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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Glucose Transport Modulators of Insulin Action Metabolic Regulation Tor Signaling Cell Growth Differentiation PI 3-Kinase isoforms PIK3CA PIK3CB PIK3CG PIK3CD PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3C2A PIK3C3 PIK3C2G Insulin Receptor Substrates IRS1 IRS4 GAB1 SHC1 SHC3 IRS3 IRS2 SHC2 Ras-MAPK Signaling GRB2 SOS1 SOS2 RAF1 GRB10 HRAS RRAD GRB14 RAC1 RAC2 MEK/MAP Kinases MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAPK3 MAPK4 MAPK1 MAPK6 MAPK13 MAPK9 MAPK10 MAP4K1 MAP3K5 MAP3K10 MAPK8 MAPK14 MAP3K8 MAP3K12 MAP4K2 MAP3K7 MAP3K11 MAPK11 MAP3K9 MAP4K4 MAPK7 MAP3K13 MAP4K3 MAP3K6 MINK1 MAPK12 MAP4K5 MAP3K14 MAP2K7 p90 Rsk Kinases RPS6KA2 RPS6KA3 RPS6KA1 RPS6KA5 RPS6KA6 RPS6KA4 Translation Regulation EIF4E EIF4EBP1 p70 S6 Kinases RPS6KB1 RPS6KB2 Transcriptional Regulators & Immediate Early Genes FOXO1 EGR1 FOS JUN FOXO3 ELK1 SRF Vesicular Trafficking CYTH3 ARF6 ARF4 CBL CBLB CBLC RAPGEF1 CAP1 SORBS1 RHOJ LOC100138767 RHOQ CRK FLOT1 FLOT2 RAB4A STXBP4 VAMP2 SNAP25 SNAP23 EHD1 EHD2 MYO1C KIF5B KIF3A TBC1D4 STXBP1 STXBP2 STXBP3 STX4 SH2B2 PDK/Akt Signaling PDPK1 AKT1 AKT2 GSK3B GSK3A SGK1 SGK2 SGKL INSR IGF1R SLC2A4 PTEN PRKCI PRKCZ INPP4A TRIB3 PFKM GYS1 PTPN11 PPP1R3A PTPRF PTPN1 MTOR LIPE GYS2 SLC2A1 INPPL1 PRKCA PRKCB PRKCQ PRKCH PRKCD ENPP1 GYG1 PFKL RHEB MAPK8 SOCS1 SOCS3 PRKAA1 PRKAA2 IKBKB XBP1 PTP PIK3 IRS1 TSC1 TSC2 Name: Insulin Signaling Last Modified: 5/8/2012 Organism: Bos taurus
Description
Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.
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