Pregnane X receptor pathway (Homo sapiens)

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9, 39LigandPPARGC1ASRCHSP90AA1NCOA3SRPX2RXRANCOA2PSMC5UnknownNR1I2NRIP142NR1I2LigandHSP90AA1CoregulatorsGenesTATA boxXRERXRANR1I2LigandDNAJC7DNAJC7CYP3A731UGT1A65UGT1A3UGT1A955CYP2A631UGT1A4PXR target genes517, 23SLCO1B117SRPX2NCOA3FOXO1CYP4F1220CYP3A41731UGT1A1ABCC41717NRIP1CYP2B631GSTA2PSMC517PPARGC1ANCOA1NCOA2ABCB117CoregulatorsCYP2C931CYP3A5CYP2C193131SULT2A127ABCC2ABCC344Drug and steroidmetabolism44Phase 2metabolismMulti-drugresistanceOther


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Bibliography

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  1. Lindsey S, Papoutsakis ET; ''The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization.''; Br J Haematol, 2011 PubMed Europe PMC Scholia
  2. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  3. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia
  4. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  5. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  6. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  7. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  8. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''''; , PubMed Europe PMC Scholia
  9. ''''; , PubMed Europe PMC Scholia
  10. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  11. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  12. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  13. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  14. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  15. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  16. Hashimoto K, Mori M; ''''; , PubMed Europe PMC Scholia
  17. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  18. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  19. Li AC, Glass CK; ''''; , PubMed Europe PMC Scholia
  20. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  21. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  22. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  23. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  24. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  25. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  26. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  27. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  28. Nilsson S, Gustafsson JÃ…; ''''; , PubMed Europe PMC Scholia
  29. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  30. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''''; , PubMed Europe PMC Scholia
  31. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  32. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  33. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  34. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  35. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  36. Bock KW; ''''; , PubMed Europe PMC Scholia
  37. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  38. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  39. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  40. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  41. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  42. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  43. ''''; , PubMed Europe PMC Scholia
  44. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  45. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  46. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed Europe PMC Scholia
  47. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  48. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  49. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124933view13:31, 1 January 2023EgonwRemoved biopax duplication
124932view13:30, 1 January 2023EgonwOntology Term : 'signaling pathway' added !
124931view13:30, 1 January 2023EgonwOntology Term : 'PW:0001229' removed !
116466view10:07, 7 May 2021EweitzModified title
110712view14:51, 28 May 2020Fehrhartremoved unknown node
106535view00:00, 6 September 2019KhanspersModified description
105789view19:47, 15 August 2019KhanspersModified description
94905view23:29, 12 October 2017Khanspersremoving empty comment
94792view23:02, 5 October 2017AlexanderPicoConverted lines
94782view22:31, 5 October 2017AlexanderPicoConverted lines
88344view16:04, 1 August 2016FehrhartOntology Term : 'xenobiotic metabolic pathway' added !
79556view12:58, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79537view14:56, 24 March 2015RiannefijtenModified description
79536view14:54, 24 March 2015Riannefijtenchanged pathway nodes to labels
79535view14:52, 24 March 2015Riannefijtenadded reference, fixed unconnected lines
79479view12:49, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for pregnane X receptor agonist.
78484view10:28, 7 January 2015MaintBotadded missing graphIds
78257view22:19, 17 December 2014KhanspersModified title
78218view15:07, 14 December 2014MaintBotUpdated the GPML schema.
78217view15:06, 14 December 2014MaintBotModified title
78089view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCB1GeneProductENSG00000085563 (Ensembl Human)
ABCC2GeneProductENSG00000023839 (Ensembl Human)
ABCC3GeneProductENSG00000108846 (Ensembl Human)
ABCC4GeneProductENSG00000125257 (Ensembl Human)
CYP2A6GeneProductENSG00000255974 (Ensembl Human)
CYP2B6GeneProductENSG00000197408 (Ensembl Human)
CYP2C19GeneProductENSG00000165841 (Ensembl Human)
CYP2C9GeneProductENSG00000138109 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP3A5GeneProductENSG00000106258 (Ensembl Human)
CYP3A7GeneProductENSG00000160870 (Ensembl Human)
CYP4F12GeneProductENSG00000186204 (Ensembl Human)
DNAJC7GeneProductENSG00000168259 (Ensembl Human)
Drug and steroid metabolismPathway
FOXO1GeneProductENSG00000150907 (Ensembl Human)
GSTA2GeneProductENSG00000244067 (Ensembl Human)
HSP90AA1GeneProductENSG00000080824 (Ensembl Human)
Multi-drug resistancePathway
NCOA1GeneProductENSG00000084676 (Ensembl Human)
NCOA2GeneProductENSG00000140396 (Ensembl Human)
NCOA3GeneProductENSG00000124151 (Ensembl Human)
NR1I2GeneProductENSG00000144852 (Ensembl Human)
NRIP1GeneProductENSG00000180530 (Ensembl Human)
OtherPathway
PPARGC1AGeneProductENSG00000109819 (Ensembl Human)
PSMC5GeneProductENSG00000087191 (Ensembl Human)
Phase 2 metabolismPathway
RXRAGeneProductENSG00000186350 (Ensembl Human)
SLCO1B1GeneProductENSG00000134538 (Ensembl Human)
SRCGeneProductENSG00000197122 (Ensembl Human)
SRPX2GeneProductENSG00000102359 (Ensembl Human)
SULT2A1GeneProductENSG00000105398 (Ensembl Human)
UGT1A1GeneProductENSG00000241635 (Ensembl Human)
UGT1A3GeneProductENSG00000243135 (Ensembl Human)
UGT1A4GeneProductENSG00000244474 (Ensembl Human)
UGT1A6GeneProductENSG00000167165 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)
Unknown

Annotated Interactions

No annotated interactions
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