PPAR-alpha pathway (Homo sapiens)

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3, 30, 33, 49Lipoprotein metabolismmitochondrial beta-oxidationCholesterol catabolismFatty acid transportOtherTranscriptionperoxisomal beta-oxidationPhase 2 metabolismHepatocyte proliferationmitochondrial omega-oxidationLigandPPARARXRACo-activatorsGenesTATA boxPPREPPARARXRACo-activatorsLigandACAA125UGT1A921, 25NR1H325SCP2CPT1A25APOC32525FABP125CCND125PLTPDBI2525APOA225CPT2APOA12525CYP4A1125ACADMCDK425CYP7A12525MYC25SLC27A125KLK1525APOA5CDK12525CYP8B125EHHADH40PPAR alphatarget genes


Description

PPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.

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Bibliography

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  46. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
116507view10:44, 7 May 2021EweitzModified title
106549view00:11, 6 September 2019KhanspersModified description
105776view19:41, 15 August 2019KhanspersModified description
94794view23:04, 5 October 2017AlexanderPicoConverted lines
94784view22:39, 5 October 2017AlexanderPicoConverted lines
88342view16:01, 1 August 2016FehrhartOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
79689view20:08, 4 April 2015AlexanderPicoModified title
79601view05:55, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79558view13:17, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79532view14:35, 24 March 2015RiannefijtenModified description
79531view14:33, 24 March 2015Riannefijtenadded reference
79530view12:52, 24 March 2015Riannefijtenfixed unconnected lines and changed pathway nodes to labels
79473view12:23, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78517view10:29, 7 January 2015MaintBotadded missing graphIds
78225view15:29, 14 December 2014MaintBotUpdated the GPML schema.
78220view15:19, 14 December 2014MaintBotModified title
78091view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACAA1GeneProductENSG00000060971 (Ensembl Human)
ACADMGeneProductENSG00000117054 (Ensembl Human)
APOA1GeneProductENSG00000118137 (Ensembl Human)
APOA2GeneProductENSG00000158874 (Ensembl Human)
APOA5GeneProductENSG00000110243 (Ensembl Human)
APOC3GeneProductENSG00000110245 (Ensembl Human)
CCND1GeneProductENSG00000110092 (Ensembl Human)
CDK1GeneProductENSG00000170312 (Ensembl Human)
CDK4GeneProductENSG00000135446 (Ensembl Human)
CPT1AGeneProductENSG00000110090 (Ensembl Human)
CPT2GeneProductENSG00000157184 (Ensembl Human)
CYP4A11GeneProductENSG00000187048 (Ensembl Human)
CYP7A1GeneProductENSG00000167910 (Ensembl Human)
CYP8B1GeneProductENSG00000180432 (Ensembl Human)
DBIGeneProductENSG00000155368 (Ensembl Human)
EHHADHGeneProductENSG00000113790 (Ensembl Human)
FABP1GeneProductENSG00000163586 (Ensembl Human)
KLK15GeneProductENSG00000174562 (Ensembl Human)
LigandMetaboliteCHEBI:52214 (ChEBI)
MYCGeneProductENSG00000136997 (Ensembl Human)
NR1H3GeneProductENSG00000025434 (Ensembl Human)
PLTPGeneProductENSG00000100979 (Ensembl Human)
PPARAGeneProductENSG00000186951 (Ensembl Human)
RXRAGeneProductENSG00000186350 (Ensembl Human)
SCP2GeneProductENSG00000116171 (Ensembl Human)
SLC27A1GeneProductENSG00000130304 (Ensembl Human)
UGT1A9GeneProductENSG00000241119 (Ensembl Human)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2878"
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