Endoderm differentiation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusSTAT1NANOGCDYLNME1RFX7RARGFOXN3NAA15MBTD1CTBP2CEBPZWWC1PBX1KDM4ASP4TCF7L1ZNF462MAD2L2AEBP2ASCC3TCEAL2GLI2MIR141 Targets(Induced in Stem Cells)SFMBT1MBTD1LRPPRCTAF4BTAF5FOXO1FOXN3WWC1AEBP2SP4RARGMIR132 Targets(Induced in Stem Cells)UBR5SOX21C1QBPZIC3TRIM71DNMT3BWDHD1JARID2CTBP2MTF2ZIC5AEBP2NCAPG2ZNF281GRHL2TET1MIR375 Targets(Induced in Stem Cells)BTAF1ZFHX4PAX3ZBTB17MIR132 Targets(Induced in Ectoderm)PTHLHEPB41L5LAMC1PRDM14SMAD3RTF1TGFB1NODALBPTFSOX17GATA4HNF1BPAX9LEO1OTX2DAB2SFRP1GDF3NOTCH1HOXA1EXT1PAF1PABPC1EOMESPOU5F1ONECUT1FOXA1NKX2-1CTNNB1TCF7MIXL1CTR9DUSP5SMAD4WNT8AELAVL1CER1FOXA2DKK1APPTNRC6CBMPR1ATBX21SMAD2CAND1BMP7SOX2NOGDUSP4CDC73LEF1HOXC11HHEXGATA6JARID2LHX1MIR653ELK4DIP2APIAS1CRTC1AHDC1PBX3NLKBCORL1ZFHX4MIR375 Targets(Induced in Ectoderm)PLCH1WDFY2RARGGRHL2ASCC3NABP2ZNF462MBTD1TOXTRERF1MIR373 Targets(Induced in Stem Cells)PARP8WDFY2SESN1RGS10CUL4BDDAH1SESN1ZNF462ELP4PHF6TOX3C11orf30MIR373 Targets(Induced in Ectoderm)PBX1SCHIP1PLCH1PARP8TRIM5CEP250HPRT1PBX1TCF4SLC2A12ACACAC11orf30ATP8B2HPRT1TRERF1VAV3TCF4MIR653 Targets(Induced in Ectoderm)MIR653 Targets(Induced in Stem Cells)MIR373MIR375MIR141MIR132NR3C1DUSP2EZH2FOXH1SIAH2RAB38APCSOX7MAP2K3WNT3Name: Endoderm DifferentiationOrganism: Homo sapiens


Description

No description

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Quality Tags

Image:Featured.pngReview changes for Featured
Image:Curated.pngReview changes for Approved

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

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  1. Chappell, Sun, Singh, Dalton; ''MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7''; Genes Dev, 2013 PubMed Europe PMC Scholia
  2. Tsuneyoshi, Tan, Poobalan, Sumi, Nakatsuji, Suemori, Dunn; ''The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.''; Genes Dev., 2012 PubMed Europe PMC Scholia
  3. Sui, Mfopou, Geens, Sermon, Bouwens; ''FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.''; Biochem Biophys Res Commun., 2012 PubMed Europe PMC Scholia
  4. Kim, Yoon, Chuong, Oyolu, Wills, Gupta, Baker; ''Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs''; Developmental Biology, 2011 PubMed Europe PMC Scholia
  5. Futaki, Hayashi, Emoto, Weber, Sekiguchi; ''Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression.''; Mol Cell Biol., 2004 PubMed Europe PMC Scholia
  6. Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP; ''Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.''; Development, 2008 PubMed Europe PMC Scholia
  7. Putzke, Rothman; ''Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.''; Proc Natl Acad Sci USA, 2010 PubMed Europe PMC Scholia
  8. Bourillot, Aksoy, Schreiber, Wianny, Schulz, Hummel, Hubner, Savatier; ''Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.''; Stem Cells, 2009 PubMed Europe PMC Scholia
  9. Kang, Won, Rhee, Ro; ''Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development.''; Molecules and Cells, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137822
Featured
Approved
view06:46, 8 March 2025EgonwModified description
116557view12:54, 7 May 2021EweitzModified title
106401view21:32, 28 August 2019KhanspersModified description
105583view04:42, 10 August 2019KhanspersModified description
88152view11:40, 27 July 2016Mkutmonfix invalid uniprot identifiers
88151view11:37, 27 July 2016Mkutmonfix invalid uniprot identifiers
87981view13:20, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
83014view12:38, 17 November 2015FehrhartUpdate of outdated identifiers
80410view23:41, 17 June 2015AlexanderPicoAdded Type information to deficient datanodes
80092view19:38, 6 May 2015Khanspersupdated color for miRNA nodes
79852view03:39, 20 April 2015NsalomonisModified description
79785view15:48, 16 April 2015Mkutmonfixed unconnected line
78496view10:28, 7 January 2015MaintBotadded missing graphIds
77746view20:53, 16 October 2014EgonwFixed two PubMed identifiers.
77718view21:56, 15 October 2014NsalomonisSpecify description
77699view18:17, 10 October 2014NsalomonisSpecify description
77689view18:26, 8 October 2014NsalomonisSpecify description
77683view19:41, 7 October 2014NsalomonisSpecify description
77680view18:26, 7 October 2014NsalomonisNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACACAGeneProductACACA (Uniprot-TrEMBL)
AEBP2GeneProductAEBP2 (Uniprot-TrEMBL)
AHDC1GeneProductAHDC1 (Uniprot-TrEMBL)
APCGeneProductENSG00000134982 (Ensembl)
APPENSG00000142192 (Ensembl)
ASCC3GeneProductASCC3 (Uniprot-TrEMBL)
ATP8B2GeneProductATP8B2 (Uniprot-TrEMBL)
BCORL1GeneProductBCORL1 (Uniprot-TrEMBL)
BMP7ENSG00000101144 (Ensembl)
BMPR1AENSG00000107779 (Ensembl)
BPTFENSG00000171634 (Ensembl)
BTAF1GeneProductBTAF1 (Uniprot-TrEMBL)
C11orf30GeneProductC11orf30 (Uniprot-TrEMBL)
C1QBPGeneProductC1QBP (Uniprot-TrEMBL)
CAND1ENSG00000111530 (Ensembl)
CDC73ENSG00000134371 (Ensembl)
CDYLGeneProductCDYL (Uniprot-TrEMBL)
CEBPZGeneProductCEBPZ (Uniprot-TrEMBL)
CEP250GeneProductCEP250 (Uniprot-TrEMBL)
CER1ENSG00000147869 (Ensembl)
CRTC1GeneProductCRTC1 (Uniprot-TrEMBL)
CTBP2GeneProductCTBP2 (Uniprot-TrEMBL)
CTNNB1ENSG00000168036 (Ensembl)
CTR9ENSG00000198730 (Ensembl)
CUL4BGeneProductCUL4B (Uniprot-TrEMBL)
DAB2ENSG00000153071 (Ensembl)
DDAH1GeneProductDDAH1 (Uniprot-TrEMBL)
DIP2AGeneProductDIP2A (Uniprot-TrEMBL)
DKK1ENSG00000107984 (Ensembl)
DNMT3BGeneProductDNMT3B (Uniprot-TrEMBL)
DUSP2GeneProductENSG00000158050 (Ensembl)
DUSP4ENSG00000120875 (Ensembl)
DUSP5ENSG00000138166 (Ensembl)
ELAVL1ENSG00000066044 (Ensembl)
ELK4GeneProductELK4 (Uniprot-TrEMBL)
ELP4GeneProductELP4 (Uniprot-TrEMBL)
EOMESENSG00000163508 (Ensembl)
EPB41L5ENSG00000115109 (Ensembl)
EXT1ENSG00000182197 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FOXA1ENSG00000129514 (Ensembl)
FOXA2ENSG00000125798 (Ensembl)
FOXH1GeneProductENSG00000160973 (Ensembl)
FOXN3GeneProductFOXN3 (Uniprot-TrEMBL)
FOXO1GeneProductFOXO1 (Uniprot-TrEMBL)
GATA4ENSG00000136574 (Ensembl)
GATA6ENSG00000141448 (Ensembl)
GDF3ENSG00000184344 (Ensembl)
GLI2GeneProductGLI2 (Uniprot-TrEMBL)
GRHL2GeneProductGRHL2 (Uniprot-TrEMBL)
HHEXENSG00000152804 (Ensembl)
HNF1BENSG00000108753 (Ensembl)
HOXA1ENSG00000105991 (Ensembl)
HOXC11ENSG00000123388 (Ensembl)
HPRT1GeneProductHPRT1 (Uniprot-TrEMBL)
JARID2ENSG00000008083 (Ensembl)
JARID2GeneProductJARID2 (Uniprot-TrEMBL)
KDM4AGeneProductKDM4A (Uniprot-TrEMBL)
LAMC1ENSG00000135862 (Ensembl)
LEF1ENSG00000138795 (Ensembl)
LEO1ENSG00000166477 (Ensembl)
LHX1ENSG00000132130 (Ensembl)
LRPPRCGeneProductLRPPRC (Uniprot-TrEMBL)
MAD2L2GeneProductMAD2L2 (Uniprot-TrEMBL)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MBTD1GeneProductMBTD1 (Uniprot-TrEMBL)
MIR132GeneProductENSG00000207724 (Ensembl)
MIR141GeneProductENSG00000207708 (Ensembl)
MIR373GeneProductENSG00000199143 (Ensembl)
MIR375GeneProductENSG00000198973 (Ensembl)
MIR653GeneProductENSG00000199143 (Ensembl)
MIXL1ENSG00000185155 (Ensembl)
MTF2GeneProductMTF2 (Uniprot-TrEMBL)
NAA15GeneProductNAA15 (Uniprot-TrEMBL)
NABP2GeneProductNABP2 (Uniprot-TrEMBL)
NANOGENSG00000111704 (Ensembl)
NCAPG2GeneProductNCAPG2 (Uniprot-TrEMBL)
NKX2-1ENSG00000136352 (Ensembl)
NLKGeneProductNLK (Uniprot-TrEMBL)
NME1GeneProductNME1 (Uniprot-TrEMBL)
NODALENSG00000156574 (Ensembl)
NOGENSG00000183691 (Ensembl)
NOTCH1ENSG00000148400 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
ONECUT1ENSG00000169856 (Ensembl)
OTX2ENSG00000165588 (Ensembl)
PABPC1ENSG00000070756 (Ensembl)
PAF1ENSG00000006712 (Ensembl)
PARP8GeneProductPARP8 (Uniprot-TrEMBL)
PAX3GeneProductPAX3 (Uniprot-TrEMBL)
PAX9ENSG00000198807 (Ensembl)
PBX1GeneProductPBX1 (Uniprot-TrEMBL)
PBX3GeneProductPBX3 (Uniprot-TrEMBL)
PHF6GeneProductPHF6 (Uniprot-TrEMBL)
PIAS1GeneProductPIAS1 (Uniprot-TrEMBL)
PLCH1GeneProductPLCH1 (Uniprot-TrEMBL)
POU5F1ENSG00000204531 (Ensembl)
PRDM14ENSG00000147596 (Ensembl)
PTHLHENSG00000087494 (Ensembl)
RAB38GeneProductENSG00000123892 (Ensembl)
RARGGeneProductRARG (Uniprot-TrEMBL)
RFX7GeneProductRFX7 (Uniprot-TrEMBL)
RGS10GeneProductRGS10 (Uniprot-TrEMBL)
RTF1ENSG00000137815 (Ensembl)
SCHIP1GeneProductSCHIP1 (Uniprot-TrEMBL)
SESN1GeneProductSESN1 (Uniprot-TrEMBL)
SFMBT1GeneProductSFMBT1 (Uniprot-TrEMBL)
SFRP1ENSG00000104332 (Ensembl)
SIAH2GeneProductENSG00000181788 (Ensembl)
SLC2A12GeneProductSLC2A12 (Uniprot-TrEMBL)
SMAD2ENSG00000175387 (Ensembl)
SMAD3ENSG00000166949 (Ensembl)
SMAD4ENSG00000141646 (Ensembl)
SOX17ENSG00000164736 (Ensembl)
SOX21GeneProductSOX21 (Uniprot-TrEMBL)
SOX2ENSG00000181449 (Ensembl)
SOX7GeneProductENSG00000171056 (Ensembl)
SP4GeneProductSP4 (Uniprot-TrEMBL)
STAT1ENSG00000115415 (Ensembl)
TAF4BGeneProductTAF4B (Uniprot-TrEMBL)
TAF5GeneProductTAF5 (Uniprot-TrEMBL)
TBX21ENSG00000073861 (Ensembl)
TCEAL2GeneProductTCEAL2 (Uniprot-TrEMBL)
TCF4GeneProductTCF4 (Uniprot-TrEMBL)
TCF7ENSG00000081059 (Ensembl)
TCF7L1GeneProductTCF7L1 (Uniprot-TrEMBL)
TET1GeneProductTET1 (Uniprot-TrEMBL)
TGFB1ENSG00000105329 (Ensembl)
TNRC6CENSG00000078687 (Ensembl)
TOX3GeneProductTOX3 (Uniprot-TrEMBL)
TOXGeneProductTOX (Uniprot-TrEMBL)
TRERF1GeneProductTRERF1 (Uniprot-TrEMBL)
TRIM5GeneProductTRIM5 (Uniprot-TrEMBL)
TRIM71GeneProductTRIM71 (Uniprot-TrEMBL)
UBR5GeneProductUBR5 (Uniprot-TrEMBL)
VAV3GeneProductVAV3 (Uniprot-TrEMBL)
WDFY2GeneProductWDFY2 (Uniprot-TrEMBL)
WDHD1GeneProductWDHD1 (Uniprot-TrEMBL)
WNT3GeneProductENSG00000108379 (Ensembl)
WNT8AENSG00000061492 (Ensembl)
WWC1GeneProductWWC1 (Uniprot-TrEMBL)
ZBTB17GeneProductZBTB17 (Uniprot-TrEMBL)
ZFHX4GeneProductZFHX4 (Uniprot-TrEMBL)
ZIC3GeneProductZIC3 (Uniprot-TrEMBL)
ZIC5GeneProductZIC5 (Uniprot-TrEMBL)
ZNF281GeneProductZNF281 (Uniprot-TrEMBL)
ZNF462GeneProductZNF462 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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