miRNA targets in ECM and membrane receptors (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none miRNAGene ProductExtracellular MatrixLegendPredicted inhibition of protein expression by miRNAExtracellular proteinsLAMA4SDC2mir-7-1-3pmir-30c-1mir-30c-2mir-30d-3pCOL3A1THBS2COL4A2COL4A1COL5A3COL6A1COL6A2COL1A2COL5A2COL6A3COL5A1TNXBLAMB2THBS1LAMC1FN1mir-29c-5pmir-141-5pmir-148b-3pmir-200a-5pmir-25-3pmir-532-5pmir-589-5pmir-548d-1mir548d-2mir-141-3pmir-30b-5pmir-92a-1mir-92a-2mir-200c-3pITGB6ITGB5ITGA11ITGA1Cytoplasmmir-107mir-30e-5pmir-219-1-3pmir-15b-3pmir-200b-3pmir-200c-5pmir-200b-5pmir-429Transmembrane receptorsName: Pan-cancer miRNA-target network involving ECM-receptor interactionsOrganism: Homo sapiens


Description

Based on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptors (bottom panel) to mediate cell-to-cell communications.

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:NonTypical.pngAnnotated lists

Ontology Terms

 

Bibliography

  1. Li Y, Zhang Z; ''Potential microRNA-mediated oncogenic intercellular communication revealed by pan-cancer analysis.''; Sci Rep, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137756
Approved
view18:31, 7 March 2025KhanspersModified description
128292view02:54, 30 January 2024EweitzRefine legend, standardize case
120808view12:29, 11 January 2022SusanOntology Term : 'cell-extracellular matrix signaling pathway' added !
105863view23:21, 15 August 2019KhanspersModified description
103009view15:18, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
87847view11:49, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
87378view11:05, 22 July 2016MaintBotadded missing graphids
83020view13:39, 17 November 2015FehrhartUpdate of outdated identifiers
79746view21:08, 8 April 2015KhanspersModified title
79678view23:21, 3 April 2015Khanspersoverhaul
79677view22:24, 3 April 2015Khanspersupdated lines
79643view21:02, 31 March 2015Khansperslayout change
79642view20:59, 31 March 2015KhanspersModified description
79641view20:58, 31 March 2015Khanspersupdated literature reference
79640view20:55, 31 March 2015KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
COL1A2GeneProductENSG00000164692 (Ensembl)
COL3A1GeneProductENSG00000168542 (Ensembl)
COL4A1GeneProductENSG00000187498 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
COL5A1GeneProductENSG00000130635 (Ensembl)
COL5A2GeneProductENSG00000204262 (Ensembl)
COL5A3GeneProductENSG00000080573 (Ensembl)
COL6A1GeneProductENSG00000142156 (Ensembl)
COL6A2GeneProductENSG00000142173 (Ensembl)
COL6A3GeneProductENSG00000163359 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
ITGA11GeneProductENSG00000137809 (Ensembl)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGB5GeneProductENSG00000082781 (Ensembl)
ITGB6GeneProductENSG00000115221 (Ensembl)
LAMA4GeneProductENSG00000112769 (Ensembl)
LAMB2GeneProductENSG00000172037 (Ensembl)
LAMC1GeneProductENSG00000135862 (Ensembl)
SDC2GeneProductENSG00000169439 (Ensembl)
THBS1GeneProductENSG00000137801 (Ensembl)
THBS2GeneProductENSG00000186340 (Ensembl)
TNXBGeneProductENSG00000168477 (Ensembl)
mir-107RnaENSG00000198997 (Ensembl)
mir-141-3pGeneProductENSG00000207708 (Ensembl)
mir-141-5pGeneProductENSG00000207708 (Ensembl)
mir-148b-3pGeneProductENSG00000199122 (Ensembl)
mir-15b-3pRnaENSG00000207779 (Ensembl)
mir-200a-5pGeneProductENSG00000207607 (Ensembl)
mir-200b-3pGeneProductENSG00000207730 (Ensembl)
mir-200b-5pGeneProductENSG00000207730 (Ensembl)
mir-200c-3pGeneProductENSG00000207713 (Ensembl)
mir-200c-5pGeneProductENSG00000207713 (Ensembl)
mir-219-1-3pRnaENSG00000199036 (Ensembl)
mir-25-3pGeneProductENSG00000207547 (Ensembl)
mir-29c-5pGeneProductENSG00000207966 (Ensembl)
mir-30b-5pGeneProductENSG00000207582 (Ensembl)
mir-30c-1GeneProductENSG00000207962 (Ensembl)
mir-30c-2GeneProductENSG00000199094 (Ensembl)
mir-30d-3pGeneProductENSG00000199153 (Ensembl)
mir-30e-5pRnaENSG00000198974 (Ensembl)
mir-429GeneProductENSG00000198976 (Ensembl)
mir-532-5pGeneProductENSG00000207758 (Ensembl)
mir-548d-1GeneProductENSG00000207704 (Ensembl)
mir-589-5pGeneProductENSG00000207973 (Ensembl)
mir-7-1-3pRnaENSG00000207603 (Ensembl)
mir-92a-1GeneProductENSG00000207968 (Ensembl)
mir-92a-2GeneProductENSG00000208034 (Ensembl)
mir548d-2GeneProductENSG00000207688 (Ensembl)

Annotated Interactions

No annotated interactions

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