Pathogenic Escherichia coli infection (Bos taurus)
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Toxins
ROCK2
ARHGEF2
E-CADHERIN
HCLS1
OCLN
TUBA1C
ITGB1
TUBB6
PRKCA
ACTB
StxB
TUBB1
ARPC2
NCK2
StxA
YWHAQ
TUBB2B
Tir
EZR
Apoptosis
TUBB3
Tir
TUBA1B
EspG2
CD14
Phosphatidylethanolamine
TUBA3D
TUBA4A
TUBB4Q
KRT18
Tight junction
EspF
actin-related protein 2/3 complex subunit 1B-like
EspF
ACTG1
EspH
TUBA3E
ARPC3
Adherens junction
OCLN
CTNNB1
TLR5
TUBB4B
MD2
ARPC1A
EspH
TUBAL3
ARPC1B
FYN
TUBB8
WASL
TUBB5
ARPC5L
TUBB2B
EspG
TUBA3C
EspG2
Regulation of actin cytoskeleton
CDC42
ARPC5
EspFU
CLDN1
YWHAZ
Flagellar assembly
CTTN
Eae
TUBB4A
NCL
EspFU
EspG
EspFU
WAS
TLR4
Map
RHOA
Regulation of actin cytoskeleton
TUBA8
NCK1
ABL1
Toll-like receptor signaling pathway
Bfp
TUBA1A
ROCK1
Map
ARPC4
Pathogen: Enteropathogenic escherichia coli (EPEC)
Enterohermorrhagic escherichia coli (EHEC)
Pilus
LEE-encoded effectors
non-LEE-encoded effectors
Prophage-carried effectors
Type III protein
secretion system
Flagellin
LPS
Host: Small intestinal epithelial cell (EPEC)
Large intestinal epithelial cell (EHEC)
NleH
NleA
Inflammation
Stress fiber formation
Pedestal formation
Cytoskeleton
rearrangement
Disruption of
microtuble network
Retraction of filopodium
Filipodium formation
Alterations in the
IF network architecture
Disruption of tight junctions
Disruption of adherens junctions
Disruption of barrier
function and increase in
monolayer permeability
Redistribution
Mitochondrial dysfunction
outer membrane protein
p+
p+
Translocation
Intestinal tract
Kidney .......
Inhibition of protein synthesis
TUBB6
TUBB1
TUBB4Q
TUBB8
TUBB2B
TUBB4A
TUBB4B
TUBB5
TUBB2B
TUBB3
Description
Sources:
KEGG
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP2272(78594)
with a 61.0% conversion rate.
Try the New WikiPathways
View approved pathways at
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Quality Tags
Ontology Terms
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Bibliography
No bibliography
History
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Revision
Action
Time
User
Comment
80723
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15:23, 30 June 2015
Mkutmon
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABL1
GeneProduct
ENSBTAG00000017976 (Ensembl)
Original kegg element: gene;35;hsa:25 hsa:2534
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
ACTB
GeneProduct
ENSBTAG00000026199 (Ensembl)
Original kegg element: gene;55;hsa:60 hsa:71
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTG1
GeneProduct
ENSBTAG00000006189 (Ensembl)
Original kegg element: gene;55;hsa:60 hsa:71
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
ARHGEF2
GeneProduct
ENSBTAG00000000113 (Ensembl)
Original kegg element: gene;42;hsa:9181
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9181
ARPC1A
GeneProduct
ENSBTAG00000004242 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10552
ARPC1B
GeneProduct
ENSBTAG00000046248 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10095
ARPC2
GeneProduct
ENSBTAG00000010386 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10109
ARPC3
GeneProduct
ENSBTAG00000005345 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10094
ARPC4
GeneProduct
ENSBTAG00000007964 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10093
ARPC5
GeneProduct
ENSBTAG00000045582 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10092
ARPC5L
GeneProduct
ENSBTAG00000015278 (Ensembl)
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81873
Adherens junction
GeneProduct
Original kegg element: map;5;path:hsa04520
Apoptosis
GeneProduct
Original kegg element: map;19;path:hsa04210
Bfp
GeneProduct
CD14
GeneProduct
ENSBTAG00000015032 (Ensembl)
Original kegg element: gene;2;hsa:929
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:929
CDC42
GeneProduct
ENSBTAG00000001700 (Ensembl)
Original kegg element: gene;32;hsa:998
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CLDN1
GeneProduct
ENSBTAG00000013148 (Ensembl)
Original kegg element: gene;39;hsa:9076
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9076
CTNNB1
GeneProduct
ENSBTAG00000016420 (Ensembl)
Original kegg element: gene;26;hsa:1499
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
CTTN
GeneProduct
ENSBTAG00000006071 (Ensembl)
Original kegg element: gene;27;hsa:2017 hsa:3059
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2017
E-CADHERIN
GeneProduct
ENSBTAG00000015991 (Ensembl)
Original kegg element: gene;17;hsa:999
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999
EZR
GeneProduct
ENSBTAG00000010347 (Ensembl)
Original kegg element: gene;31;hsa:7430
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7430
Eae
GeneProduct
EspF
GeneProduct
EspFU
GeneProduct
EspG
GeneProduct
EspG2
GeneProduct
EspH
GeneProduct
FYN
GeneProduct
ENSBTAG00000011851 (Ensembl)
Original kegg element: gene;35;hsa:25 hsa:2534
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
Flagellar assembly
GeneProduct
Original kegg element: map;4;path:map02040
HCLS1
GeneProduct
ENSBTAG00000001009 (Ensembl)
Original kegg element: gene;27;hsa:2017 hsa:3059
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3059
ITGB1
GeneProduct
ENSBTAG00000015910 (Ensembl)
Original kegg element: gene;40;hsa:3688
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
KRT18
GeneProduct
ENSBTAG00000001517 (Ensembl)
Original kegg element: gene;25;hsa:3875
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3875
MD2
GeneProduct
ENSBTAG00000008864 (Ensembl)
Original kegg element: gene;3;hsa:23643
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23643
Map
GeneProduct
NCK1
GeneProduct
ENSBTAG00000018427 (Ensembl)
Original kegg element: gene;41;hsa:4690 hsa:8440
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4690
NCK2
GeneProduct
ENSBTAG00000015205 (Ensembl)
Original kegg element: gene;41;hsa:4690 hsa:8440
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8440
NCL
GeneProduct
ENSBTAG00000016174 (Ensembl)
Original kegg element: gene;45;hsa:4691
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4691
NleA
GeneProduct
NleH
GeneProduct
OCLN
GeneProduct
Original kegg element: gene;30;hsa:100506658 hsa:4950
OCLN
GeneProduct
ENSBTAG00000000561 (Ensembl)
Original kegg element: gene;30;hsa:100506658 hsa:4950
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:100506658
PRKCA
GeneProduct
ENSBTAG00000001061 (Ensembl)
Original kegg element: gene;36;hsa:5578
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
Phosphatidylethanolamine
Metabolite
C00350 (KEGG Compound)
RHOA
GeneProduct
ENSBTAG00000004279 (Ensembl)
Original kegg element: gene;44;hsa:387
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
ROCK1
GeneProduct
ENSBTAG00000008403 (Ensembl)
Original kegg element: gene;28;hsa:6093 hsa:9475
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
ROCK2
GeneProduct
ENSBTAG00000005847 (Ensembl)
Original kegg element: gene;28;hsa:6093 hsa:9475
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475
Regulation of actin cytoskeleton
GeneProduct
Original kegg element: map;20;path:hsa04810
StxA
GeneProduct
StxB
GeneProduct
TLR4
GeneProduct
ENSBTAG00000006240 (Ensembl)
Original kegg element: gene;9;hsa:7099
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7099
TLR5
GeneProduct
ENSBTAG00000000477 (Ensembl)
Original kegg element: gene;10;hsa:7100
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7100
TUBA1A
GeneProduct
ENSBTAG00000001489 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7846
TUBA1B
GeneProduct
ENSBTAG00000012244 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10376
TUBA1C
GeneProduct
ENSBTAG00000039992 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84790
TUBA3C
GeneProduct
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Multiple homologues found: En:ENSBTAG00000030979;En:ENSBTAG00000030979;
TUBA3D
GeneProduct
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Multiple homologues found: En:ENSBTAG00000030979;En:ENSBTAG00000030979;
TUBA3E
GeneProduct
ENSBTAG00000030979 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112714
TUBA4A
GeneProduct
ENSBTAG00000030974 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7277
TUBA8
GeneProduct
ENSBTAG00000018530 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51807
TUBAL3
GeneProduct
ENSBTAG00000017740 (Ensembl)
Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79861
TUBB1
GeneProduct
ENSBTAG00000018785 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81027
TUBB2B
GeneProduct
ENSBTAG00000004093 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:347733
TUBB2B
GeneProduct
ENSBTAG00000046886 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7280
TUBB3
GeneProduct
ENSBTAG00000023730 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10381
TUBB4A
GeneProduct
ENSBTAG00000021013 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10382
TUBB4B
GeneProduct
ENSBTAG00000025274 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10383
TUBB4Q
GeneProduct
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB5
GeneProduct
ENSBTAG00000006969 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:203068
TUBB6
GeneProduct
ENSBTAG00000046337 (Ensembl)
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84617
TUBB8
GeneProduct
Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
Tight junction
GeneProduct
Original kegg element: map;6;path:hsa04530
Tir
GeneProduct
Toll-like receptor signaling pathway
GeneProduct
Original kegg element: map;7;path:hsa04620
Type III protein secretion system
GeneProduct
Original kegg element: map;4;path:map02040
WAS
GeneProduct
ENSBTAG00000046555 (Ensembl)
Original kegg element: gene;37;hsa:7454 hsa:8976
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7454
WASL
GeneProduct
ENSBTAG00000004643 (Ensembl)
Original kegg element: gene;37;hsa:7454 hsa:8976
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8976
YWHAQ
GeneProduct
ENSBTAG00000002108 (Ensembl)
Original kegg element: gene;18;hsa:10971
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
YWHAZ
GeneProduct
ENSBTAG00000000236 (Ensembl)
Original kegg element: gene;23;hsa:7534
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534
actin-related protein 2/3 complex subunit 1B-like
GeneProduct
Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
Annotated Interactions
No annotated interactions
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