniprot-TrEMBL)
RXRAProteinP19793 (Uniprot-TrEMBL)
SIN3A [nucleoplasm]ProteinQ96ST3 (Uniprot-TrEMBL)
SIN3B-1 [nucleoplasm]ProteinO75182-1 (Uniprot-TrEMBL)
SLC27A1ProteinQ6PCB7 (Uniprot-TrEMBL)
SMARCD3 [nucleoplasm]ProteinQ6STE5 (Uniprot-TrEMBL)
SP1(1-785) [nucleoplasm]ProteinP08047 (Uniprot-TrEMBL)
SREBF1-1(1-490) [nucleoplasm]ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 [nucleoplasm]ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) [nucleoplasm]ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A/1C/2:NF-Y:HMGCS1 geneComplexREACT_148333 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneComplexREACT_148107 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneComplexREACT_148301 (Reactome)
SULT2A1(2-285)ProteinQ06520 (Uniprot-TrEMBL)
TBL1X [nucleoplasm]ProteinO60907 (Uniprot-TrEMBL)
TBL1XProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 [nucleoplasm]ProteinQ9BZK7 (Uniprot-TrEMBL)
TBL1XR1ProteinQ9BZK7 (Uniprot-TrEMBL)
TEAD1 [nucleoplasm]ProteinP28347 (Uniprot-TrEMBL)
TEAD2 [nucleoplasm]ProteinQ15562 (Uniprot-TrEMBL)
TEAD3(1-435) [nucleoplasm]ProteinQ99594 (Uniprot-TrEMBL)
TEAD4 [nucleoplasm]ProteinQ15561 (Uniprot-TrEMBL)
TEAD:WWTR1(TAZ)ComplexREACT_120065 (Reactome)
TEAD:YAP1ComplexREACT_119773 (Reactome)
TGS1 [nucleoplasm]ProteinQ96RS0 (Uniprot-TrEMBL)
TIAM2(2-1701)ProteinQ8IVF5 (Uniprot-TrEMBL)
TNFRSF21ProteinO75509 (Uniprot-TrEMBL)
TRIB3ProteinQ96RU7 (Uniprot-TrEMBL)
TXNRD1ProteinQ16881 (Uniprot-TrEMBL)
UGT1A9ProteinO60656 (Uniprot-TrEMBL)
WWTR1 [nucleoplasm]ProteinQ9GZV5 (Uniprot-TrEMBL)
YAP1 [nucleoplasm]ProteinP46937 (Uniprot-TrEMBL)
ferriheme b [nucleoplasm]MetaboliteCHEBI:36144 (ChEBI)
p-BMAL1:p-CLOCK/NPAS2:DNAComplexREACT_25790 (Reactome)
p-S-ARNTL [nucleoplasm]ProteinO00327 (Uniprot-TrEMBL)
p-S-CLOCK [nucleoplasm]ProteinO15516 (Uniprot-TrEMBL)
p-S-NPAS2 [nucleoplasm]ProteinQ99743 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
4xPalmC-CD36ArrowREACT_27168 (Reactome)
ABCA1ArrowREACT_115994 (Reactome)
ABCB4ArrowREACT_115807 (Reactome)
ACADMArrowREACT_116020 (Reactome)
ACOX1-1ArrowREACT_115624 (Reactome)
ACSL1ArrowREACT_115978 (Reactome)
AGTArrowREACT_115879 (Reactome)
ALAS1 gene:NRF1:PPARGC1BArrowREACT_115949 (Reactome)
ALAS1 gene:NRF1:PPARGC1BREACT_115949 (Reactome)
ALAS1ArrowREACT_115949 (Reactome)
ANGPTL4ArrowREACT_27173 (Reactome)
ANKRD1ArrowREACT_115878 (Reactome)
APOA1(25-266)ArrowREACT_116159 (Reactome)
APOA2(24-100)ArrowREACT_116133 (Reactome)
APOA5ArrowREACT_115631 (Reactome)
CPT1AArrowREACT_115644 (Reactome)
CPT2ArrowREACT_115927 (Reactome)
CTGFArrowREACT_116163 (Reactome)
CYP1A1ArrowREACT_116079 (Reactome)
CYP4A11ArrowREACT_115547 (Reactome)
CYP7A1ArrowREACT_115550 (Reactome)
Coactivators of PPARalphaREACT_19175 (Reactome)
Corepressors of PPARalphaArrowREACT_19175 (Reactome)
Corepressors of PPARalphaREACT_19283 (Reactome)
ESRRAArrowREACT_115949 (Reactome)
FABP1:Ligands of PPARAREACT_19175 (Reactome)
FABP1ArrowREACT_115721 (Reactome)
FABP1ArrowREACT_19175 (Reactome)
FADS1(1-444)ArrowREACT_115953 (Reactome)
FDFT1ArrowREACT_115945 (Reactome)
FHL2ArrowREACT_116040 (Reactome)
G0S2ArrowREACT_115967 (Reactome)
GLIPR1ArrowREACT_115533 (Reactome)
GRHL1ArrowREACT_115770 (Reactome)
HMGCR-1ArrowREACT_115997 (Reactome)
HMGCS1ArrowREACT_115739 (Reactome)
HMGCS2ArrowREACT_116136 (Reactome)
ME1ArrowREACT_115847 (Reactome)
NPAS2ArrowREACT_116112 (Reactome)
NR1D1 (REV-ERBA):heme:CorepressorTBarREACT_116112 (Reactome)
PEX11AArrowREACT_115962 (Reactome)
PLIN2ArrowREACT_115542 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115533 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115542 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115547 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115550 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115593 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115624 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115625 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115631 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115644 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115677 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115721 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115729 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115739 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115770 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115777 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115807 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115815 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115847 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115875 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115878 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115879 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115927 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115945 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115949 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115953 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115962 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115967 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115978 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115979 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115994 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115997 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116020 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116040 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116079 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116112 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116133 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116136 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116159 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_116163 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_19175 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_25084 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_27168 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_27173 (Reactome)
PPARA:RXRA HeterodimerArrowREACT_19370 (Reactome)
PPARA:RXRA HeterodimerREACT_19283 (Reactome)
PPARA:RXRA Repressor ComplexArrowREACT_19283 (Reactome)
PPARA:RXRA Repressor ComplexREACT_19175 (Reactome)
PPARAArrowREACT_25084 (Reactome)
PPARAREACT_19370 (Reactome)
PPARG:Fatty

Acid:RXRA:Mediator:Coactivator

Complex		ArrowREACT_27168 (Reactome)
PPARG:Fatty

Acid:RXRA:Mediator:Coactivator

Complex		ArrowREACT_27173 (Reactome)
Peroxisome

Proliferator Receptor Element

(PPRE)		REACT_19370 (Reactome)
REACT_115533 (Reactome) The GLIPR1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115542 (Reactome) The Adipophilin (PLIN2) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115547 (Reactome) The CYP4A11 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115550 (Reactome) The CYP7A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115593 (Reactome) The TIAM2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115624 (Reactome) The ACOX1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115625 (Reactome) The RGL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115631 (Reactome) The APOA5 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115644 (Reactome) The CPT1A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115677 (Reactome) The TXNRD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115721 (Reactome) The FABP1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115729 (Reactome) The SULT2A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115739 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115770 (Reactome) The GRHL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115777 (Reactome) The UGT1A9 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115807 (Reactome) The ABCB4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115815 (Reactome) The TRIB3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115847 (Reactome) The ME1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115875 (Reactome) The TNFRSF21 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115878 (Reactome) The ANKRD1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115879 (Reactome) The AGT gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115927 (Reactome) The CPT2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115945 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115949 (Reactome) The ALAS1 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. The ALAS1 precursor is imported into the mitochodrial matrix where it catalyzes the synthesis of 5-aminolevulinate from glycine and succinyl-CoA as part of heme biosynthesis.
REACT_115953 (Reactome) The FADS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115962 (Reactome) The PEX11A gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115967 (Reactome) The G0S2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115978 (Reactome) The ACSL1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115979 (Reactome) The FATP1 (SLC27A1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115994 (Reactome) The ABCA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115997 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116020 (Reactome) The ACADM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116040 (Reactome) The FHL2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116079 (Reactome) The CYP1A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116112 (Reactome) The NPAS2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of NPAS2 is enhanced by the RORA:Coactivator complex and repressed by the REV-ERBA:Corepressor complex.
REACT_116133 (Reactome) The APOA2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116136 (Reactome) The HMGCS2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116159 (Reactome) The APOA1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_116163 (Reactome) The CTGF gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of the CTGF gene is increased by both YAP1:TEAD and WWTR1(TAZ):TEAD transcriptional coactivator:transcription factor complexes, so that CTFG is one of the many genes whose expression is downregulated by the action of the hippo cascade (Zhang et al. 2009; Zhao et al. 2008).
REACT_19175 (Reactome) PPAR-alpha is activated by binding polyunsaturated fatty acids especially those having 18-22 carbon groups and 2-6 double bonds. These ligands bind the C-terminal region of PPAR-alpha and include linoleic acid, linolenic acids, arachidonic acid, and eicosapentaenoic acid. The fibrate drugs are also agonists of PPAR-alpha.
Binding of a ligand causes a conformational change in PPAR-alpha so that it recruits coactivators. By analogy with the closely related receptor PPAR-gamma, PPAR-alpha probably binds TBL1 and TBLR1, which are responsible for recruiting the 19S proteasome to degrade corepressors during the exchange of corepressors for coactivators. The coactivators belong to the CBP-SRC-HAT complex (CBP/p300, SRC1, SRC2, SRC3, CARM1, SWI/SNF, BAF60C, PRIC320, and PRIC285), the ASC complex (PRIP/ASC2, PIMT), and the TRAP-DRIP-ARC-MEDIATOR complex (TRAP130, PBP/TRAP220). The coactivators contain LXXLL motifs (Nuclear Receptor Boxes) that interact with the AF-2 region in nuclear receptors such as PPAR-alpha.
REACT_19283 (Reactome) In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.
REACT_19370 (Reactome) Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a type II nuclear receptor (its subcellular location is independent of ligand binding) related to PPAR-beta/delta and PPAR-gamma. PPAR-alpha is expressed highly in the liver where if functions to control lipid metabolism, especially fatty acid oxidation.
PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha). The heterodimers bind peroxisome proliferator receptor elements (PPREs) in and around genes regulated by PPAR-alpha.
REACT_25084 (Reactome) The PPARA gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, BMAL1:CLOCK heterodimers bind the scond intron of the PPARA gene and activate transcription of PPARA.
REACT_27168 (Reactome) The Platelet glycoprotein IV gene (CD36, PAS IV, GPIV) is transcribed to yield mRNA and the mRNA is translated to yield proteind.
REACT_27173 (Reactome) The ANGPTL4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
RGL1ArrowREACT_115625 (Reactome)
ROR-alpha:CoactivatorArrowREACT_115644 (Reactome)
ROR-alpha:CoactivatorArrowREACT_116112 (Reactome)
RXRAREACT_19370 (Reactome)
SLC27A1ArrowREACT_115979 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneArrowREACT_115739 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneREACT_115739 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneArrowREACT_115945 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneREACT_115945 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneArrowREACT_115997 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneREACT_115997 (Reactome)
SULT2A1(2-285)ArrowREACT_115729 (Reactome)
TBL1XR1REACT_19283 (Reactome)
TBL1XREACT_19283 (Reactome)
TEAD:WWTR1(TAZ)ArrowREACT_116163 (Reactome)
TEAD:YAP1ArrowREACT_116163 (Reactome)
TIAM2(2-1701)ArrowREACT_115593 (Reactome)
TNFRSF21ArrowREACT_115875 (Reactome)
TRIB3ArrowREACT_115815 (Reactome)
TXNRD1ArrowREACT_115677 (Reactome)
UGT1A9ArrowREACT_115777 (Reactome)
p-BMAL1:p-CLOCK/NPAS2:DNAArrowREACT_25084 (Reactome)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2797"
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