Monoamine transport (Bos taurus)

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173121325231812, 171, 16, 188, 19221812202521254, 18292510, 142, 1225112316151124, 3015292762911252928513320, 2619791625101228231517514152522916Small MoleculeProtein ModificationNucleusNegative RegulationNegative ExpressionGolgiCell MembraneProteinSynthesis TransportExpressionBindingRegulationLEGENDNegative TransportTSC2SYN1RBL2AMPHSTX1AHEPESSCAMP2reserpinenoradrenalineanisomycinPVRL2TNFSLC5A7FBXO32SLC6A2INTB3SB 203580CDC25CNOS1ACHEdopamineepinephrineDBHTDO24-Aminobutanoic acidTNFRSF11BcatecholaminesAGTSLC6A3serotoninTPH2Hemicholinium-3HRH3MAPK14TGFB1I1Phorbol esterSLC6A1IL1R1citalopramUNC13BL-tryptophanADORA2ATHPPP2CBIL1BSLC6A4


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP727(79969) with a 100.0% conversion rate.

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Bibliography

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  1. Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR; ''Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  2. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N; ''Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75.''; Neuroscience, 2008 PubMed Europe PMC Scholia
  3. Hahn MK, Blakely RD; ''The functional impact of SLC6 transporter genetic variation.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  4. Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S; ''Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  5. Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM Jr, Paul SM, Rudorfer MV, Sausville E, Schatzberg AF, Scolnick EM, Suppes T; ''''; , PubMed Europe PMC Scholia
  6. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD; ''Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  7. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  8. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD; ''A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  9. Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI; ''Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia
  10. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  11. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  12. Zhu CB, Blakely RD, Hewlett WA; ''The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters.''; Neuropsychopharmacology, 2006 PubMed Europe PMC Scholia
  13. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  14. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  15. Hahn MK, Blakely RD; ''Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.''; Pharmacogenomics J, 2002 PubMed Europe PMC Scholia
  16. Miner LH, Schroeter S, Blakely RD, Sesack SR; ''Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals.''; J Comp Neurol, 2003 PubMed Europe PMC Scholia
  17. Savchenko V, Sung U, Blakely RD; ''Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody.''; Mol Cell Neurosci, 2003 PubMed Europe PMC Scholia
  18. Hahn MK, Robertson D, Blakely RD; ''A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  19. Iwamoto H, Blakely RD, De Felice LJ; ''Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  20. Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, France CP, Gore JC, Daws LC, Avison MJ, Galli A; ''Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  21. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  22. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD; ''Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  23. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD; ''p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  24. Sung U, Blakely RD; ''Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A.''; Mol Cell Neurosci, 2007 PubMed Europe PMC Scholia
  25. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  26. Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD; ''Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  27. Dipace C, Sung U, Binda F, Blakely RD, Galli A; ''Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes.''; Mol Pharmacol, 2007 PubMed Europe PMC Scholia
  28. Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  29. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  30. Steiner JA, Carneiro AM, Blakely RD; ''Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.''; Traffic, 2008 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
134259view05:04, 18 July 2024EgonwRemoved template comments
117553view11:18, 21 May 2021EweitzModified title
107058view14:14, 17 September 2019MaintBotChEBI identifier normalization
80663view15:21, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-Aminobutanoic acidMetabolite56-12-2 (CAS)
ACHEGeneProductENSBTAG00000001139 (Ensembl)
  • acetylcholinesterase (Yt blood group)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43
ADORA2AGeneProductENSBTAG00000016944 (Ensembl)
  • adenosine A2a receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:135
AGTGeneProductENSBTAG00000012393 (Ensembl)
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:183
AMPHGeneProductENSBTAG00000031967 (Ensembl)
  • amphiphysin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:273
CDC25CGeneProductENSBTAG00000005293 (Ensembl)
  • cell division cycle 25 homolog C (S. pombe)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995
DBHGeneProductENSBTAG00000004508 (Ensembl)
  • dopamine beta-hydroxylase (dopamine beta-monooxygenase)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1621
FBXO32GeneProductENSBTAG00000016194 (Ensembl)
  • F-box protein 32
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114907
HEPESMetabolite7365-45-9 (CAS)
HRH3GeneProductENSBTAG00000031625 (Ensembl)
  • histamine receptor H3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11255
Hemicholinium-3Metabolite312-45-8 (CAS)
IL1BGeneProductENSBTAG00000001321 (Ensembl)
  • interleukin 1 beta
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL1R1GeneProductENSBTAG00000005273 (Ensembl)
  • interleukin 1 receptor, type I
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
INTB3GeneProductENSBTAG00000009987 (Ensembl)
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
L-tryptophanMetabolite73-22-3 (CAS)
MAPK14GeneProductENSBTAG00000020783 (Ensembl)
  • mitogen activated protein kinase 14
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
NOS1GeneProductENSBTAG00000002023 (Ensembl)
  • nitric oxide synthase 1 (neuronal)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
PPP2CBGeneProductENSBTAG00000009245 (Ensembl)
  • protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
PVRL2GeneProductENSBTAG00000015318 (Ensembl)
  • poliovirus receptor-related 2 (herpesvirus entry mediator B)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5819
Phorbol esterMetabolite16561-29-8 (CAS)
RBL2GeneProductENSBTAG00000016243 (Ensembl)
  • retinoblastoma-like 2 (p130)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
SB 203580Metabolite152121-47-6 (CAS)
SCAMP2GeneProductENSBTAG00000005844 (Ensembl)
  • secretory carrier membrane protein 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10066
SLC5A7GeneProductENSBTAG00000004352 (Ensembl)
  • solute carrier family 5 (choline transporter), member 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60482
SLC6A1GeneProductENSBTAG00000005857 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6529
SLC6A2GeneProductENSBTAG00000003353 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6530
SLC6A3GeneProductENSBTAG00000015843 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6531
SLC6A4GeneProductENSBTAG00000019349 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6532
STX1AGeneProductENSBTAG00000017075 (Ensembl)
  • syntaxin 1A (brain)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6804
SYN1GeneProductENSBTAG00000005042 (Ensembl)
  • synapsin I
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6853
TDO2GeneProductENSBTAG00000011062 (Ensembl)
  • tryptophan 2,3-dioxygenase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6999
TGFB1I1GeneProductENSBTAG00000002391 (Ensembl)
  • transforming growth factor beta 1 induced transcript 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041
THGeneProductENSBTAG00000026768 (Ensembl)
  • tyrosine hydroxylase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7054
TNFGeneProductENSBTAG00000025471 (Ensembl)
  • tumor necrosis factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
TNFRSF11BGeneProductENSBTAG00000007423 (Ensembl)
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4982
TPH2GeneProductENSBTAG00000020792 (Ensembl)
  • tryptophan hydroxylase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:121278
TSC2GeneProductENSBTAG00000020617 (Ensembl)
  • tuberous sclerosis 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7249
UNC13BGeneProductENSBTAG00000011397 (Ensembl)
  • unc-13 homolog B (C. elegans)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10497
anisomycinMetabolite338412 (ChEBI)
catecholaminesMetabolite33567 (ChEBI)
citalopramMetabolite59729-33-8 (CAS)
dopamineMetabolite51-61-6 (CAS)
epinephrineMetabolite51-43-4 (CAS)
noradrenalineMetabolite51-41-2 (CAS)
reserpineMetabolite50-55-5 (CAS)
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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