PCSK9-mediated LDL receptor degradation (Homo sapiens)

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1LDL particlesGolgi apparatusEndocytosisHepatocyteLDLRPCSK9PCSK9LDLRLDLRLDL-receptor synthesisLDLRPCSK9LDLRLysosomaldegradationPCSK9LDLRPCSK9LDLRPCSK9SecretionLDL-receptor recyclingLDLREndosomeLDLRLDLR


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brautbar A, Ballantyne CM; ''Pharmacological strategies for lowering LDL cholesterol: statins and beyond.''; Nat Rev Cardiol, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135533view01:47, 23 September 2024EweitzFix truncated text
135221view11:44, 8 August 2024EweitzIncrease font size
135220view11:42, 8 August 2024EweitzEconomize layout
128066view00:05, 24 January 2024EweitzA bit more mitigation of Golgi distortion in website
128065view00:04, 24 January 2024EweitzTry further mitigating Golgi distortion in website rendering
128064view00:03, 24 January 2024EweitzMitigate Golgi distortion (site shows it partly extracellular, PathVisio shows it fully intracellular); upgrade "LDL particles" label to "LDL cholesterol" metabolite node
128063view23:55, 23 January 2024EweitzOntology Term : 'cholesterol metabolic pathway' added !
128062view23:52, 23 January 2024EweitzOntology Term : 'hepatocyte' added !
116729view10:27, 11 May 2021EweitzModified title
89409view20:16, 10 September 2016AlexanderPicoModified title
89108view15:11, 22 August 2016EveloModified description
89107view15:10, 22 August 2016EveloModified title
89106view15:10, 22 August 2016EveloModified title
89105view15:09, 22 August 2016EveloModified description
88292view15:00, 1 August 2016FehrhartOntology Term : 'lipoprotein metabolic pathway' added !
83009view09:34, 17 November 2015FehrhartUpdated ensembl ID for LDLR
78515view10:29, 7 January 2015MaintBotadded missing graphIds
77448view13:36, 9 September 2014SusanConnect line
77430view11:51, 8 September 2014SusanModified description
77429view11:50, 8 September 2014SusanNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
LDLRGeneProductENSG00000270150 (Ensembl)
PCSK9GeneProductENSG00000169174 (Ensembl)

Annotated Interactions

No annotated interactions

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