Mesodermal commitment pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none AHDC1BCORL1CRTC1DIP2AELK4NLKPBX3PIAS1ZFHX4MIR375 Targets(Induced in Ectoderm)EXT1EXT2NucleusEctodermSpecificationPLCH1WDFY2SESN1DDAH1PBX1PARP8HPRT1TCF4ACACATRERF1MIR653 Targets(Induced in Stem Cells)WDFY2PARP8RGS10CUL4BSESN1SCHIP1PLCH1TRIM5CEP250PBX1SLC2A12C11orf30ATP8B2HPRT1VAV3TCF4MIR653 Targets(Induced in Ectoderm)C2orf44CSRP2CCND1CCDC6ASCC3CCDC88AARL4AC6orf201MIR372 Targets(Induced in Stem Cells)PRKACAEOMESNOGGDF3RARGGRHL2ASCC3NABP2ZNF462MBTD1TOXTRERF1MIR373 Targets(Induced in Stem Cells)TEAD2NODALHES7SMAD1SMAD3FOXC1KLF5PAX6ARID5BHNF4AGATA6FOXC1FOXA1PITX2FOXA2RARBBHLHE40GATA3SOX17MIR200A and MIR141 Targets(Induced in Endoderm)JAK2ZIC2TRIM28MEIS1ADAM19FOXA2MSGN1FGF8AXIN2SMAD4DLL1YAP1ATP8B2CEP250C11orf30C9orf72CSRP2ARL4ACCND1MIR372 Targets(Induced in Ectoderm)ZNF462ELP4PHF6TOX3C11orf30MIR373 Targets(Induced in Ectoderm)BMP4MIR302CHTTTEAD1BMPR2MACF1MIR125B1TBX6TACVR2ATBX3SMAD6WNT3ATCF7L1FGFR1MIR373LATS1TBX1KDM6AAXIN1EPB41L5BMP7ACVR2BNANOGSNAI1POU5F1NANOGMIXL1RPL38FOXH1CHRDFOXC2WNT3KLF4SETD2BMPR1AINHBASOX2LEF1PRKAR1AMIR200AMIR141-5pHMGA2SRFTWSG1HAND1PPP2CAACVR1SMAD2DKK1LEFTY1LEFTY2AMHMIR653MIR372FZD4FZD5FZD8MesodermSpecificationNFE2L2SOX2MIR375Name: Mesodermal Commitment PathwayOrganism: Homo sapiens


Description

No description

Comments

 
Developed using Gene Ontology mesoderm process associated genes and interactions from the software NetPerspective (AltAnalyze). A preliminary layout was obtained using the exported SIF file in Cytoscape's Cerebral plugin.

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Quality Tags

Image:Featured.pngReview changes for Featured
Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : steroid metabolic pathway
 

Bibliography

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  1. Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H; ''Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.''; Nature, 2011 PubMed Europe PMC Scholia
  2. Wong SS, Ritner C, Ramachandran S, Aurigui J, Pitt C, Chandra P, Ling VB, Yabut O, Bernstein HS; ''miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in embryonic stem cells.''; PLoS One, 2012 PubMed Europe PMC Scholia
  3. White PH, Chapman DL; ''Dll1 is a downstream target of Tbx6 in the paraxial mesoderm.''; Genesis, 2005 PubMed Europe PMC Scholia
  4. Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP; ''T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.''; Genes Dev, 1999 PubMed Europe PMC Scholia
  5. Chen YL, Liu B, Zhou ZN, Hu RY, Fei C, Xie ZH, Ding X; ''Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  6. Bessho Y, Miyoshi G, Sakata R, Kageyama R; ''Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm.''; Genes Cells, 2001 PubMed Europe PMC Scholia
  7. Barroso-delJesus A, Lucena-Aguilar G, Sanchez L, Ligero G, Gutierrez-Aranda I, Menendez P; ''The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in embryonic stem cells.''; FASEB J, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137825
Featured
Approved
view06:48, 8 March 2025EgonwModified description
118395view14:06, 27 May 2021Mkutmonpublication ref fix
116397view00:00, 7 May 2021EweitzModified title
110685view13:26, 28 May 2020Marvin M2changed types unknown to geneproducts
106642view21:04, 12 September 2019KhanspersModified description
105645view05:10, 10 August 2019KhanspersModified description
102044view18:49, 26 November 2018Khanspersfixed labels
101908view17:03, 16 November 2018EgonwRemoved "undefined" as data source.
87780view11:11, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
85459view15:25, 18 May 2016Mshel016Adding Ensembl annotations
85452view06:44, 17 May 2016Mkutmonfix broken annotations
85446view13:46, 16 May 2016Mshel016Quick edit to datanode annotation or property
85445view13:34, 16 May 2016Mshel016Quick edit to datanode annotation or property
85444view13:26, 16 May 2016Mshel016Quick edit to datanode annotation or property
80151view18:50, 14 May 2015KhanspersChanged color and type for miRNA nodes
79850view03:35, 20 April 2015NsalomonisModified description
78577view14:50, 7 January 2015MaintBotadded missing graphIds
77690view18:30, 8 October 2014NsalomonisSpecify description
77685view19:42, 7 October 2014NsalomonisNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACACAGeneProductACACA (Uniprot-TrEMBL)
ACVR1ENSG00000115170 (Ensembl)
ACVR2AENSG00000121989 (Ensembl)
ACVR2BENSG00000114739 (Ensembl)
ADAM19GeneProductADAM19 (Uniprot-TrEMBL)
AHDC1GeneProductAHDC1 (Uniprot-TrEMBL)
AMHENSG00000104899 (Ensembl)
ARID5BGeneProductARID5B (Uniprot-TrEMBL)
ARL4AGeneProductARL4A (Uniprot-TrEMBL)
ASCC3GeneProductASCC3 (Uniprot-TrEMBL)
ATP8B2GeneProductATP8B2 (Uniprot-TrEMBL)
AXIN1ENSG00000103126 (Ensembl)
AXIN2GeneProductENSG00000168646 (Ensembl)
BCORL1GeneProductBCORL1 (Uniprot-TrEMBL)
BHLHE40GeneProductBHLHE40 (Uniprot-TrEMBL)
BMP4ENSG00000125378 (Ensembl)
BMP7ENSG00000101144 (Ensembl)
BMPR1AENSG00000107779 (Ensembl)
BMPR2ENSG00000204217 (Ensembl)
C11orf30GeneProductC11orf30 (Uniprot-TrEMBL)
C2orf44GeneProductC2orf44 (Uniprot-TrEMBL)
C6orf201GeneProductC6orf201 (Uniprot-TrEMBL)
C9orf72GeneProductC9orf72 (Uniprot-TrEMBL)
CCDC6GeneProductCCDC6 (Uniprot-TrEMBL)
CCDC88AGeneProductCCDC88A (Uniprot-TrEMBL)
CCND1GeneProductCCND1 (Uniprot-TrEMBL)
CEP250GeneProductCEP250 (Uniprot-TrEMBL)
CHRDENSG00000090539 (Ensembl)
CRTC1GeneProductCRTC1 (Uniprot-TrEMBL)
CSRP2GeneProductCSRP2 (Uniprot-TrEMBL)
CUL4BGeneProductCUL4B (Uniprot-TrEMBL)
DDAH1GeneProductDDAH1 (Uniprot-TrEMBL)
DIP2AGeneProductDIP2A (Uniprot-TrEMBL)
DKK1ENSG00000107984 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
ELK4GeneProductELK4 (Uniprot-TrEMBL)
ELP4GeneProductELP4 (Uniprot-TrEMBL)
EOMESENSG00000163508 (Ensembl)
EPB41L5ENSG00000115109 (Ensembl)
EXT1ENSG00000182197 (Ensembl)
EXT2ENSG00000151348 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FGFR1ENSG00000077782 (Ensembl)
FOXA1GeneProductFOXA1 (Uniprot-TrEMBL)
FOXA2GeneProductFOXA2 (Uniprot-TrEMBL)
FOXC1ENSG00000054598 (Ensembl)
FOXC1GeneProductFOXC1 (Uniprot-TrEMBL)
FOXC2ENSG00000176692 (Ensembl)
FOXH1ENSG00000160973 (Ensembl)
FZD4GeneProductENSG00000174804 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
GATA3GeneProductGATA3 (Uniprot-TrEMBL)
GATA6GeneProductGATA6 (Uniprot-TrEMBL)
GDF3ENSG00000184344 (Ensembl)
GRHL2GeneProductGRHL2 (Uniprot-TrEMBL)
HAND1ENSG00000113196 (Ensembl)
HES7GeneProductENSG00000179111 (Ensembl)
HMGA2ENSG00000149948 (Ensembl)
HNF4AGeneProductHNF4A (Uniprot-TrEMBL)
HPRT1GeneProductHPRT1 (Uniprot-TrEMBL)
HTTENSG00000197386 (Ensembl)
INHBAENSG00000122641 (Ensembl)
JAK2ENSG00000096968 (Ensembl)
KDM6AENSG00000147050 (Ensembl)
KLF4ENSG00000136826 (Ensembl)
KLF5GeneProductKLF5 (Uniprot-TrEMBL)
LATS1GeneProductENSG00000131023 (Ensembl)
LEF1ENSG00000138795 (Ensembl)
LEFTY1GeneProductENSG00000243709 (Ensembl)
LEFTY2GeneProductENSG00000143768 (Ensembl)
MACF1ENSG00000127603 (Ensembl)
MBTD1GeneProductMBTD1 (Uniprot-TrEMBL)
MEIS1GeneProductMEIS1 (Uniprot-TrEMBL)
MIR125B1GeneProductENSG00000207971 (Ensembl)
MIR141-5pGeneProductENSG00000207708 (Ensembl)
MIR200AGeneProductENSG00000207607 (Ensembl)
MIR302CGeneProductENSG00000199102 (Ensembl)
MIR372GeneProductENSG00000199095 (Ensembl)
MIR373GeneProductENSG00000199143 (Ensembl)
MIR375GeneProductENSG00000198973 (Ensembl)
MIR653GeneProductENSG00000199143 (Ensembl)
MIXL1GeneProductENSG00000185155 (Ensembl)
MSGN1GeneProductMSGN1 (Uniprot-TrEMBL)
NABP2GeneProductNABP2 (Uniprot-TrEMBL)
NANOGGeneProductENSG00000111704 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NLKGeneProductNLK (Uniprot-TrEMBL)
NODALENSG00000156574 (Ensembl)
NOGENSG00000183691 (Ensembl)
PARP8GeneProductPARP8 (Uniprot-TrEMBL)
PAX6GeneProductPAX6 (Uniprot-TrEMBL)
PBX1GeneProductPBX1 (Uniprot-TrEMBL)
PBX3GeneProductPBX3 (Uniprot-TrEMBL)
PHF6GeneProductPHF6 (Uniprot-TrEMBL)
PIAS1GeneProductPIAS1 (Uniprot-TrEMBL)
PITX2GeneProductPITX2 (Uniprot-TrEMBL)
PLCH1GeneProductPLCH1 (Uniprot-TrEMBL)
POU5F1GeneProductENSG00000204531 (Ensembl)
PPP2CAENSG00000113575 (Ensembl)
PRKACAENSG00000072062 (Ensembl)
PRKAR1AENSG00000108946 (Ensembl)
RARBGeneProductRARB (Uniprot-TrEMBL)
RARGGeneProductRARG (Uniprot-TrEMBL)
RGS10GeneProductRGS10 (Uniprot-TrEMBL)
RPL38ENSG00000172809 (Ensembl)
SCHIP1GeneProductSCHIP1 (Uniprot-TrEMBL)
SESN1GeneProductSESN1 (Uniprot-TrEMBL)
SETD2ENSG00000181555 (Ensembl)
SLC2A12GeneProductSLC2A12 (Uniprot-TrEMBL)
SMAD1ENSG00000170365 (Ensembl)
SMAD2ENSG00000175387 (Ensembl)
SMAD3ENSG00000166949 (Ensembl)
SMAD4ENSG00000141646 (Ensembl)
SMAD6GeneProductENSG00000137834 (Ensembl)
SNAI1ENSG00000124216 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX2GeneProductENSG00000181449 (Ensembl)
SRFENSG00000112658 (Ensembl)
TGeneProduct
TBX1ENSG00000184058 (Ensembl)
TBX3ENSG00000135111 (Ensembl)
TBX6GeneProductENSG00000149922 (Ensembl)
TCF4GeneProductTCF4 (Uniprot-TrEMBL)
TCF7L1ENSG00000152284 (Ensembl)
TEAD1ENSG00000187079 (Ensembl)
TEAD2ENSG00000074219 (Ensembl)
TOX3GeneProductTOX3 (Uniprot-TrEMBL)
TOXGeneProductTOX (Uniprot-TrEMBL)
TRERF1GeneProductTRERF1 (Uniprot-TrEMBL)
TRIM28GeneProductTRIM28 (Uniprot-TrEMBL)
TRIM5GeneProductTRIM5 (Uniprot-TrEMBL)
TWSG1ENSG00000128791 (Ensembl)
VAV3GeneProductVAV3 (Uniprot-TrEMBL)
WDFY2GeneProductWDFY2 (Uniprot-TrEMBL)
WNT3AENSG00000154342 (Ensembl)
WNT3ENSG00000108379 (Ensembl)
YAP1ENSG00000137693 (Ensembl)
ZFHX4GeneProductZFHX4 (Uniprot-TrEMBL)
ZIC2GeneProductZIC2 (Uniprot-TrEMBL)
ZNF462GeneProductZNF462 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions
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