p53 signaling (Mus musculus)

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G2 arrest (sustained)DNA damageGenotoxic stressCell cycle arrestTarget genesG1 arrest (sustained)EndpointInhibition ofangiogenesisand metastasisp53 negative feedbackExosome mediated secretionStress signalsApoptosisInhibition of IGF-1/mTOR pathwayDNA repair and damagepreventionSesn1Siah1bmmu-let-7b-5pCasp9Igf1Pmaip1Trp73BidCdkn1aCcnd2mmu-miR-362-5pBaxSerpinb5mmu-miR-295-3pmmu-miR-103a-3pCdkn2aSesn2mmu-miR-21-5pShisa5mmu-miR-18a-5pCd82mmu-miR-21a-5pCdk1mmu-miR-122-5pBai1Casp8mmu-miR-486-5pGadd45gCcne2Bbc3Rprmmmu-miR-29b-3pmmu-miR-149-5pSesn3mmu-miR-17-5pCyctCcng2Zmat3Trp53mmu-miR-758-3pmmu-miR-449a-5pApaf1mmu-miR-302d-3pCcnd1Mdm4Ei24mmu-miR-34b-5pmmu-miR-181b-5pGm5593Gtse1Ccng1mmu-miR-16-5pSerpine1mmu-miR-340-5pRfwd2Ppm1dmmu-miR-9-5pmmu-miR-297a-5pTsc2Ddb2mmu-miR-223-3pCycsmmu-miR-301b-3pmmu-miR-19b-3pSiah1aPerpThbs1Cdk2Chek2Sfnmmu-miR-24-3pFasmmu-miR-216a-5pRchy1mmu-miR-145a-5pmmu-miR-425-5pmmu-miR-294-3pCdk6Casp3mmu-miR-1a-3pCcnb1Gadd45aSteap3mmu-miR-15a-5pCcnd3mmu-miR-30e-5pmmu-miR-217-5pIgfbp3Mdm2mmu-miR-291a-3pCdk4Rrm2bmmu-miR-20a-5pmmu-miR-124-3pCcnb2Rrm2mmu-miR-503-5pmmu-miR-7b-5pmmu-miR-195a-5pPidd1AtmAtrGadd45bPtenmmu-miR-291b-3pmmu-miR-181a-5pCcne1Ccnb3Chek1Gadd45gGadd45bGadd45aIgfbp3Mdm2Siah1aSiah1bmmu-miR-425-5pmmu-miR-16-5pmmu-miR-17-5pmmu-miR-301b-3pmmu-miR-301b-3pmmu-miR-301b-3pmmu-miR-19b-3pmmu-miR-19b-3pmmu-miR-19b-3pmmu-miR-503-5pmmu-let-7b-5pmmu-miR-19b-3pmmu-miR-340-5pmmu-miR-34b-5pmmu-miR-149-5pmmu-miR-362-5pmmu-miR-15a-5pmmu-miR-362-5pmmu-miR-15a-5pmmu-miR-15a-5pmmu-miR-24-3p


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC; ''Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.''; Mutagenesis, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
88290view14:54, 1 August 2016FehrhartOntology Term : 'p53 signaling pathway' added !
87396view11:05, 22 July 2016MaintBotadded missing graphids
85041view08:42, 10 April 2016EgonwRemoved an incorrect mim-conversion annotation.
82881view12:20, 11 November 2015JmeliusCorrect outdated id
82354view11:33, 27 September 2015EgonwAdded GraphIDs to DataNodes that had none.
80199view22:15, 20 May 2015MaintBotconnected interactions and added literature ref
79094view09:20, 2 March 2015LindarieswijkModified description
79093view09:19, 2 March 2015LindarieswijkModified description
79092view09:15, 2 March 2015LindarieswijkNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apaf1GeneProduct11783 (Entrez Gene)
AtmGeneProduct11920 (Entrez Gene)
AtrGeneProduct245000 (Entrez Gene)
Bai1GeneProduct107831 (Entrez Gene)
BaxGeneProduct12028 (Entrez Gene)
Bbc3GeneProduct170770 (Entrez Gene)
BidGeneProduct12122 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp8GeneProduct12370 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Ccnb1GeneProduct268697 (Entrez Gene)
Ccnb2GeneProduct12442 (Entrez Gene)
Ccnb3GeneProduct209091 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Ccne2GeneProduct12448 (Entrez Gene)
Ccng1GeneProduct12450 (Entrez Gene)
Ccng2GeneProduct12452 (Entrez Gene)
Cd82GeneProduct12521 (Entrez Gene)
Cdk1GeneProduct12534 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdk4GeneProduct12567 (Entrez Gene)
Cdk6GeneProduct12571 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn2aGeneProduct12578 (Entrez Gene)
Chek1GeneProduct12649 (Entrez Gene)
Chek2GeneProduct50883 (Entrez Gene)
CycsGeneProduct13063 (Entrez Gene)
CyctGeneProduct13067 (Entrez Gene)
Ddb2GeneProduct107986 (Entrez Gene)
Ei24GeneProduct13663 (Entrez Gene)
FasGeneProduct14102 (Entrez Gene)
Gadd45aGeneProduct13197 (Entrez Gene)
Gadd45bGeneProduct17873 (Entrez Gene)
Gadd45gGeneProduct23882 (Entrez Gene)
Gm5593GeneProduct434175 (Entrez Gene)
Gtse1GeneProduct29870 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igfbp3GeneProduct16009 (Entrez Gene)
Mdm2GeneProduct17246 (Entrez Gene)
Mdm4GeneProduct17248 (Entrez Gene)
PerpGeneProduct64058 (Entrez Gene)
Pidd1GeneProduct57913 (Entrez Gene)
Pmaip1GeneProduct58801 (Entrez Gene)
Ppm1dGeneProduct53892 (Entrez Gene)
PtenGeneProduct19211 (Entrez Gene)
Rchy1GeneProduct68098 (Entrez Gene)
Rfwd2GeneProduct26374 (Entrez Gene)
RprmGeneProduct67874 (Entrez Gene)
Rrm2GeneProduct20135 (Entrez Gene)
Rrm2bGeneProduct382985 (Entrez Gene)
Serpinb5GeneProduct20724 (Entrez Gene)
Serpine1GeneProduct18787 (Entrez Gene)
Sesn1GeneProduct140742 (Entrez Gene)
Sesn2GeneProduct230784 (Entrez Gene)
Sesn3GeneProduct75747 (Entrez Gene)
SfnGeneProduct55948 (Entrez Gene)
Shisa5GeneProduct66940 (Entrez Gene)
Siah1aGeneProduct20437 (Entrez Gene)
Siah1bGeneProduct20438 (Entrez Gene)
Steap3GeneProduct68428 (Entrez Gene)
Thbs1GeneProduct21825 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Trp73GeneProduct22062 (Entrez Gene)
Tsc2GeneProduct22084 (Entrez Gene)
Zmat3GeneProduct22401 (Entrez Gene)
mmu-let-7b-5pGeneProductmmu-let-7b-5p (miRBase mature sequence)
mmu-miR-103a-3pGeneProductmmu-miR-103a-3p (miRBase mature sequence)
mmu-miR-122-5pGeneProductmmu-miR-122-5p (miRBase mature sequence)
mmu-miR-124-3pGeneProductmmu-miR-124-3p (miRBase mature sequence)
mmu-miR-145a-5pGeneProductmmu-miR-145a-5p (miRBase mature sequence)
mmu-miR-149-5pGeneProductmmu-miR-149-5p (miRBase mature sequence)
mmu-miR-15a-5pGeneProductmmu-miR-15a-5p (miRBase mature sequence)
mmu-miR-16-5pGeneProductmmu-miR-16-5p (miRBase mature sequence)
mmu-miR-17-5pGeneProductmmu-miR-17-5p (miRBase mature sequence)
mmu-miR-181a-5pGeneProductmmu-miR-181a-5p (miRBase mature sequence)
mmu-miR-181b-5pGeneProductmmu-miR-181b-5p (miRBase mature sequence)
mmu-miR-18a-5pGeneProductmmu-miR-18a-5p (miRBase mature sequence)
mmu-miR-195a-5pGeneProductmmu-miR-195a-5p (miRBase mature sequence)
mmu-miR-19b-3pGeneProductmmu-miR-19b-3p (miRBase mature sequence)
mmu-miR-1a-3pGeneProductmmu-miR-1a-3p (miRBase mature sequence)
mmu-miR-20a-5pGeneProductmmu-miR-20a-5p (miRBase mature sequence)
mmu-miR-21-5pGeneProductmmu-miR-21-5p (miRBase mature sequence)
mmu-miR-216a-5pGeneProductmmu-miR-216a-5p (miRBase mature sequence)
mmu-miR-217-5pGeneProductmmu-miR-217-5p (miRBase mature sequence)
mmu-miR-21a-5pGeneProductmmu-miR-21a-5p (miRBase mature sequence)
mmu-miR-223-3pGeneProductmmu-miR-223-3p (miRBase mature sequence)
mmu-miR-24-3pGeneProductmmu-miR-24-3p (miRBase mature sequence)
mmu-miR-291a-3pGeneProductmmu-miR-291a-3p (miRBase mature sequence)
mmu-miR-291b-3pGeneProductmmu-miR-291b-3p (miRBase mature sequence)
mmu-miR-294-3pGeneProductmmu-miR-294-3p (miRBase mature sequence)
mmu-miR-295-3pGeneProductmmu-miR-295-3p (miRBase mature sequence)
mmu-miR-297a-5pGeneProductmmu-miR-297a-5p (miRBase mature sequence)
mmu-miR-29b-3pGeneProductmmu-miR-29b-3p (miRBase mature sequence)
mmu-miR-301b-3pGeneProductmmu-miR-301b-3p (miRBase mature sequence)
mmu-miR-302d-3pGeneProductmmu-miR-302d-3p (miRBase mature sequence)
mmu-miR-30e-5pGeneProductmmu-miR-30e-5p (miRBase mature sequence)
mmu-miR-340-5pGeneProductmmu-miR-340-5p (miRBase mature sequence)
mmu-miR-34b-5pGeneProductmmu-miR-34b-5p (miRBase mature sequence)
mmu-miR-362-5pGeneProductmmu-miR-362-5p (miRBase mature sequence)
mmu-miR-425-5pGeneProductmmu-miR-425-5p (miRBase mature sequence)
mmu-miR-449a-5pGeneProductmmu-miR-449a-5p (miRBase mature sequence)
mmu-miR-486-5pGeneProductmmu-miR-486-5p (miRBase mature sequence)
mmu-miR-503-5pGeneProductmmu-miR-503-5p (miRBase mature sequence)
mmu-miR-758-3pGeneProductmmu-miR-758-3p (miRBase mature sequence)
mmu-miR-7b-5pGeneProductmmu-miR-7b-5p (miRBase mature sequence)
mmu-miR-9-5pGeneProductmmu-miR-9-5p (miRBase mature sequence)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2902"
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