PPAR-alpha pathway (Homo sapiens)

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3, 30, 33, 49Hepatocyte proliferationPhase 2 metabolismLipoprotein metabolismmitochondrial beta-oxidationTranscriptionFatty acid transportperoxisomal beta-oxidationCholesterol catabolismmitochondrial omega-oxidationOtherLigandPPARARXRACo-activatorsGenesTATA boxPPREPPARARXRACo-activatorsLigandACAA1UGT1A92521, 25NR1H3SCP225CPT1A2525APOC325FABP125CCND1PLTP2525DBI25APOA225CPT2APOA12525CYP4A1125ACADMCDK42525CYP7A125MYC25SLC27A125KLK1525APOA5CDK125CYP8B12525EHHADH40PPAR alphatarget genes


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Bibliography

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  1. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  2. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  3. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  4. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  5. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  6. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  7. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  8. ''''; , PubMed Europe PMC Scholia
  9. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  10. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  11. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  12. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  13. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  14. Nilsson S, Gustafsson JÃ…; ''''; , PubMed Europe PMC Scholia
  15. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  16. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  17. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  18. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  19. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  20. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  21. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  22. Hashimoto K, Mori M; ''''; , PubMed Europe PMC Scholia
  23. ''''; , PubMed Europe PMC Scholia
  24. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''''; , PubMed Europe PMC Scholia
  25. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  26. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''''; , PubMed Europe PMC Scholia
  27. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  28. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  29. Lindsey S, Papoutsakis ET; ''''; , PubMed Europe PMC Scholia
  30. Bock KW; ''''; , PubMed Europe PMC Scholia
  31. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  32. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  33. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  34. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  35. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  36. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  37. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  38. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  39. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  40. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  41. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  42. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia
  43. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed Europe PMC Scholia
  44. Li AC, Glass CK; ''''; , PubMed Europe PMC Scholia
  45. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  46. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  47. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  48. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  49. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116507view10:44, 7 May 2021EweitzModified title
106549view00:11, 6 September 2019KhanspersModified description
105776view19:41, 15 August 2019KhanspersModified description
94794view23:04, 5 October 2017AlexanderPicoConverted lines
94784view22:39, 5 October 2017AlexanderPicoConverted lines
88342view16:01, 1 August 2016FehrhartOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
79689view20:08, 4 April 2015AlexanderPicoModified title
79601view05:55, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79558view13:17, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79532view14:35, 24 March 2015RiannefijtenModified description
79531view14:33, 24 March 2015Riannefijtenadded reference
79530view12:52, 24 March 2015Riannefijtenfixed unconnected lines and changed pathway nodes to labels
79473view12:23, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78517view10:29, 7 January 2015MaintBotadded missing graphIds
78225view15:29, 14 December 2014MaintBotUpdated the GPML schema.
78220view15:19, 14 December 2014MaintBotModified title
78091view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACAA1GeneProductENSG00000060971 (Ensembl Human)
ACADMGeneProductENSG00000117054 (Ensembl Human)
APOA1GeneProductENSG00000118137 (Ensembl Human)
APOA2GeneProductENSG00000158874 (Ensembl Human)
APOA5GeneProductENSG00000110243 (Ensembl Human)
APOC3GeneProductENSG00000110245 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CPT1AGeneProductENSG00000110090 (Ensembl Human)
CPT2GeneProductENSG00000157184 (Ensembl Human)
CYP4A11GeneProductENSG00000187048 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human)
CYP8B1GeneProductENSG00000180432 (Ensembl Human)
DBIGeneProductENSG00000155368 (Ensembl Human)
EHHADHGeneProductENSG00000113790 (Ensembl Human)
FABP1GeneProductENSG00000163586 (Ensembl Human)
KLK15GeneProductENSG00000174562 (Ensembl Human)
LigandMetaboliteCHEBI:52214 (ChEBI)
MYCGeneProductENSG00000136997 (Ensembl Human)
NR1H3GeneProductENSG00000025434 (Ensembl Human)
PLTPGeneProductENSG00000100979 (Ensembl Human)
PPARAGeneProductENSG00000186951 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
SCP2GeneProductENSG00000116171 (Ensembl Human)
SLC27A1GeneProductENSG00000130304 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)

Annotated Interactions

No annotated interactions

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