Intracellular trafficking of CFTR (Rattus norvegicus)
From WikiPathways
Description
This pathway describes the mechanism of endo- and exocytosis of CFTR channel, based on the article: “New insights into cystic fibrosis: molecular switches that regulate CFTR” by Guggino et al. 2006.
On the left side (in red) the endocytic mechanism is shown. Respectively in green on the right sight the exocytic mechanism. We integrated the functions of PDZ proteins, SNAREs and Rho GTPases.
Quality Tags
Ontology Terms
Saving...Bibliography
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- Wennerberg K, Rossman KL, Der CJ; ''The Ras superfamily at a glance.''; J Cell Sci, 2005 PubMed Europe PMC Scholia
- Charest A, Lane K, McMahon K, Housman DE; ''Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
- Cheng J, Cebotaru V, Cebotaru L, Guggino WB; ''Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.''; Mol Biol Cell, 2010 PubMed Europe PMC Scholia
- Swiatecka-Urban A, Duhaime M, Coutermarsh B, Karlson KH, Collawn J, Milewski M, Cutting GR, Guggino WB, Langford G, Stanton BA; ''PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
- Picciano JA, Ameen N, Grant BD, Bradbury NA; ''Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator.''; Am J Physiol Cell Physiol, 2003 PubMed Europe PMC Scholia
- Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, Pagano RE, Riordan JR; ''Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator.''; Mol Biol Cell, 2004 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CAL | GeneProduct | 362650 (Entrez Gene)  | |
| CFTR | Protein | AAA73561.1 (Other) | |
| Cftr | Protein | ENSRNOG00000008284 (Ensembl) | |
| Cl - | Metabolite | ||
| Ezrin | Protein | NP_062230.1 (Ensembl) | |
| Ezrin | Protein | NP_062230.1 (Uniprot-TrEMBL) | |
| Myosin-VI | Protein | 315840 (Other) | |
| NHERF1 | Protein | Q9JJ19 (Uniprot-TrEMBL) | |
| Rab11a | GeneProduct | ENSRNOG00000011302 (Ensembl) | |
| Rab5a | Protein | ENSRNOG00000012180 (Ensembl) | |
| Rab7 | GeneProduct | ENSRNOG00000012247 (Ensembl) | |
| Rab9 | Protein | ENSRNOG00000030443 (Ensembl) | |
| SYN6 | GeneProduct | ||
| Tc10 | GeneProduct | 85428 (Entrez Gene) |
Annotated Interactions
No annotated interactions
