Vascular smooth muscle contraction (Bos taurus)

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ContractionRELAXCATION+pDepolarizationIntravasal pressure/stretchMyofilamentsVasoconstrictors+pReduction of intracellular Ca2+ concentrationReduction of contractile system Ca2+ sensitivityCrossbreidge-pHyperpolarizationPLA2G12BGsBNPCalcium signal PathwayACTG2CACNA1CMYLKNOGUCY1A3GNA11AdrenomedullinPRKCGArachidonateCALM3phospholipase A2PTGIRPLA2G2D4PRKACBCACNA1DADCY7CAMP20-HETEITPR1PLA2G6ADCY6BRAFRAF1EndothelinANPIP3ADCY9ADCY3ITPR2PLCB2PRKXPLA2G4EK+CGRPGNAQPLCB4cGMPADCY2MYL9GUCY1A2GNA12PGI2PLA2G2CPKGMYLK2MYL6BPLA2G1BARHGEF12KCNMB1Ca2+CYP4A22PLA2G2AKCNU1DAGRAMP2PRKCQPLA2G4Aphospholipase A2RAMP1AdenosineITPR3PRKCDPRKCECACNA1SMHCEETNPR-BEDNRACALML5ARHGEF1AGTR1GNA13ADRA1AvasopressinAVPR1BPLA2G2FADRA1BGUCY1B3PLCB3PRKACAPLA2G10PPP1CCKCNMB4ADCY4MYL6Ca2+PRKCAArachidonic acid metabolismKCNMB2RAMP3PRKCBADCY8CaDKCNMB3KCNMA1ROCK2PLA2G5CALM1PPP1CBADCY5PPP1R12CCPI-17CALMPLA2G12AMAP2K2CALM2PLA2G2AMYLK4ACTA2PPP1R12AAngiotensin IIADORA2AROCK1PPP1CAPLCB1PLA2G4BRhOAPLA2G4FADCY1ADRA1DCALML6ADORA2BCa2+CACNA1FARAFARHGEF11PLA2G4DMAPK1MAPK3CALCRLPLA2G2D1K+PLA2G3NPR-APRKCHPLA2G2EMYLK3NorepinephrineCNPCYP4A11IRAGAVPR1AMAP2K1PPP1R12BCACNA1FCACNA1DCACNA1SCACNA1CKCNMB2KCNU1KCNMB3KCNMB4KCNMB1KCNMA1ITPR2ITPR1ITPR3MYLK2MYLKMYLK4MYLK3MyosinACTG2MYL6MHCMYL9ACTA2MYL6BMyosinPPP1CCPPP1CBPPP1R12CPPP1CAPPP1R12BPPP1R12AVasodilators+p+p+p+p+p+p+p+p-p


Description

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
140184view05:45, 5 August 2025EgonwModified description
140182view05:44, 5 August 2025EgonwMore unicode
139980view05:02, 15 July 2025EgonwCalcium ion with unicode
107057view14:14, 17 September 2019MaintBotChEBI identifier normalization
87857view11:54, 25 July 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
82870view16:22, 10 November 2015JmeliusCorrect outdated id
80970view12:08, 6 July 2015Mkutmonfixed graphid problem
80968view12:00, 6 July 2015Mkutmonfixed unconnected lines
79750view08:51, 9 April 2015Zarichanged identyfier for CACNA1C
79732view11:42, 7 April 2015ZariModified description
79731view11:34, 7 April 2015ZariNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
20-HETEMetabolite34306 (ChEBI)
ACTA2GeneProduct515610 (Entrez Gene)
ACTG2GeneProduct281595 (Entrez Gene)
ADCY1GeneProduct281601 (Entrez Gene)
ADCY2GeneProduct510708 (Entrez Gene)
ADCY3GeneProduct535603 (Entrez Gene)
ADCY4GeneProduct788151 (Entrez Gene)
ADCY5GeneProduct505740 (Entrez Gene)
ADCY6GeneProduct509936 (Entrez Gene)
ADCY7GeneProduct281603 (Entrez Gene)
ADCY8GeneProduct535017 (Entrez Gene)
ADCY9GeneProduct525482 (Entrez Gene)
ADORA2AGeneProduct617828 (Entrez Gene)
ADORA2BGeneProduct529760 (Entrez Gene)
ADRA1AGeneProduct282134 (Entrez Gene)
ADRA1BGeneProduct407140 (Entrez Gene)
ADRA1DGeneProduct539543 (Entrez Gene)
AGTR1GeneProduct281607 (Entrez Gene)
ANPMetabolite80233 (ChEBI)
ARAFGeneProduct540421 (Entrez Gene)
ARHGEF11GeneProduct511220 (Entrez Gene)
ARHGEF12GeneProduct503575 (Entrez Gene)
ARHGEF1GeneProduct513377 (Entrez Gene)
AVPR1AGeneProduct538439 (Entrez Gene)
AVPR1BGeneProduct282861 (Entrez Gene)
AdenosineMetabolite
AdrenomedullinMetabolite80339 (ChEBI)
Angiotensin IIMetabolite2719 (ChEBI)
ArachidonateMetabolite15843 (ChEBI)
Arachidonic acid metabolismPathway
BNPMetabolite80234 (ChEBI)
BRAFGeneProduct536051 (Entrez Gene)
CACNA1CGeneProduct408015 (Entrez Gene)
CACNA1DGeneProduct408013 (Entrez Gene)
CACNA1FGeneProduct509779 (Entrez Gene)
CACNA1SGeneProduct100337204 (Entrez Gene)
CALCRLGeneProduct527140 (Entrez Gene)
CALM1GeneProduct617095 (Entrez Gene)
CALM2GeneProduct100297344 (Entrez Gene)
CALMGeneProduct326597 (Entrez Gene)
CALM3GeneProduct520277 (Entrez Gene)
CALML5GeneProduct520404 (Entrez Gene)
CALML6GeneProduct617412 (Entrez Gene)
CAMPMetabolite17489 (ChEBI)
CGRPMetabolite80337 (ChEBI)
CNPMetabolite80235 (ChEBI)
CPI-17GeneProduct615348 (Entrez Gene)
CYP4A11GeneProduct511890 (Entrez Gene)
CYP4A22GeneProduct516085 (Entrez Gene)
Ca2+Metabolite29108 (ChEBI)
Ca2+Metabolite29108 (ChEBI)
CaDGeneProduct281660 (Entrez Gene)
Calcium signal PathwayPathway
DAGMetabolite18035 (ChEBI)
EDNRAGeneProduct281749 (Entrez Gene)
EETMetabolite34157 (ChEBI)
EndothelinMetabolite80240 (ChEBI)
GNA11GeneProduct281788 (Entrez Gene)
GNA12GeneProduct515159 (Entrez Gene)
GNA13GeneProduct505611 (Entrez Gene)
GNAQGeneProduct536654 (Entrez Gene)
GUCY1A2GeneProduct613600 (Entrez Gene)
GUCY1A3GeneProduct281216 (Entrez Gene)
GUCY1B3GeneProduct282433 (Entrez Gene)
GsGeneProduct281793 (Entrez Gene)
IP3Metabolite16595 (ChEBI)
IRAGGeneProduct281918 (Entrez Gene)
ITPR1GeneProduct317697 (Entrez Gene)
ITPR2GeneProduct281878 (Entrez Gene)
ITPR3GeneProduct281879 (Entrez Gene)
K+Metabolite29103 (ChEBI)
KCNMA1GeneProduct282573 (Entrez Gene)
KCNMB1GeneProduct407176 (Entrez Gene)
KCNMB2GeneProduct534568 (Entrez Gene)
KCNMB3GeneProduct539609 (Entrez Gene)
KCNMB4GeneProduct520448 (Entrez Gene)
KCNU1GeneProduct524144 (Entrez Gene)
MAP2K1GeneProduct533199 (Entrez Gene)
MAP2K2GeneProduct510434 (Entrez Gene)
MAPK1GeneProduct327672 (Entrez Gene)
MAPK3GeneProduct531391 (Entrez Gene)
MHCGeneProduct
MYL6GeneProduct281341 (Entrez Gene)
MYL6BGeneProduct515421 (Entrez Gene)
MYL9GeneProduct505964 (Entrez Gene)
MYLK2GeneProduct533378 (Entrez Gene)
MYLKGeneProduct338037 (Entrez Gene)
MYLK3GeneProduct526379 (Entrez Gene)
MYLK4GeneProduct518025 (Entrez Gene)
NOMetabolite16480 (ChEBI)
NPR-AGeneProduct533048 (Entrez Gene)
NPR-BGeneProduct281357 (Entrez Gene)
NorepinephrineMetabolite18357 (ChEBI)
PGI2Metabolite15552 (ChEBI)
PKGGeneProduct
PLA2G10GeneProduct613966 (Entrez Gene)
PLA2G12AGeneProduct527214 (Entrez Gene)
PLA2G12BGeneProduct100337447 (Entrez Gene)
PLA2G1BGeneProduct282457 (Entrez Gene)
PLA2G2AGeneProduct507201 (Entrez Gene)
PLA2G2AGeneProduct521383 (Entrez Gene)
PLA2G2CGeneProduct504978 (Entrez Gene)
PLA2G2D1GeneProduct494318 (Entrez Gene)
PLA2G2D4GeneProduct503625 (Entrez Gene)
PLA2G2EGeneProduct506243 (Entrez Gene)
PLA2G2FGeneProduct541294 (Entrez Gene)
PLA2G3GeneProduct527631 (Entrez Gene)
PLA2G4AGeneProduct525072 (Entrez Gene)
PLA2G4BGeneProduct505485 (Entrez Gene)
PLA2G4DGeneProduct531209 (Entrez Gene)
PLA2G4EGeneProduct526364 (Entrez Gene)
PLA2G4FGeneProduct522866 (Entrez Gene)
PLA2G5GeneProduct614911 (Entrez Gene)
PLA2G6GeneProduct535381 (Entrez Gene)
PLCB1GeneProduct287026 (Entrez Gene)
PLCB2GeneProduct508888 (Entrez Gene)
PLCB3GeneProduct515669 (Entrez Gene)
PLCB4GeneProduct281985 (Entrez Gene)
PPP1CAGeneProduct516175 (Entrez Gene)
PPP1CBGeneProduct538829 (Entrez Gene)
PPP1CCGeneProduct282318 (Entrez Gene)
PPP1R12AGeneProduct538606 (Entrez Gene)
PPP1R12BGeneProduct100337338 (Entrez Gene)
PPP1R12CGeneProduct512431 (Entrez Gene)
PRKACAGeneProduct282322 (Entrez Gene)
PRKACBGeneProduct282323 (Entrez Gene)
PRKCAGeneProduct282001 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCEGeneProduct507041 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
PRKCHGeneProduct518542 (Entrez Gene)
PRKCQGeneProduct505901 (Entrez Gene)
PRKXGeneProduct505773 (Entrez Gene)
PTGIRGeneProduct520278 (Entrez Gene)
RAF1GeneProduct521196 (Entrez Gene)
RAMP1GeneProduct617017 (Entrez Gene)
RAMP2GeneProduct504230 (Entrez Gene)
RAMP3GeneProduct613547 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene)
ROCK2GeneProduct282041 (Entrez Gene)
RhOAGeneProduct338049 (Entrez Gene)
cGMPMetabolite16356 (ChEBI)
phospholipase A2GeneProduct104974671 (Entrez Gene)
phospholipase A2GeneProduct615045 (Entrez Gene)
vasopressinMetabolite34543 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2912"
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