Iron metabolism in placenta (Bos taurus)

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14, 24118, 9, 22Ferritinfoetal livertransporter ? clathrin-coated early endosome signal ? mitochondrion5, 18, 2510, 1724?pH 6-7?stimulateApical?basolateralunknown interactionsinhibitHEPHL1FeIISLC40A1IRP1TfR1 RNAHAMPIREB2FeIIITFTFR1foetal HAMP?STEAP36, 16242542, 2619, 21TFR120TFTFR13TFSTEAP3late endosome TFR1TFSTEAP34lysosomeTFR1TFpH 5-6H+?SLC11A2MCOLN17H+FeIIMCOLN17SLC11A212, 25?foetal TF13TFR215TFmaternal liverTF1, 23??FTH1RNAFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIFeIIFeIIFeII


Description

During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. This description of Iron pathway through the placenta, and its regulation is purposed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2007 with a 100% conversion rate.

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Bibliography

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  1. Puri C; ''Loss of myosin VI no insert isoform (NoI) induces a defect in clathrin-mediated endocytosis and leads to caveolar endocytosis of transferrin receptor.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  2. Bou-Abdallah F, Santambrogio P, Levi S, Arosio P, Chasteen ND; ''Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin.''; J Mol Biol, 2005 PubMed Europe PMC Scholia
  3. Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV; ''A general map of iron metabolism and tissue-specific subnetworks.''; Mol Biosyst, 2009 PubMed Europe PMC Scholia
  4. Dezier JF, Vernet M, Damour O, Guillemin G, Le Treut A, Paris M, Plomteux G, Pressac M, Revenant MC, Rymer JC; ''[The coefficient of saturation of iron in transferrin].''; Ann Biol Clin (Paris), 1988 PubMed Europe PMC Scholia
  5. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H; ''The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.''; Nature, 2008 PubMed Europe PMC Scholia
  6. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA; ''Cloning and characterization of a mammalian proton-coupled metal-ion transporter.''; Nature, 1997 PubMed Europe PMC Scholia
  7. Hudson DM, Krisinger MJ, Griffiths TA, Macgillivray RT; ''Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.''; J Cell Biochem, 2008 PubMed Europe PMC Scholia
  8. Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD; ''Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.''; Nat Genet, 2005 PubMed Europe PMC Scholia
  9. Zoller H, Theurl I, Koch R, Kaser A, Weiss G; ''Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.''; Blood Cells Mol Dis, 2002 PubMed Europe PMC Scholia
  10. Callus BA, Iacopetta BJ, Kühn LC, Morgan EH; ''Effects of overexpression of the transferrin receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron.''; Eur J Biochem, 1996 PubMed Europe PMC Scholia
  11. Stys A, Galy B, Starzynski RR, Smuda E, Drapier JC, Lipinski P, Bouton C; ''Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  12. Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R; ''Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  13. Gambling L, Lang C, McArdle HJ; ''Fetal regulation of iron transport during pregnancy.''; Am J Clin Nutr, 2011 PubMed Europe PMC Scholia
  14. Steere AN, Byrne SL, Chasteen ND, Mason AB; ''Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
  15. Mandò C, Tabano S, Colapietro P, Pileri P, Colleoni F, Avagliano L, Doi P, Bulfamante G, Miozzo M, Cetin I; ''Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas.''; Placenta, 2011 PubMed Europe PMC Scholia
  16. Bergamaschi G, Bergamaschi P, Carlevati S, Cazzola M; ''Transferrin receptor expression in the human placenta.''; Haematologica, 1990 PubMed Europe PMC Scholia
  17. Chen J, Wang J, Meyers KR, Enns CA; ''Transferrin-directed internalization and cycling of transferrin receptor 2.''; Traffic, 2009 PubMed Europe PMC Scholia
  18. Macara IG, Hoy TG, Harrison PM; ''The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.''; Biochem J, 1972 PubMed Europe PMC Scholia
  19. Habtemichael EN, Brewer PD, Romenskaia I, Mastick CC; ''Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  20. Anderson GJ, Frazer DM, McLaren GD; ''Iron absorption and metabolism.''; Curr Opin Gastroenterol, 2009 PubMed Europe PMC Scholia
  21. Griffiths TA, Mauk AG, MacGillivray RT; ''Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity.''; Biochemistry, 2005 PubMed Europe PMC Scholia
  22. Ganz T; ''Hepcidin and iron regulation, 10 years later.''; Blood, 2011 PubMed Europe PMC Scholia
  23. Bou-Abdallah F, Biasiotto G, Arosio P, Chasteen ND; ''The putative "nucleation site" in human H-chain ferritin is not required for mineralization of the iron core.''; Biochemistry, 2004 PubMed Europe PMC Scholia
  24. Georgieff MK, Berry SA, Wobken JD, Leibold EA; ''Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency.''; Placenta, 1999 PubMed Europe PMC Scholia
  25. Zoller H, Theurl I, Koch RO, McKie AT, Vogel W, Weiss G; ''Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.''; Gastroenterology, 2003 PubMed Europe PMC Scholia
  26. Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ; ''Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.''; J Nutr, 2010 PubMed Europe PMC Scholia

History

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80898view15:30, 30 June 2015Mkutmonhomology conversion
79168view05:32, 6 March 2015MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
FTH1RNARnaENSG00000167996 (Ensembl)
FeIIMetabolite15438-31-0 (CAS)
FeIIIMetabolite20074-52-6 (CAS)
HAMPProteinENSBTAG00000017042 (Ensembl Cow)
HEPHL1GeneProductENSBTAG00000022960 (Ensembl Cow)
IREB2GeneProductENSBTAG00000002504 (Ensembl Cow)
IRP1GeneProductENSBTAG00000000555 (Ensembl Cow)
MCOLN1GeneProductENSBTAG00000005592 (Ensembl Cow)
SLC11A2GeneProductENSBTAG00000032914 (Ensembl Cow)
SLC40A1GeneProductENSBTAG00000010498 (Ensembl Cow)
STEAP3GeneProductENSBTAG00000007111 (Ensembl Cow)
TFProteinENSBTAG00000007273 (Ensembl Cow) Transferrin
TFR1ProteinENSBTAG00000032719 (Ensembl Cow) Transferrin receptor
TFR2GeneProductENSBTAG00000011738 (Ensembl Cow) Transferrin receptor
TfR1 RNARnaENSG00000072274 (Ensembl)
foetal HAMP?ProteinENSBTAG00000017042 (Ensembl Cow) HAMP
foetal TFProteinENSBTAG00000007273 (Ensembl Cow) Transferrin

Annotated Interactions

No annotated interactions
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