Mecp2 and associated Rett syndrome (Mus musculus)

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6Activation complexDNA bindingMecp2 associated diseases:- RETT-syndrome- schizophrenia- FASD (fetal alcohol syndrome)- PPM-X-syndrome- autism- Prader-Will-syndrome- Angelman-syndromeDNA condensingRepressor complextranscriptional regulation by Mecp2Chromatin structure maintenanceMicrogliaalternative splicing of:cofactorsrepressed by Mecp2OligodendrocytesMecp2 affects:- all cell types, especially neurons, astrocytes, oligodendrocytes and glial cells- neuronal differentiation- neuronal maturation- neuronal function- neuronal morphology- synaptic plasticityMicro RNA regulationAstrocytes664CNPaseOprk1HP1Sin3aMbpFgf2miR-146bCsrp1miR-197miR-296Smc3Gprin1miR-199bmiR-221Creb1miR-329NrepmiR-137MagYB1PRPF3miR-221miR-382miR-222CdonNR1GlutamateHB1miR-187miR-29bmiR-146aFut8Dlx5Ncor1Tet1Mef2cmiR-193aNf1A2bp1Apoc2Mecp2Ak087060Ak081227GamtmiR-122aBdnfmiR409miR-184miR-92miR-342miR-130miR-199Sst52771677859371087activated by Mecp2YB18


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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
129303view13:46, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
120273view12:55, 23 November 2021EgonwReplaces a PMCID with a PMID
117915view10:34, 23 May 2021EweitzModified title
107202view14:29, 17 September 2019MaintBotChEBI identifier normalization
97545view14:40, 24 May 2018Mkutmonfixed microRNA linkouts
97541view14:33, 24 May 2018Mkutmonremove special character in comment
97524view14:10, 24 May 2018TeacupChanged miRBase mature sequence database to miRBase sequence
88904view08:39, 17 August 2016Fehrhartupdate
87766view10:00, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
87765view10:00, 25 July 2016ElisaOntology Term : 'regulatory pathway pertinent to the brain' added !
83562view09:04, 25 November 2015FehrhartUpdated miRNA names according to actual annotation rules
82621view09:16, 15 October 2015Fehrhartdeleted information from retracted paper (http://www.ncbi.nlm.nih.gov/pubmed/19897480)
81213view17:52, 4 August 2015KhanspersAdded annotation for Creb1
80241view05:32, 28 May 2015Khansperschanged color of miRNA nodes
79772view13:02, 15 April 2015FehrhartImplemented miR regulation of Mecp2
79749view08:41, 9 April 2015FehrhartModified description
79748view08:38, 9 April 2015FehrhartModification of description
79747view08:35, 9 April 2015FehrhartModified description
79743view14:48, 8 April 2015Fehrhartconnected lines
79742view14:43, 8 April 2015Fehrhartadded transcriptional regulation of Mecp2
79687view19:43, 4 April 2015AlexanderPicoModified title
79665view10:03, 2 April 2015FehrhartUpdate alternative splicing path
79656view14:47, 1 April 2015FehrhartlncRNA
79655view13:11, 1 April 2015FehrhartFinished miRNA annotation
79650view10:20, 1 April 2015Fehrhartstart updating miR regulation
79649view09:13, 1 April 2015FehrhartUpdate of transcriptional regulation
79639view16:45, 31 March 2015EgonwModified title
79638view14:08, 31 March 2015FehrhartModified description
79637view14:07, 31 March 2015FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A2bp1GeneProductENSMUSG00000008658 (Ensembl) ataxin 2 binding protein 1
Ak081227GeneProduct
Ak087060GeneProduct
Apoc2GeneProductENSMUSG00000002992 (Ensembl) apolipoprotein C-II
BdnfGeneProductENSMUSG00000048482 (Ensembl) brain derived neurotrophic factor
CNPaseGeneProductENSMUSG00000006782 (Ensembl) 2',3'-cyclic nucleotide 3' phosphodiesterase
CdonGeneProductENSMUSG00000038119 (Ensembl) cell adhesion molecule-related/down-regulated by oncogenes
Creb1GeneProduct
Csrp1GeneProductENSMUSG00000026421 (Ensembl) cysteine and glycine-rich protein 1
Dlx5GeneProductENSMUSG00000029755 (Ensembl) distal-less homeobox 5
Fgf2GeneProduct
Fut8GeneProduct
GamtGeneProductENSMUSG00000020150 (Ensembl) guanidinoacetate methyltransferase
GlutamateMetabolite29987 (ChEBI)
Gprin1GeneProductENSMUSG00000069227 (Ensembl) G protein-regulated inducer of neurite outgrowth 1
HB1GeneProductchromatin factor, data obtained using human cell line and mouse primary tissue
HP1GeneProduct
MagGeneProductENSMUSG00000036634 (Ensembl) myelin-associated glycoprotein
MbpGeneProductENSMUSG00000041607 (Ensembl) myelin basic protein
Mecp2GeneProductENSMUSG00000031393 (Ensembl) methyl CpG binding protein 2
Mef2cGeneProductENSMUSG00000005583 (Ensembl) myocyte enhancer factor 2C
NR1GeneProduct
  • related to FASD (fetal alcohole spectrum disorder)
  • NMDA receptor subunit
Ncor1GeneProductENSMUSG00000018501 (Ensembl) nuclear receptor co-repressor 1
Nf1GeneProduct
NrepGeneProductENSMUSG00000042834 (Ensembl) neuronal regeneration related protein
Oprk1GeneProductENSMUSG00000025905 (Ensembl) opioid receptor, kappa 1
PRPF3GeneProductENSMUSG00000015748 (Ensembl) PRP3 pre-mRNA processing factor 3 homolog (yeast)
Sin3aGeneProductENSMUSG00000042557 (Ensembl)
Smc3GeneProductENSMUSG00000024974 (Ensembl) tructural maintenance of chromosomes 3
SstGeneProductENSMUSG00000004366 (Ensembl) Somatostatin
Tet1GeneProductENSMUSG00000047146 (Ensembl) tet methylcytosine dioxygenase 1
YB1GeneProductdata obtained with human cell line and mouse primary tissue
miR-122aRna
miR-130Rna
miR-137Rnaneuronal stem cell proliferation an differentiation
miR-146aRna
miR-146bRna
miR-184Rna
miR-187Rna
miR-193aRna
miR-197Rna
miR-199Rna
miR-199bRna
miR-221Rna
miR-222Rna
miR-296Rna
miR-29bRna
miR-329Rna
miR-342Rna
miR-382Rna
miR-92Rna
miR409Rna

Annotated Interactions

No annotated interactions

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