Farnesoid X receptor pathway (Homo sapiens)

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NR1H48FXR ligandNR1H48RXRALigandGenesTATA boxNR1H48RXRALigandFXRENR1H48LigandRXRAUGT2B4SULT2A1SLC27A5Bile acidneosynthesis17SLC10A1CYP7A1NR0B216FGF1946Bile acid &xenobiotics transport37IRS217ABCB11BAATCYP3A4FKBP516IP6K3ABCB4NR0B2PPARGC1A46SLCO2B1CYP8B1bile acidconjugation17Bile aciddetoxificationFXR Target genes17Other


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
116462view10:06, 7 May 2021EweitzModified title
106413view21:58, 28 August 2019KhanspersModified description
105593view04:46, 10 August 2019KhanspersModified description
94789view22:59, 5 October 2017AlexanderPicoConverted lines
94785view22:42, 5 October 2017AlexanderPicoConverted lines
88056view13:48, 25 July 2016SusanOntology Term : 'bile acid signaling pathway' added !
79602view05:58, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79524view09:51, 24 March 2015RiannefijtenModified description
79523view09:49, 24 March 2015Riannefijtenfixed unconnected lines, added reference, changed grouping "pathways" to labels
79485view13:10, 23 March 2015FehrhartUpdate Gen IDs and comments
79476view12:40, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78255view22:12, 17 December 2014KhanspersModified title
78226view15:31, 14 December 2014MaintBotUpdated the GPML schema.
78221view15:26, 14 December 2014MaintBotModified title
78092view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB11GeneProductENSG00000073734 (Ensembl Human)
ABCB4GeneProductENSG00000005471 (Ensembl Human)
BAATGeneProductENSG00000136881 (Ensembl Human)
Bile acid detoxificationPathway
Bile acid neosynthesisPathway
Bile acid & xenobiotics transportPathway
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human)
CYP8B1GeneProductENSG00000180432 (Ensembl Human)
FGF19GeneProductENSG00000162344 (Ensembl Human)
FKBP5GeneProductENSG00000096060 (Ensembl Human)
FXR ligandMetaboliteCHEBI:52214 (ChEBI) T3
IP6K3GeneProductENSG00000161896 (Ensembl Human)
IRS2GeneProductENSG00000185950 (Ensembl Human)
LigandMetaboliteCHEBI:52214 (ChEBI)
NR0B2GeneProductENSG00000131910 (Ensembl Human)
NR1H4GeneProductENSG00000012504 (Ensembl Human)
OtherPathway
PPARGC1AGeneProductENSG00000109819 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
SLC10A1GeneProductENSG00000100652 (Ensembl Human) inhibition
SLC27A5GeneProductENSG00000083807 (Ensembl Human)
SLCO2B1GeneProductENSG00000137491 (Ensembl Human) inhibition
SULT2A1GeneProductENSG00000105398 (Ensembl Human)
UGT2B4GeneProductENSG00000156096 (Ensembl Human)
bile acid conjugationPathway

Annotated Interactions

No annotated interactions

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