Glucocorticoid receptor pathway (Homo sapiens)

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3SignaltransductionTranscriptionMetabolismTranscriptionOtherGrowth and apoptosisNuclear receptorsInflammationTransportInflammation45454545454545JUNNR3C1NFKB239GenesTATA boxNR3C1NR3C1HSP90AA1GR ligandHSP90AA1NR3C12, 39HSP90AA1NR3C139LigandNR3C1Ligand39LigandLigandNR3C1NR3C1LigandLigandGREGenesTATA boxNR3C1NR3C1LigandLigandnGREPTGES3PTGES3PTGES3BHLHE40NAV3IL11AMIGO2SERTAD2ARL5BCXCR7CUL1FGFBP1KTN1SERPINB9CCL2ENC1PTGS2ZIC2PMP2PDE4BPLK2GR inhibitorytarget genesCCL20EDN2MGAMRGS2ALOX5APTSC22D3CDC42EP3SNAI2BIRC3SPINK13SPRY1GADD45BPRRG4FGD4SLC26A2EPB41L4BGPR115PPP1R14CBIRC2GPR153TGFBR3ANGPTL4LRRC8AANKRD1THBDCDKN1CSCNN1ASLC19A2TNFAIP3SRGNSTOMSEC14L1DNAJC15DNERMFGE8ABHD2CPEB4SDPRMT1IPETNK2B3GNT5AKAP13POU5F1TNS4S100PNR1I329NR1I2RXRA298, 22, 29GR stimulatorytarget genesGrowth and apoptosis45Signaltransduction45Other45


Description

The glucocorticoid receptor (GR, a.k.a. NR3C1) is a nuclear receptor that is activated upon binding of cortisol or glucocorticoids. It mainly regulates gene expression of several groups of genes in two ways. It can stimulate anti-inflammatory genes, or inhibit the transcription of pro-inflammatory genes.

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Bibliography

View all...
  1. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  2. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  3. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''''; , PubMed Europe PMC Scholia
  4. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  5. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia
  6. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  7. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''''; , PubMed Europe PMC Scholia
  8. Nilsson S, Gustafsson JÃ…; ''''; , PubMed Europe PMC Scholia
  9. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  10. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  11. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  12. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  13. Köhle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  14. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  15. Hashimoto K, Mori M; ''''; , PubMed Europe PMC Scholia
  16. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  17. Handschin C, Meyer UA; ''''; , PubMed Europe PMC Scholia
  18. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  19. ''''; , PubMed Europe PMC Scholia
  20. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  21. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Göttlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  22. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  23. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  24. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  25. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  26. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  27. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  28. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  29. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  30. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  31. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  32. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  33. Lindsey S, Papoutsakis ET; ''''; , PubMed Europe PMC Scholia
  34. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  35. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  36. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  37. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  38. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  39. Bock KW; ''''; , PubMed Europe PMC Scholia
  40. ''''; , PubMed Europe PMC Scholia
  41. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  42. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  43. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  44. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  45. Li AC, Glass CK; ''''; , PubMed Europe PMC Scholia
  46. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  47. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  48. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed Europe PMC Scholia
  49. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  50. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135147view23:26, 6 August 2024EweitzRemove obsolete "Version" metadata
135146view23:23, 6 August 2024EweitzEconomize layout
135145view23:17, 6 August 2024EweitzRefine alignment
135144view23:15, 6 August 2024EweitzIncrease font size
135143view21:59, 6 August 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
135142view21:57, 6 August 2024EweitzEconomize layout
135141view21:55, 6 August 2024EweitzEconomize layout
135140view21:53, 6 August 2024EweitzEconomize layout
135139view21:48, 6 August 2024EweitzEconomize layout
135138view21:47, 6 August 2024EweitzEconomize layout
117734view12:38, 22 May 2021EweitzModified title
112288view13:15, 9 October 2020Fehrhart
112287view13:14, 9 October 2020Fehrhart
87558view02:13, 25 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87557view02:13, 25 July 2016AlexanderPicoOntology Term : 'glucocorticoid signaling pathway' added !
79615view10:14, 29 March 2015EgonwConverted the 'ligand' labels to DataNode's and gave them ChEBI IDs.
79548view09:53, 25 March 2015FehrhartUpdate of GenIDs and comments
79522view09:45, 24 March 2015Riannefijtenadded reference and changed interaction lines (for X) to graphical elements
79521view09:43, 24 March 2015RiannefijtenModified description
79494view13:39, 23 March 2015RiannefijtenUpdated connections and annotations
78505view10:29, 7 January 2015MaintBotadded missing graphIds
78258view22:21, 17 December 2014KhanspersModified title
78227view15:34, 14 December 2014MaintBotUpdated the GPML schema.
78222view15:26, 14 December 2014MaintBotModified title
78093view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABHD2GeneProduct11057 (Entrez Gene) abhydrolase domain containing 2
AKAP13GeneProduct11214 (Entrez Gene) A kinase (PRKA) anchor protein 13
ALOX5APGeneProduct241 (Entrez Gene) arachidonate 5-lipoxygenase-activating protein
AMIGO2GeneProduct347902 (Entrez Gene) adhesion molecule with Ig-like domain 2
ANGPTL4GeneProduct51129 (Entrez Gene) angiopoietin-like 4
ANKRD1GeneProduct27063 (Entrez Gene) ankyrin repeat domain 1 (cardiac muscle)
ARL5BGeneProduct221079 (Entrez Gene) ADP-ribosylation factor-like 5B
B3GNT5GeneProduct84002 (Entrez Gene) UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BHLHE40GeneProduct8553 (Entrez Gene) basic helix-loop-helix family, member e40
BIRC2GeneProduct329 (Entrez Gene) baculoviral IAP repeat containing 2
BIRC3GeneProduct330 (Entrez Gene) baculoviral IAP repeat containing 3
CCL20GeneProduct6364 (Entrez Gene) chemokine (C-C motif) ligand 20
CCL2GeneProduct6347 (Entrez Gene) chemokine (C-C motif) ligand 2
CDC42EP3GeneProduct10602 (Entrez Gene) CDC42 effector protein (Rho GTPase binding) 3
CDKN1CGeneProduct1028 (Entrez Gene) cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPEB4GeneProduct80315 (Entrez Gene) cytoplasmic polyadenylation element binding protein 4
CUL1GeneProduct8454 (Entrez Gene) cullin 1
CXCR7GeneProduct57007 (Entrez Gene) atypical chemokine receptor 3
DNAJC15GeneProduct29103 (Entrez Gene) DnaJ (Hsp40) homolog, subfamily C, member 15
DNERGeneProduct92737 (Entrez Gene) delta/notch-like EGF repeat containing
EDN2GeneProduct1907 (Entrez Gene) endothelin 2
ENC1GeneProduct8507 (Entrez Gene) ectodermal-neural cortex 1 (with BTB domain)
EPB41L4BGeneProduct54566 (Entrez Gene) erythrocyte membrane protein band 4.1 like 4B
ETNK2GeneProduct55224 (Entrez Gene) ethanolamine kinase 2
FGD4GeneProduct121512 (Entrez Gene) FYVE, RhoGEF and PH domain containing 4
FGFBP1GeneProduct9982 (Entrez Gene) fibroblast growth factor binding protein 1
GADD45BGeneProduct4616 (Entrez Gene) growth arrest and DNA-damage-inducible, beta
GPR115GeneProduct221393 (Entrez Gene) adhesion G protein-coupled receptor F4
GPR153GeneProduct387509 (Entrez Gene) G protein-coupled receptor 153
HSP90AA1GeneProduct3320 (Entrez Gene) heat shock protein 90kDa alpha (cytosolic), class A member 1
IL11GeneProduct3589 (Entrez Gene) interleukin 11
JUNGeneProduct3725 (Entrez Gene) jun proto-oncogene
KTN1GeneProduct3895 (Entrez Gene) kinectin 1 (kinesin receptor)
LRRC8AGeneProduct56262 (Entrez Gene) leucine rich repeat containing 8 family, member A
MFGE8GeneProduct4240 (Entrez Gene) milk fat globule-EGF factor 8 protein
MGAMGeneProduct8972 (Entrez Gene) maltase-glucoamylase
MT1IPGeneProduct644314 (Entrez Gene) metallothionein 1I, pseudogene
NAV3GeneProduct89795 (Entrez Gene) neuron navigator 3
NFKB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR1I2GeneProduct8856 (Entrez Gene) nuclear receptor subfamily 1, group I, member 2
NR1I3GeneProduct9970 (Entrez Gene) nuclear receptor subfamily 1, group I, member 3
NR3C1GeneProduct2908 (Entrez Gene) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDE4BGeneProduct5142 (Entrez Gene) phosphodiesterase 4B, cAMP-specific
PLK2GeneProduct10769 (Entrez Gene) polo-like kinase 2
PMP2GeneProduct5375 (Entrez Gene) peripheral myelin protein 2
POU5F1GeneProduct5460 (Entrez Gene) POU class 5 homeobox 1
PPP1R14CGeneProduct81706 (Entrez Gene) protein phosphatase 1, regulatory (inhibitor) subunit 14C
PRRG4GeneProduct79056 (Entrez Gene) proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTGES3GeneProduct10728 (Entrez Gene) prostaglandin E synthase 3 (cytosolic)
PTGS2GeneProduct5743 (Entrez Gene) prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS2GeneProduct5997 (Entrez Gene) regulator of G-protein signaling 2
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
S100PGeneProduct6286 (Entrez Gene) S100 calcium binding protein P
SCNN1AGeneProduct6337 (Entrez Gene) sodium channel, non voltage gated 1 alpha subunit
SDPRGeneProduct8436 (Entrez Gene) serum deprivation response
SEC14L1GeneProduct6397 (Entrez Gene) SEC14-like 1 (S. cerevisiae)
SERPINB9GeneProduct5272 (Entrez Gene) serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERTAD2GeneProduct9792 (Entrez Gene) SERTA domain containing 2
SLC19A2GeneProduct10560 (Entrez Gene) solute carrier family 19 (thiamine transporter), member 2
SLC26A2GeneProduct1836 (Entrez Gene) solute carrier family 26 (anion exchanger), member 2
SNAI2GeneProduct6591 (Entrez Gene) snail family zinc finger 2
SPINK13GeneProduct153218 (Entrez Gene) serine peptidase inhibitor, Kazal type 13 (putative)
SPRY1GeneProduct10252 (Entrez Gene) sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGNGeneProduct5552 (Entrez Gene) serglycin
STOMGeneProduct2040 (Entrez Gene) stomatin
TGFBR3GeneProduct7049 (Entrez Gene) transforming growth factor, beta receptor III
THBDGeneProduct7056 (Entrez Gene) thrombomodulin
TNFAIP3GeneProduct7128 (Entrez Gene) tumor necrosis factor, alpha-induced protein 3
TNS4GeneProduct84951 (Entrez Gene) tensin 4
TSC22D3GeneProduct1831 (Entrez Gene) TSC22 domain family, member 3
ZIC2GeneProduct7546 (Entrez Gene) Zic family member 2

Annotated Interactions

No annotated interactions

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