Methylation pathways (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC Scholia
2. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	137145	view	23:18, 27 February 2025	Khanspers	Modified description
	117787	view	14:04, 22 May 2021	Eweitz	Modified title
	107581	view	05:35, 23 October 2019	Khanspers	Modified description
	107579	view	05:33, 23 October 2019	Khanspers	Modified description
	107578	view	05:32, 23 October 2019	Khanspers	Modified description
	107577	view	05:32, 23 October 2019	Khanspers	Modified description
	107576	view	05:31, 23 October 2019	Khanspers	Modified description
	107575	view	05:29, 23 October 2019	Khanspers	Modified description
	106829	view	13:30, 17 September 2019	MaintBot	HMDB identifier normalization
	106645	view	21:07, 12 September 2019	Khanspers	Modified description
	105503	view	05:56, 8 August 2019	Khanspers	Modified description
	88909	view	09:24, 17 August 2016	MirellaKalafati	Ontology Term : 'classic metabolic pathway' added !
	79563	view	16:07, 25 March 2015	Zari	Changed ID for INMT gene
	68981	view	17:42, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	59186	view	18:51, 22 February 2013	MaintBot	Updated Ensembl and UniProt data source
	44906	view	10:26, 6 October 2011	MartijnVanIersel	Ontology Term : 'protein modification pathway' added !
	41158	view	23:41, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	39758	view	07:23, 17 January 2011	AlexanderPico	more specific title
	33416	view	14:51, 30 November 2009	MaintBot	Removed group label
	30265	view	20:06, 25 July 2009	AlexanderPico
	30035	view	10:24, 29 June 2009	Pieter Giesbertz	Added literature reference
	30033	view	09:38, 29 June 2009	Pieter Giesbertz	Added literature reference
	29741	view	22:38, 1 June 2009	Khanspers	Modified categories
	29687	view	11:37, 27 May 2009	Pieter Giesbertz	Specify description
	29671	view	08:09, 26 May 2009	Pieter Giesbertz	Added co-substrate synthesis
	29349	view	07:55, 28 April 2009	Pieter Giesbertz	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ATP	Metabolite	HMDB00538 (HMDB)
COMT	GeneProduct	ENSG00000093010 (Ensembl)
HNMT	GeneProduct	ENSG00000150540 (Ensembl)
INMT	GeneProduct	ENSG00000241644 (Ensembl)
L-Methionine	Metabolite	HMDB00696 (HMDB)
MAT1A	GeneProduct	ENSG00000151224 (Ensembl)
MAT2A	GeneProduct	ENSG00000168906 (Ensembl)
MAT2B	GeneProduct	ENSG00000038274 (Ensembl)
N-methylated substrate	Metabolite
NNMT	GeneProduct	ENSG00000166741 (Ensembl)
O-methylated substrate	Metabolite
PNMT	GeneProduct	ENSG00000141744 (Ensembl)
Phosphate	Metabolite	HMDB01429 (HMDB)
S-Adenosylhomocysteine	Metabolite	HMDB00939 (HMDB)
S-Adenosylmethionine	Metabolite	HMDB01185 (HMDB)
S-methylated substrate	Metabolite
Substrate	Metabolite
TPMT	GeneProduct	ENSG00000137364 (Ensembl)

Annotated Interactions

No annotated interactions