PDGF pathway (Bos taurus)

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ERK1/2(MAPK3/MAPK1)PMAP2K4RASA1STAT1SOS1JUNPDGFASTAT3PTPN11GRB2MAPK8MAP2K1NFkBMAPK3PDGFBMAP3K1HRASRAF1PDGFRBSHC1MAPK1PLCG1PDGFA1-10NFkBSTAT1STAT3STAT3STAT1PPPPSTAT3STAT1PPPJAK1PPCyclic AMP(cAMP)DAGProstaglandin I2(PGI2)IP3COIIPIP2[4',5']Ca2+Phospholipid(containing arachidonic acid)PLA2G4ACell proliferationCachannel[Ca2+]iArachidonic acidELK1FOSSRFNa+/H+exchangerH+NaPIK3R1PSRCPTIAM1VAV2RAC1RHOAARFIP2PAK1VAV1CDC42WASLFilopodiaFormationActin,Stress Fibersand AdhesionLamellipodiaFormationCell MigrationCHUKAktPathwayBIKBAPDegradation


Description

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds made between the 1st

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2526(80006) with a 92.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Heldin CH, Hammacher A, Nistأ©r M, Westermark B; ''Structural and functional aspects of platelet-derived growth factor.''; Br J Cancer, 1988 PubMed Europe PMC Scholia
  2. Hannink M, Donoghue DJ; ''Structure and function of platelet-derived growth factor (PDGF) and related proteins.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  3. Claesson-Welsh L, Heldin CH; ''Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.''; Acta Oncol, 1989 PubMed Europe PMC Scholia
  4. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S; ''PDGF: the nuts and bolts of signalling toolbox.''; Tumour Biol, 2011 PubMed Europe PMC Scholia
  5. Heldin CH; ''Autocrine PDGF stimulation in malignancies.''; Ups J Med Sci, 2012 PubMed Europe PMC Scholia
  6. Heldin CH, Westermark B; ''Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.''; Br Med Bull, 1989 PubMed Europe PMC Scholia
  7. Antoniades HN; ''PDGF: a multifunctional growth factor.''; Baillieres Clin Endocrinol Metab, 1991 PubMed Europe PMC Scholia
  8. Kawahara RS, Deng ZW, Deuel TF; ''PDGF and the small inducible gene (SIG) family: roles in the inflammatory response.''; Adv Exp Med Biol, 1991 PubMed Europe PMC Scholia
  9. Andrae J, Gallini R, Betsholtz C; ''Role of platelet-derived growth factors in physiology and medicine.''; Genes Dev, 2008 PubMed Europe PMC Scholia
  10. Smith CL, Tallquist MD; ''PDGF function in diverse neural crest cell populations.''; Cell Adh Migr, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117588view11:24, 21 May 2021EweitzModified title
115747view11:16, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
107066view14:15, 17 September 2019MaintBotChEBI identifier normalization
105947view11:47, 16 August 2019MaintBotHMDB identifier normalization
101990view18:36, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
96313view09:03, 8 March 2018MkutmonUpdated homology conversion
92373view16:19, 30 May 2017DdiglesOntology Term : 'platelet-derived growth factor signaling pathway' added !
92319view09:32, 22 May 2017RyanmillerOntology Term : 'Jak-Stat signaling pathway' added !
92219view15:31, 11 May 2017EgonwRemoved incorrect CAS annotations (10043-52-4 is CaCl2)
80787view15:26, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

Ca

c h a n n e

l		Protein

Na+/H+

e x c h a n g e

r		Protein
ARFIP2ProteinENSBTAG00000003566 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53365
Actin,

Stress Fibers

and Adhesion		PathwayWP306 (WikiPathways)
Akt PathwayPathway
Arachidonic acidMetaboliteHMDB01043 (HMDB)
BIKBAGeneProductENSBTAG00000016683 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P25963
CDC42ProteinENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P60953
CHUKProteinENSBTAG00000007591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15111
COIIProteinENSBTAG00000043556 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P00403
Ca2+Metabolite10043-52-4 (CAS)
Cell MigrationPathway
Cell proliferationPathway
Cyclic AMP (cAMP)MetaboliteHMDB00058 (HMDB)
DAGMetaboliteLMGL02010000 (LIPID MAPS)
DegradationPathway
ELK1GeneProductENSBTAG00000015817 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P19419
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01100
Filopodia FormationPathway
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P62993
H+Metabolite10043-52-4 (CAS)
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
IP3Metabolite16595 (ChEBI)
JAK1ProteinENSBTAG00000003147 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P23458
JUNGeneProductENSBTAG00000004037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05412
Lamellipodia FormationPathway
MAP2K1GeneProductENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q02750
MAP2K4GeneProductENSBTAG00000012103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13233
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPK8GeneProductENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P45983
NFkBGeneProduct
NaMetabolite10043-52-4 (CAS)
PAK1ProteinENSBTAG00000010191 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13153
PDGFAGeneProductENSBTAG00000014541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5154
PDGFBGeneProductENSBTAG00000021697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5155
PDGFRBGeneProductENSBTAG00000002804 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113721
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27986
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PLA2G4AGeneProductENSBTAG00000013298 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116711
PLCG1GeneProductENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181
PTPN11GeneProductENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q06124
Phospholipid (containing arachidonic acid)MetaboliteCHEBI:16247 (ChEBI)
Prostaglandin I2 (PGI2)MetaboliteHMDB01335 (HMDB)
RAC1ProteinENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P63000
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04049
RASA1GeneProductENSBTAG00000009565 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145715
RHOAProteinENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P61586
SHC1ProteinENSBTAG00000019838 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P29353
SOS1ProteinENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q07889
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P12931
SRFGeneProductENSBTAG00000012777 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P11831
STAT1ProteinENSBTAG00000007867 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P42224
STAT3ProteinENSBTAG00000021523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P40763
TIAM1ProteinENSBTAG00000017839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q13009
VAV1ProteinENSBTAG00000039160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15498
VAV2ProteinENSBTAG00000004511 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P52735
WASLProteinENSBTAG00000004643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O00401
[Ca2+]iMetabolite10043-52-4 (CAS)

Annotated Interactions

No annotated interactions
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