Statin pathway (Bos taurus)

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12PlasmaLiver cellPeripheral tissuesEnterocyteActivationSqualeneAcetyl-CoASQLEbta-mir-33bAPOA5ACSS1PDIA2LCATHMGCRCholesterolPLTPbta-mir-33aAPOC3CholesterolMevalonateLIPCDAGAcyl-CoATriglycerideCETPFatty acidSOAT1APOEIDLAPOA2CholesterolCYP7A1PhospholipidCholic AcidLipoproteinsLDLLPLAPOA4Cholesterol esterLDLRABCA1ABCG5CholesterolABCG8ABCA1APOC1LRP1HDLSCARB1VLDLAPOBAPOA1DGAT1FDFT1APOC2StatinMTTPInhibitionTransportCatalysis


Description

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism.

Sources: PharmGKB and Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP430(78268) with a 90.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia
  2. Wetterau JR, Lin MC, Jamil H; ''Microsomal triglyceride transfer protein.''; Biochim Biophys Acta, 1997 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129529view01:24, 9 May 2024EweitzOntology Term : '' added !
117611view11:39, 21 May 2021EweitzModified title
106004view11:53, 16 August 2019MaintBotHMDB identifier normalization
103263view07:46, 20 February 2019EgonwMore specific ChEBI identifier.
82697view18:42, 22 October 2015EgonwMore specific ChEBI identifiers.
80853view15:28, 30 June 2015Mkutmonhomology conversion
71420view19:02, 17 October 2013MaintBotAutomated update of data sources
67658view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
63383view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
40555view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
38712view19:31, 23 September 2010AlexanderPico
35546view14:20, 12 February 2010Thomasadded literature, cosmetic change
33794view00:14, 9 December 2009MaintBotAutomatic update of empty xrefs
31678view11:43, 14 August 2009MaintBotFixed group labels
30610view22:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCA1GeneProductENSBTAG00000020661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
ABCG5GeneProductENSBTAG00000016365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
ABCG8GeneProductENSBTAG00000016366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
ACSS1ProteinENSBTAG00000004281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532
APOA1GeneProductENSBTAG00000002258 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335
APOA2GeneProductENSBTAG00000009212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336
APOA4GeneProductENSBTAG00000019770 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337
APOA5GeneProductENSBTAG00000019764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519
APOBGeneProductENSBTAG00000008505 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338
APOC1GeneProduct
APOC2GeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000020558;En:ENSBTAG00000020558;
APOC3GeneProductENSBTAG00000012398 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345
APOEGeneProductENSBTAG00000010123 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Acyl-CoAMetaboliteHMDB03419 (HMDB)
CETPGeneProduct
CYP7A1GeneProductENSBTAG00000005287 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
Cholesterol esterMetaboliteC02530 (KEGG Compound)
CholesterolMetabolite57-88-5 (CAS)
Cholic AcidMetabolite81-25-4 (CAS)
DAGMetaboliteC00165 (KEGG Compound)
DGAT1GeneProductENSBTAG00000026356 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694
FDFT1GeneProductENSBTAG00000012432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222
Fatty acidMetaboliteC00162 (KEGG Compound)
HDLMetaboliteC01834 (KEGG Compound)
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156
IDLMetaboliteC01834 (KEGG Compound)
LCATGeneProductENSBTAG00000018043 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931
LDLMetaboliteC01834 (KEGG Compound)
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
LIPCGeneProductENSBTAG00000005479 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
LRP1GeneProductENSBTAG00000010830 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035
LipoproteinsMetaboliteCHEBI:6495 (ChEBI)
MTTPProteinENSBTAG00000011944 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547
MevalonateMetaboliteCHEBI:25350 (ChEBI)
PDIA2ProteinENSBTAG00000016575 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714
PLTPGeneProductENSBTAG00000000559 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360
PhospholipidMetaboliteC00865 (KEGG Compound)
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
SOAT1GeneProductENSBTAG00000004059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646
SQLEGeneProductENSBTAG00000005498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713
SqualeneMetaboliteHMDB00256 (HMDB)
StatinMetaboliteCHEBI:35664 (ChEBI)
TriglycerideMetaboliteC00422 (KEGG Compound)
VLDLMetaboliteC01834 (KEGG Compound)
bta-mir-33aGeneProductENSBTAG00000029975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932
bta-mir-33bGeneProductENSBTAG00000036437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839

Annotated Interactions

No annotated interactions
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